Details for: TSSK1B

Gene ID: 83942

Symbol: TSSK1B

Ensembl ID: ENSG00000212122

Description: testis specific serine kinase 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.2379
    Cell Significance Index: 3.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0887
    Cell Significance Index: 1.2100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0570
    Cell Significance Index: 0.8100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0524
    Cell Significance Index: 0.7000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0452
    Cell Significance Index: 0.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0405
    Cell Significance Index: 0.5800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0202
    Cell Significance Index: 0.2800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0080
    Cell Significance Index: 0.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0001
    Cell Significance Index: -0.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0026
    Cell Significance Index: -0.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0028
    Cell Significance Index: -1.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0029
    Cell Significance Index: -1.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0048
    Cell Significance Index: -2.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0053
    Cell Significance Index: -3.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0071
    Cell Significance Index: -0.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0078
    Cell Significance Index: -1.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0089
    Cell Significance Index: -0.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0102
    Cell Significance Index: -1.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0115
    Cell Significance Index: -1.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0123
    Cell Significance Index: -0.6400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0123
    Cell Significance Index: -0.5000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0135
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0140
    Cell Significance Index: -1.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0174
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0228
    Cell Significance Index: -3.8900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0304
    Cell Significance Index: -0.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0319
    Cell Significance Index: -1.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0324
    Cell Significance Index: -1.8200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0333
    Cell Significance Index: -0.4200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0394
    Cell Significance Index: -0.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0400
    Cell Significance Index: -1.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0403
    Cell Significance Index: -1.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0419
    Cell Significance Index: -1.3400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0463
    Cell Significance Index: -0.9700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0501
    Cell Significance Index: -0.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0507
    Cell Significance Index: -1.1100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0561
    Cell Significance Index: -2.0600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0569
    Cell Significance Index: -1.4200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0578
    Cell Significance Index: -0.6700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0593
    Cell Significance Index: -0.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0608
    Cell Significance Index: -1.6000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0632
    Cell Significance Index: -1.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0654
    Cell Significance Index: -1.5100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0667
    Cell Significance Index: -0.9000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0683
    Cell Significance Index: -0.8900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0710
    Cell Significance Index: -1.5400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0716
    Cell Significance Index: -1.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0721
    Cell Significance Index: -1.5300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0722
    Cell Significance Index: -1.4400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0723
    Cell Significance Index: -1.5100
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0753
    Cell Significance Index: -0.8600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0754
    Cell Significance Index: -0.9100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0772
    Cell Significance Index: -1.5500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0809
    Cell Significance Index: -2.0200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0834
    Cell Significance Index: -1.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0851
    Cell Significance Index: -2.0400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0854
    Cell Significance Index: -0.8200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0856
    Cell Significance Index: -1.4800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0856
    Cell Significance Index: -1.1000
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0861
    Cell Significance Index: -1.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0862
    Cell Significance Index: -1.4400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0866
    Cell Significance Index: -1.1100
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0874
    Cell Significance Index: -0.7800
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0875
    Cell Significance Index: -0.8300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0926
    Cell Significance Index: -1.2300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0930
    Cell Significance Index: -0.9500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0933
    Cell Significance Index: -0.9400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0953
    Cell Significance Index: -1.1200
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0954
    Cell Significance Index: -0.9500
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0977
    Cell Significance Index: -1.0400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0981
    Cell Significance Index: -0.8500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0983
    Cell Significance Index: -1.1600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0992
    Cell Significance Index: -1.1900
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1000
    Cell Significance Index: -0.9600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1004
    Cell Significance Index: -1.5300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1019
    Cell Significance Index: -1.1100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1029
    Cell Significance Index: -1.2300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1045
    Cell Significance Index: -0.6200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1055
    Cell Significance Index: -1.0000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1063
    Cell Significance Index: -1.5500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1076
    Cell Significance Index: -1.2800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1082
    Cell Significance Index: -1.3300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1106
    Cell Significance Index: -1.0700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1110
    Cell Significance Index: -1.0000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1114
    Cell Significance Index: -1.5300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1120
    Cell Significance Index: -0.9800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1129
    Cell Significance Index: -1.9300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1134
    Cell Significance Index: -1.3400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1144
    Cell Significance Index: -1.8400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1155
    Cell Significance Index: -1.6200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1156
    Cell Significance Index: -1.6200
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.1205
    Cell Significance Index: -0.8400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1208
    Cell Significance Index: -1.6700
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.1212
    Cell Significance Index: -1.2800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1223
    Cell Significance Index: -1.9800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1231
    Cell Significance Index: -1.6200
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.1233
    Cell Significance Index: -0.8900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1247
    Cell Significance Index: -1.2900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1257
    Cell Significance Index: -1.6400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1257
    Cell Significance Index: -1.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TSSK1B is a testis-specific gene, exclusively expressed in cells of the male reproductive system, including spermatids and other reproductive cells. Its expression is also found in other cell types, such as progenitor cells, microglial cells, and endothelial cells. The gene encodes a serine/threonine kinase enzyme, TSSK1_HUMAN, which shares sequence homology with other serine/threonine kinases. TSSK1B is characterized by its ability to phosphorylate and regulate various proteins, influencing cellular signaling pathways. **Pathways and Functions:** TSSK1B is involved in several cellular signaling pathways, including: 1. **Acrosomal vesicle formation**: TSSK1B plays a crucial role in regulating the formation of acrosomal vesicles, essential for sperm capacitation and fertilization. 2. **Protein phosphorylation**: As a serine/threonine kinase enzyme, TSSK1B phosphorylates and regulates various proteins, influencing cellular signaling pathways. 3. **Motile cilium**: TSSK1B is involved in regulating the motility of cilia, essential for maintaining cellular homeostasis and development. 4. **Protein binding**: TSSK1B interacts with various proteins, modulating their activity and function. **Clinical Significance:** TSSK1B's expression in different cell types suggests its involvement in various diseases and conditions. Some of the clinical significance of TSSK1B includes: 1. **Reproductive disorders**: Abnormal expression of TSSK1B in spermatids and other reproductive cells may contribute to male infertility and reproductive disorders. 2. **Cancer**: TSSK1B's role in regulating protein phosphorylation and signaling pathways makes it a potential target for cancer therapy. 3. **Neurological disorders**: TSSK1B's involvement in regulating cilia motility and protein binding may contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Inflammatory diseases**: TSSK1B's expression in microglial cells and other immune cells suggests its involvement in inflammatory diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, TSSK1B is a serine/threonine kinase enzyme with a complex role in various cellular processes. Its involvement in reproductive disorders, cancer, neurological disorders, and inflammatory diseases highlights the need for further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 2870860000

