Details for: IGHV1 18

Gene ID: 28468

Symbol: IGHV1 18

Ensembl ID: ENSG00000211945

Description: immunoglobulin heavy variable 1-18

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6354
    Cell Significance Index: 9.8300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0992
    Cell Significance Index: 1.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0041
    Cell Significance Index: -3.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0082
    Cell Significance Index: -1.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0190
    Cell Significance Index: -2.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0361
    Cell Significance Index: -3.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0414
    Cell Significance Index: -5.3500
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0448
    Cell Significance Index: -0.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0652
    Cell Significance Index: -4.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0653
    Cell Significance Index: -3.3900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0683
    Cell Significance Index: -0.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0703
    Cell Significance Index: -1.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0731
    Cell Significance Index: -5.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0736
    Cell Significance Index: -2.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1072
    Cell Significance Index: -2.8200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1251
    Cell Significance Index: -2.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1266
    Cell Significance Index: -4.4500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1324
    Cell Significance Index: -1.4800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1338
    Cell Significance Index: -1.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1420
    Cell Significance Index: -4.0900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1452
    Cell Significance Index: -3.7000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1464
    Cell Significance Index: -1.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1546
    Cell Significance Index: -3.7500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1693
    Cell Significance Index: -3.3100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1697
    Cell Significance Index: -4.2400
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1825
    Cell Significance Index: -2.0700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1870
    Cell Significance Index: -2.4200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1898
    Cell Significance Index: -2.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1966
    Cell Significance Index: -3.2900
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1967
    Cell Significance Index: -1.3100
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.1992
    Cell Significance Index: -1.5200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2002
    Cell Significance Index: -2.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2007
    Cell Significance Index: -3.7100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2044
    Cell Significance Index: -2.1200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2117
    Cell Significance Index: -2.8800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2146
    Cell Significance Index: -2.5300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2175
    Cell Significance Index: -2.2900
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.2182
    Cell Significance Index: -1.8600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2202
    Cell Significance Index: -3.7400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2209
    Cell Significance Index: -3.2600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2233
    Cell Significance Index: -2.9200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2244
    Cell Significance Index: -3.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2273
    Cell Significance Index: -10.6000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2274
    Cell Significance Index: -3.8300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2317
    Cell Significance Index: -3.9600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2398
    Cell Significance Index: -5.5400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2466
    Cell Significance Index: -3.4200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2476
    Cell Significance Index: -2.9400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2500
    Cell Significance Index: -2.6600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2533
    Cell Significance Index: -3.2100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2544
    Cell Significance Index: -2.8800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2545
    Cell Significance Index: -3.4900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2581
    Cell Significance Index: -3.0500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2659
    Cell Significance Index: -3.3600
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.2673
    Cell Significance Index: -1.7400
  • Cell Name: collagen secreting cell (CL0000667)
    Fold Change: -0.2677
    Cell Significance Index: -1.4900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.2737
    Cell Significance Index: -2.5400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2746
    Cell Significance Index: -3.3200
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.2782
    Cell Significance Index: -2.6700
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.2797
    Cell Significance Index: -2.5600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2810
    Cell Significance Index: -3.5100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2831
    Cell Significance Index: -4.1400
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2874
    Cell Significance Index: -3.6100
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.2887
    Cell Significance Index: -2.3200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2889
    Cell Significance Index: -3.1600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2892
    Cell Significance Index: -2.9600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2918
    Cell Significance Index: -3.8400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2959
    Cell Significance Index: -2.1200
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.2967
    Cell Significance Index: -2.2800
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.2974
    Cell Significance Index: -2.9100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3007
    Cell Significance Index: -3.4600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3025
    Cell Significance Index: -3.9700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.3123
    Cell Significance Index: -3.6900
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.3142
    Cell Significance Index: -3.1900
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.3174
    Cell Significance Index: -3.2400
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3176
    Cell Significance Index: -3.4800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3180
    Cell Significance Index: -5.6200
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.3193
    Cell Significance Index: -2.9200
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.3241
    Cell Significance Index: -3.6000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3246
    Cell Significance Index: -3.9900
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.3251
    Cell Significance Index: -2.9000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.3261
    Cell Significance Index: -3.5800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.3264
    Cell Significance Index: -3.5100
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.3269
    Cell Significance Index: -3.3700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3297
    Cell Significance Index: -3.6500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.3304
    Cell Significance Index: -3.3500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3306
    Cell Significance Index: -3.9300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.3311
    Cell Significance Index: -3.5700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3316
    Cell Significance Index: -4.0000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.3316
    Cell Significance Index: -3.5900
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.3327
    Cell Significance Index: -2.3200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3332
    Cell Significance Index: -3.6900
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.3340
    Cell Significance Index: -4.0600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3352
    Cell Significance Index: -4.0200
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.3371
    Cell Significance Index: -3.1900
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.3375
    Cell Significance Index: -3.3300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.3386
    Cell Significance Index: -2.1000
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.3401
    Cell Significance Index: -3.7500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3441
    Cell Significance Index: -3.9600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3444
    Cell Significance Index: -4.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV1 18 is a member of the immunoglobulin heavy variable region (IGHV) family, which accounts for approximately 30% of the human genome's sequence. The IGHV1 18 gene is characterized by its unique sequence and structure, which enables it to bind to specific epitopes on antigens. This gene exhibits high variability, with multiple alleles and polymorphisms, allowing for diverse antigen recognition and immune response generation. **Pathways and Functions:** IGHV1 18 is integral to the immune response, participating in various signaling pathways that regulate B-cell activation, differentiation, and proliferation. The primary function of IGHV1 18 is antigen binding, which occurs through the interaction between the variable region of the heavy chain and the antigen. This binding event triggers a cascade of downstream signaling events, including the activation of B-cell receptor signaling pathways, which ultimately lead to the production of antibodies. IGHV1 18 also plays a crucial role in the regulation of immune cell development and function. The gene is expressed in various immune cells, including B cells, T cells, and natural killer cells, and is involved in the regulation of their proliferation, differentiation, and survival. Furthermore, IGHV1 18 is also expressed in non-immune cells, such as epithelial cells and stem cells, where it may participate in the regulation of cellular processes, including differentiation and proliferation. **Clinical Significance:** IGHV1 18 has significant clinical implications, particularly in the context of immune-mediated disorders. The gene's role in antigen recognition and immune response generation makes it an attractive target for the development of novel immunotherapies, such as cancer vaccines and immune therapies. Additionally, the high variability of IGHV1 18 makes it a valuable tool for the analysis of immune responses in various diseases, including autoimmune disorders and infectious diseases. Furthermore, IGHV1 18 has been implicated in the pathogenesis of several diseases, including autoimmune disorders, such as rheumatoid arthritis and lupus, as well as cancer, such as multiple myeloma and lymphoma. Understanding the molecular mechanisms of IGHV1 18 may provide valuable insights into the development of targeted therapies for these diseases. In conclusion, IGHV1 18 is a critical component of the immune system, playing a pivotal role in antigen recognition and immune response generation. Its significance extends beyond the immune system, with implications for various cellular processes and disease pathogenesis. Further research on IGHV1 18 is necessary to fully elucidate its molecular mechanisms and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.