Details for: GABRA6

Gene ID: 2559

Symbol: GABRA6

Ensembl ID: ENSG00000145863

Description: gamma-aminobutyric acid type A receptor subunit alpha6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.5516
    Cell Significance Index: 55.8700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.8623
    Cell Significance Index: 14.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.7790
    Cell Significance Index: 13.3500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7419
    Cell Significance Index: 17.9700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.6086
    Cell Significance Index: 8.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4890
    Cell Significance Index: 21.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4547
    Cell Significance Index: 17.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4112
    Cell Significance Index: 147.5000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.3718
    Cell Significance Index: 3.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2820
    Cell Significance Index: 18.9600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.2714
    Cell Significance Index: 3.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2015
    Cell Significance Index: 5.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0703
    Cell Significance Index: 4.3200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: 0.0575
    Cell Significance Index: 0.6300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0361
    Cell Significance Index: 0.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0278
    Cell Significance Index: 5.5700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0181
    Cell Significance Index: 0.4400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0125
    Cell Significance Index: 0.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0078
    Cell Significance Index: 1.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0034
    Cell Significance Index: 4.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0020
    Cell Significance Index: 3.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0013
    Cell Significance Index: -2.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0015
    Cell Significance Index: -2.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0065
    Cell Significance Index: -4.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0070
    Cell Significance Index: -2.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0071
    Cell Significance Index: -5.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0084
    Cell Significance Index: -3.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0092
    Cell Significance Index: -5.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0127
    Cell Significance Index: -1.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0133
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0176
    Cell Significance Index: -3.0100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0190
    Cell Significance Index: -0.1800
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.0214
    Cell Significance Index: -0.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0250
    Cell Significance Index: -4.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0254
    Cell Significance Index: -5.3500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0270
    Cell Significance Index: -0.3700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0317
    Cell Significance Index: -0.4100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0326
    Cell Significance Index: -0.3800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0352
    Cell Significance Index: -0.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0366
    Cell Significance Index: -3.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0396
    Cell Significance Index: -4.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0402
    Cell Significance Index: -4.6000
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0616
    Cell Significance Index: -0.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0644
    Cell Significance Index: -1.8000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0651
    Cell Significance Index: -2.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0690
    Cell Significance Index: -5.3000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0693
    Cell Significance Index: -1.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0760
    Cell Significance Index: -2.4200
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0764
    Cell Significance Index: -0.4000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0765
    Cell Significance Index: -1.0200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0782
    Cell Significance Index: -1.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0911
    Cell Significance Index: -3.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0927
    Cell Significance Index: -5.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0955
    Cell Significance Index: -4.4900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0974
    Cell Significance Index: -3.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0994
    Cell Significance Index: -5.1800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1018
    Cell Significance Index: -2.2000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1020
    Cell Significance Index: -1.2200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1067
    Cell Significance Index: -1.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1080
    Cell Significance Index: -5.6700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1094
    Cell Significance Index: -2.7300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1136
    Cell Significance Index: -2.2800
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1137
    Cell Significance Index: -1.3000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1138
    Cell Significance Index: -1.2400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1220
    Cell Significance Index: -1.7100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1350
    Cell Significance Index: -3.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1392
    Cell Significance Index: -4.8900
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.1447
    Cell Significance Index: -1.1100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1458
    Cell Significance Index: -2.8700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1538
    Cell Significance Index: -3.2100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1578
    Cell Significance Index: -3.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1614
    Cell Significance Index: -4.6500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1645
    Cell Significance Index: -3.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1651
    Cell Significance Index: -4.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1673
    Cell Significance Index: -4.3000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1710
    Cell Significance Index: -2.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1772
    Cell Significance Index: -5.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1824
    Cell Significance Index: -4.8700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1854
    Cell Significance Index: -2.3400
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.1868
    Cell Significance Index: -1.9200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1947
    Cell Significance Index: -2.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1948
    Cell Significance Index: -4.0400
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1971
    Cell Significance Index: -1.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1984
    Cell Significance Index: -4.9600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2022
    Cell Significance Index: -4.1200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2053
    Cell Significance Index: -5.0100
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.2062
    Cell Significance Index: -1.4300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2080
    Cell Significance Index: -3.0200
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.2323
    Cell Significance Index: -2.3400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2403
    Cell Significance Index: -4.6900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2446
    Cell Significance Index: -4.2300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2453
    Cell Significance Index: -3.3100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2571
    Cell Significance Index: -3.6600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2600
    Cell Significance Index: -2.6900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2621
    Cell Significance Index: -3.8700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2637
    Cell Significance Index: -4.4400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2774
    Cell Significance Index: -3.6400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2786
    Cell Significance Index: -3.7600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2791
    Cell Significance Index: -4.1200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2807
    Cell Significance Index: -3.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Subunit structure**: The GABRA6 gene product is a subunit of the GABA-A receptor, a ligand-gated chloride channel that mediates the inhibitory effects of GABA (gamma-aminobutyric acid), the primary inhibitory neurotransmitter in the brain. 2. **Distribution**: GABRA6 is widely expressed in various cell types, including neurons, progenitor cells, and hematopoietic stem cells, highlighting its role in multiple developmental and physiological processes. 3. **Functional specificity**: The GABRA6 subunit is specifically involved in regulating postsynaptic membrane potential and synaptic transmission, suggesting its critical role in fine-tuning neural excitability. **Pathways and Functions** 1. **GABAergic signaling pathway**: GABRA6 is integral to the GABA-A receptor complex, which mediates the inhibitory effects of GABA. The receptor's activation leads to the opening of chloride channels, causing hyperpolarization of the postsynaptic neuron and reducing excitability. 2. **Regulation of postsynaptic membrane potential**: The GABRA6 subunit contributes to the regulation of postsynaptic membrane potential, influencing neuronal excitability and synaptic transmission. 3. **Inhibitory synapse assembly**: GABRA6 is involved in the assembly of inhibitory synapses, which are critical for regulating neural circuitry and maintaining proper neural function. 4. **Signal transduction**: The GABRA6 subunit participates in signal transduction pathways, modulating the activity of downstream signaling molecules and influencing neural excitability. **Clinical Significance** 1. **Neurological disorders**: Alterations in GABRA6 expression have been linked to various neurological disorders, including epilepsy, anxiety, and schizophrenia. These findings underscore the gene's importance in maintaining proper neural function and circuitry. 2. **Pharmacological applications**: The GABRA6 subunit is a target for several anxiolytic and anticonvulsant medications, highlighting its potential as a therapeutic target for treating neurological disorders. 3. **Developmental implications**: GABRA6 is expressed in progenitor cells and hematopoietic stem cells, suggesting its role in developmental processes and potentially highlighting its involvement in neurodevelopmental disorders. In conclusion, the GABRA6 gene plays a critical role in regulating neuronal excitability and synaptic transmission through its involvement in the GABA-A receptor complex. Alterations in GABRA6 expression have significant implications for neurological disorders and highlight its potential as a therapeutic target. Further research is necessary to fully elucidate the gene's functions and its role in maintaining proper neural function.

