Details for: FOXD4

Gene ID: 2298

Symbol: FOXD4

Ensembl ID: ENSG00000170122

Description: forkhead box D4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1878
    Cell Significance Index: 2.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1039
    Cell Significance Index: 5.4000
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.1023
    Cell Significance Index: 1.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0923
    Cell Significance Index: 5.8200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0627
    Cell Significance Index: 0.8700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0613
    Cell Significance Index: 0.7400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0440
    Cell Significance Index: 0.7300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0397
    Cell Significance Index: 0.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0381
    Cell Significance Index: 1.0200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0339
    Cell Significance Index: 0.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0335
    Cell Significance Index: 1.5200
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.0279
    Cell Significance Index: 0.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0193
    Cell Significance Index: 0.4000
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0163
    Cell Significance Index: 0.2100
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0074
    Cell Significance Index: 0.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0057
    Cell Significance Index: 2.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0046
    Cell Significance Index: 0.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0037
    Cell Significance Index: 0.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0036
    Cell Significance Index: 0.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0032
    Cell Significance Index: 0.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0004
    Cell Significance Index: 0.2400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0004
    Cell Significance Index: -0.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0004
    Cell Significance Index: -0.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0008
    Cell Significance Index: -0.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0009
    Cell Significance Index: -0.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0010
    Cell Significance Index: -0.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0010
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0010
    Cell Significance Index: -0.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0013
    Cell Significance Index: -0.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0014
    Cell Significance Index: -0.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0019
    Cell Significance Index: -0.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0027
    Cell Significance Index: -0.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0033
    Cell Significance Index: -0.4000
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0041
    Cell Significance Index: -0.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0041
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0043
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0047
    Cell Significance Index: -1.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0064
    Cell Significance Index: -0.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0064
    Cell Significance Index: -0.8300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0068
    Cell Significance Index: -0.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0073
    Cell Significance Index: -0.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0073
    Cell Significance Index: -0.3400
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0074
    Cell Significance Index: -0.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0077
    Cell Significance Index: -0.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0102
    Cell Significance Index: -0.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0104
    Cell Significance Index: -0.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0108
    Cell Significance Index: -0.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0111
    Cell Significance Index: -0.6800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0111
    Cell Significance Index: -0.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0113
    Cell Significance Index: -0.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0114
    Cell Significance Index: -0.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0118
    Cell Significance Index: -0.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0122
    Cell Significance Index: -0.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0123
    Cell Significance Index: -0.2600
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.0126
    Cell Significance Index: -0.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0128
    Cell Significance Index: -0.6500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0132
    Cell Significance Index: -0.2700
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0141
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0143
    Cell Significance Index: -0.1800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0144
    Cell Significance Index: -0.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0146
    Cell Significance Index: -0.3900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0148
    Cell Significance Index: -0.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0149
    Cell Significance Index: -0.6600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0160
    Cell Significance Index: -0.2000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0162
    Cell Significance Index: -0.4100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0176
    Cell Significance Index: -0.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0191
    Cell Significance Index: -0.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0193
    Cell Significance Index: -0.7300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0193
    Cell Significance Index: -0.2100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0196
    Cell Significance Index: -0.4100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0196
    Cell Significance Index: -0.5600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0199
    Cell Significance Index: -0.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0203
    Cell Significance Index: -0.5700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0213
    Cell Significance Index: -0.2200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0218
    Cell Significance Index: -0.8900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0228
    Cell Significance Index: -0.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0229
    Cell Significance Index: -0.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0230
    Cell Significance Index: -0.8000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0232
    Cell Significance Index: -0.3300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0238
    Cell Significance Index: -0.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0239
    Cell Significance Index: -0.6900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0250
    Cell Significance Index: -0.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0251
    Cell Significance Index: -0.7400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0252
    Cell Significance Index: -0.6100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0254
    Cell Significance Index: -0.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0273
    Cell Significance Index: -0.7300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0275
    Cell Significance Index: -0.4600
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0281
    Cell Significance Index: -0.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0288
    Cell Significance Index: -0.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0290
    Cell Significance Index: -0.7400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0290
    Cell Significance Index: -0.8300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0292
    Cell Significance Index: -0.3700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0296
    Cell Significance Index: -0.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0296
    Cell Significance Index: -0.6200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0299
    Cell Significance Index: -0.7300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0301
    Cell Significance Index: -0.3300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0302
    Cell Significance Index: -0.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FOXD4 is a transcription factor that belongs to the forkhead box family, characterized by its conserved DNA-binding domain. This domain allows FOXD4 to interact with specific DNA sequences, regulating gene expression in various cell types. FOXD4 is predominantly expressed in cells involved in immune functions, including endothelial cells, goblet cells, and GABAergic interneurons. Its expression is also observed in other cell types, such as intestinal epithelial cells, indicating its role in broader biological processes. **Pathways and Functions:** FOXD4 is involved in several key pathways, including: 1. **Anatomical structure morphogenesis**: FOXD4 regulates the development and differentiation of cells involved in immune functions, such as endothelial cells and goblet cells. 2. **Cell differentiation**: FOXD4 acts as a transcription factor, influencing the differentiation of cells into specific lineages, including immune cells. 3. **Chromatin regulation**: FOXD4 modulates chromatin structure, affecting the accessibility of transcription factors to specific DNA sequences. 4. **DNA-binding transcription factor activity**: FOXD4 interacts with specific DNA sequences, regulating gene expression in immune cells. **Clinical Significance:** FOXD4 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: Alterations in FOXD4 expression have been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: FOXD4 has been identified as a tumor suppressor gene, with altered expression observed in several types of cancer, including colon and lung cancer. 3. **Neurological disorders**: FOXD4 has been implicated in neurological disorders, such as autism and schizophrenia, where its expression is altered in affected individuals. In conclusion, FOXD4 is a critical transcription factor involved in immune regulation, development, and disease. Further research is needed to fully understand the mechanisms by which FOXD4 regulates immune responses and to explore its therapeutic potential in various immune-related disorders. **Recommendations:** 1. **Investigate FOXD4 expression in specific immune cell types**: To better understand the role of FOXD4 in immune regulation and to identify potential therapeutic targets. 2. **Explore FOXD4's involvement in autoimmune diseases**: To elucidate the mechanisms underlying FOXD4's role in autoimmune diseases and to develop novel therapeutic strategies. 3. **Investigate FOXD4's relationship with cancer and neurological disorders**: To determine the functional significance of FOXD4 in these diseases and to explore potential therapeutic applications. By continued research, we can gain a deeper understanding of the FOXD4 gene's role in immune regulation and disease, ultimately leading to the development of innovative therapeutic strategies.

