Details for: TRDV2

Gene ID: 28517

Symbol: TRDV2

Ensembl ID: ENSG00000211821

Description: T cell receptor delta variable 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,090
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 6.77
    Marker Score: 43,618
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.7
    Marker Score: 8,282
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.14
    Marker Score: 13,067
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,848
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,180
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 799
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,838
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,063
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.72
    Marker Score: 483
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 387
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.56
    Marker Score: 769
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.44
    Marker Score: 117
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.42
    Marker Score: 176
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.33
    Marker Score: 322
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.27
    Marker Score: 209
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.2
    Marker Score: 495
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.19
    Marker Score: 272
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.19
    Marker Score: 586
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.18
    Marker Score: 155
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.16
    Marker Score: 71
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.15
    Marker Score: 93
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.15
    Marker Score: 159
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.12
    Marker Score: 69
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.08
    Marker Score: 84
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.07
    Marker Score: 146
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 69
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.07
    Marker Score: 50
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.07
    Marker Score: 116
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 134
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.06
    Marker Score: 45
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.06
    Marker Score: 86
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.06
    Marker Score: 142
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.05
    Marker Score: 42
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.05
    Marker Score: 69
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.05
    Marker Score: 575
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.04
    Marker Score: 183
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.04
    Marker Score: 35
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.04
    Marker Score: 2,194
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.04
    Marker Score: 66
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.04
    Marker Score: 32
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.03
    Marker Score: 38
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: group 2 innate lymphoid cell (CL0001069)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.03
    Marker Score: 67
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.03
    Marker Score: 35
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.02
    Marker Score: 40
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.02
    Marker Score: 59
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.02
    Marker Score: 150
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.01
    Marker Score: 32
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.01
    Marker Score: 9

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRDV2 is a member of the T cell receptor delta family, which is characterized by its unique structure and function. The gamma-delta T cell receptor complex, comprising TRDV2, is a heterodimeric receptor that recognizes a wide range of antigens, including peptides, lipids, and sugars. The expression of TRDV2 is significantly regulated, with its levels varying across different cell types and developmental stages. The gamma-delta T cell receptor complex is also known for its ability to recognize and respond to tissue-specific antigens, making it a crucial component of the immune system's ability to regulate self-tolerance and tolerance to self-antigens. **Pathways and Functions:** TRDV2 is involved in various signaling pathways that regulate the activation, proliferation, and differentiation of γδT cells. The gamma-delta T cell receptor complex interacts with antigen-presenting cells, such as dendritic cells and macrophages, to initiate an immune response. The signaling pathways activated by TRDV2 include the activation of protein kinase C (PKC) and the mitogen-activated protein kinase (MAPK) pathway, which ultimately lead to the activation of transcription factors, such as NFAT and NF-κB. These transcription factors regulate the expression of genes involved in the immune response, including cytokines, chemokines, and cell surface molecules. In addition to its role in the adaptive immune response, TRDV2 is also involved in the innate immune response, particularly in the recognition and elimination of pathogens. The gamma-delta T cell receptor complex is capable of recognizing and responding to viral and bacterial antigens, making it a crucial component of the innate immune system's ability to recognize and eliminate pathogens. **Clinical Significance:** Dysregulation of TRDV2 expression has been implicated in various immune-related disorders, including autoimmune diseases, cancer, and infectious diseases. For example, aberrant expression of TRDV2 has been observed in patients with multiple sclerosis, type 1 diabetes, and rheumatoid arthritis, suggesting a link between TRDV2 dysregulation and the development of these diseases. Additionally, TRDV2 has been shown to play a role in the recognition and elimination of cancer cells, making it a potential target for cancer immunotherapy. Furthermore, the gamma-delta T cell receptor complex, including TRDV2, has been shown to be involved in the regulation of self-tolerance and tolerance to self-antigens. Dysregulation of TRDV2 expression has been implicated in autoimmune diseases, such as type 1 diabetes and multiple sclerosis, where the immune system fails to recognize self-antigens and attacks the body's own tissues. In conclusion, TRDV2 is a critical component of the immune system, playing a pivotal role in the recognition and elimination of pathogens, cancer cells, and self-antigens. Its dysregulation has been implicated in various immune-related disorders, making it a potential target for the development of novel therapeutic strategies. Further research is needed to fully elucidate the role of TRDV2 in the immune system and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.