Details for: TRAV41

Gene ID: 28640

Symbol: TRAV41

Ensembl ID: ENSG00000211820

Description: T cell receptor alpha variable 41

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1543
    Cell Significance Index: 1.7300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0568
    Cell Significance Index: 0.5700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0117
    Cell Significance Index: 0.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0116
    Cell Significance Index: 1.4900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0055
    Cell Significance Index: 0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0022
    Cell Significance Index: -1.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0039
    Cell Significance Index: -2.1200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0091
    Cell Significance Index: -0.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0096
    Cell Significance Index: -1.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0103
    Cell Significance Index: -2.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0156
    Cell Significance Index: -2.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0175
    Cell Significance Index: -1.7900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0249
    Cell Significance Index: -0.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0315
    Cell Significance Index: -1.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0336
    Cell Significance Index: -2.1700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0359
    Cell Significance Index: -0.6100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0458
    Cell Significance Index: -0.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0490
    Cell Significance Index: -1.3100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0500
    Cell Significance Index: -1.2100
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0531
    Cell Significance Index: -0.4400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0635
    Cell Significance Index: -0.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0703
    Cell Significance Index: -2.0700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0710
    Cell Significance Index: -1.8100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0758
    Cell Significance Index: -1.0400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0821
    Cell Significance Index: -1.0300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0867
    Cell Significance Index: -1.1800
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0902
    Cell Significance Index: -0.2800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0945
    Cell Significance Index: -1.5300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0947
    Cell Significance Index: -1.0900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0948
    Cell Significance Index: -1.1200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0961
    Cell Significance Index: -2.2200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0962
    Cell Significance Index: -1.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0980
    Cell Significance Index: -2.6700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0999
    Cell Significance Index: -1.1800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1033
    Cell Significance Index: -0.8800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1105
    Cell Significance Index: -1.6100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1122
    Cell Significance Index: -1.0500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1138
    Cell Significance Index: -2.2300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1156
    Cell Significance Index: -1.1800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1178
    Cell Significance Index: -1.1900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1189
    Cell Significance Index: -1.6900
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1195
    Cell Significance Index: -1.1700
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1198
    Cell Significance Index: -1.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1201
    Cell Significance Index: -2.0100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1205
    Cell Significance Index: -2.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1207
    Cell Significance Index: -2.2300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1227
    Cell Significance Index: -1.6300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1238
    Cell Significance Index: -1.1900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1244
    Cell Significance Index: -1.6100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1252
    Cell Significance Index: -1.0800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1254
    Cell Significance Index: -1.3000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1282
    Cell Significance Index: -1.3300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1282
    Cell Significance Index: -1.6200
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1303
    Cell Significance Index: -1.6500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1340
    Cell Significance Index: -2.2900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1347
    Cell Significance Index: -1.5900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1360
    Cell Significance Index: -1.7900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1375
    Cell Significance Index: -1.0700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1381
    Cell Significance Index: -2.2200
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.1382
    Cell Significance Index: -1.4800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1387
    Cell Significance Index: -1.7500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1405
    Cell Significance Index: -1.3700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1409
    Cell Significance Index: -2.1400
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.1411
    Cell Significance Index: -1.4400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1412
    Cell Significance Index: -1.5000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1417
    Cell Significance Index: -1.8200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1421
    Cell Significance Index: -1.8700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1433
    Cell Significance Index: -1.9100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1435
    Cell Significance Index: -1.5400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1439
    Cell Significance Index: -1.4600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1443
    Cell Significance Index: -1.5300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1452
    Cell Significance Index: -1.2700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1453
    Cell Significance Index: -1.9000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1455
    Cell Significance Index: -1.6400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1455
    Cell Significance Index: -2.0400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1458
    Cell Significance Index: -2.2600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1463
    Cell Significance Index: -1.9100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1469
    Cell Significance Index: -1.2400
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1476
    Cell Significance Index: -1.0200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1476
    Cell Significance Index: -1.8700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1503
    Cell Significance Index: -1.6200
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1504
    Cell Significance Index: -1.4700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1509
    Cell Significance Index: -1.7500
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1532
    Cell Significance Index: -1.8400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1544
    Cell Significance Index: -2.1200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1548
    Cell Significance Index: -1.5600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1550
    Cell Significance Index: -1.4700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1580
    Cell Significance Index: -1.8800
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1589
    Cell Significance Index: -1.4300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1591
    Cell Significance Index: -1.7400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1594
    Cell Significance Index: -2.1500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1595
    Cell Significance Index: -1.9600
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1601
    Cell Significance Index: -1.6300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1610
    Cell Significance Index: -1.9300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1612
    Cell Significance Index: -1.1600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1625
    Cell Significance Index: -1.8600
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1628
    Cell Significance Index: -1.6300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1635
    Cell Significance Index: -1.9900
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1643
    Cell Significance Index: -1.5200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1661
    Cell Significance Index: -2.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** TRAV41 is located on chromosome 6q22.3, a region rich in immune-related genes. Its expression is observed in a diverse range of cell types, including T lymphocytes, oligodendrocyte precursor cells, microglial cells, and endothelial cells. 2. **Cellular Specificity:** The expression of TRAV41 is highly specific, with a strong association with early T lineage precursors, indicating its involvement in T cell development and maturation. 3. **Gene Family:** TRAV41 is part of the TRAV gene family, which comprises 55 genes encoding Vα domains of the TCR complex. These genes are essential for generating diversity in the TCR repertoire, allowing for the recognition of a vast array of antigens. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRAV41 plays a crucial role in the adaptive immune response by contributing to the diversity of the TCR repertoire. The unique Vα domain encoded by TRAV41 enables T cells to recognize and respond to a wide range of antigens, facilitating the elimination of pathogens and tumor cells. 2. **T Cell Development and Maturation:** TRAV41 expression is associated with early T lineage precursors, suggesting its involvement in the development and maturation of T cells. This gene may regulate the transition from progenitor cells to functional T cells. 3. **Immunological Tolerance:** The expression of TRAV41 in regulatory T cells and other immunosuppressive cells may contribute to immunological tolerance, preventing excessive or inappropriate immune responses. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations or deletions in the TRAV41 gene may lead to immunodeficiency disorders, such as severe combined immunodeficiency (SCID), characterized by impaired T cell development and function. 2. **Autoimmune Diseases:** Altered expression or function of TRAV41 may contribute to autoimmune diseases, such as multiple sclerosis, where the immune system mistakenly attacks the central nervous system. 3. **Cancer Immunology:** The role of TRAV41 in T cell recognition and response to tumor antigens makes it an attractive target for cancer immunotherapy. In conclusion, TRAV41 is a critical component of the adaptive immune response, playing a pivotal role in T cell development, maturation, and function. Its unique Vα domain contributes to the diversity of the TCR repertoire, enabling the recognition of a wide range of antigens. Further research into the functions and clinical significance of TRAV41 will provide valuable insights into the mechanisms of immune regulation and the development of novel immunotherapies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.