Genular Protein ID: 809986782

Symbol: GBRA6_HUMAN

Name: GABA(A) receptor subunit alpha-6

UniProtKB Accession Codes:

Q16445 A8K096 Q4VAV2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 ComplexPortal 5 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 85 DrugCentral 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 20 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 4 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8632757

Title: Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors.

PubMed ID: 8632757

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 453
  • Mass: 51024
  • Checksum: 5C9F85845BC8E3B0
  • Sequence:
    • MASSLPWLCI ILWLENALGK LEVEGNFYSE NVSRILDNLL EGYDNRLRPG FGGAVTEVKT 
DIYVTSFGPV SDVEMEYTMD VFFRQTWTDE RLKFGGPTEI LSLNNLMVSK IWTPDTFFRN 
GKKSIAHNMT TPNKLFRIMQ NGTILYTMRL TINADCPMRL VNFPMDGHAC PLKFGSYAYP 
KSEIIYTWKK GPLYSVEVPE ESSSLLQYDL IGQTVSSETI KSNTGEYVIM TVYFHLQRKM 
GYFMIQIYTP CIMTVILSQV SFWINKESVP ARTVFGITTV LTMTTLSISA RHSLPKVSYA 
TAMDWFIAVC FAFVFSALIE FAAVNYFTNL QTQKAKRKAQ FAAPPTVTIS KATEPLEAEI 
VLHPDSKYHL KKRITSLSLP IVSSSEANKV LTRAPILQST PVTPPPLSPA FGGTSKIDQY 
SRILFPVAFA GFNLVYWVVY LSKDTMEVSS SVE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.