Details for: TRDV2

Gene ID: 28517

Symbol: TRDV2

Ensembl ID: ENSG00000211821

Description: T cell receptor delta variable 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 3.8634
    Cell Significance Index: 45.6600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.0190
    Cell Significance Index: 12.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5112
    Cell Significance Index: 13.6800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.4452
    Cell Significance Index: 5.6300
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.1767
    Cell Significance Index: 1.4500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0788
    Cell Significance Index: 1.0300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0532
    Cell Significance Index: 0.2900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0051
    Cell Significance Index: 0.0800
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0017
    Cell Significance Index: -1.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0040
    Cell Significance Index: -1.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0075
    Cell Significance Index: -1.5000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0078
    Cell Significance Index: -0.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0135
    Cell Significance Index: -1.8500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0153
    Cell Significance Index: -0.2600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0191
    Cell Significance Index: -0.2600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0215
    Cell Significance Index: -0.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0215
    Cell Significance Index: -1.3900
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0242
    Cell Significance Index: -0.1800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0313
    Cell Significance Index: -0.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0334
    Cell Significance Index: -0.9100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.0336
    Cell Significance Index: -0.0900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0340
    Cell Significance Index: -0.4400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0368
    Cell Significance Index: -0.9400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0398
    Cell Significance Index: -0.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0449
    Cell Significance Index: -1.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0449
    Cell Significance Index: -2.1100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0474
    Cell Significance Index: -0.5100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0481
    Cell Significance Index: -1.2000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0492
    Cell Significance Index: -0.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0505
    Cell Significance Index: -1.1100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0518
    Cell Significance Index: -0.6100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0537
    Cell Significance Index: -0.6400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0553
    Cell Significance Index: -1.4100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0565
    Cell Significance Index: -0.7800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0576
    Cell Significance Index: -0.4600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0636
    Cell Significance Index: -1.0300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0677
    Cell Significance Index: -1.1400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0682
    Cell Significance Index: -0.8100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0711
    Cell Significance Index: -1.3900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0736
    Cell Significance Index: -0.9200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0751
    Cell Significance Index: -0.8500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0765
    Cell Significance Index: -0.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0783
    Cell Significance Index: -1.3100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0807
    Cell Significance Index: -1.6100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0810
    Cell Significance Index: -0.8400
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0815
    Cell Significance Index: -0.6600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0849
    Cell Significance Index: -1.5700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0880
    Cell Significance Index: -0.7500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0881
    Cell Significance Index: -1.1500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0883
    Cell Significance Index: -1.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0885
    Cell Significance Index: -1.7300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0920
    Cell Significance Index: -1.5900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0926
    Cell Significance Index: -1.2500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0941
    Cell Significance Index: -0.9600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0949
    Cell Significance Index: -0.9000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0960
    Cell Significance Index: -1.2600
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0963
    Cell Significance Index: -0.9500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0966
    Cell Significance Index: -1.3400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0979
    Cell Significance Index: -1.4500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0979
    Cell Significance Index: -0.9100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0986
    Cell Significance Index: -1.0000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0988
    Cell Significance Index: -1.3000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1006
    Cell Significance Index: -1.1000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1027
    Cell Significance Index: -1.3400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1027
    Cell Significance Index: -1.4600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1027
    Cell Significance Index: -1.5200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1028
    Cell Significance Index: -1.3200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1030
    Cell Significance Index: -1.3000
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1030
    Cell Significance Index: -1.1000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1033
    Cell Significance Index: -1.2000
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1035
    Cell Significance Index: -0.8900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1038
    Cell Significance Index: -1.1500
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.1050
    Cell Significance Index: -0.9300
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1089
    Cell Significance Index: -0.9800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1090
    Cell Significance Index: -0.9700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1094
    Cell Significance Index: -1.1100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1102
    Cell Significance Index: -1.3300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1103
    Cell Significance Index: -1.3000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1112
    Cell Significance Index: -1.2800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1114
    Cell Significance Index: -1.9200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1120
    Cell Significance Index: -1.2200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1137
    Cell Significance Index: -1.4100
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.1138
    Cell Significance Index: -1.3000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1139
    Cell Significance Index: -1.3900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1145
    Cell Significance Index: -1.2900
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1148
    Cell Significance Index: -1.4000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1162
    Cell Significance Index: -1.3300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1173
    Cell Significance Index: -1.7100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1174
    Cell Significance Index: -1.5600
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.1174
    Cell Significance Index: -1.1600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1176
    Cell Significance Index: -1.3900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1178
    Cell Significance Index: -1.5100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1196
    Cell Significance Index: -1.4700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1205
    Cell Significance Index: -1.2500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1208
    Cell Significance Index: -1.4200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1214
    Cell Significance Index: -1.3200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1215
    Cell Significance Index: -1.4700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1230
    Cell Significance Index: -1.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRDV2 is a member of the T cell receptor delta family, which is characterized by its unique structure and function. The gamma-delta T cell receptor complex, comprising TRDV2, is a heterodimeric receptor that recognizes a wide range of antigens, including peptides, lipids, and sugars. The expression of TRDV2 is significantly regulated, with its levels varying across different cell types and developmental stages. The gamma-delta T cell receptor complex is also known for its ability to recognize and respond to tissue-specific antigens, making it a crucial component of the immune system's ability to regulate self-tolerance and tolerance to self-antigens. **Pathways and Functions:** TRDV2 is involved in various signaling pathways that regulate the activation, proliferation, and differentiation of γδT cells. The gamma-delta T cell receptor complex interacts with antigen-presenting cells, such as dendritic cells and macrophages, to initiate an immune response. The signaling pathways activated by TRDV2 include the activation of protein kinase C (PKC) and the mitogen-activated protein kinase (MAPK) pathway, which ultimately lead to the activation of transcription factors, such as NFAT and NF-κB. These transcription factors regulate the expression of genes involved in the immune response, including cytokines, chemokines, and cell surface molecules. In addition to its role in the adaptive immune response, TRDV2 is also involved in the innate immune response, particularly in the recognition and elimination of pathogens. The gamma-delta T cell receptor complex is capable of recognizing and responding to viral and bacterial antigens, making it a crucial component of the innate immune system's ability to recognize and eliminate pathogens. **Clinical Significance:** Dysregulation of TRDV2 expression has been implicated in various immune-related disorders, including autoimmune diseases, cancer, and infectious diseases. For example, aberrant expression of TRDV2 has been observed in patients with multiple sclerosis, type 1 diabetes, and rheumatoid arthritis, suggesting a link between TRDV2 dysregulation and the development of these diseases. Additionally, TRDV2 has been shown to play a role in the recognition and elimination of cancer cells, making it a potential target for cancer immunotherapy. Furthermore, the gamma-delta T cell receptor complex, including TRDV2, has been shown to be involved in the regulation of self-tolerance and tolerance to self-antigens. Dysregulation of TRDV2 expression has been implicated in autoimmune diseases, such as type 1 diabetes and multiple sclerosis, where the immune system fails to recognize self-antigens and attacks the body's own tissues. In conclusion, TRDV2 is a critical component of the immune system, playing a pivotal role in the recognition and elimination of pathogens, cancer cells, and self-antigens. Its dysregulation has been implicated in various immune-related disorders, making it a potential target for the development of novel therapeutic strategies. Further research is needed to fully elucidate the role of TRDV2 in the immune system and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.