Details for: PLA2G10

Gene ID: 8399

Symbol: PLA2G10

Ensembl ID: ENSG00000069764

Description: phospholipase A2 group X

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 6.7639
    Cell Significance Index: 101.3500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 5.7673
    Cell Significance Index: -3.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 4.0301
    Cell Significance Index: 182.6700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 3.2092
    Cell Significance Index: 34.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.9594
    Cell Significance Index: 153.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.0551
    Cell Significance Index: 334.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7682
    Cell Significance Index: 1596.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.6649
    Cell Significance Index: -4.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5476
    Cell Significance Index: 168.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4610
    Cell Significance Index: 170.2600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.3892
    Cell Significance Index: 14.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1313
    Cell Significance Index: 111.9100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.9243
    Cell Significance Index: 8.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9191
    Cell Significance Index: 32.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8246
    Cell Significance Index: 57.0300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.7631
    Cell Significance Index: 19.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6916
    Cell Significance Index: 19.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4512
    Cell Significance Index: 9.6100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.4024
    Cell Significance Index: 2.5000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.3805
    Cell Significance Index: 6.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2675
    Cell Significance Index: 50.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1472
    Cell Significance Index: 3.6800
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.1240
    Cell Significance Index: 1.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0942
    Cell Significance Index: 16.0800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0873
    Cell Significance Index: 2.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0726
    Cell Significance Index: 39.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0723
    Cell Significance Index: 13.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0557
    Cell Significance Index: 0.7600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0503
    Cell Significance Index: 0.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0252
    Cell Significance Index: 5.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0187
    Cell Significance Index: 14.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0186
    Cell Significance Index: 0.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0109
    Cell Significance Index: 0.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0106
    Cell Significance Index: 2.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0097
    Cell Significance Index: 0.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0063
    Cell Significance Index: 0.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0055
    Cell Significance Index: 0.6800
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.0034
    Cell Significance Index: 0.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0025
    Cell Significance Index: 0.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0014
    Cell Significance Index: 2.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0011
    Cell Significance Index: 2.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: 0.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0006
    Cell Significance Index: -0.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0010
    Cell Significance Index: -1.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0016
    Cell Significance Index: -0.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0054
    Cell Significance Index: -3.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0055
    Cell Significance Index: -4.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0066
    Cell Significance Index: -3.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0070
    Cell Significance Index: -3.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0078
    Cell Significance Index: -4.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0089
    Cell Significance Index: -4.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0105
    Cell Significance Index: -1.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0112
    Cell Significance Index: -3.2100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0116
    Cell Significance Index: -0.0800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0118
    Cell Significance Index: -0.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0127
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0139
    Cell Significance Index: -1.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0203
    Cell Significance Index: -4.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0280
    Cell Significance Index: -0.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0326
    Cell Significance Index: -3.3900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0371
    Cell Significance Index: -0.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0383
    Cell Significance Index: -2.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0384
    Cell Significance Index: -4.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0394
    Cell Significance Index: -2.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0399
    Cell Significance Index: -4.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0408
    Cell Significance Index: -2.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0426
    Cell Significance Index: -4.3500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0450
    Cell Significance Index: -0.5000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0475
    Cell Significance Index: -0.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0519
    Cell Significance Index: -3.8700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0531
    Cell Significance Index: -1.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0560
    Cell Significance Index: -1.5000
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0575
    Cell Significance Index: -0.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0588
    Cell Significance Index: -1.5700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0628
    Cell Significance Index: -0.1400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0651
    Cell Significance Index: -0.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0656
    Cell Significance Index: -1.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0657
    Cell Significance Index: -0.7500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0682
    Cell Significance Index: -1.0300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0702
    Cell Significance Index: -0.5100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0711
    Cell Significance Index: -1.0500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0726
    Cell Significance Index: -1.5900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0787
    Cell Significance Index: -0.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0814
    Cell Significance Index: -2.8500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0814
    Cell Significance Index: -1.1700
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0885
    Cell Significance Index: -0.8000
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0898
    Cell Significance Index: -0.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0907
    Cell Significance Index: -2.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0933
    Cell Significance Index: -4.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0934
    Cell Significance Index: -2.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0935
    Cell Significance Index: -3.0600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0941
    Cell Significance Index: -0.9600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0944
    Cell Significance Index: -1.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0967
    Cell Significance Index: -4.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0969
    Cell Significance Index: -2.4900
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.1037
    Cell Significance Index: -0.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1101
    Cell Significance Index: -4.0400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1102
    Cell Significance Index: -2.7500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1106
    Cell Significance Index: -2.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1112
    Cell Significance Index: -2.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Phospholipase A2 activity**: PLA2G10 is a phospholipase A2 enzyme that hydrolyzes phospholipids to produce lysophospholipids and free fatty acids. 2. **Multiple expression patterns**: PLA2G10 is expressed in various cell types, including immune cells, epithelial cells, and neurons. 3. **Regulation of inflammation**: PLA2G10 has been shown to regulate inflammation by modulating the production of pro-inflammatory mediators. 4. **Lipid metabolism**: PLA2G10 is involved in lipid metabolism, including the breakdown of phospholipids and the production of lysophospholipids. 5. **Cell signaling**: PLA2G10 can act as a signaling molecule, influencing various cellular processes, including cell proliferation, differentiation, and survival. **Pathways and Functions:** 1. **Inflammation**: PLA2G10 regulates inflammation by modulating the production of pro-inflammatory mediators, such as prostaglandins and leukotrienes. 2. **Lipid metabolism**: PLA2G10 is involved in the breakdown of phospholipids and the production of lysophospholipids, which are important for various cellular processes. 3. **Cell signaling**: PLA2G10 can act as a signaling molecule, influencing various cellular processes, including cell proliferation, differentiation, and survival. 4. **Acrosome reaction**: PLA2G10 has been shown to regulate the acrosome reaction, a critical step in fertilization. 5. **Immune response**: PLA2G10 is involved in the regulation of immune responses, including the activation of macrophages and the production of cytokines. **Clinical Significance:** 1. **Inflammatory disorders**: Dysregulation of PLA2G10 has been implicated in various inflammatory disorders, including arthritis, asthma, and inflammatory bowel disease. 2. **Cancer**: PLA2G10 has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer. 3. **Cardiovascular diseases**: PLA2G10 has been implicated in the development of cardiovascular diseases, including atherosclerosis and cardiovascular remodeling. 4. **Neurological disorders**: PLA2G10 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 5. **Fertilization**: PLA2G10 plays a critical role in fertilization, and dysregulation of PLA2G10 has been implicated in infertility. In conclusion, PLA2G10 is a complex gene that plays a critical role in various biological processes, including inflammation, lipid metabolism, and cell signaling. Its dysregulation has been implicated in various diseases, including inflammatory disorders, cancer, and cardiovascular diseases. Further research is needed to fully understand the role of PLA2G10 in human health and disease.

