Details for: SPO11

Gene ID: 23626

Symbol: SPO11

Ensembl ID: ENSG00000054796

Description: SPO11 initiator of meiotic double strand breaks

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.9283
    Cell Significance Index: 14.5600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.6271
    Cell Significance Index: 8.2300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.5076
    Cell Significance Index: 9.9300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4233
    Cell Significance Index: 6.1700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.3584
    Cell Significance Index: 3.7100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2276
    Cell Significance Index: 3.2600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.1498
    Cell Significance Index: 1.4800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0995
    Cell Significance Index: 1.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0392
    Cell Significance Index: 1.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0240
    Cell Significance Index: 0.6300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0216
    Cell Significance Index: 0.3500
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0182
    Cell Significance Index: 0.1600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0178
    Cell Significance Index: 0.3000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0172
    Cell Significance Index: 0.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0064
    Cell Significance Index: 0.1400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0060
    Cell Significance Index: 0.0800
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0053
    Cell Significance Index: 0.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0006
    Cell Significance Index: 0.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0003
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0001
    Cell Significance Index: -0.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0003
    Cell Significance Index: -0.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0003
    Cell Significance Index: -0.1300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0003
    Cell Significance Index: 0.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0005
    Cell Significance Index: -0.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0006
    Cell Significance Index: -0.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0007
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0007
    Cell Significance Index: -0.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0007
    Cell Significance Index: -0.0300
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0009
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0015
    Cell Significance Index: -0.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0015
    Cell Significance Index: -0.1600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0024
    Cell Significance Index: -0.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0025
    Cell Significance Index: -0.1400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0025
    Cell Significance Index: -0.0200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0027
    Cell Significance Index: -0.0900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0030
    Cell Significance Index: -0.0400
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0034
    Cell Significance Index: -0.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0034
    Cell Significance Index: -0.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0035
    Cell Significance Index: -0.1100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0036
    Cell Significance Index: -0.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0037
    Cell Significance Index: -0.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0037
    Cell Significance Index: -0.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0043
    Cell Significance Index: -0.2000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0044
    Cell Significance Index: -0.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0045
    Cell Significance Index: -0.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0046
    Cell Significance Index: -0.1300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0057
    Cell Significance Index: -0.1000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0058
    Cell Significance Index: -0.0700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0060
    Cell Significance Index: -0.1500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0065
    Cell Significance Index: -0.1300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0066
    Cell Significance Index: -0.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0066
    Cell Significance Index: -0.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0067
    Cell Significance Index: -0.1800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0068
    Cell Significance Index: -0.0800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0069
    Cell Significance Index: -0.1500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0069
    Cell Significance Index: -0.0900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0070
    Cell Significance Index: -0.1700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0071
    Cell Significance Index: -0.1500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0071
    Cell Significance Index: -0.1400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0074
    Cell Significance Index: -0.1800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0075
    Cell Significance Index: -0.1500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0075
    Cell Significance Index: -0.1000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0077
    Cell Significance Index: -0.0900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0077
    Cell Significance Index: -0.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0079
    Cell Significance Index: -0.2000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0080
    Cell Significance Index: -0.0700
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0081
    Cell Significance Index: -0.0900
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0085
    Cell Significance Index: -0.0900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0085
    Cell Significance Index: -0.1000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0087
    Cell Significance Index: -0.1500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0089
    Cell Significance Index: -0.1300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0091
    Cell Significance Index: -0.0800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0092
    Cell Significance Index: -0.1000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0093
    Cell Significance Index: -0.1900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0093
    Cell Significance Index: -0.1300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0093
    Cell Significance Index: -0.1100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0096
    Cell Significance Index: -0.2300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0097
    Cell Significance Index: -0.1400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0098
    Cell Significance Index: -0.1300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0098
    Cell Significance Index: -0.1400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0100
    Cell Significance Index: -0.1200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0102
    Cell Significance Index: -0.1500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0103
    Cell Significance Index: -0.0900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0105
    Cell Significance Index: -0.1600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0106
    Cell Significance Index: -0.0900
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0107
    Cell Significance Index: -0.1200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0108
    Cell Significance Index: -0.1500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0109
    Cell Significance Index: -0.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0110
    Cell Significance Index: -0.1500
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0110
    Cell Significance Index: -0.1200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0111
    Cell Significance Index: -0.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0112
    Cell Significance Index: -0.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The SPO11 gene is characterized by its high expression levels in cells involved in reproduction and immune function, including germ cells, dendritic cells, and granulocytes. The protein product of SPO11, SPO11_HUMAN, is a meiotic recombination protein that exhibits specific localization to the synaptonemal complex, a structure essential for the proper alignment and pairing of homologous chromosomes during meiosis. The SPO11 protein has been shown to have a high affinity for metal ions, which is thought to be essential for its enzymatic activity. **Pathways and Functions** The SPO11 gene is involved in several key pathways, including: 1. **Meiotic DNA double-strand break formation**: SPO11 is specifically involved in the initiation of double-strand breaks during meiosis, which are essential for the shuffling of genetic material. 2. **Meiotic DNA double-strand break processing**: The SPO11 protein facilitates the processing of double-strand breaks, which ultimately leads to the repair of these breaks and the formation of haploid gametes. 3. **Meiotic recombination**: SPO11 is involved in the recombination process, which involves the exchange of genetic material between homologous chromosomes. 4. **Double-strand break repair involved in meiotic recombination**: The SPO11 protein plays a crucial role in the repair of double-strand breaks, which is essential for the proper completion of meiotic recombination. **Clinical Significance** Dysregulation of the SPO11 gene has been implicated in various genetic disorders, including: 1. **Meiotic disorders**: Mutations in the SPO11 gene have been associated with meiotic disorders, such as meiotic arrest and failure to undergo meiosis. 2. **Reproductive failure**: Abnormalities in SPO11 expression have been linked to reproductive failure, including infertility and miscarriage. 3. **Cancer**: The SPO11 protein has been implicated in the development of certain types of cancer, including breast and ovarian cancer. In conclusion, the SPO11 gene plays a critical role in the meiotic recombination process, and its dysregulation can have significant implications for reproductive health and cancer development. Further research is needed to fully understand the mechanisms by which SPO11 functions and to explore the therapeutic potential of targeting this gene in the treatment of related disorders.

