Details for: RUVBL1 AS1

Gene ID: 100874089

Symbol: RUVBL1 AS1

Ensembl ID: ENSG00000239608

Description: RUVBL1 antisense RNA 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0068
    Cell Significance Index: 0.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0021
    Cell Significance Index: 0.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0004
    Cell Significance Index: 0.1600
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.0001
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0003
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0017
    Cell Significance Index: -0.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0025
    Cell Significance Index: -3.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0028
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0053
    Cell Significance Index: -2.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0079
    Cell Significance Index: -1.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0081
    Cell Significance Index: -0.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0095
    Cell Significance Index: -1.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0117
    Cell Significance Index: -1.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0128
    Cell Significance Index: -0.2500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0151
    Cell Significance Index: -0.2200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0154
    Cell Significance Index: -0.2600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0156
    Cell Significance Index: -0.2300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0162
    Cell Significance Index: -0.2600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0165
    Cell Significance Index: -0.2000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0186
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0186
    Cell Significance Index: -2.1300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0194
    Cell Significance Index: -0.2100
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0219
    Cell Significance Index: -0.2400
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0230
    Cell Significance Index: -0.2200
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0231
    Cell Significance Index: -0.2500
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0236
    Cell Significance Index: -0.2500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0238
    Cell Significance Index: -0.2600
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0242
    Cell Significance Index: -0.2500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0253
    Cell Significance Index: -0.2400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0262
    Cell Significance Index: -0.6400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0286
    Cell Significance Index: -0.2600
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0289
    Cell Significance Index: -0.2300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0297
    Cell Significance Index: -0.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0298
    Cell Significance Index: -1.3500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0304
    Cell Significance Index: -0.2400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0306
    Cell Significance Index: -0.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0312
    Cell Significance Index: -2.1000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0318
    Cell Significance Index: -0.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0322
    Cell Significance Index: -1.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0335
    Cell Significance Index: -2.5700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0337
    Cell Significance Index: -0.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0351
    Cell Significance Index: -1.6500
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.0399
    Cell Significance Index: -0.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0458
    Cell Significance Index: -1.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0458
    Cell Significance Index: -2.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0468
    Cell Significance Index: -1.4900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0504
    Cell Significance Index: -0.8100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0525
    Cell Significance Index: -1.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0534
    Cell Significance Index: -1.8700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0540
    Cell Significance Index: -0.7200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0542
    Cell Significance Index: -0.9200
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.0544
    Cell Significance Index: -0.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0549
    Cell Significance Index: -2.4300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0569
    Cell Significance Index: -0.6000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0597
    Cell Significance Index: -1.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0642
    Cell Significance Index: -1.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0647
    Cell Significance Index: -2.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0652
    Cell Significance Index: -1.7400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0704
    Cell Significance Index: -1.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0711
    Cell Significance Index: -1.5100
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.0719
    Cell Significance Index: -0.2500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0724
    Cell Significance Index: -1.1000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0729
    Cell Significance Index: -1.1800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0757
    Cell Significance Index: -1.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0764
    Cell Significance Index: -2.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0773
    Cell Significance Index: -1.5300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0773
    Cell Significance Index: -1.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0774
    Cell Significance Index: -2.0700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0792
    Cell Significance Index: -0.9500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0795
    Cell Significance Index: -1.6600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0812
    Cell Significance Index: -1.6300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0815
    Cell Significance Index: -1.0700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0816
    Cell Significance Index: -1.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0817
    Cell Significance Index: -2.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0833
    Cell Significance Index: -2.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0852
    Cell Significance Index: -2.2400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0858
    Cell Significance Index: -1.2300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0871
    Cell Significance Index: -1.6100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0895
    Cell Significance Index: -1.3000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0919
    Cell Significance Index: -1.1800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0923
    Cell Significance Index: -1.8400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0932
    Cell Significance Index: -1.0200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0954
    Cell Significance Index: -1.3900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0974
    Cell Significance Index: -3.0800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0996
    Cell Significance Index: -1.1600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0997
    Cell Significance Index: -2.3900
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1003
    Cell Significance Index: -1.5000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1029
    Cell Significance Index: -1.7800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1038
    Cell Significance Index: -1.4400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1041
    Cell Significance Index: -2.0400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1042
    Cell Significance Index: -1.1700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1042
    Cell Significance Index: -1.4600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1116
    Cell Significance Index: -1.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1128
    Cell Significance Index: -2.8200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1156
    Cell Significance Index: -1.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1183
    Cell Significance Index: -3.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RUVBL1 AS1 is a long non-coding RNA (lncRNA) that is antisense to the RUVBL1 gene, which encodes a ubiquitin ligase. Unlike many other lncRNAs, RUVBL1 AS1 exhibits a unique expression pattern, with significant levels detected in progenitor cells, pericytes, endothelial cells, and stem cells. This gene is also expressed in various immune cells, including granulocyte-monocyte progenitor cells, immature innate lymphoid cells, and goblet cells. The expression of RUVBL1 AS1 is tightly regulated, with studies suggesting that it is involved in the regulation of cellular proliferation, differentiation, and survival. **Pathways and Functions:** RUVBL1 AS1 has been implicated in several key pathways that regulate immune cell development and function. One of the most significant pathways involves the regulation of the Wnt/β-catenin signaling pathway, which is crucial for the development and maintenance of stem cells and progenitor cells. RUVBL1 AS1 has been shown to act as a negative regulator of this pathway, promoting the suppression of Wnt/β-catenin activity and thereby inhibiting the proliferation and differentiation of immune cells. Additionally, RUVBL1 AS1 has been implicated in the regulation of the PI3K/AKT signaling pathway, which is involved in the survival and proliferation of immune cells. **Clinical Significance:** The study of RUVBL1 AS1 has significant implications for our understanding of immune cell development and regulation. Dysregulation of RUVBL1 AS1 has been implicated in various immune-related disorders, including autoimmune diseases and cancer. For example, studies have shown that RUVBL1 AS1 is downregulated in patients with multiple sclerosis, a disease characterized by immune-mediated damage to the central nervous system. Additionally, RUVBL1 AS1 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma, suggesting that it may play a role in tumorigenesis. In conclusion, RUVBL1 AS1 is a complex gene that plays a critical role in regulating immune cell development and function. Further study of this gene is necessary to fully elucidate its mechanisms of action and to explore its therapeutic potential in immune-related disorders. As our understanding of RUVBL1 AS1 continues to evolve, it is likely to provide valuable insights into the molecular mechanisms underlying immune homeostasis and the development of novel therapeutic strategies for immune-related diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.