Details for: GPR33

Gene ID: 2856

Symbol: GPR33

Ensembl ID: ENSG00000214943

Description: G protein-coupled receptor 33

Associated with

  • Complement receptor activity
    (GO:0004875)
  • Complement receptor mediated signaling pathway
    (GO:0002430)
  • G protein-coupled receptor activity
    (GO:0004930)
  • Inflammatory response
    (GO:0006954)
  • Phospholipase c-activating g protein-coupled receptor signaling pathway
    (GO:0007200)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 2.52
    Marker Score: 4342
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.96
    Marker Score: 2192
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.26
    Marker Score: 1200
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7692
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1475
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 496
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.72
    Marker Score: 1158
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.69
    Marker Score: 668
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.67
    Marker Score: 531
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.52
    Marker Score: 1051
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.47
    Marker Score: 276
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.41
    Marker Score: 367
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.28
    Marker Score: 527
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.25
    Marker Score: 3884
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.18
    Marker Score: 205.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.15
    Marker Score: 89
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.14
    Marker Score: 68
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.14
    Marker Score: 161.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.1
    Marker Score: 199
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.08
    Marker Score: 88
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.08
    Marker Score: 466
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.06
    Marker Score: 41
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.03
    Marker Score: 17.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 73.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.03
    Marker Score: 107
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.02
    Marker Score: 41
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.02
    Marker Score: 288
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.02
    Marker Score: 44
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.02
    Marker Score: 37
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.01
    Marker Score: 40
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.01
    Marker Score: 57
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.01
    Marker Score: 22
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.01
    Marker Score: 23

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Other Information

## Summary GPR33 is a G protein-coupled receptor (GPCR) that is expressed in various cell types. It is involved in a variety of cellular processes, including inflammation, cell migration, and cell growth. ## Key characteristics * **Structure:** GPR33 is a transmembrane protein with seven transmembrane domains and a cytoplasmic tail. * **Expression:** It is highly expressed in immune cells, including T cells, B cells, and dendritic cells. * **Function:** GPR33 is a key regulator of inflammation. It is expressed on activated T cells and macrophages and is involved in the regulation of inflammatory responses. It also plays a role in the regulation of cell migration and survival. ## Pathways and functions * **Complement receptor activity:** GPR33 is a receptor for complement proteins, which are a family of proteins that are involved in inflammation and immunity. When GPR33 binds to complement proteins, it activates the complement receptor-mediated signaling pathway. This pathway leads to the activation of downstream signaling molecules, including the release of inflammatory cytokines and the recruitment of immune cells to the site of inflammation. * **G protein-coupled receptor activity:** GPR33 is also a GPCR that is involved in the regulation of cell migration and growth. When GPR33 binds to its ligand, it activates the G protein-coupled receptor pathway. This pathway leads to the activation of downstream signaling molecules, including the migration of cells and the proliferation of cells. * **Inflammatory response:** GPR33 is also involved in the regulation of inflammation. When GPR33 binds to complement proteins, it activates the complement receptor-mediated signaling pathway. This pathway leads to the release of inflammatory cytokines and the recruitment of immune cells to the site of inflammation. ## Clinical significance GPR33 is a promising target for the treatment of inflammatory diseases. Mutations in the GPR33 gene have been linked to the development of a variety of inflammatory diseases, including rheumatoid arthritis, asthma, and inflammatory bowel disease. Targeting GPR33 with antibodies or small molecules could therefore provide a new treatment for these diseases.

Genular Protein ID: 2817161496

Symbol: GPR33_HUMAN

Name: Probable G-protein coupled receptor 33

UniProtKB Accession Codes:

Q49SQ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 2 Ensembl 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15987686

Title: The rise and fall of the chemoattractant receptor GPR33.

PubMed ID: 15987686

DOI: 10.1074/jbc.m503586200

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

Sequence Information:

  • Length: 333
  • Mass: 38232
  • Checksum: 72AE74EEC8FE6CB8
  • Sequence:
    • MDLINSTDYL INASTLVRNS TQFLAPASKM IIALSLYISS IIGTITNGLY LWVLRFKMKQ 
TVNTLLFFHL ILSYFISTMI LPFMATSQLQ DNHWNFGTAL CKVFNGTLSL GMFTSVFFLS 
AIGLDRYLLT LHPVWSQQHR TPRWASSIVL GVWISAAALS IPYLIFRETH HDRKGKVTCQ 
NNYAVSTNWE SKEMQASRQW IHVACFISRF LLGFLLPFFI IIFCYERVAS KVKERSLFKS 
SKPFKVMMTA IISFFVCWMP YHIHQGLLLT TNQSLLLELT LILTVLTTSF NTIFSPTLYL 
FVGENFKKVF KKSILALFES TFSEDSSVER TQT

Genular Protein ID: 3813332430

Symbol: D8VER1_HUMAN

Name: N/A

UniProtKB Accession Codes:

D8VER1

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 2 PROSITE 2 Pfam 1 RefSeq 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 20399748

Title: Involvement of the chemokine-like receptor GPR33 in innate immunity.

PubMed ID: 20399748

DOI: 10.1016/j.bbrc.2010.04.077

Sequence Information:

  • Length: 333
  • Mass: 38233
  • Checksum: 7FF512C88A9C6E30
  • Sequence:
    • MDLINSTDYL INASTLVRNS TQFLAPASKM IIALSLYISS IIGTITDGLY LWVLRFKMKQ 
TVNTLLFFHL ILSYFISTMI LPFMATSQLQ DNHWNFGTAL CKVFNGTLSL GMFTSVFFLS 
AIGLDRYLLT LHPVWSQQHR TPRWASSIVL GVWISAAALS IPYLIFRETH HDRKGKVTCQ 
NNYAVSTNWE SKEMQASRQW IHVACFISRF LLGFLLPFFI IIFCYERVAS KVKERSLFKS 
SKPFKVMMTA IISFFVCWMP YHIHQGLLLT TNQSLLLELT LILTVLTTSF NTIFSPTLYL 
FVGENFKKVF KKSILALFES TFSEDSSVER TQT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.