Details for: BHLHE23

Gene ID: 128408

Symbol: BHLHE23

Ensembl ID: ENSG00000125533

Description: basic helix-loop-helix family member e23

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.9282
    Cell Significance Index: 11.1000
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.7880
    Cell Significance Index: 8.0500
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.5690
    Cell Significance Index: 7.2900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.2074
    Cell Significance Index: 2.4600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 0.1464
    Cell Significance Index: 1.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0447
    Cell Significance Index: 0.6400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0300
    Cell Significance Index: 0.2300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0040
    Cell Significance Index: -0.0700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0060
    Cell Significance Index: -0.1200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0137
    Cell Significance Index: -0.1600
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0271
    Cell Significance Index: -0.3400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0282
    Cell Significance Index: -0.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0326
    Cell Significance Index: -1.8300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0404
    Cell Significance Index: -0.4800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0434
    Cell Significance Index: -0.6000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0489
    Cell Significance Index: -0.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0504
    Cell Significance Index: -10.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0525
    Cell Significance Index: -1.1500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0553
    Cell Significance Index: -0.7200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0571
    Cell Significance Index: -0.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0599
    Cell Significance Index: -1.5800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0646
    Cell Significance Index: -0.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0669
    Cell Significance Index: -1.7100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0680
    Cell Significance Index: -0.7600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0686
    Cell Significance Index: -0.6500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0701
    Cell Significance Index: -0.8900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0743
    Cell Significance Index: -0.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0754
    Cell Significance Index: -2.1600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0778
    Cell Significance Index: -1.0200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0803
    Cell Significance Index: -2.0500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0809
    Cell Significance Index: -1.1800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0885
    Cell Significance Index: -1.1100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0902
    Cell Significance Index: -1.0300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0904
    Cell Significance Index: -1.1900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0905
    Cell Significance Index: -1.7700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0942
    Cell Significance Index: -1.5300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0990
    Cell Significance Index: -1.1700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1017
    Cell Significance Index: -1.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1030
    Cell Significance Index: -2.1600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1035
    Cell Significance Index: -1.7700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1057
    Cell Significance Index: -1.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1093
    Cell Significance Index: -1.8300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1100
    Cell Significance Index: -1.0000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1175
    Cell Significance Index: -1.2800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1248
    Cell Significance Index: -1.7500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1252
    Cell Significance Index: -1.4800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1308
    Cell Significance Index: -1.6800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1336
    Cell Significance Index: -1.5500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1363
    Cell Significance Index: -1.5400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1367
    Cell Significance Index: -1.6800
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1378
    Cell Significance Index: -1.6800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1393
    Cell Significance Index: -1.6700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1394
    Cell Significance Index: -1.7600
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1397
    Cell Significance Index: -1.7500
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.1400
    Cell Significance Index: -1.7600
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1402
    Cell Significance Index: -1.7500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1411
    Cell Significance Index: -1.7100
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.1413
    Cell Significance Index: -1.6200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1425
    Cell Significance Index: -1.5000
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.1426
    Cell Significance Index: -1.7600
  • Cell Name: diffuse bipolar 4 cell (CL4033031)
    Fold Change: -0.1438
    Cell Significance Index: -1.7500
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.1448
    Cell Significance Index: -1.8000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1451
    Cell Significance Index: -1.8000
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: -0.1471
    Cell Significance Index: -1.8000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1472
    Cell Significance Index: -1.6300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1473
    Cell Significance Index: -1.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1476
    Cell Significance Index: -1.7600
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1487
    Cell Significance Index: -1.8100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1494
    Cell Significance Index: -1.9500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1500
    Cell Significance Index: -1.6900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1505
    Cell Significance Index: -1.5200
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1516
    Cell Significance Index: -1.9200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1548
    Cell Significance Index: -1.5600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1550
    Cell Significance Index: -1.8300
  • Cell Name: diffuse bipolar 6 cell (CL4033032)
    Fold Change: -0.1559
    Cell Significance Index: -1.8000
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.1576
    Cell Significance Index: -1.6000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1597
    Cell Significance Index: -1.7300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1599
    Cell Significance Index: -1.8900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1611
    Cell Significance Index: -1.8300
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.1613
    Cell Significance Index: -1.7400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1646
    Cell Significance Index: -1.6700
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1648
    Cell Significance Index: -1.6100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1649
    Cell Significance Index: -1.7400
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1662
    Cell Significance Index: -1.5200
  • Cell Name: OFFx cell (CL4033036)
    Fold Change: -0.1664
    Cell Significance Index: -1.8900
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1665
    Cell Significance Index: -1.7700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1668
    Cell Significance Index: -1.6500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1670
    Cell Significance Index: -1.9900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1677
    Cell Significance Index: -2.1600
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.1702
    Cell Significance Index: -1.8300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1704
    Cell Significance Index: -2.0700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1707
    Cell Significance Index: -2.2400
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1723
    Cell Significance Index: -1.7900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1751
    Cell Significance Index: -2.2900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1757
    Cell Significance Index: -1.8300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1773
    Cell Significance Index: -1.7700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1789
    Cell Significance Index: -1.9000
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1814
    Cell Significance Index: -1.8800
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1819
    Cell Significance Index: -2.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation:** BHLHE23 acts as a transcription factor, binding to specific DNA sequences and regulating the expression of target genes. 2. **Cell fate commitment:** BHLHE23 is involved in the commitment of progenitor cells to specific lineages, including immune cells. 3. **Neuronal development:** BHLHE23 is also expressed in neuronal cells, where it regulates the development and maintenance of oligodendrocyte precursor cells. 4. **Cellular differentiation:** BHLHE23 promotes the differentiation of macrophages and microglial cells, essential for immune surveillance and tissue homeostasis. 5. **Protein-protein interactions:** BHLHE23 interacts with other transcription factors and proteins, modulating its activity and subcellular localization. **Pathways and Functions:** 1. **Axon development:** BHLHE23 regulates the development and maintenance of oligodendrocyte precursor cells, essential for neuronal axon growth and myelination. 2. **Chromatin remodeling:** BHLHE23 interacts with chromatin-modifying enzymes, influencing chromatin structure and gene expression. 3. **RNA polymerase II-specific transcription:** BHLHE23 regulates the expression of genes involved in immune cell development and function, using RNA polymerase II as the primary transcriptional machinery. 4. **E-box binding:** BHLHE23 binds to E-box motifs, a common regulatory element in many target genes, to modulate their expression. 5. **Sensory organ development:** BHLHE23 is expressed in sensory organs, where it regulates the development and maintenance of sensory cells. **Clinical Significance:** 1. **Immune-related disorders:** Dysregulation of BHLHE23 has been implicated in various immune-related disorders, including autoimmune diseases, inflammatory conditions, and cancer. 2. **Neurological disorders:** BHLHE23 dysfunction has been linked to neurological disorders, such as multiple sclerosis, where it regulates the development and maintenance of oligodendrocyte precursor cells. 3. **Cancer:** BHLHE23 has been identified as a potential oncogene, contributing to tumorigenesis and cancer progression. 4. **Infectious diseases:** BHLHE23 plays a critical role in the development and function of immune cells, making it a potential target for the development of novel therapeutic strategies against infectious diseases. In conclusion, BHLHE23 is a critical component in the regulation of immune cell development, differentiation, and function. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of this gene in maintaining immune homeostasis. Further research is necessary to fully elucidate the role of BHLHE23 in human health and disease.

