Details for: TRBV7 5

Gene ID: 28593

Symbol: TRBV7 5

Ensembl ID: ENSG00000227550

Description: T cell receptor beta variable 7-5 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.6393
    Cell Significance Index: 8.3900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3691
    Cell Significance Index: 5.3800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0426
    Cell Significance Index: 0.5600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0205
    Cell Significance Index: 0.2400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0089
    Cell Significance Index: 0.1000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0041
    Cell Significance Index: 0.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0034
    Cell Significance Index: 0.1800
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0007
    Cell Significance Index: -0.1400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0038
    Cell Significance Index: -0.0800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0039
    Cell Significance Index: -0.0700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0041
    Cell Significance Index: -0.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0041
    Cell Significance Index: -0.1300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0043
    Cell Significance Index: -0.0700
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0045
    Cell Significance Index: -0.0400
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0046
    Cell Significance Index: -0.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0050
    Cell Significance Index: -0.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0055
    Cell Significance Index: -0.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0057
    Cell Significance Index: -0.1500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0067
    Cell Significance Index: -0.0800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0081
    Cell Significance Index: -0.1100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0084
    Cell Significance Index: -0.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0090
    Cell Significance Index: -0.1900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0092
    Cell Significance Index: -0.1200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0094
    Cell Significance Index: -0.2400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0094
    Cell Significance Index: -0.1900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0101
    Cell Significance Index: -0.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0104
    Cell Significance Index: -0.1000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0110
    Cell Significance Index: -0.1300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0112
    Cell Significance Index: -0.1500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0113
    Cell Significance Index: -0.1400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0115
    Cell Significance Index: -0.1200
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0117
    Cell Significance Index: -0.0900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0123
    Cell Significance Index: -0.1200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0124
    Cell Significance Index: -0.1700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0129
    Cell Significance Index: -0.1500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0130
    Cell Significance Index: -0.1600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0131
    Cell Significance Index: -0.1400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0135
    Cell Significance Index: -0.2500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0136
    Cell Significance Index: -0.1600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0138
    Cell Significance Index: -0.1400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0147
    Cell Significance Index: -0.1700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0150
    Cell Significance Index: -0.1400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0154
    Cell Significance Index: -0.1200
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.0155
    Cell Significance Index: -0.1500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0156
    Cell Significance Index: -0.1200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0158
    Cell Significance Index: -0.1500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0158
    Cell Significance Index: -0.1500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0158
    Cell Significance Index: -0.1800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0160
    Cell Significance Index: -0.1500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0165
    Cell Significance Index: -0.1900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0179
    Cell Significance Index: -0.1500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0181
    Cell Significance Index: -0.2000
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0186
    Cell Significance Index: -0.1600
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0187
    Cell Significance Index: -0.1700
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0199
    Cell Significance Index: -0.1700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0200
    Cell Significance Index: -0.2500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0206
    Cell Significance Index: -0.1300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0208
    Cell Significance Index: -0.2100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0211
    Cell Significance Index: -0.2200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0217
    Cell Significance Index: -0.2500
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.0224
    Cell Significance Index: -0.2200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0225
    Cell Significance Index: -0.1900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0226
    Cell Significance Index: -0.2400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0227
    Cell Significance Index: -0.2300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0231
    Cell Significance Index: -0.2500
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0235
    Cell Significance Index: -0.2600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0238
    Cell Significance Index: -0.2400
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0238
    Cell Significance Index: -0.2200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0238
    Cell Significance Index: -0.2000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0240
    Cell Significance Index: -0.2400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0245
    Cell Significance Index: -0.2900
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0245
    Cell Significance Index: -0.2600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0255
    Cell Significance Index: -0.2200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0257
    Cell Significance Index: -0.1500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0261
    Cell Significance Index: -0.1700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0267
    Cell Significance Index: -0.2600
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0280
    Cell Significance Index: -0.2900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0280
    Cell Significance Index: -0.2600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0286
    Cell Significance Index: -0.2500
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0299
    Cell Significance Index: -0.2700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0326
    Cell Significance Index: -0.2900
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0335
    Cell Significance Index: -0.2800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0385
    Cell Significance Index: -0.2100
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0390
    Cell Significance Index: -0.2900
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0407
    Cell Significance Index: -0.2800
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: -0.0470
    Cell Significance Index: -0.2100
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.0493
    Cell Significance Index: -0.2300
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0853
    Cell Significance Index: -0.2600
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.1055
    Cell Significance Index: -0.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** TRBV7-5 is a pseudogene, meaning that it lacks the functional coding capacity to produce a protein. However, its expression suggests that it may play a regulatory or paralogous role in the immune system. 2. **Widespread expression:** TRBV7-5 is expressed in multiple cell types, including immune cells, CNS cells, and hematopoietic progenitor cells, highlighting its potential involvement in various physiological processes. 3. **Cell-type specificity:** The expression pattern of TRBV7-5 varies across different cell types, suggesting that it may play distinct roles in each tissue. 4. **Evolutionary conservation:** The conservation of TRBV7-5 across species suggests that it may have evolved to perform a vital function in the immune system. **Pathways and Functions:** 1. **Immune regulation:** TRBV7-5 may play a role in regulating immune responses, possibly by modulating the activity of T cells or influencing the expression of other immune-related genes. 2. **Tissue homeostasis:** The expression of TRBV7-5 in CNS cells and endothelial cells suggests that it may contribute to the maintenance of tissue homeostasis and the regulation of cellular interactions. 3. **Cell differentiation:** TRBV7-5 may influence the differentiation of hematopoietic progenitor cells, which could impact the development of the immune system. 4. **Neurotransmission:** The expression of TRBV7-5 in glutamatergic neurons and GABAergic interneurons suggests that it may be involved in neurotransmission and synaptic plasticity. **Clinical Significance:** 1. **Immunological disorders:** Alterations in TRBV7-5 expression may contribute to the development of immunological disorders, such as autoimmune diseases or cancer. 2. **Neurological disorders:** The expression of TRBV7-5 in CNS cells may be linked to the pathogenesis of neurological disorders, such as Alzheimer's disease or multiple sclerosis. 3. **Cancer:** TRBV7-5 may play a role in the regulation of immune responses in cancer, influencing the development and progression of tumors. 4. **Gene therapy:** Understanding the functions of TRBV7-5 may provide insights into the development of novel gene therapies targeting the immune system or CNS disorders. In conclusion, the TRBV7-5 gene is a complex and enigmatic pseudogene that plays a crucial role in the regulation of immune responses and tissue homeostasis. Further research is necessary to elucidate the functions of TRBV7-5 and its potential applications in the treatment of immunological and neurological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.