Details for: GPR33

Gene ID: 2856

Symbol: GPR33

Ensembl ID: ENSG00000214943

Description: G protein-coupled receptor 33

Associated with

  • Complement receptor activity
    (GO:0004875)
  • Complement receptor mediated signaling pathway
    (GO:0002430)
  • G protein-coupled receptor activity
    (GO:0004930)
  • Inflammatory response
    (GO:0006954)
  • Phospholipase c-activating g protein-coupled receptor signaling pathway
    (GO:0007200)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7972
    Cell Significance Index: 19.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1101
    Cell Significance Index: 2.4100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1050
    Cell Significance Index: 1.8000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0681
    Cell Significance Index: 0.9800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0555
    Cell Significance Index: 0.5300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0228
    Cell Significance Index: 0.5700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0126
    Cell Significance Index: 0.2200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0109
    Cell Significance Index: 0.1700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0106
    Cell Significance Index: 0.1100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0105
    Cell Significance Index: 0.1700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0079
    Cell Significance Index: 0.0700
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.0056
    Cell Significance Index: 0.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0016
    Cell Significance Index: 0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0012
    Cell Significance Index: 0.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0011
    Cell Significance Index: 0.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: 0.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0001
    Cell Significance Index: -0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0006
    Cell Significance Index: -0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0008
    Cell Significance Index: -0.5400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0013
    Cell Significance Index: -0.5800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0022
    Cell Significance Index: -0.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0028
    Cell Significance Index: -0.4100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0030
    Cell Significance Index: -0.0300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0034
    Cell Significance Index: -0.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0035
    Cell Significance Index: -0.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0040
    Cell Significance Index: -0.1100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0066
    Cell Significance Index: -0.0800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0069
    Cell Significance Index: -0.1000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0074
    Cell Significance Index: -0.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0080
    Cell Significance Index: -0.5400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0083
    Cell Significance Index: -0.0900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0088
    Cell Significance Index: -0.1300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0090
    Cell Significance Index: -0.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0094
    Cell Significance Index: -0.5300
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0096
    Cell Significance Index: -0.1100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0097
    Cell Significance Index: -0.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0104
    Cell Significance Index: -0.4600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0110
    Cell Significance Index: -0.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0113
    Cell Significance Index: -0.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0116
    Cell Significance Index: -0.4400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0116
    Cell Significance Index: -0.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0119
    Cell Significance Index: -0.3900
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.0122
    Cell Significance Index: -0.1200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0127
    Cell Significance Index: -0.1600
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0128
    Cell Significance Index: -0.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0131
    Cell Significance Index: -0.3500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0133
    Cell Significance Index: -0.1400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0151
    Cell Significance Index: -0.3200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0155
    Cell Significance Index: -0.1000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0156
    Cell Significance Index: -0.1700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0157
    Cell Significance Index: -0.1800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0158
    Cell Significance Index: -0.5000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0163
    Cell Significance Index: -0.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0164
    Cell Significance Index: -0.4100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0171
    Cell Significance Index: -0.2000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0177
    Cell Significance Index: -0.3700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0181
    Cell Significance Index: -0.3900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0181
    Cell Significance Index: -0.3100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0184
    Cell Significance Index: -0.4700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0188
    Cell Significance Index: -0.1300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0192
    Cell Significance Index: -0.3800
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0194
    Cell Significance Index: -0.1900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0196
    Cell Significance Index: -0.3900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0197
    Cell Significance Index: -0.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0200
    Cell Significance Index: -0.5700
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0206
    Cell Significance Index: -0.1100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0221
    Cell Significance Index: -0.4500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0223
    Cell Significance Index: -0.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0225
    Cell Significance Index: -0.4400
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0228
    Cell Significance Index: -0.2400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0234
    Cell Significance Index: -0.3000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0239
    Cell Significance Index: -0.4700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0243
    Cell Significance Index: -0.2900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0244
    Cell Significance Index: -0.3600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0247
    Cell Significance Index: -0.3000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0247
    Cell Significance Index: -0.3200
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0248
    Cell Significance Index: -0.1800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0252
    Cell Significance Index: -0.3400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0271
    Cell Significance Index: -0.5300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0274
    Cell Significance Index: -0.3900
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0278
    Cell Significance Index: -0.2800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0280
    Cell Significance Index: -0.3600
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: -0.0283
    Cell Significance Index: -0.0400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0289
    Cell Significance Index: -0.5000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0292
    Cell Significance Index: -0.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0294
    Cell Significance Index: -0.4900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0299
    Cell Significance Index: -0.4100
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0307
    Cell Significance Index: -0.3000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0310
    Cell Significance Index: -0.3500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0312
    Cell Significance Index: -0.4100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0316
    Cell Significance Index: -0.4800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0325
    Cell Significance Index: -0.4700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0334
    Cell Significance Index: -0.4800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0341
    Cell Significance Index: -0.4300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0344
    Cell Significance Index: -0.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPR33 is a G protein-coupled receptor that exhibits a high degree of sequence homology with other G protein-coupled receptors. Its structure consists of seven transmembrane domains, which are critical for ligand binding and signal transduction. GPR33 is highly expressed in various cell types, including immune cells, epithelial cells, and stem cells, suggesting its involvement in multiple cellular processes. **Pathways and Functions:** GPR33 is activated by a variety of ligands, including complement receptors, which are crucial for immune response and inflammation. Upon activation, GPR33 triggers the activation of phospholipase C, leading to the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 and DAG stimulate the release of calcium ions from intracellular stores, which in turn activates various signaling pathways, including the NF-κB and MAPK pathways. These pathways are involved in the regulation of immune responses, inflammation, and cell survival. **Clinical Significance:** GPR33 has been implicated in various immune-mediated diseases, including autoimmune disorders, inflammatory bowel disease, and cancer. Its expression in immune cells suggests that GPR33 may play a role in the pathogenesis of these diseases. For example, studies have shown that GPR33 is overexpressed in patients with rheumatoid arthritis, suggesting its potential as a therapeutic target for this disease. Additionally, GPR33 has been shown to regulate the function of T cells and B cells, which are critical for immune response and inflammation. Furthermore, GPR33 has been implicated in the regulation of cell proliferation and apoptosis, which are critical processes in cancer development. Its expression in cancer cells suggests that GPR33 may play a role in cancer progression and metastasis. In conclusion, GPR33 is a multifunctional receptor that plays a significant role in immune response, inflammation, and cell signaling. Its expression in immune cells and its involvement in various signaling pathways suggest its potential as a therapeutic target for immune-related disorders. Further studies are needed to fully elucidate the role of GPR33 in human disease and to explore its therapeutic potential. **Recommendations:** 1. Further studies are needed to fully elucidate the role of GPR33 in human disease. 2. GPR33 should be considered as a potential therapeutic target for immune-related disorders, including autoimmune diseases and cancer. 3. The development of specific GPR33 agonists or antagonists may provide a novel approach to treating these diseases. 4. The expression of GPR33 in various cell types should be further investigated to understand its role in different diseases. **Limitations:** 1. The current understanding of GPR33's role in human disease is limited by the availability of experimental models and clinical data. 2. Further studies are needed to fully elucidate the mechanisms by which GPR33 regulates immune responses and inflammation. 3. The development of specific GPR33 agonists or antagonists may be challenging due to the complexity of the receptor's signaling pathways. **Future Directions:** 1. The development of specific GPR33 agonists or antagonists may provide a novel approach to treating immune-related disorders. 2. The expression of GPR33 in various cell types should be further investigated to understand its role in different diseases. 3. The role of GPR33 in cancer development and progression should be further investigated to understand its potential as a therapeutic target.

