Details for: FOXD4

Gene ID: 2298

Symbol: FOXD4

Ensembl ID: ENSG00000170122

Description: forkhead box D4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.37
    Marker Score: 2387
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.39
    Marker Score: 1007
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 863
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 493
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7688
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4827
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 515
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71840
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48065
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 468
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.96
    Marker Score: 443
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 379
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 331
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 498
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 468
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.72
    Marker Score: 1358
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 505
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.32
    Marker Score: 652
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.32
    Marker Score: 397
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.24
    Marker Score: 3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.22
    Marker Score: 104
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.19
    Marker Score: 116
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.17
    Marker Score: 344
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.16
    Marker Score: 64
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.1
    Marker Score: 95
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.1
    Marker Score: 55
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.08
    Marker Score: 116
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.06
    Marker Score: 64.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.06
    Marker Score: 172
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.05
    Marker Score: 133
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 24.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 49
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.03
    Marker Score: 139
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.03
    Marker Score: 94
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.03
    Marker Score: 62.5
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.02
    Marker Score: 40
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.02
    Marker Score: 64
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 40
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.02
    Marker Score: 35
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.02
    Marker Score: 77
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.02
    Marker Score: 33
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.02
    Marker Score: 34
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.02
    Marker Score: 15

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Other Information

**Key characteristics:** - The FOXD4 gene is located on chromosome 17p13.2. - It is a member of the forkhead family of transcription factors, which are characterized by their ability to bind to specific DNA sequences and regulate gene expression. - The FOXD4 gene is expressed in a variety of cell types, including blood vessel endothelial cells, colon goblet cells, intestinal stem cells, transit amplifying cells, goblet cells, enterocytes, tuft cells, and cerebral cortex GABAergic interneurons. **Pathways and functions:** - FOXD4 is a key regulator of epithelial-mesenchymal transition (EMT), a process by which epithelial cells lose their epithelial characteristics and acquire mesenchymal characteristics. EMT is important for the development of various tissues, including the skin, lungs, and gut. - FOXD4 is also involved in the regulation of cell differentiation and survival. It is expressed in cells that are committed to becoming epithelial cells and is essential for the proper differentiation of these cells. - The expression of FOXD4 is also important for the maintenance of tissue integrity and the prevention of cancer. In cancer cells, FOXD4 is often overexpressed, which can lead to the development of tumors. **Clinical significance:** - Mutations in the FOXD4 gene have been linked to a number of human diseases, including colorectal cancer, lung cancer, and heart disease. - Targeting FOXD4 has been explored as a therapeutic strategy for cancer and other diseases that are characterized by epithelial-mesenchymal transition or impaired cell differentiation. - However, the development of FOXD4 inhibitors has also been challenging due to the fact that the protein is also expressed in normal cells.

Genular Protein ID: 653932344

Symbol: FOXD4_HUMAN

Name: Forkhead box protein D4

UniProtKB Accession Codes:

Q12950 B2RN05 B9EGL7 Q5VVK1 Q8WXT6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12234674

Title: FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines.

PubMed ID: 12234674

DOI: 10.1016/s0378-1119(02)00702-3

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7957066

Title: Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.

PubMed ID: 7957066

DOI: 10.1002/j.1460-2075.1994.tb06827.x

PubMed ID: 12421752

Title: Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions.

PubMed ID: 12421752

DOI: 10.1101/gr.338402

Sequence Information:

  • Length: 439
  • Mass: 47309
  • Checksum: 0CAB30E9283535A2
  • Sequence:
    • MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEEE AASQQFLEQS LQPGLQVARW 
GGVALPREHI EGGGGPSDPS EFGTEFRAPP RSAAASEDAR QPAKPPSSYI ALITMAILQS 
PHKRLTLSGI CAFISDRFPY YRRKFPAWQN SIRHNLSLND CFVKIPREPG RPGKGNYWSL 
DPASQDMFDN GSFLRRRKRF QRHQPTPGAH LPHPFPLPAA HAALHNPRPG PLLGAPAPPQ 
PVPGAYPNTG PGRRPYALLH PHPPRYLLLS APAYAGAPKK AEGADLATPA PFPCCSPHLV 
LSLGRRARVW RRHREADASL SALRVSCKGS GERVQGLRRV CPRPRGATAP CSSDRQACRT 
ILQQQQRHQE EDCANGCAPT KGAVLGGHLS AASALLRYQA VAEGSGLTSL AAPLGGEGTS 
PVFLVSPTPS SLAESAGPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.