Details for: FSHR

Gene ID: 2492

Symbol: FSHR

Ensembl ID: ENSG00000170820

Description: follicle stimulating hormone receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 5.04
    Marker Score: 32497.5
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.55
    Marker Score: 4360
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 4.38
    Marker Score: 12784
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.59
    Marker Score: 30347
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.35
    Marker Score: 9561
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.44
    Marker Score: 7003.5
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 2.43
    Marker Score: 7200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.18
    Marker Score: 1501
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.81
    Marker Score: 3428
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169708
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.36
    Marker Score: 2773
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 863.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.32
    Marker Score: 770
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.22
    Marker Score: 1367
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7692
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.02
    Marker Score: 611
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1
    Marker Score: 15698
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71788
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48009
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 652
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.85
    Marker Score: 268
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.76
    Marker Score: 342
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.68
    Marker Score: 647
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.66
    Marker Score: 1544.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 429.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.64
    Marker Score: 6062.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.64
    Marker Score: 301.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.62
    Marker Score: 298
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.6
    Marker Score: 3594
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.6
    Marker Score: 345
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 445
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.54
    Marker Score: 173
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.52
    Marker Score: 218
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.51
    Marker Score: 814
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.5
    Marker Score: 499
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.47
    Marker Score: 150
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.46
    Marker Score: 623
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.45
    Marker Score: 200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.42
    Marker Score: 256.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.4
    Marker Score: 230
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.4
    Marker Score: 125
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.38
    Marker Score: 223
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.38
    Marker Score: 465
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.37
    Marker Score: 95
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.36
    Marker Score: 321
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.35
    Marker Score: 206
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.34
    Marker Score: 417
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.34
    Marker Score: 137
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.31
    Marker Score: 62.5
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.28
    Marker Score: 143
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.28
    Marker Score: 1672
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.28
    Marker Score: 244
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.27
    Marker Score: 124
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.27
    Marker Score: 79
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.26
    Marker Score: 1072.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.26
    Marker Score: 535
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.26
    Marker Score: 169
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.24
    Marker Score: 64.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.24
    Marker Score: 1583
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.24
    Marker Score: 66.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.24
    Marker Score: 526
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.24
    Marker Score: 62.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.24
    Marker Score: 64.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.24
    Marker Score: 124
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.23
    Marker Score: 830
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.23
    Marker Score: 59.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.22
    Marker Score: 523.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.22
    Marker Score: 90
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.22
    Marker Score: 225
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 119
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 0.22
    Marker Score: 64.5
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.22
    Marker Score: 903
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.21
    Marker Score: 262.5
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.21
    Marker Score: 66.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.21
    Marker Score: 60.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.2
    Marker Score: 64.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.2
    Marker Score: 194
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.2
    Marker Score: 343
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.2
    Marker Score: 73
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2
    Marker Score: 57.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.19
    Marker Score: 89
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.19
    Marker Score: 50.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.19
    Marker Score: 226
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.18
    Marker Score: 228
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.17
    Marker Score: 67.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.17
    Marker Score: 1706.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.17
    Marker Score: 37

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Other Information

**Key characteristics:** * FSHR is a single-pass membrane protein with a molecular weight of approximately 140 kDa. * It is expressed in high levels in the testes and ovaries of females. * It is also expressed in low levels in the brain and other peripheral tissues. * FSHR is a key regulator of female reproductive function. * It is responsible for the production of follicle-stimulating hormone (FSH), which stimulates the growth and development of ovarian follicles. * FSHR is also involved in the regulation of male reproductive function, including the development of the male reproductive tract and the production of testosterone. **Pathways and functions:** * FSHR signaling is activated by follicle-stimulating hormone (FSH). * FSH binds to FSHR on the surface of ovarian and testicular cells. * This binding triggers a cascade of events that ultimately lead to the production of estrogen and progesterone, which are hormones that regulate female reproductive function. * FSHR also plays a role in the regulation of male reproductive function. * In males, FSHR is expressed in Leydig cells in the testes. * Binding of FSHR by estrogen induces the proliferation and differentiation of Leydig cells into sperm cells. * FSHR also plays a role in the regulation of spermatogenesis, the process of sperm production. **Clinical significance:** * Mutations in the FSHR gene have been linked to a number of reproductive disorders in humans. * These disorders include polycystic ovary syndrome (PCOS), which is characterized by the formation of multiple cysts on the ovaries. * Mutations in FSHR have also been linked to infertility in men. * FSHR is a promising target for the treatment of reproductive disorders. **Additional notes:** * FSHR is a highly conserved gene, with a similar gene found in other mammals. * FSHR is a well-studied gene, and there are a number of drugs that target it for the treatment of reproductive disorders. * The development of these drugs has led to a significant improvement in the treatment of female infertility.

