Details for: PYDC2

Gene ID: 152138

Symbol: PYDC2

Ensembl ID: ENSG00000253548

Description: pyrin domain containing 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.4810
    Cell Significance Index: 4.9200
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.1674
    Cell Significance Index: 1.0500
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.0178
    Cell Significance Index: 0.2400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0125
    Cell Significance Index: 0.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0068
    Cell Significance Index: 1.3700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0037
    Cell Significance Index: 0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0004
    Cell Significance Index: -0.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0005
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0021
    Cell Significance Index: -0.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0045
    Cell Significance Index: -0.1900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0135
    Cell Significance Index: -0.1600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0140
    Cell Significance Index: -0.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0184
    Cell Significance Index: -1.0400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0208
    Cell Significance Index: -0.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0251
    Cell Significance Index: -0.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0263
    Cell Significance Index: -0.8600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0327
    Cell Significance Index: -0.3900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0345
    Cell Significance Index: -0.8600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0347
    Cell Significance Index: -0.7600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0350
    Cell Significance Index: -0.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0365
    Cell Significance Index: -1.0500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0409
    Cell Significance Index: -0.4400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0425
    Cell Significance Index: -1.0200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0432
    Cell Significance Index: -0.8500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0435
    Cell Significance Index: -0.9400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0443
    Cell Significance Index: -0.9400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0448
    Cell Significance Index: -0.9000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0472
    Cell Significance Index: -0.6700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0478
    Cell Significance Index: -0.9500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0532
    Cell Significance Index: -0.9200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0538
    Cell Significance Index: -0.5100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0539
    Cell Significance Index: -0.7400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0542
    Cell Significance Index: -0.7200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0543
    Cell Significance Index: -0.8300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0555
    Cell Significance Index: -0.6400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0561
    Cell Significance Index: -0.5900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0569
    Cell Significance Index: -0.6600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0575
    Cell Significance Index: -0.9300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0584
    Cell Significance Index: -0.7100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0588
    Cell Significance Index: -0.6000
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0590
    Cell Significance Index: -0.5500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0611
    Cell Significance Index: -0.9900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0615
    Cell Significance Index: -0.7300
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0616
    Cell Significance Index: -0.6500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0634
    Cell Significance Index: -0.7600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0636
    Cell Significance Index: -0.7100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0671
    Cell Significance Index: -0.9400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0683
    Cell Significance Index: -1.0000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0684
    Cell Significance Index: -0.9000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0694
    Cell Significance Index: -0.7200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0713
    Cell Significance Index: -0.9300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0729
    Cell Significance Index: -0.9200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0735
    Cell Significance Index: -0.6900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0756
    Cell Significance Index: -1.0200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0756
    Cell Significance Index: -0.8700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0757
    Cell Significance Index: -0.9300
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0761
    Cell Significance Index: -0.9500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0784
    Cell Significance Index: -0.9900
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0784
    Cell Significance Index: -0.9500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0804
    Cell Significance Index: -0.9200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0807
    Cell Significance Index: -0.9600
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0814
    Cell Significance Index: -1.0200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0823
    Cell Significance Index: -1.0600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0826
    Cell Significance Index: -0.9000
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.0834
    Cell Significance Index: -0.8800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0838
    Cell Significance Index: -1.0400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0841
    Cell Significance Index: -1.0200
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0843
    Cell Significance Index: -0.9800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0845
    Cell Significance Index: -0.8900
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.0845
    Cell Significance Index: -1.0500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0846
    Cell Significance Index: -1.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0847
    Cell Significance Index: -1.0100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0867
    Cell Significance Index: -0.9800
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0875
    Cell Significance Index: -1.0000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0877
    Cell Significance Index: -0.9400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0924
    Cell Significance Index: -0.9800
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0957
    Cell Significance Index: -1.0400
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.0963
    Cell Significance Index: -0.9500
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0974
    Cell Significance Index: -1.0900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0998
    Cell Significance Index: -1.0400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1042
    Cell Significance Index: -0.9700
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1062
    Cell Significance Index: -0.8100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1224
    Cell Significance Index: -1.0100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1293
    Cell Significance Index: -0.9400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1326
    Cell Significance Index: -1.0200
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.1355
    Cell Significance Index: -0.9400
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.1500
    Cell Significance Index: -0.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Pyrin domain structure**: The PYDC2 protein contains a pyrin domain, a conserved structural motif found in proteins involved in immune regulation and inflammation. 2. **Negative regulation of inflammatory responses**: PYDC2 acts as a negative regulator of inflammatory responses by inhibiting the activity of key inflammatory mediators, such as NF-κB, IL-1β, and NLRP3 inflammasome. 3. **Cell-type specific expression**: PYDC2 is expressed in a variety of cell types, including microglial cells, endothelial cells, and neurons, highlighting its potential role in different tissues and organs. 4. **Protein binding capabilities**: PYDC2 interacts with multiple proteins, including NF-κB, IL-1β, and NLRP3, suggesting its ability to modulate complex signaling networks. **Pathways and Functions** PYDC2 is involved in several key pathways, including: 1. **Inflammatory response regulation**: PYDC2 negatively regulates the inflammatory response by inhibiting the activity of key inflammatory mediators, such as NF-κB, IL-1β, and NLRP3 inflammasome. 2. **Negative regulation of NF-κB transcription factor activity**: PYDC2 inhibits the activity of NF-κB, a transcription factor involved in inflammation and immune response. 3. **Negative regulation of NLRP3 inflammasome complex assembly**: PYDC2 prevents the assembly of the NLRP3 inflammasome, a multiprotein complex involved in the activation of inflammatory responses. 4. **Negative regulation of tumor necrosis factor-mediated signaling pathway**: PYDC2 inhibits the activity of tumor necrosis factor (TNF), a cytokine involved in inflammation and immune response. **Clinical Significance** The dysregulation of PYDC2 has been implicated in various diseases, including: 1. **Autoimmune disorders**: Alterations in PYDC2 expression may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Inflammatory disorders**: Dysregulation of PYDC2 may contribute to the pathogenesis of inflammatory disorders, such as atherosclerosis and inflammatory bowel disease. 3. **Neurological disorders**: PYDC2 expression has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, suggesting its potential role in the regulation of neuronal function and survival. In conclusion, PYDC2 is a critical gene involved in the regulation of inflammatory responses and immune system function. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying its function and its potential therapeutic applications.

Genular Protein ID: 1344128242

Symbol: PYDC2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q56P42

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 17339483

Title: Pyrin-only protein 2 modulates NF-kappaB and disrupts ASC:CLR interactions.

PubMed ID: 17339483

DOI: 10.4049/jimmunol.178.6.3837

PubMed ID: 17178784

Title: Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation.

PubMed ID: 17178784

DOI: 10.1128/iai.01315-06

PubMed ID: 21362197

Title: Recent evolution of the NF-kappaB and inflammasome regulating protein POP2 in primates.

PubMed ID: 21362197

DOI: 10.1186/1471-2148-11-56

PubMed ID: 24871464

Title: The CLRX.1/NOD24 (NLRP2P) pseudogene codes a functional negative regulator of NF-kappaB, pyrin-only protein 4.

PubMed ID: 24871464

DOI: 10.1038/gene.2014.30

Sequence Information:

  • Length: 97
  • Mass: 10795
  • Checksum: E2EE7A27FB90E586
  • Sequence:
    • MASSAELDFN LQALLEQLSQ DELSKFKSLI RTISLGKELQ TVPQTEVDKA NGKQLVEIFT 
SHSCSYWAGM AAIQVFEKMN QTHLSGRADE HCVMPPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.