Details for: TRBV7 5

Gene ID: 28593

Symbol: TRBV7 5

Ensembl ID: ENSG00000227550

Description: T cell receptor beta variable 7-5 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,095
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.7
    Marker Score: 8,288
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,854
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,185
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.29
    Marker Score: 736
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,843
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,068
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.19
    Marker Score: 81
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 31
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.02
    Marker Score: 39
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 22
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0
    Marker Score: 23
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 97
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 65
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 23
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 7

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** TRBV7-5 is a pseudogene, meaning that it lacks the functional coding capacity to produce a protein. However, its expression suggests that it may play a regulatory or paralogous role in the immune system. 2. **Widespread expression:** TRBV7-5 is expressed in multiple cell types, including immune cells, CNS cells, and hematopoietic progenitor cells, highlighting its potential involvement in various physiological processes. 3. **Cell-type specificity:** The expression pattern of TRBV7-5 varies across different cell types, suggesting that it may play distinct roles in each tissue. 4. **Evolutionary conservation:** The conservation of TRBV7-5 across species suggests that it may have evolved to perform a vital function in the immune system. **Pathways and Functions:** 1. **Immune regulation:** TRBV7-5 may play a role in regulating immune responses, possibly by modulating the activity of T cells or influencing the expression of other immune-related genes. 2. **Tissue homeostasis:** The expression of TRBV7-5 in CNS cells and endothelial cells suggests that it may contribute to the maintenance of tissue homeostasis and the regulation of cellular interactions. 3. **Cell differentiation:** TRBV7-5 may influence the differentiation of hematopoietic progenitor cells, which could impact the development of the immune system. 4. **Neurotransmission:** The expression of TRBV7-5 in glutamatergic neurons and GABAergic interneurons suggests that it may be involved in neurotransmission and synaptic plasticity. **Clinical Significance:** 1. **Immunological disorders:** Alterations in TRBV7-5 expression may contribute to the development of immunological disorders, such as autoimmune diseases or cancer. 2. **Neurological disorders:** The expression of TRBV7-5 in CNS cells may be linked to the pathogenesis of neurological disorders, such as Alzheimer's disease or multiple sclerosis. 3. **Cancer:** TRBV7-5 may play a role in the regulation of immune responses in cancer, influencing the development and progression of tumors. 4. **Gene therapy:** Understanding the functions of TRBV7-5 may provide insights into the development of novel gene therapies targeting the immune system or CNS disorders. In conclusion, the TRBV7-5 gene is a complex and enigmatic pseudogene that plays a crucial role in the regulation of immune responses and tissue homeostasis. Further research is necessary to elucidate the functions of TRBV7-5 and its potential applications in the treatment of immunological and neurological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.