Details for: OR2J2

Gene ID: 26707

Symbol: OR2J2

Ensembl ID: ENSG00000204700

Description: olfactory receptor family 2 subfamily J member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1935
    Cell Significance Index: 3.0700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1421
    Cell Significance Index: 1.8300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.1074
    Cell Significance Index: 1.2100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0223
    Cell Significance Index: 0.5600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.0177
    Cell Significance Index: 0.1500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: 0.0158
    Cell Significance Index: 0.1600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0127
    Cell Significance Index: 0.1600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0115
    Cell Significance Index: 0.1300
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.0106
    Cell Significance Index: 0.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0084
    Cell Significance Index: 0.4400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0059
    Cell Significance Index: 0.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0027
    Cell Significance Index: 0.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0014
    Cell Significance Index: 0.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0008
    Cell Significance Index: 0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0001
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0002
    Cell Significance Index: -0.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.5000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0008
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0009
    Cell Significance Index: -0.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0010
    Cell Significance Index: -0.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0012
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0013
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0015
    Cell Significance Index: -0.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0018
    Cell Significance Index: -0.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0030
    Cell Significance Index: -0.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0034
    Cell Significance Index: -0.1200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0038
    Cell Significance Index: -0.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0041
    Cell Significance Index: -0.6000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0042
    Cell Significance Index: -0.0500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0049
    Cell Significance Index: -0.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0061
    Cell Significance Index: -0.3400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0062
    Cell Significance Index: -0.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0062
    Cell Significance Index: -0.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0084
    Cell Significance Index: -0.2300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0088
    Cell Significance Index: -0.1400
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0101
    Cell Significance Index: -0.0800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0111
    Cell Significance Index: -0.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0118
    Cell Significance Index: -0.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0119
    Cell Significance Index: -0.5600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0120
    Cell Significance Index: -0.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0122
    Cell Significance Index: -0.3900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0122
    Cell Significance Index: -0.1600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0126
    Cell Significance Index: -0.2500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0128
    Cell Significance Index: -0.1300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0128
    Cell Significance Index: -0.1400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0136
    Cell Significance Index: -0.3400
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0139
    Cell Significance Index: -0.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0143
    Cell Significance Index: -0.5400
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0147
    Cell Significance Index: -0.1700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0149
    Cell Significance Index: -0.3000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0165
    Cell Significance Index: -0.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0169
    Cell Significance Index: -0.3900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0176
    Cell Significance Index: -0.2200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0191
    Cell Significance Index: -0.4100
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0191
    Cell Significance Index: -0.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0194
    Cell Significance Index: -0.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0195
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.0196
    Cell Significance Index: -0.1800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0197
    Cell Significance Index: -0.2400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0201
    Cell Significance Index: -0.3500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0203
    Cell Significance Index: -0.2400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0208
    Cell Significance Index: -0.4100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0208
    Cell Significance Index: -0.2500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0213
    Cell Significance Index: -0.2400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0218
    Cell Significance Index: -0.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0223
    Cell Significance Index: -0.6000
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0229
    Cell Significance Index: -0.2700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0239
    Cell Significance Index: -0.4800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0244
    Cell Significance Index: -0.5900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0249
    Cell Significance Index: -0.3000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0254
    Cell Significance Index: -0.3700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0263
    Cell Significance Index: -0.4000
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0269
    Cell Significance Index: -0.3000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0275
    Cell Significance Index: -0.4700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0278
    Cell Significance Index: -0.3700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0286
    Cell Significance Index: -0.5600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0291
    Cell Significance Index: -0.5800
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0292
    Cell Significance Index: -0.3200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0295
    Cell Significance Index: -0.2800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0299
    Cell Significance Index: -0.1600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0301
    Cell Significance Index: -0.3800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0307
    Cell Significance Index: -0.4300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0310
    Cell Significance Index: -0.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0317
    Cell Significance Index: -0.5300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0319
    Cell Significance Index: -0.3300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0323
    Cell Significance Index: -0.4600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0324
    Cell Significance Index: -0.5600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0328
    Cell Significance Index: -0.3800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0335
    Cell Significance Index: -0.4800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0337
    Cell Significance Index: -0.3400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0342
    Cell Significance Index: -0.3700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0349
    Cell Significance Index: -0.5400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0351
    Cell Significance Index: -0.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0351
    Cell Significance Index: -0.3800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0352
    Cell Significance Index: -0.5700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0352
    Cell Significance Index: -0.4400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0365
    Cell Significance Index: -0.4800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0373
    Cell Significance Index: -0.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The OR2J2 gene belongs to the olfactory receptor family, which consists of over 400 genes that encode for G protein-coupled receptors (GPCRs) responsible for detecting odorant molecules in the air. OR2J2 is specifically part of the olfactory receptor family 2 subfamily J, which is known for its high expression in the nasal cavity and its role in detecting a wide range of odorants. The OR2J2 gene is highly conserved across species, suggesting its evolutionary importance in olfactory perception. **Pathways and Functions:** The OR2J2 gene plays a crucial role in the detection of chemical stimuli involved in sensory perception of smell. Upon binding to odorant molecules, the OR2J2 receptor activates a signaling cascade that ultimately leads to the transmission of signals to the brain, where they are interpreted as specific odors. This process involves the following pathways: 1. **G protein-coupled receptor activity**: The OR2J2 receptor binds to odorant molecules, triggering a conformational change that activates the G protein. 2. **G protein-coupled receptor signaling pathway**: The activated G protein stimulates the activation of adenylyl cyclase, leading to the production of cyclic AMP (cAMP). 3. **Olfactory signaling pathway**: The cAMP signaling pathway ultimately leads to the activation of downstream signaling molecules, such as phospholipase C, which triggers the production of second messengers. 4. **Sensory perception**: The final output of the OR2J2 signaling pathway is the perception of specific odors, which is essential for our ability to detect and distinguish different smells. **Significantly Expressed Cells:** The OR2J2 gene is highly expressed in various cell types, including: 1. **Goblet cells**: Found in the respiratory tract, goblet cells produce mucus that traps odorant molecules, allowing them to be detected by the OR2J2 receptor. 2. **Absorptive cells**: These cells are responsible for the absorption of nutrients and oxygen, and are also involved in the detection of odorant molecules. 3. **Intestinal crypt stem cells**: These stem cells are responsible for the regeneration of the intestinal epithelium and are also expressed in the OR2J2 gene. 4. **Neoplastic cells**: Cancer cells often express the OR2J2 gene, suggesting its potential role in cancer development and progression. 5. **B cells**: B cells, a type of immune cell, also express the OR2J2 gene, suggesting its potential role in immune function. **Clinical Significance:** The OR2J2 gene has significant implications for various diseases and disorders, including: 1. **Olfactory disorders**: Mutations in the OR2J2 gene have been associated with olfactory dysfunction, which can lead to anosmia (loss of smell) and hyposmia (reduced sense of smell). 2. **Cancer**: The OR2J2 gene is overexpressed in various types of cancer, including lung, breast, and colon cancer, suggesting its potential role in cancer development and progression. 3. **Immune function**: The OR2J2 gene is expressed in B cells, which are involved in immune function, suggesting its potential role in immune disorders. 4. **Neurological disorders**: The OR2J2 gene has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, suggesting its potential role in neurodegenerative diseases. In conclusion, the OR2J2 gene plays a critical role in olfactory perception and is also implicated in various diseases and disorders. Further research is needed to fully understand the functions and clinical significance of this gene.

