Details for: TRBJ2 3

Gene ID: 28626

Symbol: TRBJ2 3

Ensembl ID: ENSG00000211767

Description: T cell receptor beta joining 2-3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 2.0026
    Cell Significance Index: 26.2800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.7042
    Cell Significance Index: 3.8400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0886
    Cell Significance Index: 1.1200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0733
    Cell Significance Index: 0.7900
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.0122
    Cell Significance Index: 0.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0027
    Cell Significance Index: -0.5400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0064
    Cell Significance Index: -0.1300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0074
    Cell Significance Index: -0.1200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0074
    Cell Significance Index: -0.1800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0085
    Cell Significance Index: -0.1000
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0110
    Cell Significance Index: -0.1000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0114
    Cell Significance Index: -0.2100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0122
    Cell Significance Index: -0.2100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0130
    Cell Significance Index: -0.2200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0147
    Cell Significance Index: -0.2000
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0148
    Cell Significance Index: -0.1100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0154
    Cell Significance Index: -0.3900
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0179
    Cell Significance Index: -0.1500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0192
    Cell Significance Index: -0.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0217
    Cell Significance Index: -0.4600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0230
    Cell Significance Index: -0.3000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0237
    Cell Significance Index: -0.2000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0238
    Cell Significance Index: -0.2100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0254
    Cell Significance Index: -0.5000
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0259
    Cell Significance Index: -0.2400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0262
    Cell Significance Index: -0.3000
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0264
    Cell Significance Index: -0.2400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0266
    Cell Significance Index: -0.5400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0286
    Cell Significance Index: -0.3400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0289
    Cell Significance Index: -0.3200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0304
    Cell Significance Index: -0.3400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0304
    Cell Significance Index: -0.3800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0307
    Cell Significance Index: -0.3100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0309
    Cell Significance Index: -0.4100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0327
    Cell Significance Index: -0.3100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0329
    Cell Significance Index: -0.4300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0329
    Cell Significance Index: -0.4000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0330
    Cell Significance Index: -0.3400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0336
    Cell Significance Index: -0.3200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0342
    Cell Significance Index: -0.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0343
    Cell Significance Index: -0.3300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0345
    Cell Significance Index: -0.4000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0347
    Cell Significance Index: -0.4100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0348
    Cell Significance Index: -0.4500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0354
    Cell Significance Index: -0.3200
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0359
    Cell Significance Index: -0.3400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0361
    Cell Significance Index: -0.4100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0368
    Cell Significance Index: -0.3900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0374
    Cell Significance Index: -0.3500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0380
    Cell Significance Index: -0.3900
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0384
    Cell Significance Index: -0.4000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0396
    Cell Significance Index: -0.4100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0398
    Cell Significance Index: -0.4200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0400
    Cell Significance Index: -0.3700
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0407
    Cell Significance Index: -0.3400
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0408
    Cell Significance Index: -0.3300
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.0415
    Cell Significance Index: -0.4100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0417
    Cell Significance Index: -0.4800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0423
    Cell Significance Index: -0.5000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0430
    Cell Significance Index: -0.5800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0431
    Cell Significance Index: -0.4200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0437
    Cell Significance Index: -0.4600
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0442
    Cell Significance Index: -0.4100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0442
    Cell Significance Index: -0.3800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0448
    Cell Significance Index: -0.5200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0456
    Cell Significance Index: -0.5600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0469
    Cell Significance Index: -0.4100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0473
    Cell Significance Index: -0.4400
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0479
    Cell Significance Index: -0.3900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0488
    Cell Significance Index: -0.5400
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0494
    Cell Significance Index: -0.3400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0501
    Cell Significance Index: -0.5000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0501
    Cell Significance Index: -0.4600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0502
    Cell Significance Index: -0.5900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0514
    Cell Significance Index: -0.4000
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0520
    Cell Significance Index: -0.4800
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0535
    Cell Significance Index: -0.4300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0558
    Cell Significance Index: -0.5700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0559
    Cell Significance Index: -0.6000
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0561
    Cell Significance Index: -0.5000
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0578
    Cell Significance Index: -0.4300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0588
    Cell Significance Index: -0.4700
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0590
    Cell Significance Index: -0.5400
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.0613
    Cell Significance Index: -0.5000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0614
    Cell Significance Index: -0.7800
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0627
    Cell Significance Index: -0.6500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0639
    Cell Significance Index: -0.5800
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0658
    Cell Significance Index: -0.7100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0661
    Cell Significance Index: -0.7200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0674
    Cell Significance Index: -0.5700
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0687
    Cell Significance Index: -0.7000
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0691
    Cell Significance Index: -0.4500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0844
    Cell Significance Index: -0.8000
  • Cell Name: collagen secreting cell (CL0000667)
    Fold Change: -0.0863
    Cell Significance Index: -0.4800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0897
    Cell Significance Index: -0.4800
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1132
    Cell Significance Index: -0.3500
  • Cell Name: T-helper 2 cell (CL0000546)
    Fold Change: -0.1304
    Cell Significance Index: -0.3600
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1304
    Cell Significance Index: -0.8700
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.2968
    Cell Significance Index: -0.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **TCR complex component:** TRBJ2 is a part of the TCR complex, which is a heterodimeric receptor composed of an alpha chain and a beta chain. The beta chain, including TRBJ2, is responsible for antigen recognition and signal transduction. 2. **Diverse expression patterns:** TRBJ2 is expressed in a wide range of immune cells, including natural killer cells, mature gamma-delta T cells, plasma cells, megakaryocytes, and various subsets of T cells, highlighting its broad functional significance. 3. **Antigen recognition and binding:** TRBJ2, along with the alpha chain, recognizes and binds to specific antigens, triggering an immune response. 4. **Signal transduction and activation:** Upon antigen binding, TRBJ2 initiates signal transduction pathways that activate T cells, leading to their proliferation, differentiation, and effector function. **Pathways and Functions:** 1. **Adaptive immune response:** TRBJ2 is essential for the adaptive immune response, which involves the recognition and elimination of pathogens and foreign substances. 2. **T cell activation and proliferation:** TRBJ2 plays a critical role in the activation and proliferation of T cells, which is necessary for an effective immune response. 3. **Cytotoxic T cell function:** TRBJ2 is expressed in cytotoxic T cells, which are crucial for eliminating infected cells or tumor cells. 4. **Regulation of immune responses:** TRBJ2 has been implicated in the regulation of immune responses, including the modulation of inflammation and the prevention of autoimmune diseases. **Clinical Significance:** The understanding of TRBJ2's function and significance has far-reaching implications for the treatment of various diseases, including: 1. **Cancer immunotherapy:** TRBJ2's role in cytotoxic T cell function makes it a promising target for cancer immunotherapies. 2. **Autoimmune diseases:** The regulation of immune responses by TRBJ2 may provide insights into the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Vaccine development:** TRBJ2's expression in various immune cells makes it a potential target for vaccine development. 4. **Immunomodulatory therapies:** The modulation of TRBJ2 expression and function may provide a new avenue for immunomodulatory therapies, which could be used to treat a range of diseases. In conclusion, TRBJ2 is a critical component of the adaptive immune system, playing a pivotal role in the recognition and elimination of pathogens and foreign substances. Its understanding has significant implications for the treatment of various diseases, making it an attractive target for immunotherapeutic interventions.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.