Details for: ACTN4
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 4.94
Marker Score: 87,763 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 3.95
Marker Score: 3,769 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 3.92
Marker Score: 3,383 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 3.7
Marker Score: 15,411 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 3.5
Marker Score: 17,172 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 3.04
Marker Score: 9,548 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.03
Marker Score: 2,153 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.96
Marker Score: 7,218 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.89
Marker Score: 3,043 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 2.83
Marker Score: 5,979 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.82
Marker Score: 17,960 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.76
Marker Score: 5,319 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.71
Marker Score: 5,950 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 2.58
Marker Score: 1,754 - Cell Name: basal cell (CL0000646)
Fold Change: 2.57
Marker Score: 3,323 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.56
Marker Score: 9,073 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 2.55
Marker Score: 57,055 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.53
Marker Score: 6,381 - Cell Name: podocyte (CL0000653)
Fold Change: 2.51
Marker Score: 928 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.5
Marker Score: 10,470 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.5
Marker Score: 790 - Cell Name: lymphocyte (CL0000542)
Fold Change: 2.49
Marker Score: 1,260 - Cell Name: enterocyte (CL0000584)
Fold Change: 2.49
Marker Score: 11,955 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.48
Marker Score: 1,955 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.46
Marker Score: 85,197 - Cell Name: intestine goblet cell (CL0019031)
Fold Change: 2.44
Marker Score: 2,341 - Cell Name: supporting cell (CL0000630)
Fold Change: 2.43
Marker Score: 4,571 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.41
Marker Score: 6,667 - Cell Name: acinar cell (CL0000622)
Fold Change: 2.41
Marker Score: 1,702 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.4
Marker Score: 2,568 - Cell Name: endothelial cell (CL0000115)
Fold Change: 2.4
Marker Score: 2,153 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 2.4
Marker Score: 691 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 2.35
Marker Score: 2,530 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.32
Marker Score: 1,384 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 2.3
Marker Score: 2,168 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.29
Marker Score: 3,370 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 2.29
Marker Score: 3,074 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 2.29
Marker Score: 1,519 - Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 2.27
Marker Score: 5,769 - Cell Name: hepatoblast (CL0005026)
Fold Change: 2.26
Marker Score: 7,395 - Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 2.24
Marker Score: 2,405 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.21
Marker Score: 17,252 - Cell Name: stromal cell (CL0000499)
Fold Change: 2.21
Marker Score: 2,586 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.2
Marker Score: 5,909 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.18
Marker Score: 16,250 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.18
Marker Score: 4,349 - Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.18
Marker Score: 823 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 2.17
Marker Score: 1,454 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.17
Marker Score: 3,845 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.17
Marker Score: 538 - Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 2.15
Marker Score: 2,802 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.15
Marker Score: 2,374 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.15
Marker Score: 1,251 - Cell Name: endocardial cell (CL0002350)
Fold Change: 2.14
Marker Score: 1,207 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.12
Marker Score: 18,303 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.11
Marker Score: 1,228 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 2.11
Marker Score: 1,387 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 2.11
Marker Score: 2,187 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.09
Marker Score: 1,854 - Cell Name: epithelial cell (CL0000066)
Fold Change: 2.07
Marker Score: 3,300 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 2.07
Marker Score: 527 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.07
Marker Score: 3,008 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.05
Marker Score: 4,820 - Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.05
Marker Score: 727 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 2.04