Genular Protein ID: 1146273272

Symbol: FSHR_HUMAN

Name: Follicle-stimulating hormone receptor

UniProtKB Accession Codes:

P23945 A0A0A0MSC5 A8K947 G5CBS7 G5E967 J3KQ00 Q05AH0 Q16225 Q4QRJ3 Q4ZFZ2 Q53RW2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EMBL 17 EMDB 2 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 5 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1709010

Title: Cloning and sequencing of human FSH receptor cDNA.

PubMed ID: 1709010

DOI: 10.1016/0006-291x(91)91682-3

PubMed ID: 1322283

Title: Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts.

PubMed ID: 1322283

DOI: 10.1210/endo.131.2.1322283

PubMed ID: 1301382

Title: The cloning of the human follicle stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells.

PubMed ID: 1301382

DOI: 10.1016/0303-7207(92)90220-z

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1359889

Title: Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor.

PubMed ID: 1359889

DOI: 10.1016/0006-291x(92)91341-m

PubMed ID: 7926278

Title: Characterization of the 5' flanking region of the human follicle-stimulating hormone receptor gene.

PubMed ID: 7926278

DOI: 10.1016/0303-7207(94)90102-3

PubMed ID: 7916967

Title: Localization of the human FSH receptor to chromosome 2p21 using a genomic probe comprising exon 10.

PubMed ID: 7916967

DOI: 10.1677/jme.0.0120265

PubMed ID: 11847099

Title: Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors.

PubMed ID: 11847099

DOI: 10.1093/emboj/21.4.504

PubMed ID: 11872202

Title: Alternatively spliced variants of the follicle-stimulating hormone receptor gene in the testis of infertile men.

PubMed ID: 11872202

DOI: 10.1016/s0015-0282(01)03221-6

PubMed ID: 17030088

Title: APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex.

PubMed ID: 17030088

DOI: 10.1016/j.mce.2006.08.014

PubMed ID: 8747461

Title: Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions.

PubMed ID: 8747461

DOI: 10.1016/s0969-2126(01)00272-6

PubMed ID: 15662415

Title: Structure of human follicle-stimulating hormone in complex with its receptor.

PubMed ID: 15662415

DOI: 10.1038/nature03206

PubMed ID: 24692546

Title: Evidence for follicle-stimulating hormone receptor as a functional trimer.

PubMed ID: 24692546

DOI: 10.1074/jbc.m114.549592

PubMed ID: 7553856

Title: Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure.

PubMed ID: 7553856

DOI: 10.1016/0092-8674(95)90275-9

PubMed ID: 9100567

Title: A mutation in the follicle-stimulating hormone receptor occurs frequently in human ovarian sex cord tumors.

PubMed ID: 9100567

DOI: 10.1210/jcem.82.4.3870

PubMed ID: 8636335

Title: An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man.

PubMed ID: 8636335

DOI: 10.1210/jcem.81.4.8636335

PubMed ID: 9851774

Title: The frequency of an inactivating point mutation (566C-->T) of the human follicle-stimulating hormone receptor gene in four populations using allele-specific hybridization and time-resolved fluorometry.

PubMed ID: 9851774

DOI: 10.1210/jcem.83.12.5306

PubMed ID: 9769327

Title: A novel phenotype related to partial loss of function mutations of the follicle stimulating hormone receptor.

PubMed ID: 9769327

DOI: 10.1172/jci3795

PubMed ID: 10551778

Title: New natural inactivating mutations of the follicle-stimulating hormone receptor: correlations between receptor function and phenotype.

PubMed ID: 10551778

DOI: 10.1210/mend.13.11.0370

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 12059813

Title: Distribution and function of FSH receptor genetic variants in normal men.

PubMed ID: 12059813

DOI: 10.1046/j.1439-0272.2002.00493.x

PubMed ID: 11889179

Title: A novel mutation in the FSH receptor inhibiting signal transduction and causing primary ovarian failure.

PubMed ID: 11889179

DOI: 10.1210/jcem.87.3.8319

PubMed ID: 12571157

Title: A novel loss of function mutation in exon 10 of the FSH receptor gene causing hypergonadotrophic hypogonadism: clinical and molecular characteristics.

PubMed ID: 12571157

DOI: 10.1093/humrep/deg046

PubMed ID: 12915623

Title: Delayed puberty and primary amenorrhea associated with a novel mutation of the human follicle-stimulating hormone receptor: clinical, histological, and molecular studies.

PubMed ID: 12915623

DOI: 10.1210/jc.2003-030217

PubMed ID: 12930927

Title: A chorionic gonadotropin-sensitive mutation in the follicle-stimulating hormone receptor as a cause of familial gestational spontaneous ovarian hyperstimulation syndrome.

PubMed ID: 12930927

DOI: 10.1056/nejmoa030065

PubMed ID: 12930928

Title: Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor.

