IGHV1 2 | ENSG00000211934 | NCBI 28474

Details for: IGHV1 2

Gene ID: 28474

Symbol: IGHV1 2

Ensembl ID: ENSG00000211934

Description: immunoglobulin heavy variable 1-2

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: early T lineage precursor (CL0002425)
Fold Change: 3.2355
Cell Significance Index: 46.9800
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.9750
Cell Significance Index: 12.0600
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.4466
Cell Significance Index: 2.2400
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3608
Cell Significance Index: 23.2800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2176
Cell Significance Index: 5.8200
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.2145
Cell Significance Index: 1.1400
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.2121
Cell Significance Index: 2.6900
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.0254
Cell Significance Index: 0.2100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0133
Cell Significance Index: 1.7000
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.0106
Cell Significance Index: 0.0500
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0000
Cell Significance Index: 0.0000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0038
Cell Significance Index: -2.9000
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.0345
Cell Significance Index: -0.4200
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0351
Cell Significance Index: -4.5300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0391
Cell Significance Index: -3.9900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0455
Cell Significance Index: -2.1200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0489
Cell Significance Index: -2.5400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0509
Cell Significance Index: -3.1200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0580
Cell Significance Index: -4.3200
Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.0632
Cell Significance Index: -0.8000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0642
Cell Significance Index: -2.9100
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0696
Cell Significance Index: -0.9000
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0705
Cell Significance Index: -0.9900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0719
Cell Significance Index: -9.8700
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0730
Cell Significance Index: -0.8000
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0799
Cell Significance Index: -1.9400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0812
Cell Significance Index: -16.2900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0858
Cell Significance Index: -3.1500
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.0899
Cell Significance Index: -1.0200
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0928
Cell Significance Index: -2.3700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1024
Cell Significance Index: -11.7300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1052
Cell Significance Index: -3.0300
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.1181
Cell Significance Index: -1.3900
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1245
Cell Significance Index: -3.1700
Cell Name: thymocyte (CL0000893)
Fold Change: -0.1322
Cell Significance Index: -1.6700
Cell Name: peg cell (CL4033014)
Fold Change: -0.1424
Cell Significance Index: -3.2900
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.1457
Cell Significance Index: -0.9700
Cell Name: plasma cell (CL0000786)
Fold Change: -0.1531
Cell Significance Index: -1.7100
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.1581
Cell Significance Index: -2.5600
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.1587
Cell Significance Index: -2.0800
Cell Name: naive B cell (CL0000788)
Fold Change: -0.1596
Cell Significance Index: -1.6800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1607
Cell Significance Index: -2.6900
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.1698
Cell Significance Index: -3.3200
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1703
Cell Significance Index: -2.4400
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.1718
Cell Significance Index: -1.9200
Cell Name: leukocyte (CL0000738)
Fold Change: -0.1749
Cell Significance Index: -2.9700
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.1768
Cell Significance Index: -2.0900
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.1784
Cell Significance Index: -2.6000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1793
Cell Significance Index: -5.1400
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.1815
Cell Significance Index: -2.0600
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.1845
Cell Significance Index: -2.5100
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.1911
Cell Significance Index: -2.8000
Cell Name: B cell (CL0000236)
Fold Change: -0.1946
Cell Significance Index: -2.3000
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.1988
Cell Significance Index: -2.3600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2006
Cell Significance Index: -9.4300
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.2034
Cell Significance Index: -2.4600
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.2065
Cell Significance Index: -2.2200
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: -0.2069
Cell Significance Index: -2.1000
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.2071
Cell Significance Index: -3.5400
Cell Name: memory B cell (CL0000787)
Fold Change: -0.2124
Cell Significance Index: -2.2600
Cell Name: immature B cell (CL0000816)
Fold Change: -0.2135
Cell Significance Index: -2.0200
Cell Name: mature B cell (CL0000785)
Fold Change: -0.2135
Cell Significance Index: -1.3900
Cell Name: mural cell (CL0008034)
Fold Change: -0.2136
