Details for: TRAV18

Gene ID: 28665

Symbol: TRAV18

Ensembl ID: ENSG00000211798

Description: T cell receptor alpha variable 18

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.1000
    Cell Significance Index: 0.9000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0513
    Cell Significance Index: 0.2800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0407
    Cell Significance Index: 0.4600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0134
    Cell Significance Index: 0.1300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0120
    Cell Significance Index: 0.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0006
    Cell Significance Index: -0.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0050
    Cell Significance Index: -0.9100
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.0051
    Cell Significance Index: -0.0500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0062
    Cell Significance Index: -0.0600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0069
    Cell Significance Index: -0.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0093
    Cell Significance Index: -1.1400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0123
    Cell Significance Index: -0.2000
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0124
    Cell Significance Index: -0.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0214
    Cell Significance Index: -1.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0228
    Cell Significance Index: -1.0600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0239
    Cell Significance Index: -0.5800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0277
    Cell Significance Index: -0.4700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0296
    Cell Significance Index: -0.3500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0306
    Cell Significance Index: -0.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0310
    Cell Significance Index: -0.8300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0328
    Cell Significance Index: -0.4800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0331
    Cell Significance Index: -0.4500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0359
    Cell Significance Index: -0.7200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0367
    Cell Significance Index: -0.3800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0424
    Cell Significance Index: -0.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0431
    Cell Significance Index: -1.1000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0445
    Cell Significance Index: -0.7500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0451
    Cell Significance Index: -1.1500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0452
    Cell Significance Index: -0.7800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0483
    Cell Significance Index: -0.6200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0484
    Cell Significance Index: -0.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0486
    Cell Significance Index: -1.0200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0505
    Cell Significance Index: -0.4300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0519
    Cell Significance Index: -0.7700
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0538
    Cell Significance Index: -0.3700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0567
    Cell Significance Index: -0.9700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0575
    Cell Significance Index: -0.6800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0599
    Cell Significance Index: -0.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0630
    Cell Significance Index: -1.0600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0634
    Cell Significance Index: -0.8200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0643
    Cell Significance Index: -0.6500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0644
    Cell Significance Index: -1.2600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0649
    Cell Significance Index: -0.8200
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0665
    Cell Significance Index: -1.0700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0668
    Cell Significance Index: -0.7800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0671
    Cell Significance Index: -0.9200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0682
    Cell Significance Index: -1.2600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0682
    Cell Significance Index: -1.1000
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0685
    Cell Significance Index: -0.7100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0707
    Cell Significance Index: -0.7700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0717
    Cell Significance Index: -0.6800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0718
    Cell Significance Index: -0.9500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0719
    Cell Significance Index: -0.7300
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0733
    Cell Significance Index: -0.7700
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0743
    Cell Significance Index: -0.6800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0762
    Cell Significance Index: -0.9000
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0766
    Cell Significance Index: -0.9100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0766
    Cell Significance Index: -1.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0770
    Cell Significance Index: -0.7400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0771
    Cell Significance Index: -0.8000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0773
    Cell Significance Index: -0.8200
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0773
    Cell Significance Index: -0.9400
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0778
    Cell Significance Index: -0.6500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0781
    Cell Significance Index: -0.8300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0796
    Cell Significance Index: -0.8500
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0796
    Cell Significance Index: -0.7800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0803
    Cell Significance Index: -0.8200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0804
    Cell Significance Index: -0.9700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0808
    Cell Significance Index: -0.9300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0812
    Cell Significance Index: -0.9600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0816
    Cell Significance Index: -1.2400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0832
    Cell Significance Index: -0.9300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0835
    Cell Significance Index: -1.1700
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0842
    Cell Significance Index: -1.0000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0846
    Cell Significance Index: -0.7300
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0849
    Cell Significance Index: -0.7300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0850
    Cell Significance Index: -1.1100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0854
    Cell Significance Index: -1.0500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0872
    Cell Significance Index: -0.9200
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0882
    Cell Significance Index: -0.8300
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0887
    Cell Significance Index: -0.9300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0887
    Cell Significance Index: -1.0800
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0893
    Cell Significance Index: -0.7400
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0893
    Cell Significance Index: -0.8400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0903
    Cell Significance Index: -0.8800
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0907
    Cell Significance Index: -0.8300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0920
    Cell Significance Index: -1.1900
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0928
    Cell Significance Index: -0.9700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0930
    Cell Significance Index: -1.0800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0931
    Cell Significance Index: -1.1000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0933
    Cell Significance Index: -0.9400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0933
    Cell Significance Index: -1.1400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0937
    Cell Significance Index: -1.0100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0941
    Cell Significance Index: -0.9600
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0952
    Cell Significance Index: -0.9500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0958
    Cell Significance Index: -1.0300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0961
    Cell Significance Index: -1.0800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0963
    Cell Significance Index: -1.2800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0967
    Cell Significance Index: -1.2700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0969
    Cell Significance Index: -1.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Variable Region:** TRAV18 is a part of the variable region of the alpha-beta TCR, which is responsible for recognizing and binding to specific antigens. 2. **Significant Expression:** TRAV18 is expressed in a range of immune cells, including conventional dendritic cells, granulocytes, and T lymphocytes. 3. **Cellular Specificity:** The expression of TRAV18 is highly specific to certain cell types, highlighting its importance in T cell development and function. 4. **Pathway and Ontology:** TRAV18 is involved in the adaptive immune response and T cell receptor complex pathways, underscoring its critical role in the immune system. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRAV18 plays a crucial role in the adaptive immune response by enabling alpha-beta T cells to recognize and respond to specific antigens. 2. **T Cell Receptor Complex:** The TRAV18 gene is integral to the TCR complex, which is responsible for recognizing and binding to antigens on the surface of pathogens and tumor cells. 3. **T Cell Development:** TRAV18 is essential for the development and maturation of alpha-beta T cells, which are critical for the adaptive immune response. 4. **Antigen Recognition:** The variable region of TRAV18, including the TRAV18 gene, is responsible for recognizing and binding to specific antigens, allowing T cells to differentiate and respond to pathogens and tumor cells. **Clinical Significance:** 1. **Immunodeficiency Diseases:** Mutations or deletions in the TRAV18 gene can lead to immunodeficiency diseases, such as severe combined immunodeficiency (SCID), which highlights the importance of this gene in T cell development and function. 2. **Cancer Immunotherapy:** TRAV18 can serve as a target for cancer immunotherapy, as it is highly expressed in certain types of cancer cells, such as leukemia and lymphoma. 3. **Vaccine Development:** TRAV18 can be used as a target for vaccine development, as it is highly specific to certain cell types and can be used to induce immune responses against specific pathogens. 4. **Immunological Research:** Understanding the functions of TRAV18 can provide valuable insights into the mechanisms of the adaptive immune response and the development of novel immunotherapies. In conclusion, the TRAV18 gene plays a critical role in the adaptive immune response and T cell receptor complex, and its dysregulation can lead to immunodeficiency diseases and cancer. Further research into the functions of TRAV18 can provide valuable insights into the mechanisms of the immune system and the development of novel immunotherapies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.