Details for: GPR78

Gene ID: 27201

Symbol: GPR78

Ensembl ID: ENSG00000155269

Description: G protein-coupled receptor 78

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 6.2045
    Cell Significance Index: 57.1400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 4.3937
    Cell Significance Index: 27.3000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.8780
    Cell Significance Index: 45.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.7618
    Cell Significance Index: 10.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7371
    Cell Significance Index: 38.2900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5434
    Cell Significance Index: 7.9200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.5077
    Cell Significance Index: 3.3700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3650
    Cell Significance Index: 5.7900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.2743
    Cell Significance Index: 3.4700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0910
    Cell Significance Index: 2.2700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0863
    Cell Significance Index: 1.0900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0792
    Cell Significance Index: 0.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0642
    Cell Significance Index: 11.5700
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.0500
    Cell Significance Index: 0.3600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0414
    Cell Significance Index: 0.7100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0374
    Cell Significance Index: 0.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0303
    Cell Significance Index: 0.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0264
    Cell Significance Index: 1.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0158
    Cell Significance Index: 1.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0140
    Cell Significance Index: 0.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0133
    Cell Significance Index: 0.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0120
    Cell Significance Index: 0.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0091
    Cell Significance Index: 2.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0064
    Cell Significance Index: 2.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0053
    Cell Significance Index: 0.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0031
    Cell Significance Index: 0.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0019
    Cell Significance Index: 0.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0013
    Cell Significance Index: 0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0010
    Cell Significance Index: 1.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0003
    Cell Significance Index: 0.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -0.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0005
    Cell Significance Index: -0.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0009
    Cell Significance Index: -0.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0013
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0013
    Cell Significance Index: -0.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0015
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0017
    Cell Significance Index: -1.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0017
    Cell Significance Index: -1.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0022
    Cell Significance Index: -1.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0024
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0065
    Cell Significance Index: -1.3600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0069
    Cell Significance Index: -0.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0082
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0089
    Cell Significance Index: -1.0200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0094
    Cell Significance Index: -0.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0098
    Cell Significance Index: -0.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0104
    Cell Significance Index: -0.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0122
    Cell Significance Index: -1.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0126
    Cell Significance Index: -0.4000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0162
    Cell Significance Index: -0.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0168
    Cell Significance Index: -1.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0176
    Cell Significance Index: -0.2400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0200
    Cell Significance Index: -0.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0218
    Cell Significance Index: -1.3400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0221
    Cell Significance Index: -0.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0226
    Cell Significance Index: -1.2700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0233
    Cell Significance Index: -0.5800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0241
    Cell Significance Index: -0.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0269
    Cell Significance Index: -0.8800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0272
    Cell Significance Index: -0.8600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0276
    Cell Significance Index: -0.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0279
    Cell Significance Index: -1.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0283
    Cell Significance Index: -0.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0294
    Cell Significance Index: -0.8400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0327
    Cell Significance Index: -0.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0328
    Cell Significance Index: -0.8800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0338
    Cell Significance Index: -0.3200
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.0340
    Cell Significance Index: -0.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0348
    Cell Significance Index: -1.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0350
    Cell Significance Index: -0.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0373
    Cell Significance Index: -1.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0430
    Cell Significance Index: -0.8400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0431
    Cell Significance Index: -0.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0434
    Cell Significance Index: -1.1400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0446
    Cell Significance Index: -0.7500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0456
    Cell Significance Index: -0.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0488
    Cell Significance Index: -1.0400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0494
    Cell Significance Index: -0.4200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0510
    Cell Significance Index: -0.6800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0537
    Cell Significance Index: -1.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0541
    Cell Significance Index: -1.5500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0542
    Cell Significance Index: -1.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0547
    Cell Significance Index: -0.9200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0551
    Cell Significance Index: -0.6400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0551
    Cell Significance Index: -1.0900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0554
    Cell Significance Index: -1.1600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0559
    Cell Significance Index: -1.1000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0566
    Cell Significance Index: -1.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0568
    Cell Significance Index: -1.1400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0583
    Cell Significance Index: -2.5300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0617
    Cell Significance Index: -1.0400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0619
    Cell Significance Index: -1.2100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0622
    Cell Significance Index: -1.2400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0632
    Cell Significance Index: -0.5200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0658
    Cell Significance Index: -1.5200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0666
    Cell Significance Index: -0.8100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0671
    Cell Significance Index: -0.9900
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0675
    Cell Significance Index: -1.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0677
    Cell Significance Index: -2.7700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0682
    Cell Significance Index: -1.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPR78 is a member of the G-protein coupled receptor family, which is characterized by its ability to bind to ligands and activate downstream signaling pathways. Key characteristics of GPR78 include: * Expression in multiple cell types, including immune cells such as plasma cells and goblet cells, and neural cells such as retinal bipolar neurons and cerebral cortex GABAergic interneurons * Involvement in adenylate cyclase-activating g protein-coupled receptor signaling pathway * Protein binding capabilities, suggesting a potential role in protein-protein interactions * Association with plasma membrane, suggesting a role in cell surface signaling **Pathways and Functions:** GPR78 is involved in multiple signaling pathways, including: * Adenylate cyclase-activating g protein-coupled receptor signaling pathway: This pathway involves the activation of adenylate cyclase, leading to an increase in cAMP levels and subsequent activation of downstream signaling pathways * G protein-coupled receptor activity: GPR78's ability to bind to ligands and activate downstream signaling pathways suggests a role in G protein-coupled receptor activity * Plasma membrane: GPR78's association with the plasma membrane suggests a role in cell surface signaling * Protein binding: GPR78's protein binding capabilities suggest a potential role in protein-protein interactions **Clinical Significance:** The clinical significance of GPR78 remains to be fully elucidated, but its expression in multiple cell types and its involvement in key signaling pathways suggest a potential role in various diseases, including: * Immune disorders: GPR78's expression in immune cells such as plasma cells and goblet cells suggests a potential role in immune regulation and disease * Neurological disorders: GPR78's expression in neural cells such as retinal bipolar neurons and cerebral cortex GABAergic interneurons suggests a potential role in neural regulation and disease * Cancer: GPR78's expression in cancer cells such as kidney proximal convoluted tubule epithelial cells suggests a potential role in cancer development and progression In conclusion, GPR78 is a novel member of the G-protein coupled receptor family that has been implicated in multiple signaling pathways and has been found to be significantly expressed in various tissues, including the immune system and the nervous system. Further studies are needed to fully elucidate the functional significance of GPR78 and its potential role in various diseases.