Genular Protein ID: 11580251

Symbol: BHE23_HUMAN

Name: Class E basic helix-loop-helix protein 23

UniProtKB Accession Codes:

Q8NDY6 B2RP69

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14516699

Title: Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening.

PubMed ID: 14516699

DOI: 10.1016/s0925-4773(03)00130-8

Sequence Information:

  • Length: 225
  • Mass: 23665
  • Checksum: 77B5720A3CE42E85
  • Sequence:
    • MAELKSLSGD AYLALSHGYA AAAAGLAYGA AREPEAARGY GTPGPGGDLP AAPAPRAPAQ 
AAESSGEQSG DEDDAFEQRR RRRGPGSAAD GRRRPREQRS LRLSINARER RRMHDLNDAL 
DGLRAVIPYA HSPSVRKLSK IATLLLAKNY ILMQAQALDE MRRLVAFLNQ GQGLAAPVNA 
APLTPFGQAT VCPFSAGAAL GPCPDKCAAF SGTPSALCKH CHEKP

Genular Protein ID: 3720383461

Symbol: A0A087WXG3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WXG3

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 241
  • Mass: 25167
  • Checksum: 53EED45A89CDF183
  • Sequence:
    • MSIRPPGEPP SPGGAAMAEL KSLSGDAYLA LSHGYAAAAA GLAYGAAREP EAARGYGTPG 
PGGDLPAAPA PRAPAQAAES SGEQSGDEDD AFEQRRRRRG PGSAADGRRR PREQRSLRLS 
INARERRRMH DLNDALDGLR AVIPYAHSPS VRKLSKIATL LLAKNYILMQ AQALDEMRRL 
VAFLNQGQGL AAPVNAAPLT PFGQATVCPF SAGAALGPCP DKCAAFSGTP SALCKHCHEK 
P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.