Details for: TRAJ47

Gene ID: 28708

Symbol: TRAJ47

Ensembl ID: ENSG00000211842

Description: T cell receptor alpha joining 47

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 10.7860
    Cell Significance Index: 210.8900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 3.7431
    Cell Significance Index: 47.3000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.8654
    Cell Significance Index: 45.1900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3770
    Cell Significance Index: 4.9500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0898
    Cell Significance Index: 1.4600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0319
    Cell Significance Index: 0.4100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0268
    Cell Significance Index: 0.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0048
    Cell Significance Index: 0.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0007
    Cell Significance Index: 0.2400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0019
    Cell Significance Index: -0.0800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0063
    Cell Significance Index: -0.0700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0065
    Cell Significance Index: -0.0900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0069
    Cell Significance Index: -0.0700
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0071
    Cell Significance Index: -0.0900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0072
    Cell Significance Index: -0.1500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0085
    Cell Significance Index: -0.1300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0088
    Cell Significance Index: -0.1200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0089
    Cell Significance Index: -0.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0122
    Cell Significance Index: -0.4000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0132
    Cell Significance Index: -0.3300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0139
    Cell Significance Index: -0.2400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0140
    Cell Significance Index: -0.2800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0155
    Cell Significance Index: -0.3400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0186
    Cell Significance Index: -0.2200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0195
    Cell Significance Index: -0.2200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0200
    Cell Significance Index: -0.2700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0207
    Cell Significance Index: -0.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0218
    Cell Significance Index: -0.2600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0226
    Cell Significance Index: -0.4500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0228
    Cell Significance Index: -0.3900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0229
    Cell Significance Index: -0.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0234
    Cell Significance Index: -0.5000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0240
    Cell Significance Index: -0.2500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0269
    Cell Significance Index: -0.3400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0276
    Cell Significance Index: -0.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0283
    Cell Significance Index: -0.6200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0312
    Cell Significance Index: -0.4000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0318
    Cell Significance Index: -0.3400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0334
    Cell Significance Index: -0.4100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0357
    Cell Significance Index: -0.4200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0369
    Cell Significance Index: -0.4900
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0401
    Cell Significance Index: -0.5000
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0425
    Cell Significance Index: -0.4900
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0455
    Cell Significance Index: -0.5700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0455
    Cell Significance Index: -0.5000
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0457
    Cell Significance Index: -0.4900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0462
    Cell Significance Index: -0.5600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0502
    Cell Significance Index: -0.5800
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0502
    Cell Significance Index: -0.6300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0516
    Cell Significance Index: -0.6100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0527
    Cell Significance Index: -0.6300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0551
    Cell Significance Index: -0.6100
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0555
    Cell Significance Index: -0.5000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0574
    Cell Significance Index: -0.4900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0616
    Cell Significance Index: -0.8100
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0624
    Cell Significance Index: -0.6100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0631
    Cell Significance Index: -0.5900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0637
    Cell Significance Index: -0.4900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0639
    Cell Significance Index: -0.6000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0662
    Cell Significance Index: -0.7400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0665
    Cell Significance Index: -0.6300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0681
    Cell Significance Index: -0.6000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0700
    Cell Significance Index: -0.7100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0703
    Cell Significance Index: -0.5800
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0716
    Cell Significance Index: -0.8200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0733
    Cell Significance Index: -0.7000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0779
    Cell Significance Index: -0.8400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0786
    Cell Significance Index: -0.6100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0822
    Cell Significance Index: -0.8300
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0972
    Cell Significance Index: -0.8500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1072
    Cell Significance Index: -1.0800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1152
    Cell Significance Index: -1.0100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1252
    Cell Significance Index: -1.0800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1284
    Cell Significance Index: -1.0400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1327
    Cell Significance Index: -1.1200
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.1365
    Cell Significance Index: -1.1200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1375
    Cell Significance Index: -1.0700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1669
    Cell Significance Index: -0.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell-type specificity**: TRAJ47 is expressed in a diverse range of immune cells, including CD8-positive and CD4-positive T cells, natural killer T cells, B cells, and innate lymphoid cells. 2. **T cell receptor alpha joining**: The TRAJ47 gene is part of the T cell receptor (TCR) complex, which is essential for recognizing and binding to antigens. 3. **Diversity and complexity**: The TRAJ47 gene is involved in the development and diversification of the T cell repertoire, allowing for the recognition of a wide range of antigens. 4. **Regulatory functions**: TRAJ47 may play a role in regulating T cell activation, proliferation, and differentiation, influencing the overall immune response. **Pathways and Functions:** 1. **TCR signaling**: TRAJ47 is involved in the TCR signaling pathway, which is critical for the activation and proliferation of T cells. 2. **Notch signaling**: TRAJ47 has been shown to interact with the Notch signaling pathway, which regulates T cell development and differentiation. 3. **JAK/STAT signaling**: TRAJ47 may also be involved in the JAK/STAT signaling pathway, which is essential for the regulation of T cell activation and cytokine production. 4. **Antigen presentation**: TRAJ47 may play a role in the presentation of antigens to T cells, influencing the overall immune response. **Clinical Significance:** 1. **Immunodeficiency disorders**: Mutations in the TRAJ47 gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Autoimmune diseases**: TRAJ47 may contribute to the development of autoimmune diseases, such as multiple sclerosis and type 1 diabetes, by promoting T cell activation and autoantigen recognition. 3. **Cancer immunotherapy**: TRAJ47 may be a target for cancer immunotherapy, as it is involved in the regulation of T cell activation and proliferation. 4. **Innate immunity**: TRAJ47 plays a crucial role in the development and function of innate lymphoid cells, which are essential for the early response to infections. In conclusion, the TRAJ47 gene is a complex and multifaceted component of the immune system, involved in the development and function of various immune cells. Further research is necessary to fully elucidate its role in the immune system and to explore its potential as a therapeutic target for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.