Marker Score: 1,755 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.04
Marker Score: 3,380 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.03
Marker Score: 486 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.02
Marker Score: 2,864 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 2.02
Marker Score: 2,437 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2
Marker Score: 2,126 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.99
Marker Score: 1,634 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.98
Marker Score: 856 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.98
Marker Score: 579 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.97
Marker Score: 2,000 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.97
Marker Score: 566 - Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.96
Marker Score: 2,841 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.96
Marker Score: 5,334 - Cell Name: erythroblast (CL0000765)
Fold Change: 1.94
Marker Score: 1,209 - Cell Name: club cell (CL0000158)
Fold Change: 1.93
Marker Score: 2,255 - Cell Name: contractile cell (CL0000183)
Fold Change: 1.93
Marker Score: 1,046 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.93
Marker Score: 619 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.92
Marker Score: 12,515 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.91
Marker Score: 30,683 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.91
Marker Score: 21,520 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.91
Marker Score: 1,904 - Cell Name: secretory cell (CL0000151)
Fold Change: 1.91
Marker Score: 3,486 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.91
Marker Score: 2,194 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.9
Marker Score: 889 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.9
Marker Score: 2,298 - Cell Name: stem cell (CL0000034)
Fold Change: 1.89
Marker Score: 4,492 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.89
Marker Score: 4,284 - Cell Name: pneumocyte (CL0000322)
Fold Change: 1.89
Marker Score: 3,032 - Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.88
Marker Score: 16,330 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.88
Marker Score: 7,232 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.87
Marker Score: 889 - Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.87
Marker Score: 1,692 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.87
Marker Score: 3,068 - Cell Name: endocrine cell (CL0000163)
Fold Change: 1.86
Marker Score: 964 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.86
Marker Score: 4,442 - Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 1.85
Marker Score: 1,862
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 135020461
Symbol: ACTN4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10656685
Title: The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells.
PubMed ID: 10656685
PubMed ID: 22567897
Title: Novel splicing isoform of actin-binding protein alpha-actinin 4 in epidermoid carcinoma cells A431.
PubMed ID: 22567897
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16344560
Title: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
PubMed ID: 16344560
DOI: 10.1101/gr.4039406
PubMed ID: 9508771
Title: Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion.
PubMed ID: 9508771
PubMed ID: 12042308
Title: Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
PubMed ID: 12042308
PubMed ID: 15772161
Title: CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling.
PubMed ID: 15772161
PubMed ID: 17289661
Title: Molecular composition of IMP1 ribonucleoprotein granules.
PubMed ID: 17289661
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 33228246
Title: ACTN4 Mediates SEPT14 Mutation-Induced Sperm Head Defects.
PubMed ID: 33228246
PubMed ID: 15988023
Title: Structural dynamics of alpha-actinin-vinculin interactions.
PubMed ID: 15988023
PubMed ID: 18164029
Title: Crystal structure of the actin-binding domain of alpha-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis.
PubMed ID: 18164029
PubMed ID: 22351778
Title: Familial focal segmental glomerulosclerosis (FSGS)-linked alpha-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors.
PubMed ID: 22351778
PubMed ID: 10700177
Title: Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis.
PubMed ID: 10700177
DOI: 10.1038/73456
PubMed ID: 18436095
Title: Familial focal segmental glomerulosclerosis associated with an ACTN4 mutation and paternal germline mosaicism.
PubMed ID: 18436095
PubMed ID: 22732337
Title: Mutations in podocyte genes are a rare cause of primary FSGS associated with ESRD in adult patients.
PubMed ID: 22732337
DOI: 10.5414/cn107320
PubMed ID: 23890478
Title: Mutational analysis of ACTN4, encoding alpha-actinin 4, in patients with focal segmental glomerulosclerosis using HRM method.
PubMed ID: 23890478
PubMed ID: 23014460
Title: Mutations in the INF2 gene account for a significant proportion of familial but not sporadic focal and segmental glomerulosclerosis.
