Details for: SPACA7

Gene ID: 122258

Symbol: SPACA7

Ensembl ID: ENSG00000153498

Description: sperm acrosome associated 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.9614
    Cell Significance Index: 43.7100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2172
    Cell Significance Index: 29.4900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.4120
    Cell Significance Index: 4.2700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.2942
    Cell Significance Index: 4.0800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1334
    Cell Significance Index: 3.3300
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0839
    Cell Significance Index: 0.6100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0652
    Cell Significance Index: 0.8400
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0577
    Cell Significance Index: 0.7300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0482
    Cell Significance Index: 0.8100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0253
    Cell Significance Index: 0.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0187
    Cell Significance Index: 0.5000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0086
    Cell Significance Index: 0.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0052
    Cell Significance Index: 0.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0041
    Cell Significance Index: 0.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0035
    Cell Significance Index: 0.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0026
    Cell Significance Index: 0.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0011
    Cell Significance Index: 1.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0006
    Cell Significance Index: 0.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0004
    Cell Significance Index: 0.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0016
    Cell Significance Index: -1.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0017
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0019
    Cell Significance Index: -0.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0020
    Cell Significance Index: -1.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0022
    Cell Significance Index: -0.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0024
    Cell Significance Index: -1.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0028
    Cell Significance Index: -0.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0035
    Cell Significance Index: -0.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0040
    Cell Significance Index: -0.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0040
    Cell Significance Index: -0.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0057
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0059
    Cell Significance Index: -1.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0089
    Cell Significance Index: -1.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0101
    Cell Significance Index: -1.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0107
    Cell Significance Index: -1.3200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0112
    Cell Significance Index: -0.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0127
    Cell Significance Index: -0.8500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0128
    Cell Significance Index: -0.1500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0133
    Cell Significance Index: -0.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0161
    Cell Significance Index: -0.2700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0168
    Cell Significance Index: -0.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0175
    Cell Significance Index: -0.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0185
    Cell Significance Index: -0.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0196
    Cell Significance Index: -0.9200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0200
    Cell Significance Index: -0.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0217
    Cell Significance Index: -0.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0219
    Cell Significance Index: -1.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0221
    Cell Significance Index: -0.6200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0231
    Cell Significance Index: -0.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0235
    Cell Significance Index: -0.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0236
    Cell Significance Index: -0.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0239
    Cell Significance Index: -0.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0276
    Cell Significance Index: -1.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0278
    Cell Significance Index: -0.8000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0316
    Cell Significance Index: -0.6700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0317
    Cell Significance Index: -0.7600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0321
    Cell Significance Index: -0.8000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0329
    Cell Significance Index: -0.4800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0338
    Cell Significance Index: -0.7300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0345
    Cell Significance Index: -0.4600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0361
    Cell Significance Index: -0.4300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0362
    Cell Significance Index: -0.4100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0374
    Cell Significance Index: -0.7500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0383
    Cell Significance Index: -0.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0386
    Cell Significance Index: -0.8000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0391
    Cell Significance Index: -1.0000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0399
    Cell Significance Index: -0.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0401
    Cell Significance Index: -1.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0402
    Cell Significance Index: -0.8700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0413
    Cell Significance Index: -0.6100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0415
    Cell Significance Index: -0.8200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0424
    Cell Significance Index: -0.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0438
    Cell Significance Index: -0.8100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0457
    Cell Significance Index: -0.5500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0459
    Cell Significance Index: -0.5000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0471
    Cell Significance Index: -0.9200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0473
    Cell Significance Index: -0.9300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0483
    Cell Significance Index: -0.6100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0491
    Cell Significance Index: -1.0500
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0498
    Cell Significance Index: -0.4500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0506
    Cell Significance Index: -0.4800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0509
    Cell Significance Index: -0.8800
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0532
    Cell Significance Index: -0.4200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0534
    Cell Significance Index: -0.7200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0545
    Cell Significance Index: -1.3300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0549
    Cell Significance Index: -0.7200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0549
    Cell Significance Index: -0.7400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0569
    Cell Significance Index: -0.7300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0583
    Cell Significance Index: -0.8300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0590
    Cell Significance Index: -0.5100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0602
    Cell Significance Index: -1.2300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0611
    Cell Significance Index: -0.6200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0611
    Cell Significance Index: -1.0300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0620
    Cell Significance Index: -0.7100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0637
    Cell Significance Index: -0.8500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0638
    Cell Significance Index: -0.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0644
    Cell Significance Index: -2.6400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0658
    Cell Significance Index: -0.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Acrosomal lumen localization:** SPACA7 is predominantly expressed in the acrosomal lumen, a region crucial for sperm cell function, particularly during fertilization. 2. **Single fertilization involvement:** The gene's involvement in single fertilization processes underscores its potential significance in regulating fertilization outcomes. 3. **Cell type specificity:** SPACA7's expression in various cell types, including progenitor cells, plasma cells, goblet cells, and neoplastic cells, highlights its pleiotropic nature. 4. **Protein association:** The SPACA7 gene encodes a protein that interacts with other acrosomal proteins, suggesting a complex regulatory network. **Pathways and Functions:** 1. **Acrosomal vesicle regulation:** SPACA7 may play a role in regulating the acrosomal vesicle, a critical component of the acrosome, which is essential for sperm cell function. 2. **Single fertilization regulation:** The gene's involvement in single fertilization processes suggests a potential role in regulating fertilization outcomes. 3. **Immune regulation:** SPACA7's expression in immune cells, such as plasma cells and goblet cells, implies a possible involvement in immune regulation. 4. **Cellular differentiation:** The gene's expression in progenitor cells and neoplastic cells suggests a potential role in cellular differentiation and tumorigenesis. **Clinical Significance:** 1. **Reproductive health:** Further research on SPACA7's role in single fertilization processes and acrosomal function may provide insights into male infertility and fertility-related disorders. 2. **Cancer research:** The gene's expression in neoplastic cells raises questions about its potential role in tumorigenesis and cancer progression. 3. **Immune system disorders:** Understanding SPACA7's involvement in immune regulation may shed light on the underlying mechanisms of immune system disorders, such as autoimmune diseases. 4. **Neurological disorders:** The gene's expression in cerebral cortex GABAergic interneurons and forebrain radial glial cells suggests a potential role in neurological disorders, such as epilepsy and neurodegenerative diseases. In conclusion, SPACA7 is a complex gene with multiple roles in immune regulation, cellular differentiation, and single fertilization processes. Further research is necessary to fully elucidate its functions and clinical significance, which may have far-reaching implications for our understanding of human biology and disease.

Genular Protein ID: 3098193713

Symbol: SPAC7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96KW9 Q5T8L1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22495889

Title: Identification of a new mouse sperm acrosome-associated protein.

PubMed ID: 22495889

DOI: 10.1530/rep-11-0270

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 195
  • Mass: 21466
  • Checksum: 09E285617F560FD8
  • Sequence:
    • MAVSQGDGTL CFVLLLCCWQ ETELRPRTVI PGSPTEIPFS SKQEDMSELL DEILVQEILD 
LNKTTPSEMP STASTLSTPL HAGIDENYQA GGSENYHELL ENLQFSPGIE VKISNDEANA 
NANLHGDPSE NYRGPQVSPG SEKSVSSKEK NSKNTQYENL SILDQILQNI GRSSGNIFHK 
EQQRTSAQRR SQGSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.