Details for: CYP7A1

Gene ID: 1581

Symbol: CYP7A1

Ensembl ID: ENSG00000167910

Description: cytochrome P450 family 7 subfamily A member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 2.5851
    Cell Significance Index: 33.4500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.3576
    Cell Significance Index: 32.3300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.7389
    Cell Significance Index: 29.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.5588
    Cell Significance Index: 49.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.1681
    Cell Significance Index: 71.6200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.6525
    Cell Significance Index: 9.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4703
    Cell Significance Index: 89.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3977
    Cell Significance Index: 78.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3358
    Cell Significance Index: 20.1600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2513
    Cell Significance Index: 3.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2394
    Cell Significance Index: 23.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2329
    Cell Significance Index: 25.3300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2278
    Cell Significance Index: 5.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1770
    Cell Significance Index: 159.8200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1681
    Cell Significance Index: 2.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1319
    Cell Significance Index: 21.4500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1296
    Cell Significance Index: 1.6400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.1276
    Cell Significance Index: 1.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1253
    Cell Significance Index: 3.6100
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.1207
    Cell Significance Index: 1.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1152
    Cell Significance Index: 7.9700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.1111
    Cell Significance Index: 1.1600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1017
    Cell Significance Index: 2.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0610
    Cell Significance Index: 1.3000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0605
    Cell Significance Index: 0.8700
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0579
    Cell Significance Index: 0.7000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0307
    Cell Significance Index: 0.4400
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.0273
    Cell Significance Index: 0.2500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0244
    Cell Significance Index: 0.4100
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.0237
    Cell Significance Index: 0.2500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0228
    Cell Significance Index: 0.3700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0205
    Cell Significance Index: 0.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0192
    Cell Significance Index: 0.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0189
    Cell Significance Index: 0.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0165
    Cell Significance Index: 0.8600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0155
    Cell Significance Index: 0.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0051
    Cell Significance Index: 0.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0043
    Cell Significance Index: 0.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0031
    Cell Significance Index: 0.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0023
    Cell Significance Index: 0.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0019
    Cell Significance Index: 0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0010
    Cell Significance Index: 0.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0004
    Cell Significance Index: 0.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0002
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0003
    Cell Significance Index: -0.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0003
    Cell Significance Index: -0.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0005
    Cell Significance Index: -0.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0010
    Cell Significance Index: -0.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0011
    Cell Significance Index: -0.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0012
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0014
    Cell Significance Index: -0.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0016
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0031
    Cell Significance Index: -0.6600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0034
    Cell Significance Index: -0.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0036
    Cell Significance Index: -0.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0038
    Cell Significance Index: -0.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0044
    Cell Significance Index: -0.7900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0054
    Cell Significance Index: -0.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0054
    Cell Significance Index: -0.7000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0055
    Cell Significance Index: -0.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0063
    Cell Significance Index: -0.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0068
    Cell Significance Index: -0.8300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0068
    Cell Significance Index: -0.0700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0072
    Cell Significance Index: -0.1000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0075
    Cell Significance Index: -0.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0075
    Cell Significance Index: -0.3500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0084
    Cell Significance Index: -0.1700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0086
    Cell Significance Index: -0.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0102
    Cell Significance Index: -0.6300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0105
    Cell Significance Index: -0.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0118
    Cell Significance Index: -0.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0128
    Cell Significance Index: -0.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0136
    Cell Significance Index: -1.0400
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0141
    Cell Significance Index: -0.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0157
    Cell Significance Index: -0.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0157
    Cell Significance Index: -0.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0160
    Cell Significance Index: -0.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0164
    Cell Significance Index: -0.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0166
    Cell Significance Index: -0.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0171
    Cell Significance Index: -0.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0174
    Cell Significance Index: -0.5700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0191
    Cell Significance Index: -0.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0192
    Cell Significance Index: -1.0800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0203
    Cell Significance Index: -0.5200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0209
    Cell Significance Index: -0.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0210
    Cell Significance Index: -0.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0227
    Cell Significance Index: -1.1800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0229
    Cell Significance Index: -0.5700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0234
    Cell Significance Index: -0.3200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0235
    Cell Significance Index: -0.3200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0239
    Cell Significance Index: -0.5000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0241
    Cell Significance Index: -0.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0244
    Cell Significance Index: -1.0800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0247
    Cell Significance Index: -0.3700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0250
    Cell Significance Index: -0.6100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0251
    Cell Significance Index: -0.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CYP7A1 is a monooxygenase enzyme that belongs to the cytochrome P450 family. It is a copper-containing enzyme that requires NADPH as a cofactor to catalyze the 7alpha-hydroxylation of cholesterol. The enzyme is highly specific for the conversion of cholesterol into 7alpha-hydroxycholesterol, and its activity is tightly regulated by various transcriptional and post-translational mechanisms. CYP7A1 is also involved in the regulation of bile acid biosynthesis, and its expression is influenced by various transcription factors, including PPARα (peroxisome proliferator-activated receptor alpha). **Pathways and Functions** CYP7A1 is involved in several key pathways, including: 1. **Bile acid biosynthesis**: CYP7A1 catalyzes the conversion of cholesterol into 7alpha-hydroxycholesterol, which is then converted into bile acids by other enzymes. 2. **Cholesterol homeostasis**: CYP7A1 plays a crucial role in regulating cholesterol levels in the body by controlling the synthesis and degradation of bile acids. 3. **Lipid metabolism**: CYP7A1 is involved in the regulation of lipid metabolism by influencing the expression of genes involved in cholesterol and bile acid biosynthesis. 4. **Cellular response to cholesterol**: CYP7A1 is activated in response to changes in dietary cholesterol intake, allowing the body to adjust its cholesterol homeostasis. 5. **Bile acid signaling pathway**: CYP7A1 is involved in the regulation of bile acid signaling pathways, which are important for maintaining intestinal homeostasis and preventing disease. **Clinical Significance** Dysregulation of CYP7A1 has been implicated in various diseases, including: 1. **Cholestatic liver diseases**: Mutations in the CYP7A1 gene have been associated with cholestatic liver diseases, such as primary biliary cirrhosis and primary sclerosing cholangitis. 2. **Hypercholesterolemia**: CYP7A1 is involved in the regulation of cholesterol levels in the body, and dysregulation of the enzyme has been linked to hypercholesterolemia. 3. **Metabolic syndrome**: CYP7A1 is involved in the regulation of lipid metabolism, and dysregulation of the enzyme has been implicated in the development of metabolic syndrome. 4. **Cancer**: CYP7A1 has been implicated in the development of certain types of cancer, including colon cancer, due to its role in regulating bile acid biosynthesis and lipid metabolism. In conclusion, CYP7A1 is a critical enzyme involved in the biosynthesis and metabolism of bile acids, cholesterol, and other steroids. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the mechanisms of CYP7A1 in maintaining human health.

