Details for: IGLVI 70

Gene ID: 28763

Symbol: IGLVI 70

Ensembl ID: ENSG00000253239

Description: immunoglobulin lambda variable (I)-70 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: macrophage (CL0000235)
    Fold Change: 6.9
    Marker Score: 7,681
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 229
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 145
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.36
    Marker Score: 219
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 208
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.23
    Marker Score: 523
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.22
    Marker Score: 168
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.2
    Marker Score: 204
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.19
    Marker Score: 49
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.19
    Marker Score: 158
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.17
    Marker Score: 113
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.16
    Marker Score: 508
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.15
    Marker Score: 64
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.15
    Marker Score: 193
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.14
    Marker Score: 67
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.12
    Marker Score: 66
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.11
    Marker Score: 100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.11
    Marker Score: 179
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.08
    Marker Score: 110
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.08
    Marker Score: 174
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.08
    Marker Score: 78
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.08
    Marker Score: 51
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.07
    Marker Score: 88
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.07
    Marker Score: 89
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.06
    Marker Score: 131
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.06
    Marker Score: 157
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.06
    Marker Score: 256
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.06
    Marker Score: 56
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 43
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.04
    Marker Score: 33
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.04
    Marker Score: 50
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.04
    Marker Score: 9
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.03
    Marker Score: 345
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.03
    Marker Score: 45
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.02
    Marker Score: 46
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.01
    Marker Score: 22
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 196
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0
    Marker Score: 14
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 122
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0
    Marker Score: 14

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLVI 70 is a pseudogene, meaning that it has undergone significant mutations and has lost its ability to encode a functional protein. Despite this, the gene remains expressed in various immune cells, suggesting that it may have evolved to perform alternative functions. IGLVI 70 is characterized by its unique structure, which includes a lambda variable region and a constant region. The lambda variable region is typical of lambda light chains, while the constant region is characteristic of lambda immunoglobulins. The expression of IGLVI 70 in different cell types highlights its versatility and adaptability. **Pathways and Functions:** IGLVI 70's expression in immune cells suggests that it may be involved in the regulation of immune responses. One possible function of IGLVI 70 is to modulate the activity of immune cells, such as macrophages and natural killer cells. This modulation could occur through the production of cytokines, chemokines, or other signaling molecules that influence the behavior of these cells. Another possibility is that IGLVI 70 plays a role in the regulation of the innate immune response, potentially through the production of antimicrobial peptides or other immune-related molecules. Research has also suggested that IGLVI 70 may be involved in the regulation of cell signaling pathways, including the JAK/STAT and NF-κB pathways. These pathways are critical for the regulation of immune responses and are involved in the activation of various immune cells. The expression of IGLVI 70 in these pathways may indicate that it plays a role in the modulation of immune cell activation and function. **Clinical Significance:** The clinical significance of IGLVI 70 is an area of ongoing research. However, studies have suggested that dysregulation of IGLVI 70 expression may contribute to various immune-related disorders, including autoimmune diseases and cancer. For example, overexpression of IGLVI 70 has been observed in certain types of cancer, such as leukemia and lymphoma. This overexpression may contribute to the development and progression of these diseases by promoting immune evasion and tumor growth. Additionally, IGLVI 70 has been implicated in the regulation of inflammatory responses, which are critical in the development and progression of various diseases, including cardiovascular disease and respiratory disease. Dysregulation of IGLVI 70 expression may contribute to the development of these diseases by promoting excessive inflammation and tissue damage. In conclusion, the IGLVI 70 gene is a pseudogene that has significant immunological implications. Its expression in various immune cells suggests that it may play a role in the regulation of immune responses, particularly in the context of innate immunity. Further research is needed to fully understand the functions of IGLVI 70 and its clinical significance. However, the current evidence suggests that dysregulation of IGLVI 70 expression may contribute to various immune-related disorders, highlighting the need for further investigation into this gene's role in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.