Details for: OR6A2

Gene ID: 8590

Symbol: OR6A2

Ensembl ID: ENSG00000184933

Description: olfactory receptor family 6 subfamily A member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 6.3869
    Cell Significance Index: -1.6200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1328
    Cell Significance Index: 27.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.8252
    Cell Significance Index: 50.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7306
    Cell Significance Index: 23.4000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.4598
    Cell Significance Index: 5.9500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2635
    Cell Significance Index: 3.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1885
    Cell Significance Index: 18.6500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1861
    Cell Significance Index: 3.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1701
    Cell Significance Index: 6.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1671
    Cell Significance Index: 7.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1647
    Cell Significance Index: 148.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1397
    Cell Significance Index: 26.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1027
    Cell Significance Index: 2.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0981
    Cell Significance Index: 19.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0877
    Cell Significance Index: 3.0800
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.0716
    Cell Significance Index: 0.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0675
    Cell Significance Index: 3.0600
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0654
    Cell Significance Index: 0.8500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0650
    Cell Significance Index: 0.8500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0649
    Cell Significance Index: 0.9300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0599
    Cell Significance Index: 0.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0500
    Cell Significance Index: 8.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0495
    Cell Significance Index: 3.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0487
    Cell Significance Index: 5.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0475
    Cell Significance Index: 2.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0455
    Cell Significance Index: 1.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0445
    Cell Significance Index: 15.9800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.0313
    Cell Significance Index: 0.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0282
    Cell Significance Index: 0.6000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: 0.0246
    Cell Significance Index: 0.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0192
    Cell Significance Index: 3.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0155
    Cell Significance Index: 1.0800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0112
    Cell Significance Index: 0.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0072
    Cell Significance Index: 0.1800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0029
    Cell Significance Index: 0.0300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0021
    Cell Significance Index: 0.0300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0010
    Cell Significance Index: 0.0200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: 0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -1.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0008
    Cell Significance Index: -1.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0012
    Cell Significance Index: -1.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0015
    Cell Significance Index: -0.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0021
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0021
    Cell Significance Index: -0.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0022
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0026
    Cell Significance Index: -1.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0027
    Cell Significance Index: -1.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0029
    Cell Significance Index: -1.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0046
    Cell Significance Index: -0.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0049
    Cell Significance Index: -0.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0051
    Cell Significance Index: -0.1100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0072
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0078
    Cell Significance Index: -1.6400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0086
    Cell Significance Index: -0.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0086
    Cell Significance Index: -0.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0087
    Cell Significance Index: -1.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0093
    Cell Significance Index: -1.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0105
    Cell Significance Index: -0.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0109
    Cell Significance Index: -1.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0134
    Cell Significance Index: -1.5800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0137
    Cell Significance Index: -0.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0139
    Cell Significance Index: -1.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0160
    Cell Significance Index: -0.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0188
    Cell Significance Index: -0.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0191
    Cell Significance Index: -0.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0194
    Cell Significance Index: -1.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0216
    Cell Significance Index: -1.6600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0217
    Cell Significance Index: -0.2300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0235
    Cell Significance Index: -0.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0239
    Cell Significance Index: -0.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0244
    Cell Significance Index: -0.8000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0257
    Cell Significance Index: -0.2800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0267
    Cell Significance Index: -0.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0286
    Cell Significance Index: -0.3900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0289
    Cell Significance Index: -0.3900
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0298
    Cell Significance Index: -0.3100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0301
    Cell Significance Index: -0.7500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0329
    Cell Significance Index: -0.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0330
    Cell Significance Index: -1.5500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0360
    Cell Significance Index: -0.7700
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0382
    Cell Significance Index: -0.3900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0393
    Cell Significance Index: -0.5100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0398
    Cell Significance Index: -0.6800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0443
    Cell Significance Index: -1.1100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0463
    Cell Significance Index: -1.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0487
    Cell Significance Index: -1.3000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0501
    Cell Significance Index: -0.6100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0506
    Cell Significance Index: -1.0000
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.0506
    Cell Significance Index: -0.5000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0510
    Cell Significance Index: -0.6200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0531
    Cell Significance Index: -0.6400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0531
    Cell Significance Index: -1.6800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0546
    Cell Significance Index: -0.8300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0552
    Cell Significance Index: -0.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0567
    Cell Significance Index: -1.6300
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.0574
    Cell Significance Index: -0.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0597
    Cell Significance Index: -1.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR6A2 is a G protein-coupled receptor (GPCR) that belongs to the olfactory receptor family. Its primary function is to detect chemical stimuli, triggering a signaling cascade that ultimately leads to the perception of smell. The gene is characterized by its ability to bind to specific odorant molecules, which activates the receptor and initiates a signaling pathway that involves G proteins and downstream effectors. OR6A2 is also notable for its expression in various cell types, including those in the central nervous system, such as GABAergic interneurons in the cerebral cortex. **Pathways and Functions:** OR6A2's involvement in sensory perception is mediated through its activation of the olfactory signaling pathway. This pathway involves the binding of odorant molecules to OR6A2, which triggers a conformational change in the receptor. This change activates G proteins, which in turn activate downstream effectors, such as adenylyl cyclase, leading to the production of cyclic AMP (cAMP). The increase in cAMP levels triggers a cascade of downstream signaling events that ultimately lead to the perception of smell. In addition to its role in sensory perception, OR6A2 has been implicated in various other biological processes, including: * Expression and translocation of olfactory receptors: OR6A2 plays a crucial role in the expression and translocation of olfactory receptors to the plasma membrane, where they can interact with odorant molecules. * G protein-coupled receptor activity: OR6A2's ability to activate G proteins and downstream effectors makes it a prime example of a GPCR. * Signal transduction: OR6A2's involvement in the olfactory signaling pathway highlights its role in signal transduction, a critical process that underlies many biological functions. **Clinical Significance:** OR6A2's involvement in sensory perception has significant implications for the diagnosis and treatment of olfactory disorders. For example, mutations in OR6A2 have been associated with Kallmann syndrome, a rare genetic disorder characterized by impaired olfaction and hypogonadism. Furthermore, OR6A2's role in the olfactory signaling pathway makes it a potential target for the development of novel therapeutic agents for the treatment of olfactory disorders. In addition to its role in sensory perception, OR6A2's involvement in other biological processes makes it a potential target for the diagnosis and treatment of various diseases, including: * Cancer: OR6A2's expression in various cell types, including those in the central nervous system, makes it a potential biomarker for cancer diagnosis and treatment. * Neurological disorders: OR6A2's involvement in the olfactory signaling pathway makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, OR6A2 is a gene that plays a critical role in sensory perception and has far-reaching implications in various biological processes. Its involvement in the olfactory signaling pathway makes it a potential target for the diagnosis and treatment of olfactory disorders, as well as other diseases. Further research is needed to fully elucidate the mechanisms underlying OR6A2's functions and to explore its potential therapeutic applications.

