Details for: ACTN1
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 3.28
Marker Score: 4,267 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 3.23
Marker Score: 15,849 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.06
Marker Score: 6,707 - Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.73
Marker Score: 1,033 - Cell Name: endocardial cell (CL0002350)
Fold Change: 2.72
Marker Score: 1,536 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.7
Marker Score: 853 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.68
Marker Score: 2,555 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.62
Marker Score: 6,155 - Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.53
Marker Score: 3,473 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.28
Marker Score: 8,794 - Cell Name: elicited macrophage (CL0000861)
Fold Change: 2.25
Marker Score: 13,651 - Cell Name: contractile cell (CL0000183)
Fold Change: 2.23
Marker Score: 1,210 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.23
Marker Score: 3,955 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.23
Marker Score: 4,282 - Cell Name: myofibroblast cell (CL0000186)
Fold Change: 2.18
Marker Score: 2,696 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 2.17
Marker Score: 1,431 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.16
Marker Score: 4,917 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.13
Marker Score: 1,247 - Cell Name: decidual cell (CL2000002)
Fold Change: 2.09
Marker Score: 9,025 - Cell Name: supporting cell (CL0000630)
Fold Change: 2.08
Marker Score: 3,917 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.07
Marker Score: 3,007 - Cell Name: muscle cell (CL0000187)
Fold Change: 2.02
Marker Score: 571 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.98
Marker Score: 505 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.96
Marker Score: 4,777 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.95
Marker Score: 1,163 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.92
Marker Score: 117,848 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.91
Marker Score: 1,090 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.89
Marker Score: 24,987 - Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.89
Marker Score: 671 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.88
Marker Score: 455 - Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.86
Marker Score: 545 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.83
Marker Score: 1,303 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.81
Marker Score: 17,177 - Cell Name: preosteoblast (CL0007010)
Fold Change: 1.8
Marker Score: 510 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.8
Marker Score: 15,429 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.79
Marker Score: 6,931 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.79
Marker Score: 13,742 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.79
Marker Score: 7,021 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.78
Marker Score: 7,462 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.76
Marker Score: 1,503 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.75
Marker Score: 2,964 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.75
Marker Score: 19,664 - Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.74
Marker Score: 391 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.73
Marker Score: 720 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.72
Marker Score: 44,124 - Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.71
Marker Score: 1,549 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.68
Marker Score: 615 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.68
Marker Score: 63,806 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.66
Marker Score: 24,751 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.64
Marker Score: 955 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.64
Marker Score: 764 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.61
Marker Score: 387 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.6
Marker Score: 6,652 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.58
Marker Score: 878 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.57
Marker Score: 2,639 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.57
Marker Score: 3,136 - Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 1.57
Marker Score: 333 - Cell Name: pericyte (CL0000669)
Fold Change: 1.56
Marker Score: 912 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1.56
Marker Score: 651 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.56
Marker Score: 2,402 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.55
Marker Score: 754 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.53
Marker Score: 3,814 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.52
Marker Score: 51,629 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.52
Marker Score: 1,746 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.51
Marker Score: 84,341 - Cell Name: osteoclast (CL0000092)
Fold Change: 1.5
Marker Score: 749 - Cell Name: rod bipolar cell (CL0000751)
Fold Change: 1.48
Marker Score: 771 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.48
Marker Score: 5,245 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.46
Marker Score: 920 - Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 1.45
Marker Score: 906 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.45
Marker Score: 1,753 - Cell Name: mural cell (CL0008034)
Fold Change: 1.45
Marker Score: 166,277 - Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.45
Marker Score: 360 - Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.43
Marker Score: 360 - Cell Name: fibroblast (CL0000057)
Fold Change: 1.42
Marker Score: 1,368 - Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.4
Marker Score: 1,964 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.39
Marker Score: 3,650 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.39
Marker Score: 1,748 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.38
Marker Score: 12,953 - Cell Name: endothelial cell (CL0000115)
Fold Change: 1.38
Marker Score: 1,233 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 1.37
Marker Score: 3,917 - Cell Name: myelocyte (CL0002193)
Fold Change: 1.37
Marker Score: 591 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.36
Marker Score: 1,415 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.35
Marker Score: 1,200 - Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.35
Marker Score: 427 - Cell Name: neutrophil (CL0000775)
Fold Change: 1.35
Marker Score: 821 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.33
Marker Score: 1,331 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.33
Marker Score: 1,606 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.32
Marker Score: 1,948 - Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 1.32
Marker Score: 456 - Cell Name: ependymal cell (CL0000065)
Fold Change: 1.32
Marker Score: 459 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.31
Marker Score: 507 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.29
Marker Score: 20,238 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.29
Marker Score: 376 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.29
Marker Score: 3,030 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.28
Marker Score: 13,224 - Cell Name: platelet (CL0000233)
Fold Change: 1.28
Marker Score: 579 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.28
Marker Score: 743 - Cell Name: keratinocyte (CL0000312)
Fold Change: 1.28
Marker Score: 1,065 - Cell Name: hepatocyte (CL0000182)
Fold Change: 1.26
Marker Score: 860
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1668419499
Symbol: ACTN1_HUMAN
Name: Alpha-actinin-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2780298
Title: The cDNA sequence of a human placental alpha-actinin.
