Details for: FRK

Gene ID: 2444

Symbol: FRK

Ensembl ID: ENSG00000111816

Description: fyn related Src family tyrosine kinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.05
    Marker Score: 1080
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.64
    Marker Score: 1260
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168323
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 863
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.23
    Marker Score: 2890
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.18
    Marker Score: 341
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18150
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.14
    Marker Score: 25506
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.08
    Marker Score: 1139
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.06
    Marker Score: 1079
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.06
    Marker Score: 2159
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.05
    Marker Score: 717
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1
    Marker Score: 6065
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1
    Marker Score: 1892
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71797
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48021
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.99
    Marker Score: 313
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.98
    Marker Score: 6325
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.96
    Marker Score: 4160
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.94
    Marker Score: 2524
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1513
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.9
    Marker Score: 990
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5006
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.87
    Marker Score: 827
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.85
    Marker Score: 1800.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.85
    Marker Score: 1408
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.85
    Marker Score: 1932
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.84
    Marker Score: 4542
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 642
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.84
    Marker Score: 2973.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.83
    Marker Score: 501
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.83
    Marker Score: 2100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.83
    Marker Score: 3966
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.82
    Marker Score: 343
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 325.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.79
    Marker Score: 5050
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.79
    Marker Score: 847
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.76
    Marker Score: 1082
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 504
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.74
    Marker Score: 1346
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 669
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.73
    Marker Score: 181
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.73
    Marker Score: 771
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.72
    Marker Score: 812
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.71
    Marker Score: 332
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.71
    Marker Score: 738
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.71
    Marker Score: 265
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.71
    Marker Score: 705
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2962
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.7
    Marker Score: 471
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.7
    Marker Score: 432
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7
    Marker Score: 4222
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.7
    Marker Score: 346
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7
    Marker Score: 12390
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.69
    Marker Score: 547
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.67
    Marker Score: 322
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.67
    Marker Score: 784
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.67
    Marker Score: 317
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.67
    Marker Score: 661
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.66
    Marker Score: 1576
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.66
    Marker Score: 1014
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.66
    Marker Score: 10545
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.65
    Marker Score: 5634
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.64
    Marker Score: 314
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.63
    Marker Score: 1542.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.62
    Marker Score: 912
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.62
    Marker Score: 1095
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.61
    Marker Score: 123
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.6
    Marker Score: 521
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.6
    Marker Score: 1145
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.6
    Marker Score: 217
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.59
    Marker Score: 1342
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.59
    Marker Score: 170
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.59
    Marker Score: 791
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.58
    Marker Score: 405
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.58
    Marker Score: 213
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.56
    Marker Score: 1932
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.56
    Marker Score: 383
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.55
    Marker Score: 318
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.53
    Marker Score: 687
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.52
    Marker Score: 481.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.52
    Marker Score: 302
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.51
    Marker Score: 1607
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.51
    Marker Score: 287
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.5
    Marker Score: 2099
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.5
    Marker Score: 3745
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.5
    Marker Score: 768
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.49
    Marker Score: 140
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.49
    Marker Score: 606
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.48
    Marker Score: 304
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 128

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * FRK is a transmembrane protein with a cytoplasmic domain and a single transmembrane domain. * It is a well-known regulator of cell differentiation and immune responses. * It is involved in the regulation of epithelial cell migration, proliferation, and differentiation. * It is also involved in the regulation of immune cell trafficking, activation, and differentiation. **Pathways and functions:** * **Atp binding:** FRK is a downstream target of the AMP-activated protein kinase (AMPK) pathway. * **Cell differentiation:** It is involved in the early stages of embryonic development and tissue differentiation. * **Extracellular region:** The extracellular domain of FRK is responsible for its interaction with extracellular matrix proteins. * **Immune system:** It plays a critical role in regulating the immune response by promoting the differentiation and activation of immune cells. * **Innate immune response:** It is involved in the activation of macrophages and neutrophils. * **Intracellular signaling by second messengers:** It can interact with phosphatases to regulate intracellular signaling pathways. * **Negative regulation of transcription by rna polymerase ii:** It acts as a negative regulator of gene expression by binding to RNA polymerase and inhibiting its activity. **Clinical significance:** * Mutations in the FRK gene have been linked to several human diseases, including kidney diseases, autoimmune disorders, and cancer. * Overexpression of FRK has been associated with cancer cell proliferation, migration, and survival. * Inhibition of FRK has shown anti-tumor effects in preclinical models. **Additional notes:** * FRK is a promising therapeutic target for cancer and autoimmune disorders. * It is a drug target in clinical trials for cancer and other diseases. * Further research is needed to understand the role of FRK in human health and disease.

Genular Protein ID: 1004438671

Symbol: FRK_HUMAN

Name: Tyrosine-protein kinase FRK

UniProtKB Accession Codes:

P42685 B4DY49 Q13128 Q9NTR5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CPTAC 3 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 2 EMBL 8 EPD 1 Ensembl 1 GO 17 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 5 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 8 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7696183

Title: Rak, a novel nuclear tyrosine kinase expressed in epithelial cells.

PubMed ID: 7696183

PubMed ID: 7510261

Title: Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene.

PubMed ID: 7510261

DOI: 10.1016/0378-1119(94)90817-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8099900

Title: Novel protein kinases expressed in human breast cancer.

PubMed ID: 8099900

DOI: 10.1002/ijc.2910540409

PubMed ID: 7664264

Title: The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb.

PubMed ID: 7664264

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19345329

Title: Rak functions as a tumor suppressor by regulating PTEN protein stability and function.

PubMed ID: 19345329

DOI: 10.1016/j.ccr.2009.02.012

PubMed ID: 19652529

Title: RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK.

PubMed ID: 19652529

DOI: 10.4161/cc.8.17.9389

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 505
  • Mass: 58254
  • Checksum: 06EC050DDBCD930B
  • Sequence:
    • MSNICQRLWE YLEPYLPCLS TEADKSTVIE NPGALCSPQS QRHGHYFVAL FDYQARTAED 
LSFRAGDKLQ VLDTLHEGWW FARHLEKRRD GSSQQLQGYI PSNYVAEDRS LQAEPWFFGA 
IGRSDAEKQL LYSENKTGSF LIRESESQKG EFSLSVLDGA VVKHYRIKRL DEGGFFLTRR 
RIFSTLNEFV SHYTKTSDGL CVKLGKPCLK IQVPAPFDLS YKTVDQWEID RNSIQLLKRL 
GSGQFGEVWE GLWNNTTPVA VKTLKPGSMD PNDFLREAQI MKNLRHPKLI QLYAVCTLED 
PIYIITELMR HGSLQEYLQN DTGSKIHLTQ QVDMAAQVAS GMAYLESRNY IHRDLAARNV 
LVGEHNIYKV ADFGLARVFK VDNEDIYESR HEIKLPVKWT APEAIRSNKF SIKSDVWSFG 
ILLYEIITYG KMPYSGMTGA QVIQMLAQNY RLPQPSNCPQ QFYNIMLECW NAEPKERPTF 
ETLRWKLEDY FETDSSYSDA NNFIR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.