Genular Protein ID: 653932344

Symbol: FOXD4_HUMAN

Name: Forkhead box protein D4

UniProtKB Accession Codes:

Q12950 B2RN05 B9EGL7 Q5VVK1 Q8WXT6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12234674

Title: FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines.

PubMed ID: 12234674

DOI: 10.1016/s0378-1119(02)00702-3

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7957066

Title: Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.

PubMed ID: 7957066

DOI: 10.1002/j.1460-2075.1994.tb06827.x

PubMed ID: 12421752

Title: Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions.

PubMed ID: 12421752

DOI: 10.1101/gr.338402

Sequence Information:

  • Length: 439
  • Mass: 47309
  • Checksum: 0CAB30E9283535A2
  • Sequence:
    • MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEEE AASQQFLEQS LQPGLQVARW 
GGVALPREHI EGGGGPSDPS EFGTEFRAPP RSAAASEDAR QPAKPPSSYI ALITMAILQS 
PHKRLTLSGI CAFISDRFPY YRRKFPAWQN SIRHNLSLND CFVKIPREPG RPGKGNYWSL 
DPASQDMFDN GSFLRRRKRF QRHQPTPGAH LPHPFPLPAA HAALHNPRPG PLLGAPAPPQ 
PVPGAYPNTG PGRRPYALLH PHPPRYLLLS APAYAGAPKK AEGADLATPA PFPCCSPHLV 
LSLGRRARVW RRHREADASL SALRVSCKGS GERVQGLRRV CPRPRGATAP CSSDRQACRT 
ILQQQQRHQE EDCANGCAPT KGAVLGGHLS AASALLRYQA VAEGSGLTSL AAPLGGEGTS 
PVFLVSPTPS SLAESAGPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.