Genular Protein ID: 2735317643

Symbol: PA2GX_HUMAN

Name: Group 10 secretory phospholipase A2

UniProtKB Accession Codes:

O15496 Q14DU3 Q6NT23

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 55 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 44 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 6 RefSeq 1 Rhea 20 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9188469

Title: Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2.

PubMed ID: 9188469

DOI: 10.1074/jbc.272.25.15745

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11694541

Title: Bactericidal properties of human and murine groups I, II, V, X, and XII secreted phospholipases A(2).

PubMed ID: 11694541

DOI: 10.1074/jbc.m109699200

PubMed ID: 12021277

Title: Potent modification of low density lipoprotein by group X secretory phospholipase A2 is linked to macrophage foam cell formation.

PubMed ID: 12021277

DOI: 10.1074/jbc.m202867200

PubMed ID: 12359733

Title: Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2.

PubMed ID: 12359733

DOI: 10.1074/jbc.m205855200

PubMed ID: 16962371

Title: The proinflammatory mediator Platelet Activating Factor is an effective substrate for human group X secreted phospholipase A2.

PubMed ID: 16962371

DOI: 10.1016/j.bbalip.2006.08.004

PubMed ID: 16146426

Title: Group V and X secretory phospholipase A2 prevents adenoviral infection in mammalian cells.

PubMed ID: 16146426

DOI: 10.1042/bj20050781

PubMed ID: 21266581

Title: Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function.

PubMed ID: 21266581

DOI: 10.1074/jbc.m110.206755

PubMed ID: 12161451

Title: Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes.

PubMed ID: 12161451

DOI: 10.1074/jbc.m202531200

Sequence Information:

  • Length: 165
  • Mass: 18153
  • Checksum: AD197A164319F102
  • Sequence:
    • MGPLPVCLPI MLLLLLPSLL LLLLLPGPGS GEASRILRVH RRGILELAGT VGCVGPRTPI 
AYMKYGCFCG LGGHGQPRDA IDWCCHGHDC CYTRAEEAGC SPKTERYSWQ CVNQSVLCGP 
AENKCQELLC KCDQEIANCL AQTEYNLKYL FYPQFLCEPD SPKCD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.