Genular Protein ID: 899063407

Symbol: OR2J2_HUMAN

Name: Olfactory receptor 2J2

UniProtKB Accession Codes:

O76002 A6NCU9 A6NLD0 B0UY53 Q32N09 Q5ST39 Q5SUJ6 Q6IF24 Q9GZK2 Q9GZL3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 25 Ensembl 8 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 312
  • Mass: 35204
  • Checksum: FB7D20BB2379C43E
  • Sequence:
    • MMIKKNASSE DFFILLGFSN WPQLEVVLFV VILIFYLMTL TGNLFIIILS YVDSHLHTPM 
YFFLSNLSFL DLCHTTSSIP QLLVNLRGPE KTISYAGCMV QLYFVLALGI AECVLLVVMS 
YDRYVAVCRP LHYTVLMHPR FCHLLAAASW VIGFTISALH SSFTFWVPLC GHRLVDHFFC 
EVPALLRLSC VDTHANELTL MVMSSIFVLI PLILILTAYG AIARAVLSMQ STTGLQKVFR 
TCGAHLMVVS LFFIPVMCMY LQPPSENSPD QGKFIALFYT VVTPSLNPLI YTLRNKHVKG 
AAKRLLGWEW GK

Genular Protein ID: 806036819

Symbol: A0A126GWS4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A126GWS4

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 2 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 312
  • Mass: 35318
  • Checksum: 79F73B3A36CA9F54
  • Sequence:
    • MMIKKNASSE DFFILLGFSN WPQLEVVLFV VILIFYLMTL TGNLFIIILS YVDSHLHTPM 
YFFLSNLSFL DLCYTTSSIP QLLVNLRGPE KTISYAGCMV QLYFVLALGI TECVLLVVMS 
YDRYVAVCRP LHYTVLMHPR FCHLLVAASW VIGFTISALH SSFTFWVPLC GHRLVDHFFC 
EVPALLRLSC VDTHANELTL MVMSSIFVLI PLILILTTYG AIARAVLSMQ STTGLQKVFR 
TCGAHLMVVS LFFIPVMCMY LQPPSENSPD QGKFIALFYT VVTPSLNPLI YTLRNKHVKG 
AAKRLLGWEW GK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.