Details for: TRAV41

Gene ID: 28640

Symbol: TRAV41

Ensembl ID: ENSG00000211820

Description: T cell receptor alpha variable 41

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,084
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 6.9
    Marker Score: 44,447
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8,277
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,843
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3,175
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,058
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.63
    Marker Score: 383
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 228
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.54
    Marker Score: 144
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 273
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 368
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 207
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.33
    Marker Score: 323
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.17
    Marker Score: 77
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.16
    Marker Score: 221
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.15
    Marker Score: 130
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.13
    Marker Score: 108
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.12
    Marker Score: 503
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.12
    Marker Score: 360
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.11
    Marker Score: 73
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.11
    Marker Score: 120
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.11
    Marker Score: 5,658
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.1
    Marker Score: 202
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1
    Marker Score: 103
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.09
    Marker Score: 91
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.09
    Marker Score: 161
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.08
    Marker Score: 32
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.08
    Marker Score: 57
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.08
    Marker Score: 136
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.07
    Marker Score: 72
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.07
    Marker Score: 768
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.07
    Marker Score: 51
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.06
    Marker Score: 131
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.05
    Marker Score: 51
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.05
    Marker Score: 39
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.05
    Marker Score: 38
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.05
    Marker Score: 57
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.05
    Marker Score: 64
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.05
    Marker Score: 119
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.04
    Marker Score: 91
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.03
    Marker Score: 45
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.03
    Marker Score: 35
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.03
    Marker Score: 293
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.03
    Marker Score: 38
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.03
    Marker Score: 74
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.03
    Marker Score: 104
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.02
    Marker Score: 40
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.02
    Marker Score: 76
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 41
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.02
    Marker Score: 103
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.02
    Marker Score: 15

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** TRAV41 is located on chromosome 6q22.3, a region rich in immune-related genes. Its expression is observed in a diverse range of cell types, including T lymphocytes, oligodendrocyte precursor cells, microglial cells, and endothelial cells. 2. **Cellular Specificity:** The expression of TRAV41 is highly specific, with a strong association with early T lineage precursors, indicating its involvement in T cell development and maturation. 3. **Gene Family:** TRAV41 is part of the TRAV gene family, which comprises 55 genes encoding Vα domains of the TCR complex. These genes are essential for generating diversity in the TCR repertoire, allowing for the recognition of a vast array of antigens. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRAV41 plays a crucial role in the adaptive immune response by contributing to the diversity of the TCR repertoire. The unique Vα domain encoded by TRAV41 enables T cells to recognize and respond to a wide range of antigens, facilitating the elimination of pathogens and tumor cells. 2. **T Cell Development and Maturation:** TRAV41 expression is associated with early T lineage precursors, suggesting its involvement in the development and maturation of T cells. This gene may regulate the transition from progenitor cells to functional T cells. 3. **Immunological Tolerance:** The expression of TRAV41 in regulatory T cells and other immunosuppressive cells may contribute to immunological tolerance, preventing excessive or inappropriate immune responses. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations or deletions in the TRAV41 gene may lead to immunodeficiency disorders, such as severe combined immunodeficiency (SCID), characterized by impaired T cell development and function. 2. **Autoimmune Diseases:** Altered expression or function of TRAV41 may contribute to autoimmune diseases, such as multiple sclerosis, where the immune system mistakenly attacks the central nervous system. 3. **Cancer Immunology:** The role of TRAV41 in T cell recognition and response to tumor antigens makes it an attractive target for cancer immunotherapy. In conclusion, TRAV41 is a critical component of the adaptive immune response, playing a pivotal role in T cell development, maturation, and function. Its unique Vα domain contributes to the diversity of the TCR repertoire, enabling the recognition of a wide range of antigens. Further research into the functions and clinical significance of TRAV41 will provide valuable insights into the mechanisms of immune regulation and the development of novel immunotherapies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.