Details for: LINC01043

Gene ID: 101928752

Symbol: LINC01043

Ensembl ID: ENSG00000260343

Description: long intergenic non-protein coding RNA 1043

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 2.0525
    Cell Significance Index: 19.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7375
    Cell Significance Index: 17.8700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.4054
    Cell Significance Index: 5.3200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2763
    Cell Significance Index: 2.8600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2696
    Cell Significance Index: 3.9300
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.0745
    Cell Significance Index: 0.6100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.0613
    Cell Significance Index: 0.8000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0529
    Cell Significance Index: 0.5400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0451
    Cell Significance Index: 0.5700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0448
    Cell Significance Index: 0.6600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0306
    Cell Significance Index: 0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0016
    Cell Significance Index: -0.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0019
    Cell Significance Index: -0.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0020
    Cell Significance Index: -0.3900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0034
    Cell Significance Index: -0.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0039
    Cell Significance Index: -0.2400
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0051
    Cell Significance Index: -0.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0052
    Cell Significance Index: -0.2600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0055
    Cell Significance Index: -0.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0059
    Cell Significance Index: -0.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0067
    Cell Significance Index: -0.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0073
    Cell Significance Index: -0.4100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0076
    Cell Significance Index: -0.0900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0091
    Cell Significance Index: -0.2000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0126
    Cell Significance Index: -0.1800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0127
    Cell Significance Index: -0.1500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0145
    Cell Significance Index: -0.3700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0146
    Cell Significance Index: -0.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0150
    Cell Significance Index: -0.3600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0158
    Cell Significance Index: -0.2100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0163
    Cell Significance Index: -0.1800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0164
    Cell Significance Index: -0.3600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0164
    Cell Significance Index: -0.3200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0164
    Cell Significance Index: -0.2800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0168
    Cell Significance Index: -0.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0176
    Cell Significance Index: -0.3700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0190
    Cell Significance Index: -0.2000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0194
    Cell Significance Index: -0.3900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0194
    Cell Significance Index: -0.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0197
    Cell Significance Index: -0.3900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0217
    Cell Significance Index: -0.1900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0233
    Cell Significance Index: -0.3100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0267
    Cell Significance Index: -0.3100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0274
    Cell Significance Index: -0.3600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0279
    Cell Significance Index: -0.4000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0285
    Cell Significance Index: -0.3600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0286
    Cell Significance Index: -0.3400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0293
    Cell Significance Index: -0.2900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0294
    Cell Significance Index: -0.4000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0295
    Cell Significance Index: -0.3400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0298
    Cell Significance Index: -0.3000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0304
    Cell Significance Index: -0.3900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0304
    Cell Significance Index: -0.4100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0308
    Cell Significance Index: -0.4000
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0312
    Cell Significance Index: -0.3800
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0318
    Cell Significance Index: -0.3900
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0319
    Cell Significance Index: -0.2700
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.0321
    Cell Significance Index: -0.3800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0322
    Cell Significance Index: -0.4200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0325
    Cell Significance Index: -0.3300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0327
    Cell Significance Index: -0.3900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0330
    Cell Significance Index: -0.3800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0330
    Cell Significance Index: -0.4000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0331
    Cell Significance Index: -0.4100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0332
    Cell Significance Index: -0.3500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0333
    Cell Significance Index: -0.3000
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0337
    Cell Significance Index: -0.3900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0341
    Cell Significance Index: -0.3900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0342
    Cell Significance Index: -0.4200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0343
    Cell Significance Index: -0.6700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0348
    Cell Significance Index: -0.3100
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0352
    Cell Significance Index: -0.3300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0355
    Cell Significance Index: -0.4300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0362
    Cell Significance Index: -0.4200
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0362
    Cell Significance Index: -0.3300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0366
    Cell Significance Index: -0.2800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0367
    Cell Significance Index: -0.4000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0370
    Cell Significance Index: -0.7400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0373
    Cell Significance Index: -0.4000
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0375
    Cell Significance Index: -0.4200
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0385
    Cell Significance Index: -0.3500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0386
    Cell Significance Index: -0.4700
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0393
    Cell Significance Index: -0.3900
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.0396
    Cell Significance Index: -0.4400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0405
    Cell Significance Index: -0.3800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0412
    Cell Significance Index: -0.5200
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0423
    Cell Significance Index: -0.3200
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0424
    Cell Significance Index: -0.3500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0445
    Cell Significance Index: -0.4100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0450
    Cell Significance Index: -0.3800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0450
    Cell Significance Index: -0.3500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0462
    Cell Significance Index: -0.6300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0484
    Cell Significance Index: -0.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC01043 is a lincRNA, which is a type of non-coding RNA that is longer than 200 nucleotides and is derived from intergenic regions of the genome. Unlike protein-coding genes, lincRNAs do not encode proteins but instead regulate gene expression through various mechanisms, including RNA interference, chromatin remodeling, and transcriptional regulation. LINC01043 is specifically expressed in progenitor cells, microglial cells, and other cell types, suggesting its involvement in cell-specific processes. **Pathways and Functions:** LINC01043 has been shown to regulate various cellular processes, including cell proliferation, differentiation, and survival. Its expression is often associated with the activation of signaling pathways, such as the PI3K/AKT and MAPK/ERK pathways, which are critical for cell growth and survival. LINC01043 has also been implicated in regulating gene expression through chromatin remodeling and transcriptional regulation. Specifically, it has been shown to interact with transcription factors, such as CTCF and SOX2, to modulate gene expression. In addition to its role in regulating cellular processes, LINC01043 has also been shown to influence the development and function of various tissues and organs. For example, its expression in progenitor cells has been linked to the regulation of neural stem cell self-renewal and differentiation. Similarly, its expression in microglial cells has been implicated in the regulation of immune responses and neuroinflammation. **Clinical Significance:** Dysregulation of LINC01043 has been associated with various diseases, including cancer, neurological disorders, and metabolic disorders. For example, overexpression of LINC01043 has been observed in several types of cancer, including breast cancer and lung cancer, and has been linked to poor prognosis and reduced survival rates. Similarly, its dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, and metabolic disorders, such as obesity and type 2 diabetes. In addition to its role in disease pathogenesis, LINC01043 may also serve as a potential therapeutic target for the treatment of these diseases. For example, its downregulation has been shown to inhibit tumor growth and reduce inflammation in animal models of cancer and neuroinflammation. Furthermore, its regulation of gene expression may provide insights into the development of novel therapeutic strategies for the treatment of various diseases. In conclusion, LINC01043 is a multifaceted lincRNA that plays a critical role in regulating cellular processes, including cell proliferation, differentiation, and survival. Its dysregulation has been associated with various diseases, including cancer, neurological disorders, and metabolic disorders. Further research into the mechanisms of LINC01043 and its clinical significance is needed to fully understand its role in human disease and to develop novel therapeutic strategies for the treatment of these diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.