PubMed ID: 12930928

DOI: 10.1056/nejmoa030064

PubMed ID: 15080154

Title: A mutation in the follicle-stimulating hormone receptor as a cause of familial spontaneous ovarian hyperstimulation syndrome.

PubMed ID: 15080154

DOI: 10.1210/jc.2003-031910

PubMed ID: 16278261

Title: Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology.

PubMed ID: 16278261

DOI: 10.1210/jc.2005-1580

PubMed ID: 17721928

Title: Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndrome.

PubMed ID: 17721928

DOI: 10.1002/humu.20604

PubMed ID: 24058690

Title: Molecular analysis of a mutated FSH receptor detected in a patient with spontaneous ovarian hyperstimulation syndrome.

PubMed ID: 24058690

DOI: 10.1371/journal.pone.0075478

PubMed ID: 25581598

Title: Functional characterization of two naturally occurring mutations (Val514Ala and Ala575Val) in follicle-stimulating hormone receptor.

PubMed ID: 25581598

DOI: 10.1210/jc.2014-3662

Sequence Information:

  • Length: 695
  • Mass: 78265
  • Checksum: 766BC421014CD5A4
  • Sequence:
    • MALLLVSLLA FLSLGSGCHH RICHCSNRVF LCQESKVTEI PSDLPRNAIE LRFVLTKLRV 
IQKGAFSGFG DLEKIEISQN DVLEVIEADV FSNLPKLHEI RIEKANNLLY INPEAFQNLP 
NLQYLLISNT GIKHLPDVHK IHSLQKVLLD IQDNINIHTI ERNSFVGLSF ESVILWLNKN 
GIQEIHNCAF NGTQLDELNL SDNNNLEELP NDVFHGASGP VILDISRTRI HSLPSYGLEN 
LKKLRARSTY NLKKLPTLEK LVALMEASLT YPSHCCAFAN WRRQISELHP ICNKSILRQE 
VDYMTQARGQ RSSLAEDNES SYSRGFDMTY TEFDYDLCNE VVDVTCSPKP DAFNPCEDIM 
GYNILRVLIW FISILAITGN IIVLVILTTS QYKLTVPRFL MCNLAFADLC IGIYLLLIAS 
VDIHTKSQYH NYAIDWQTGA GCDAAGFFTV FASELSVYTL TAITLERWHT ITHAMQLDCK 
VQLRHAASVM VMGWIFAFAA ALFPIFGISS YMKVSICLPM DIDSPLSQLY VMSLLVLNVL 
AFVVICGCYI HIYLTVRNPN IVSSSSDTRI AKRMAMLIFT DFLCMAPISF FAISASLKVP 
LITVSKAKIL LVLFHPINSC ANPFLYAIFT KNFRRDFFIL LSKCGCYEMQ AQIYRTETSS 
TVHNTHPRNG HCSSAPRVTN GSTYILVPLS HLAQN

Genular Protein ID: 2872918300

Symbol: A0A1D5RMN4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1D5RMN4

Database IDs:

ARBA 14 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 30 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 8 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 3 PeptideAtlas 1 Pfam 4 Proteomes 2 RefSeq 1 RuleBase 1 SMART 1 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 695
  • Mass: 78238
  • Checksum: 4C5BC421014CD5BE
  • Sequence:
    • MALLLVSLLA FLSLGSGCHH RICHCSNRVF LCQESKVTEI PSDLPRNAIE LRFVLTKLRV 
IQKGAFSGFG DLEKIEISQN DVLEVIEADV FSNLPKLHEI RIEKANNLLY INPEAFQNLP 
NLQYLLISNT GIKHLPDVHK IHSLQKVLLD IQDNINIHTI ERNSFVGLSF ESVILWLNKN 
GIQEIHNCAF NGTQLDELNL SDNNNLEELP NDVFHGASGP VILDISRTRI HSLPSYGLEN 
LKKLRARSTY NLKKLPTLEK LVALMEASLT YPSHCCAFAN WRRQISELHP ICNKSILRQE 
VDYMTQARGQ RSSLAEDNES SYSRGFDMTY TEFDYDLCNE VVDVTCSPKP DAFNPCEDIM 
GYNILRVLIW FISILAITGN IIVLVILTTS QYKLTVPRFL MCNLAFADLC IGIYLLLIAS 
VDIHTKSQYH NYAIDWQTGA GCDAAGFFTV FASELSVYTL TAITLERWHT ITHAMQLDCK 
VQLRHAASVM VMGWIFAFAA ALFPIFGISS YMKVSICLPM DIDSPLSQLY VMSLLVLNVL 
AFVVICGCYI HIYLTVRNPN IVSSSSDTRI AKRMAMLIFT DFLCMAPISF FAISASLKVP 
LITVSKAKIL LVLFHPINSC ANPFLYAIFT KNFRRDFFIL LSKCGCYEMQ AQIYRTETSS 
TVHNTHPRNG HCSSAPRVTS GSTYILVPLS HLAQN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.