Details for: SPO11

Gene ID: 23626

Symbol: SPO11

Ensembl ID: ENSG00000054796

Description: SPO11 initiator of meiotic double strand breaks

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.24
    Marker Score: 53,066
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,848
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,181
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.21
    Marker Score: 1,522
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.39
    Marker Score: 879
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.29
    Marker Score: 1,851
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.26
    Marker Score: 2,198
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 805
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,833
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2,537
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,061
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,356
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1,507
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,744
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,291
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 507
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.74
    Marker Score: 213
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.67
    Marker Score: 534
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.62
    Marker Score: 380
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 237
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 481
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 283
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 251
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 377
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 211
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.34
    Marker Score: 694
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.28
    Marker Score: 101
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.23
    Marker Score: 137
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.23
    Marker Score: 259
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 119
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.22
    Marker Score: 54
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.17
    Marker Score: 325
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.16
    Marker Score: 168
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.15
    Marker Score: 79
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.15
    Marker Score: 2,313
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.12
    Marker Score: 210
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.11
    Marker Score: 270
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.11
    Marker Score: 232
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 121
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.08
    Marker Score: 49
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.05
    Marker Score: 65
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.04
    Marker Score: 258
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.04
    Marker Score: 64
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.04
    Marker Score: 96
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.02
    Marker Score: 83
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.02
    Marker Score: 200
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.02
    Marker Score: 169
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.01
    Marker Score: 16

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The SPO11 gene is characterized by its high expression levels in cells involved in reproduction and immune function, including germ cells, dendritic cells, and granulocytes. The protein product of SPO11, SPO11_HUMAN, is a meiotic recombination protein that exhibits specific localization to the synaptonemal complex, a structure essential for the proper alignment and pairing of homologous chromosomes during meiosis. The SPO11 protein has been shown to have a high affinity for metal ions, which is thought to be essential for its enzymatic activity. **Pathways and Functions** The SPO11 gene is involved in several key pathways, including: 1. **Meiotic DNA double-strand break formation**: SPO11 is specifically involved in the initiation of double-strand breaks during meiosis, which are essential for the shuffling of genetic material. 2. **Meiotic DNA double-strand break processing**: The SPO11 protein facilitates the processing of double-strand breaks, which ultimately leads to the repair of these breaks and the formation of haploid gametes. 3. **Meiotic recombination**: SPO11 is involved in the recombination process, which involves the exchange of genetic material between homologous chromosomes. 4. **Double-strand break repair involved in meiotic recombination**: The SPO11 protein plays a crucial role in the repair of double-strand breaks, which is essential for the proper completion of meiotic recombination. **Clinical Significance** Dysregulation of the SPO11 gene has been implicated in various genetic disorders, including: 1. **Meiotic disorders**: Mutations in the SPO11 gene have been associated with meiotic disorders, such as meiotic arrest and failure to undergo meiosis. 2. **Reproductive failure**: Abnormalities in SPO11 expression have been linked to reproductive failure, including infertility and miscarriage. 3. **Cancer**: The SPO11 protein has been implicated in the development of certain types of cancer, including breast and ovarian cancer. In conclusion, the SPO11 gene plays a critical role in the meiotic recombination process, and its dysregulation can have significant implications for reproductive health and cancer development. Further research is needed to fully understand the mechanisms by which SPO11 functions and to explore the therapeutic potential of targeting this gene in the treatment of related disorders.

Genular Protein ID: 1400137905

Symbol: SPO11_HUMAN

Name: Meiotic recombination protein SPO11

UniProtKB Accession Codes:

Q9Y5K1 Q5TCI1 Q8N4V0 Q9NQM7 Q9NQM8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 3 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10622720

Title: Differential gene expression of mammalian SPO11/TOP6A homologs during meiosis.

PubMed ID: 10622720

DOI: 10.1016/s0014-5793(99)01546-x

PubMed ID: 10534401

Title: Cloning, characterization, and localization of mouse and human SPO11.

PubMed ID: 10534401

DOI: 10.1006/geno.1999.5955

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 396
  • Mass: 44537
  • Checksum: 117A93D1E7BEBEC8
  • Sequence:
    • MAFAPMGPEA SFFDVLDRHR ESLLAALRRG GREPPTGGSR LASSSEVLAS IENIIQDIIT 
SLARNEAPAF TIDNRSSWEN IKFEDSVGLQ MVSHCTTRKI KSDSPKSAQK FSLILKILSM 
IYKLVQSNTY ATKRDIYYTD SQLFGNQTVV DNIINDISCM LKVSRRSLHI LSTSKGLIAG 
NLRYIEEDGT KVNCTCGATA VAVPSNIQGI RNLVTDAKFV LIVEKDATFQ RLLDDNFCNK 
LSPCIMITGK GVPDLNTRLL VKKLWDTFHV PVFTLVDADP HGIEIMCIYK YGSMSMSFEA 
HHLTVPAIRW LGLLPSDLKR LNVPKDSLIP LTKRDQMKLD SILRRPYVTC QPFWRKEMEI 
MADSKMKAEI QALTFLSSDY LSRVYLPNKL KFGGWI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.