Genular Protein ID: 661670926

Symbol: CP7A1_HUMAN

Name: CYPVII

UniProtKB Accession Codes:

P22680 P78454 Q3MIL8 Q7KZ19

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 52 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PIRSF 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 Rhea 28 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8439551

Title: Structure of the gene encoding human liver cholesterol 7 alpha-hydroxylase.

PubMed ID: 8439551

DOI: 10.1016/0167-4781(93)90281-h

PubMed ID: 2384150

Title: Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7 alpha-hydroxylase.

PubMed ID: 2384150

DOI: 10.1016/0014-5793(90)80992-r

PubMed ID: 1610352

Title: Polymorphisms of human cholesterol 7 alpha-hydroxylase.

PubMed ID: 1610352

DOI: 10.1016/0006-291x(92)91665-d

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8020987

Title: Structure and nucleotide sequences of the human cholesterol 7 alpha-hydroxylase gene (CYP7).

PubMed ID: 8020987

DOI: 10.1006/geno.1994.1177

PubMed ID: 1312351

Title: Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene.

PubMed ID: 1312351

DOI: 10.1021/bi00124a014

PubMed ID: 11013305

Title: 24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A).

PubMed ID: 11013305

PubMed ID: 12077124

Title: Metabolism of 4 beta -hydroxycholesterol in humans.

PubMed ID: 12077124

DOI: 10.1074/jbc.m201712200

PubMed ID: 15796896

Title: Feedback regulation of bile acid synthesis in human liver: importance of HNF-4alpha for regulation of CYP7A1.

PubMed ID: 15796896

DOI: 10.1016/j.bbrc.2005.02.170

PubMed ID: 19965590

Title: Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.

PubMed ID: 19965590

DOI: 10.1194/jlr.m002782

PubMed ID: 21813643

Title: Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate.

PubMed ID: 21813643

DOI: 10.1074/jbc.m111.282434

PubMed ID: 12721789

Title: Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.

PubMed ID: 12721789

DOI: 10.1007/s10038-003-0021-7

Sequence Information:

  • Length: 504
  • Mass: 57661
  • Checksum: D8067E0FF6342949
  • Sequence:
    • MMTTSLIWGI AIAACCCLWL ILGIRRRQTG EPPLENGLIP YLGCALQFGA NPLEFLRANQ 
RKHGHVFTCK LMGKYVHFIT NPLSYHKVLC HGKYFDWKKF HFATSAKAFG HRSIDPMDGN 
TTENINDTFI KTLQGHALNS LTESMMENLQ RIMRPPVSSN SKTAAWVTEG MYSFCYRVMF 
EAGYLTIFGR DLTRRDTQKA HILNNLDNFK QFDKVFPALV AGLPIHMFRT AHNAREKLAE 
SLRHENLQKR ESISELISLR MFLNDTLSTF DDLEKAKTHL VVLWASQANT IPATFWSLFQ 
MIRNPEAMKA ATEEVKRTLE NAGQKVSLEG NPICLSQAEL NDLPVLDSII KESLRLSSAS 
LNIRTAKEDF TLHLEDGSYN IRKDDIIALY PQLMHLDPEI YPDPLTFKYD RYLDENGKTK 
TTFYCNGLKL KYYYMPFGSG ATICPGRLFA IHEIKQFLIL MLSYFELELI EGQAKCPPLD 
QSRAGLGILP PLNDIEFKYK FKHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.