PubMed ID: 23014460
DOI: 10.1038/ki.2012.349
Sequence Information:
- Length: 911
- Mass: 104854
- Checksum: 461580C3F22937D1
- Sequence:
MVDYHAANQS YQYGPSSAGN GAGGGGSMGD YMAQEDDWDR DLLLDPAWEK QQRKTFTAWC NSHLRKAGTQ IENIDEDFRD GLKLMLLLEV ISGERLPKPE RGKMRVHKIN NVNKALDFIA SKGVKLVSIG AEEIVDGNAK MTLGMIWTII LRFAIQDISV EETSAKEGLL LWCQRKTAPY KNVNVQNFHI SWKDGLAFNA LIHRHRPELI EYDKLRKDDP VTNLNNAFEV AEKYLDIPKM LDAEDIVNTA RPDEKAIMTY VSSFYHAFSG AQKAETAANR ICKVLAVNQE NEHLMEDYEK LASDLLEWIR RTIPWLEDRV PQKTIQEMQQ KLEDFRDYRR VHKPPKVQEK CQLEINFNTL QTKLRLSNRP AFMPSEGKMV SDINNGWQHL EQAEKGYEEW LLNEIRRLER LDHLAEKFRQ KASIHEAWTD GKEAMLKHRD YETATLSDIK ALIRKHEAFE SDLAAHQDRV EQIAAIAQEL NELDYYDSHN VNTRCQKICD QWDALGSLTH SRREALEKTE KQLEAIDQLH LEYAKRAAPF NNWMESAMED LQDMFIVHTI EEIEGLISAH DQFKSTLPDA DREREAILAI HKEAQRIAES NHIKLSGSNP YTTVTPQIIN SKWEKVQQLV PKRDHALLEE QSKQQSNEHL RRQFASQANV VGPWIQTKME EIGRISIEMN GTLEDQLSHL KQYERSIVDY KPNLDLLEQQ HQLIQEALIF DNKHTNYTME HIRVGWEQLL TTIARTINEV ENQILTRDAK GISQEQMQEF RASFNHFDKD HGGALGPEEF KACLISLGYD VENDRQGEAE FNRIMSLVDP NHSGLVTFQA FIDFMSRETT DTDTADQVIA SFKVLAGDKN FITAEELRRE LPPDQAEYCI ARMAPYQGPD AVPGALDYKS FSTALYGESD L
Genular Protein ID: 2303997419
Symbol: H7C144_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 906
- Mass: 104327
- Checksum: 85B7706D09DAFED7
- Sequence:
MVDYHAANQS YQYGPSSAGN GAGGGGSMGD YMAQEDDWDR DLLLDPAWEK QQRKTFTAWC NSHLRKAGTQ IENIDEDFRD GLKLMLLLEV ISGERLPKPE RGKMRVHKIN NVNKALDFIA SKGVKLVSIG AEEIVDGNAK MTLGMIWTII LRFAIQDISV EETSAKEGLL LWCQRKTAPY KNVNVQNFHI SWKDGLAFNA LIHRHRPELI EYDKLRKDDP VTNLNNAFEV AEKYLDIPKM LDAEDIVGTL RPDEKAIMTY VSCFYHAFSG AQKAETAANR ICKVLAVNQE NEHLMEDYEK LASDLLEWIR RTIPWLEDRV PQKTIQEMQQ KLEDFRDYRR VHKPPKVQEK CQLEINFNTL QTKLRLSNRP AFMPSEGKMV SDINNGWQHL EQAEKGYEEW LLNEIRRLER LDHLAEKFRQ KASIHEAWTD GKEAMLKHRD YETATLSDIK ALIRKHEAFE SDLAAHQDRV EQIAAIAQEL NELDYYDSHN VNTRCQKICD QWDALGSLTH SRREALEKTE KQLEAIDQLH LEYAKRAAPF NNWMESAMED LQDMFIVHTI EEIEGLISAH DQFKSTLPDA DREREAILAI HKEAQRIAES NHIKLSGSNP YTTVTPQIIN SKWEKVQQLV PKRDHALLEE QSKQQSNEHL RRQFASQANV VGPWIQTKME EIGRISIEMN GTLEDQLSHL KQYERSIVDY KPNLDLLEQQ HQLIQEALIF DNKHTNYTME HIRVGWEQLL TTIARTINEV ENQILTRDAK GISQEQMQEF RASFNHFDKK QTGSMDSDDF RALLISTGYS LGEAEFNRIM SLVDPNHSGL VTFQAFIDFM SRETTDTDTA DQVIASFKVL AGDKNFITAE ELRRELPPDQ AEYCIARMAP YQGPDAVPGA LDYKSFSTAL YGESDL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.