Details for: CYP7A1

Gene ID: 1581

Symbol: CYP7A1

Ensembl ID: ENSG00000167910

Description: cytochrome P450 family 7 subfamily A member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.11
    Marker Score: 1768
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.58
    Marker Score: 3556
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.1
    Marker Score: 1108
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.95
    Marker Score: 2176
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1175
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.58
    Marker Score: 1573
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.39
    Marker Score: 582
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 860
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 491
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4823
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 507
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16487
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71836
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48061
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.98
    Marker Score: 651
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 330
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.88
    Marker Score: 1665
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.75
    Marker Score: 1516
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.68
    Marker Score: 395
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 516
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.55
    Marker Score: 320
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.53
    Marker Score: 850
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.42
    Marker Score: 250
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.28
    Marker Score: 276
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.27
    Marker Score: 569
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 118
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.2
    Marker Score: 74
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.16
    Marker Score: 279
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.13
    Marker Score: 89
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 55
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 138
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.12
    Marker Score: 91
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.1
    Marker Score: 54
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.1
    Marker Score: 98
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.09
    Marker Score: 42
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.06
    Marker Score: 59
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.05
    Marker Score: 49
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.05
    Marker Score: 128
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.05
    Marker Score: 77
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.05
    Marker Score: 296
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.04
    Marker Score: 32
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.04
    Marker Score: 43
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.03
    Marker Score: 68
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.03
    Marker Score: 248
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.03
    Marker Score: 168
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.03
    Marker Score: 358
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.02
    Marker Score: 14

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Other Information

**Key characteristics:** * CYP7A1 is a member of the cytochrome p450 family, which are a large superfamily of enzymes that are involved in a wide range of metabolic processes. * The enzyme is a multi-functional protein that can act as a cytochrome P450 monooxygenase, a cytochrome P450 reductase, or a cytochrome P450 sulfotransferase. * CYP7A1 is involved in the metabolism of cholesterol, bile acids, and steroids. **Pathways and functions:** * CYP7A1 is involved in the biosynthesis of bile acids and bile salts from cholesterol. * The enzyme is also involved in the metabolism of hormones, such as estrogen and testosterone. * CYP7A1 is a key enzyme in the regulation of lipid metabolism. It is involved in the production of bile acids and bile salts, which are necessary for the digestion and absorption of fats. **Clinical significance:** * Mutations in the CYP7A1 gene have been linked to a number of liver diseases, including cholestasis and liver cancer. * CYP7A1 inhibitors are being investigated as potential treatments for these diseases. **Additional information:** * The CYP7A1 gene is located on chromosome 15q21.1. * The protein encoded by CYP7A1 is a transmembrane protein with a molecular weight of approximately 210 kDa. * CYP7A1 is a highly conserved protein, with a similar sequence found in organisms from humans to mice.

Genular Protein ID: 661670926

Symbol: CP7A1_HUMAN

Name: CYPVII

UniProtKB Accession Codes:

P22680 P78454 Q3MIL8 Q7KZ19

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 52 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PIR 1 PIRSF 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 Rhea 28 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8439551

Title: Structure of the gene encoding human liver cholesterol 7 alpha-hydroxylase.

PubMed ID: 8439551

DOI: 10.1016/0167-4781(93)90281-h

PubMed ID: 2384150

Title: Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7 alpha-hydroxylase.

PubMed ID: 2384150

DOI: 10.1016/0014-5793(90)80992-r

PubMed ID: 1610352

Title: Polymorphisms of human cholesterol 7 alpha-hydroxylase.

PubMed ID: 1610352

DOI: 10.1016/0006-291x(92)91665-d

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8020987

Title: Structure and nucleotide sequences of the human cholesterol 7 alpha-hydroxylase gene (CYP7).

PubMed ID: 8020987

DOI: 10.1006/geno.1994.1177

PubMed ID: 1312351

Title: Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene.

PubMed ID: 1312351

DOI: 10.1021/bi00124a014

PubMed ID: 11013305

Title: 24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A).

PubMed ID: 11013305

PubMed ID: 12077124

Title: Metabolism of 4 beta -hydroxycholesterol in humans.

PubMed ID: 12077124

DOI: 10.1074/jbc.m201712200

PubMed ID: 15796896

Title: Feedback regulation of bile acid synthesis in human liver: importance of HNF-4alpha for regulation of CYP7A1.

PubMed ID: 15796896

DOI: 10.1016/j.bbrc.2005.02.170

PubMed ID: 19965590

Title: Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.

PubMed ID: 19965590

DOI: 10.1194/jlr.m002782

PubMed ID: 21813643

Title: Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate.

PubMed ID: 21813643

DOI: 10.1074/jbc.m111.282434

PubMed ID: 12721789

Title: Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.

PubMed ID: 12721789

DOI: 10.1007/s10038-003-0021-7

Sequence Information:

  • Length: 504
  • Mass: 57661
  • Checksum: D8067E0FF6342949
  • Sequence:
    • MMTTSLIWGI AIAACCCLWL ILGIRRRQTG EPPLENGLIP YLGCALQFGA NPLEFLRANQ 
RKHGHVFTCK LMGKYVHFIT NPLSYHKVLC HGKYFDWKKF HFATSAKAFG HRSIDPMDGN 
TTENINDTFI KTLQGHALNS LTESMMENLQ RIMRPPVSSN SKTAAWVTEG MYSFCYRVMF 
EAGYLTIFGR DLTRRDTQKA HILNNLDNFK QFDKVFPALV AGLPIHMFRT AHNAREKLAE 
SLRHENLQKR ESISELISLR MFLNDTLSTF DDLEKAKTHL VVLWASQANT IPATFWSLFQ 
MIRNPEAMKA ATEEVKRTLE NAGQKVSLEG NPICLSQAEL NDLPVLDSII KESLRLSSAS 
LNIRTAKEDF TLHLEDGSYN IRKDDIIALY PQLMHLDPEI YPDPLTFKYD RYLDENGKTK 
TTFYCNGLKL KYYYMPFGSG ATICPGRLFA IHEIKQFLIL MLSYFELELI EGQAKCPPLD 
QSRAGLGILP PLNDIEFKYK FKHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.