Symbol: TSSK1_HUMAN

Name: Testis-specific serine/threonine-protein kinase 1

UniProtKB Accession Codes:

Q9BXA7 B2R8D9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 13 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15044604

Title: Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm.

PubMed ID: 15044604

DOI: 10.1093/molehr/gah052

PubMed ID: 15733851

Title: Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate.

PubMed ID: 15733851

DOI: 10.1016/j.febslet.2005.01.042

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17566264

Title: Validation of a testis specific serine/threonine kinase [TSSK] family and the substrate of TSSK1 & 2, TSKS, as contraceptive targets.

PubMed ID: 17566264

PubMed ID: 19530700

Title: Identification of peptide substrate and small molecule inhibitors of testis-specific serine/threonine kinase1 (TSSK1) by the developed assays.

PubMed ID: 19530700

DOI: 10.1021/jm9002846

PubMed ID: 20729278

Title: Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis.

PubMed ID: 20729278

DOI: 10.1093/molehr/gaq071

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 367
  • Mass: 41618
  • Checksum: 1B740988894A1589
  • Sequence:
    • MDDAAVLKRR GYLLGINLGE GSYAKVKSAY SERLKFNVAI KIIDRKKAPA DFLEKFLPRE 
IEILAMLNHC SIIKTYEIFE TSHGKVYIVM ELAVQGDLLE LIKTRGALHE DEARKKFHQL 
SLAIKYCHDL DVVHRDLKCD NLLLDKDFNI KLSDFSFSKR CLRDDSGRMA LSKTFCGSPA 
YAAPEVLQGI PYQPKVYDIW SLGVILYIMV CGSMPYDDSN IKKMLRIQKE HRVNFPRSKH 
LTGECKDLIY HMLQPDVNRR LHIDEILSHC WMQPKARGSP SVAINKEGES SRGTEPLWTP 
EPGSDKKSAT KLEPEGEAQP QAQPETKPEG TAMQMSRQSE ILGFPSKPST METEEGPPQQ 
PPETRAQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.