Cell Significance Index: -2.6000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2153
Cell Significance Index: -3.9800
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.2189
Cell Significance Index: -3.2800
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.2191
Cell Significance Index: -3.0100
Cell Name: adipocyte (CL0000136)
Fold Change: -0.2194
Cell Significance Index: -2.9300
Cell Name: B-2 B cell (CL0000822)
Fold Change: -0.2211
Cell Significance Index: -1.9600
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.2281
Cell Significance Index: -3.2000
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.2336
Cell Significance Index: -3.2400
Cell Name: stromal cell (CL0000499)
Fold Change: -0.2369
Cell Significance Index: -2.4200
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.2386
Cell Significance Index: -2.6100
Cell Name: monocyte (CL0000576)
Fold Change: -0.2407
Cell Significance Index: -2.7700
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.2454
Cell Significance Index: -2.9900
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.2460
Cell Significance Index: -2.2500
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.2462
Cell Significance Index: -2.5000
Cell Name: mast cell (CL0000097)
Fold Change: -0.2470
Cell Significance Index: -3.2500
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.2476
Cell Significance Index: -3.0100
Cell Name: neutrophil (CL0000775)
Fold Change: -0.2482
Cell Significance Index: -3.1000
Cell Name: mesangial cell (CL0000650)
Fold Change: -0.2505
Cell Significance Index: -3.1700
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.2510
Cell Significance Index: -2.5600
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.2513
Cell Significance Index: -2.8000
Cell Name: promonocyte (CL0000559)
Fold Change: -0.2582
Cell Significance Index: -2.7600
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.2594
Cell Significance Index: -4.3700
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.2616
Cell Significance Index: -3.1100
Cell Name: promyelocyte (CL0000836)
Fold Change: -0.2631
Cell Significance Index: -2.6000
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.2648
Cell Significance Index: -2.7600
Cell Name: respiratory basal cell (CL0002633)
Fold Change: -0.2656
Cell Significance Index: -2.6200
Cell Name: alveolar adventitial fibroblast (CL4028006)
Fold Change: -0.2665
Cell Significance Index: -2.9600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.2676
Cell Significance Index: -3.0400
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.2685
Cell Significance Index: -3.3000
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: -0.2687
Cell Significance Index: -3.1200
Cell Name: blood cell (CL0000081)
Fold Change: -0.2699
Cell Significance Index: -2.3000
Cell Name: plasmablast (CL0000980)
Fold Change: -0.2705
Cell Significance Index: -2.5100
Cell Name: myelocyte (CL0002193)
Fold Change: -0.2723
Cell Significance Index: -2.9100
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.2733
Cell Significance Index: -4.8300
Cell Name: club cell (CL0000158)
Fold Change: -0.2754
Cell Significance Index: -3.0000
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.2762
Cell Significance Index: -3.6300
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: -0.2772
Cell Significance Index: -3.0000
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: -0.2788
Cell Significance Index: -2.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** The IGHV1-2 gene exhibits several key characteristics that are essential for its function: 1. **Variable region**: The IGHV1-2 gene encodes for the V1 and V2 domains of the heavy chain, which are responsible for antigen recognition and binding. 2. **High expression levels**: The IGHV1-2 gene is significantly expressed in various cell types, including B cells, natural killer cells, and certain epithelial cells. 3. **Adaptive immune system involvement**: The IGHV1-2 gene plays a critical role in the adaptive immune system, particularly in the context of parasitic infections. 4. **Antigen recognition**: The V1 and V2 domains of the IGHV1-2 gene recognize and bind to specific antigens, which triggers an immune response. **Pathways and Functions** The IGHV1-2 gene is involved in various pathways and functions, including: 1. **Adaptive immune system**: The IGHV1-2 gene plays a critical role in the adaptive immune system, particularly in the context of parasitic infections. 2. **Antigen recognition**: The V1 and V2 domains of the IGHV1-2 gene recognize and bind to specific antigens, which triggers an immune response. 3. **Complement cascade**: The IGHV1-2 gene is involved in the complement cascade, which is a series of reactions that help eliminate pathogens from the body. 4. **Phagocytosis**: The IGHV1-2 gene plays a role in phagocytosis, the process by which cells engulf and internalize pathogens. 5. **Immune system regulation**: The IGHV1-2 gene is involved in regulating the immune system, particularly in the context of parasitic infections. **Clinical Significance** The IGHV1-2 gene has significant clinical implications, particularly in the context of parasitic infections, such as Leishmania parasite infection. The gene's involvement in the adaptive immune system and antigen recognition makes it a critical target for the development of novel therapeutics. Additionally, the IGHV1-2 gene's role in the complement cascade and phagocytosis makes it a potential target for the treatment of infections. In conclusion, the IGHV1-2 gene is a critical component of the adaptive immune system, particularly in the context of parasitic infections. Its involvement in antigen recognition, complement cascade, and phagocytosis makes it a significant target for the development of novel therapeutics. Further research is needed to fully understand the clinical significance of the IGHV1-2 gene and its role in the immune system.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.