EDEM1 | ENSG00000134109 | NCBI 9695

Details for: EDEM1

Gene ID: 9695

Symbol: EDEM1

Ensembl ID: ENSG00000134109

Description: ER degradation enhancing alpha-mannosidase like protein 1

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Calnexin/calreticulin cycle
(R-HSA-901042)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Er quality control compartment (erqc)
(R-HSA-901032)
Ire1alpha activates chaperones
(R-HSA-381070)
Metabolism of proteins
(R-HSA-392499)
N-glycan trimming in the er and calnexin/calreticulin cycle
(R-HSA-532668)
Post-translational protein modification
(R-HSA-597592)
Unfolded protein response (upr)
(R-HSA-381119)
Xbp1(s) activates chaperone genes
(R-HSA-381038)
Aggresome
(GO:0016235)
Calcium ion binding
(GO:0005509)
Carbohydrate metabolic process
(GO:0005975)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum mannose trimming
(GO:1904380)
Endoplasmic reticulum membrane
(GO:0005789)
Endoplasmic reticulum quality control compartment
(GO:0044322)
Erad pathway
(GO:0036503)
Mannoprotein catabolic process
(GO:0006058)
Mannose trimming involved in glycoprotein erad pathway
(GO:1904382)
Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
(GO:0004571)
Misfolded protein binding
(GO:0051787)
Positive regulation of retrograde protein transport, er to cytosol
(GO:1904154)
Protein binding
(GO:0005515)
Protein targeting to er
(GO:0045047)
Response to unfolded protein
(GO:0006986)
Ubiquitin-dependent protein catabolic process
(GO:0006511)

Other Information

Proteins

ER degradation-enhancing alpha-mannosidase-like protein 1

Genular Protein ID: 1403086130

Symbol: EDEM1_HUMAN

Name: ER degradation-enhancing alpha-mannosidase-like protein 1

UniProtKB Accession Codes:

Q92611 A8K9C8 B4DXP3

Database IDs:

Citations:

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12610306

Title: Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle.

PubMed ID: 12610306

DOI: 10.1126/science.1079474

PubMed ID: 16449189

Title: Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation.

PubMed ID: 16449189

DOI: 10.1083/jcb.200507057

PubMed ID: 19934218

Title: A dual role for EDEM1 in the processing of rod opsin.

PubMed ID: 19934218

DOI: 10.1242/jcs.055228

PubMed ID: 19524542

Title: EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex.

PubMed ID: 19524542

DOI: 10.1016/j.molcel.2009.05.018

PubMed ID: 25092655

Title: EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step.

PubMed ID: 25092655

DOI: 10.1083/jcb.201404075

Sequence Information:

Length: 657
Mass: 73768
Checksum: E0097901B3BF02FB
Sequence:

MQWRALVLGL VLLRLGLHGV LWLVFGLGPS MGFYQRFPLS FGFQRLRSPD GPASPTSGPV 
GRPGGVSGPS WLQPPGTGAA QSPRKAPRRP GPGMCGPANW GYVLGGRGRG PDEYEKRYSG 
AFPPQLRAQM RDLARGMFVF GYDNYMAHAF PQDELNPIHC RGRGPDRGDP SNLNINDVLG 
NYSLTLVDAL DTLAIMGNSS EFQKAVKLVI NTVSFDKDST VQVFEATIRV LGSLLSAHRI 
ITDSKQPFGD MTIKDYDNEL LYMAHDLAVR LLPAFENTKT GIPYPRVNLK TGVPPDTNNE 
TCTAGAGSLL VEFGILSRLL GDSTFEWVAR RAVKALWNLR SNDTGLLGNV VNIQTGHWVG 
KQSGLGAGLD SFYEYLLKSY ILFGEKEDLE MFNAAYQSIQ NYLRRGREAC NEGEGDPPLY 
VNVNMFSGQL MNTWIDSLQA FFPGLQVLIG DVEDAICLHA FYYAIWKRYG ALPERYNWQL 
QAPDVLFYPL RPELVESTYL LYQATKNPFY LHVGMDILQS LEKYTKVKCG YATLHHVIDK 
STEDRMESFF LSETCKYLYL LFDEDNPVHK SGTRYMFTTE GHIVSVDEHL RELPWKEFFS 
EEGGQDQGGK SVHRPKPHEL KVINSSSNCN RVPDERRYSL PLKSIYMRQI DQMVGLI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: EDEM1

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. PubMed ID: 9039502

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle. PubMed ID: 12610306

Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. PubMed ID: 16449189

A dual role for EDEM1 in the processing of rod opsin. PubMed ID: 19934218

EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex. PubMed ID: 19524542

EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step. PubMed ID: 25092655