Genular Protein ID: 4264371952

Symbol: OR6A2_HUMAN

Name: Olfactory receptor 6A2

UniProtKB Accession Codes:

O95222 Q3MJC7 Q6IF35 Q9H206

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9787077

Title: Organization and evolution of olfactory receptor genes on human chromosome 11.

PubMed ID: 9787077

DOI: 10.1006/geno.1998.5422

PubMed ID: 11416212

Title: Genomic analysis of orthologous mouse and human olfactory receptor loci.

PubMed ID: 11416212

DOI: 10.1073/pnas.131215398

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 327
  • Mass: 36154
  • Checksum: 9C11914D3F069FC1
  • Sequence:
    • MEWRNHSGRV SEFVLLGFPA PAPLQVLLFA LLLLAYVLVL TENTLIIMAI RNHSTLHKPM 
YFFLANMSFL EIWYVTVTIP KMLAGFVGSK QDHGQLISFE GCMTQLYFFL GLGCTECVLL 
AVMAYDRYMA ICYPLHYPVI VSGRLCVQMA AGSWAGGFGI SMVKVFLISG LSYCGPNIIN 
HFFCDVSPLL NLSCTDMSTA ELTDFILAIF ILLGPLSVTG ASYVAITGAV MHIPSAAGRY 
KAFSTCASHL TVVIIFYAAS IFIYARPKAL SAFDTNKLVS VLYAVIVPLL NPIIYCLRNQ 
EVKRALCCTL HLYQHQDPDP KKASRNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.