PubMed ID: 2780298
PubMed ID: 2349951
Title: Cloning and chromosomal localization of the human cytoskeletal alpha-actinin gene reveals linkage to the beta-spectrin gene.
PubMed ID: 2349951
PubMed ID: 18353764
Title: Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis.
PubMed ID: 18353764
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2169343
Title: Expression of human alpha-actinin in human hepatocellular carcinoma.
PubMed ID: 2169343
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 8713105
Title: Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes.
PubMed ID: 8713105
PubMed ID: 7750553
Title: Identification of the cytoskeletal protein alpha-actinin as a platelet thrombospondin-binding protein.
PubMed ID: 7750553
PubMed ID: 10369880
Title: Myotilin, a novel sarcomeric protein with two Ig-like domains, is encoded by a candidate gene for limb-girdle muscular dystrophy.
PubMed ID: 10369880
DOI: 10.1093/hmg/8.7.1329
PubMed ID: 11114196
Title: Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.
PubMed ID: 11114196
PubMed ID: 11369769
Title: The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase.
PubMed ID: 11369769
PubMed ID: 12615977
Title: The lipoma preferred partner LPP interacts with alpha-actinin.
PubMed ID: 12615977
DOI: 10.1242/jcs.00309
PubMed ID: 16464232
Title: Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring.
PubMed ID: 16464232
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 16698282
Title: Crystal structure of the actin-binding domain of alpha-actinin 1: evaluating two competing actin-binding models.
PubMed ID: 16698282
PubMed ID: 23434115
Title: ACTN1 mutations cause congenital macrothrombocytopenia.
PubMed ID: 23434115
PubMed ID: 24069336
Title: A missense mutation in the alpha-actinin 1 gene (ACTN1) is the cause of autosomal dominant macrothrombocytopenia in a large French family.
PubMed ID: 24069336
Sequence Information:
- Length: 892
- Mass: 103058
- Checksum: 6DA3E4D1A0289519
- Sequence:
MDHYDSQQTN DYMQPEEDWD RDLLLDPAWE KQQRKTFTAW CNSHLRKAGT QIENIEEDFR DGLKLMLLLE VISGERLAKP ERGKMRVHKI SNVNKALDFI ASKGVKLVSI GAEEIVDGNV KMTLGMIWTI ILRFAIQDIS VEETSAKEGL LLWCQRKTAP YKNVNIQNFH ISWKDGLGFC ALIHRHRPEL IDYGKLRKDD PLTNLNTAFD VAEKYLDIPK MLDAEDIVGT ARPDEKAIMT YVSSFYHAFS GAQKAETAAN RICKVLAVNQ ENEQLMEDYE KLASDLLEWI RRTIPWLENR VPENTMHAMQ QKLEDFRDYR RLHKPPKVQE KCQLEINFNT LQTKLRLSNR PAFMPSEGRM VSDINNAWGC LEQVEKGYEE WLLNEIRRLE RLDHLAEKFR QKASIHEAWT DGKEAMLRQK DYETATLSEI KALLKKHEAF ESDLAAHQDR VEQIAAIAQE LNELDYYDSP SVNARCQKIC DQWDNLGALT QKRREALERT EKLLETIDQL YLEYAKRAAP FNNWMEGAME DLQDTFIVHT IEEIQGLTTA HEQFKATLPD ADKERLAILG IHNEVSKIVQ TYHVNMAGTN PYTTITPQEI NGKWDHVRQL VPRRDQALTE EHARQQHNER LRKQFGAQAN VIGPWIQTKM EEIGRISIEM HGTLEDQLSH LRQYEKSIVN YKPKIDQLEG DHQLIQEALI FDNKHTNYTM EHIRVGWEQL LTTIARTINE VENQILTRDA KGISQEQMNE FRASFNHFDR DHSGTLGPEE FKACLISLGY DIGNDPQGEA EFARIMSIVD PNRLGVVTFQ AFIDFMSRET ADTDTADQVM ASFKILAGDK NYITMDELRR ELPPDQAEYC IARMAPYTGP DSVPGALDYM SFSTALYGES DL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.