Genular Protein ID: 743334891

Symbol: GPR78_HUMAN

Name: G-protein coupled receptor 78

UniProtKB Accession Codes:

Q96P69 Q8NGV3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11574155

Title: Discovery and mapping of ten novel G protein-coupled receptor genes.

PubMed ID: 11574155

DOI: 10.1016/s0378-1119(01)00651-5

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17363172

Title: Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78.

PubMed ID: 17363172

DOI: 10.1016/j.bbagen.2007.01.013

Sequence Information:

  • Length: 363
  • Mass: 39332
  • Checksum: 2C0052A0A1A22A93
  • Sequence:
    • MGPGEALLAG LLVMVLAVAL LSNALVLLCC AYSAELRTRA SGVLLVNLSL GHLLLAALDM 
PFTLLGVMRG RTPSAPGACQ VIGFLDTFLA SNAALSVAAL SADQWLAVGF PLRYAGRLRP 
RYAGLLLGCA WGQSLAFSGA ALGCSWLGYS SAFASCSLRL PPEPERPRFA AFTATLHAVG 
FVLPLAVLCL TSLQVHRVAR RHCQRMDTVT MKALALLADL HPSVRQRCLI QQKRRRHRAT 
RKIGIAIATF LICFAPYVMT RLAELVPFVT VNAQWGILSK CLTYSKAVAD PFTYSLLRRP 
FRQVLAGMVH RLLKRTPRPA STHDSSLDVA GMVHQLLKRT PRPASTHNGS VDTENDSCLQ 
QTH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.