Genular Protein ID: 2817161496

Symbol: GPR33_HUMAN

Name: Probable G-protein coupled receptor 33

UniProtKB Accession Codes:

Q49SQ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15987686

Title: The rise and fall of the chemoattractant receptor GPR33.

PubMed ID: 15987686

DOI: 10.1074/jbc.m503586200

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

Sequence Information:

  • Length: 333
  • Mass: 38232
  • Checksum: 72AE74EEC8FE6CB8
  • Sequence:
    • MDLINSTDYL INASTLVRNS TQFLAPASKM IIALSLYISS IIGTITNGLY LWVLRFKMKQ 
TVNTLLFFHL ILSYFISTMI LPFMATSQLQ DNHWNFGTAL CKVFNGTLSL GMFTSVFFLS 
AIGLDRYLLT LHPVWSQQHR TPRWASSIVL GVWISAAALS IPYLIFRETH HDRKGKVTCQ 
NNYAVSTNWE SKEMQASRQW IHVACFISRF LLGFLLPFFI IIFCYERVAS KVKERSLFKS 
SKPFKVMMTA IISFFVCWMP YHIHQGLLLT TNQSLLLELT LILTVLTTSF NTIFSPTLYL 
FVGENFKKVF KKSILALFES TFSEDSSVER TQT

Genular Protein ID: 3813332430

Symbol: D8VER1_HUMAN

Name: N/A

UniProtKB Accession Codes:

D8VER1

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 2 PROSITE 2 Pfam 1 RefSeq 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 20399748

Title: Involvement of the chemokine-like receptor GPR33 in innate immunity.

PubMed ID: 20399748

DOI: 10.1016/j.bbrc.2010.04.077

Sequence Information:

  • Length: 333
  • Mass: 38233
  • Checksum: 7FF512C88A9C6E30
  • Sequence:
    • MDLINSTDYL INASTLVRNS TQFLAPASKM IIALSLYISS IIGTITDGLY LWVLRFKMKQ 
TVNTLLFFHL ILSYFISTMI LPFMATSQLQ DNHWNFGTAL CKVFNGTLSL GMFTSVFFLS 
AIGLDRYLLT LHPVWSQQHR TPRWASSIVL GVWISAAALS IPYLIFRETH HDRKGKVTCQ 
NNYAVSTNWE SKEMQASRQW IHVACFISRF LLGFLLPFFI IIFCYERVAS KVKERSLFKS 
SKPFKVMMTA IISFFVCWMP YHIHQGLLLT TNQSLLLELT LILTVLTTSF NTIFSPTLYL 
FVGENFKKVF KKSILALFES TFSEDSSVER TQT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.