Details for: IGHV3 49

Gene ID: 28423

Symbol: IGHV3 49

Ensembl ID: ENSG00000211965

Description: immunoglobulin heavy variable 3-49

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.2692
    Cell Significance Index: -3.4000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2385
    Cell Significance Index: 3.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0280
    Cell Significance Index: 3.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0040
    Cell Significance Index: -3.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0236
    Cell Significance Index: -2.4100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0238
    Cell Significance Index: -0.4100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0411
    Cell Significance Index: -1.0300
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0509
    Cell Significance Index: -0.4200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0754
    Cell Significance Index: -2.2200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0891
    Cell Significance Index: -0.9100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1138
    Cell Significance Index: -2.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1213
    Cell Significance Index: -5.5000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1222
    Cell Significance Index: -2.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1303
    Cell Significance Index: -3.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1753
    Cell Significance Index: -3.2400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1756
    Cell Significance Index: -3.0000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1811
    Cell Significance Index: -2.1500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1828
    Cell Significance Index: -2.9600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1909
    Cell Significance Index: -2.4700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1923
    Cell Significance Index: -3.7600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1994
    Cell Significance Index: -2.7700
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.2021
    Cell Significance Index: -1.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2029
    Cell Significance Index: -9.4600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2130
    Cell Significance Index: -2.3800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2198
    Cell Significance Index: -2.9900
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2200
    Cell Significance Index: -2.4100
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.2226
    Cell Significance Index: -2.2600
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.2237
    Cell Significance Index: -1.4900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2239
    Cell Significance Index: -3.2500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2298
    Cell Significance Index: -5.3100
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.2332
    Cell Significance Index: -2.6500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2334
    Cell Significance Index: -3.2000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.2351
    Cell Significance Index: -2.2400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.2400
    Cell Significance Index: -2.5500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2414
    Cell Significance Index: -3.0500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2455
    Cell Significance Index: -3.2100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2565
    Cell Significance Index: -2.9100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2575
    Cell Significance Index: -3.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2658
    Cell Significance Index: -7.6200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2671
    Cell Significance Index: -2.9100
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2706
    Cell Significance Index: -2.9600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2718
    Cell Significance Index: -2.9300
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.2776
    Cell Significance Index: -2.5300
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.2819
    Cell Significance Index: -2.9600
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.2819
    Cell Significance Index: -2.5400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2824
    Cell Significance Index: -3.2500
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.2837
    Cell Significance Index: -2.2800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2852
    Cell Significance Index: -3.3700
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.2875
    Cell Significance Index: -3.1700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2892
    Cell Significance Index: -3.1100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2907
    Cell Significance Index: -3.3500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2920
    Cell Significance Index: -3.0800
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.2930
    Cell Significance Index: -3.2000
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.2931
    Cell Significance Index: -2.7200
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.2998
    Cell Significance Index: -3.1900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3003
    Cell Significance Index: -3.7900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.3009
    Cell Significance Index: -3.7800
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.3060
    Cell Significance Index: -3.2500
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3068
    Cell Significance Index: -2.6200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.3074
    Cell Significance Index: -3.2700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.3080
    Cell Significance Index: -3.6400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3106
    Cell Significance Index: -5.2800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3108
    Cell Significance Index: -5.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3120
    Cell Significance Index: -16.2100
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.3121
    Cell Significance Index: -2.8400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3138
    Cell Significance Index: -4.1700
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.3168
    Cell Significance Index: -2.8300
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.3181
    Cell Significance Index: -3.2300
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.3220
    Cell Significance Index: -2.9700
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.3224
    Cell Significance Index: -2.4600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3242
    Cell Significance Index: -3.2900
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.3254
    Cell Significance Index: -3.2100
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.3266
    Cell Significance Index: -3.3600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3292
    Cell Significance Index: -3.6500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3292
    Cell Significance Index: -3.7100
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.3296
    Cell Significance Index: -2.9400
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.3306
    Cell Significance Index: -3.2300
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.3308
    Cell Significance Index: -3.2300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3332
    Cell Significance Index: -3.6300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.3333
    Cell Significance Index: -2.9200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.3363
    Cell Significance Index: -3.4300
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.3427
    Cell Significance Index: -3.7100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.3452
    Cell Significance Index: -3.6600
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.3460
    Cell Significance Index: -3.0400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.3473
    Cell Significance Index: -2.6600
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.3489
    Cell Significance Index: -3.8300
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.3497
    Cell Significance Index: -3.3300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3503
    Cell Significance Index: -5.1700
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.3510
    Cell Significance Index: -3.2700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3541
    Cell Significance Index: -4.6600
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.3544
    Cell Significance Index: -3.6200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.3551
    Cell Significance Index: -4.6400
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: -0.3586
    Cell Significance Index: -3.5200
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.3600
    Cell Significance Index: -4.0000
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.3615
    Cell Significance Index: -3.3400
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.3630
    Cell Significance Index: -3.4400
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: -0.3662
    Cell Significance Index: -3.2800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.3664
    Cell Significance Index: -4.3300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3666
    Cell Significance Index: -4.5800
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.3677
    Cell Significance Index: -3.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** IGHV3-49 is located on chromosome 14q32.33 and is significantly expressed in a wide range of cell types, including endothelial cells, goblet cells, and intestinal epithelial cells. 2. **Immunoglobulin Structure:** IGHV3-49 is a heavy chain variable region gene that is part of the immunoglobulin family, which consists of heavy and light chains that assemble to form a functional antibody. 3. **Antigen Recognition:** IGHV3-49 is involved in the recognition of specific antigens, allowing B cells to differentiate and produce antibodies that recognize and bind to these antigens. 4. **Cellular Distribution:** IGHV3-49 is expressed in various cell types, including epithelial cells, which suggests its role in tissue homeostasis and immune surveillance. **Pathways and Functions:** 1. **Antigen Binding:** IGHV3-49 plays a crucial role in the binding of antibodies to specific antigens, allowing B cells to recognize and respond to pathogens and foreign substances. 2. **Immunoglobulin Complex Formation:** IGHV3-49 is involved in the assembly of immunoglobulin complexes, which are essential for the recognition and elimination of pathogens. 3. **Immune Response:** IGHV3-49 contributes to the development of the immune response by allowing B cells to differentiate and produce antibodies that recognize and bind to specific antigens. 4. **Cell Signaling:** IGHV3-49 may also be involved in cell signaling pathways, influencing the behavior of B cells and other immune cells. **Clinical Significance:** 1. **Cancer Association:** IGHV3-49 has been associated with various types of cancer, including lymphoma and leukemia, highlighting its potential role in tumorigenesis. 2. **Immunodeficiency:** Alterations in IGHV3-49 expression may contribute to immunodeficiency, as B cells may not be able to produce antibodies effectively in the absence of this gene. 3. **Autoimmune Disease:** IGHV3-49 may also be involved in autoimmune diseases, such as rheumatoid arthritis, where the immune system mistakenly attacks healthy tissues. 4. **Vaccine Development:** Understanding the role of IGHV3-49 in antigen recognition and immune response may inform the development of vaccines that target specific antigens. In conclusion, IGHV3-49 is a crucial gene that plays a vital role in the recognition and binding of antigens, contributing to the development of the immune response and tissue homeostasis. Its involvement in cancer, immunodeficiency, and autoimmune disease highlights its clinical significance and underscores the importance of further research into its biological functions.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.