Genular Protein ID: 1400137905

Symbol: SPO11_HUMAN

Name: Meiotic recombination protein SPO11

UniProtKB Accession Codes:

Q9Y5K1 Q5TCI1 Q8N4V0 Q9NQM7 Q9NQM8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 3 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10622720

Title: Differential gene expression of mammalian SPO11/TOP6A homologs during meiosis.

PubMed ID: 10622720

DOI: 10.1016/s0014-5793(99)01546-x

PubMed ID: 10534401

Title: Cloning, characterization, and localization of mouse and human SPO11.

PubMed ID: 10534401

DOI: 10.1006/geno.1999.5955

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 396
  • Mass: 44537
  • Checksum: 117A93D1E7BEBEC8
  • Sequence:
    • MAFAPMGPEA SFFDVLDRHR ESLLAALRRG GREPPTGGSR LASSSEVLAS IENIIQDIIT 
SLARNEAPAF TIDNRSSWEN IKFEDSVGLQ MVSHCTTRKI KSDSPKSAQK FSLILKILSM 
IYKLVQSNTY ATKRDIYYTD SQLFGNQTVV DNIINDISCM LKVSRRSLHI LSTSKGLIAG 
NLRYIEEDGT KVNCTCGATA VAVPSNIQGI RNLVTDAKFV LIVEKDATFQ RLLDDNFCNK 
LSPCIMITGK GVPDLNTRLL VKKLWDTFHV PVFTLVDADP HGIEIMCIYK YGSMSMSFEA 
HHLTVPAIRW LGLLPSDLKR LNVPKDSLIP LTKRDQMKLD SILRRPYVTC QPFWRKEMEI 
MADSKMKAEI QALTFLSSDY LSRVYLPNKL KFGGWI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.