Details for: IGLV5 45

Gene ID: 28781

Symbol: IGLV5 45

Ensembl ID: ENSG00000211650

Description: immunoglobulin lambda variable 5-45

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 9.5546
    Cell Significance Index: 335.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.4001
    Cell Significance Index: 109.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.8031
    Cell Significance Index: 109.5800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.7714
    Cell Significance Index: 22.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6005
    Cell Significance Index: 72.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0919
    Cell Significance Index: 23.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0855
    Cell Significance Index: 206.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8720
    Cell Significance Index: 86.2600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.7952
    Cell Significance Index: 16.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7132
    Cell Significance Index: 643.9500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.4579
    Cell Significance Index: 5.1200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3982
    Cell Significance Index: 6.0000
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.3920
    Cell Significance Index: 3.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3761
    Cell Significance Index: 61.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3526
    Cell Significance Index: 7.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3008
    Cell Significance Index: 32.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2901
    Cell Significance Index: 9.2900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2404
    Cell Significance Index: 3.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1876
    Cell Significance Index: 12.9800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0834
    Cell Significance Index: 1.0100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0307
    Cell Significance Index: 0.4500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0291
    Cell Significance Index: -0.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0294
    Cell Significance Index: -0.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0321
    Cell Significance Index: -1.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0387
    Cell Significance Index: -2.3700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1063
    Cell Significance Index: -0.6600
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.1069
    Cell Significance Index: -1.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1107
    Cell Significance Index: -11.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1156
    Cell Significance Index: -23.1900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1357
    Cell Significance Index: -1.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1411
    Cell Significance Index: -7.9200
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.1604
    Cell Significance Index: -1.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1668
    Cell Significance Index: -10.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1937
    Cell Significance Index: -9.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2092
    Cell Significance Index: -5.6000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2212
    Cell Significance Index: -2.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2374
    Cell Significance Index: -6.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3733
    Cell Significance Index: -10.7000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3803
    Cell Significance Index: -9.6900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.4020
    Cell Significance Index: -4.2700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.4034
    Cell Significance Index: -4.9900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4157
    Cell Significance Index: -10.0700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4526
    Cell Significance Index: -8.8500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.5070
    Cell Significance Index: -5.9700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.5116
    Cell Significance Index: -10.6700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.5305
    Cell Significance Index: -6.2700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.5316
    Cell Significance Index: -8.6100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.5383
    Cell Significance Index: -5.5000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.5398
    Cell Significance Index: -7.6700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.5415
    Cell Significance Index: -7.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5513
    Cell Significance Index: -10.1900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.5666
    Cell Significance Index: -6.8400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.5833
    Cell Significance Index: -9.9700
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.5976
    Cell Significance Index: -6.7700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.6014
    Cell Significance Index: -6.9200
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.6048
    Cell Significance Index: -6.4600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.6271
    Cell Significance Index: -8.6000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.6438
    Cell Significance Index: -8.4200
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.6475
    Cell Significance Index: -8.2000
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.6559
    Cell Significance Index: -6.8300
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.6565
    Cell Significance Index: -7.0200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.6592
    Cell Significance Index: -8.5300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.7006
    Cell Significance Index: -7.6300
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.7013
    Cell Significance Index: -7.1200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.7048
    Cell Significance Index: -8.8100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.7315
    Cell Significance Index: -9.7200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.7398
    Cell Significance Index: -8.0100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.7563
    Cell Significance Index: -8.9900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.7660
    Cell Significance Index: -8.9000
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.7729
    Cell Significance Index: -6.3800
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.7743
    Cell Significance Index: -9.3400
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.7763
    Cell Significance Index: -7.9300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.7868
    Cell Significance Index: -8.3000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.7890
    Cell Significance Index: -8.8200
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.7905
    Cell Significance Index: -8.7800
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.7958
    Cell Significance Index: -7.2500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.7963
    Cell Significance Index: -10.4500
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.8038
    Cell Significance Index: -7.9300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.8040
    Cell Significance Index: -10.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8052
    Cell Significance Index: -21.5000
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.8121
    Cell Significance Index: -8.7900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.8128
    Cell Significance Index: -8.7400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.8167
    Cell Significance Index: -8.3300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.8173
    Cell Significance Index: -9.6500
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.8183
    Cell Significance Index: -8.9700
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.8303
    Cell Significance Index: -8.7500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.8310
    Cell Significance Index: -9.4400
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.8311
    Cell Significance Index: -7.9500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.8312
    Cell Significance Index: -9.5700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.8365
    Cell Significance Index: -9.0700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.8532
    Cell Significance Index: -9.4500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.8542
    Cell Significance Index: -11.0000
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.8543
    Cell Significance Index: -7.2100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.8575
    Cell Significance Index: -10.1800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.8635
    Cell Significance Index: -9.5600
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.8680
    Cell Significance Index: -8.9800
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.8751
    Cell Significance Index: -9.3500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.8773
    Cell Significance Index: -11.2700
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.8777
    Cell Significance Index: -8.9100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.8793
    Cell Significance Index: -10.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin lambda variable region:** The IGLV5-45 gene encodes for a lambda light chain variable region, a critical component of the immunoglobulin structure. 2. **Significant expression in diverse cell types:** This gene is expressed in various cell types, including glutamatergic neurons, oligodendrocyte precursor cells, microglial cells, blood vessel endothelial cells, enterocytes, and immune cells. 3. **Adaptive immune response involvement:** The IGLV5-45 gene plays a role in the adaptive immune response, a complex process involving the activation and regulation of immune cells. **Pathways and Functions:** 1. **Adaptive immune response:** The IGLV5-45 gene contributes to the adaptive immune response by participating in the assembly of immunoglobulins, which are essential for recognizing and neutralizing pathogens. 2. **Immunoglobulin complex formation:** The lambda light chain variable region encoded by IGLV5-45 interacts with other immunoglobulin chains to form a functional antibody-antigen complex. 3. **Extracellular space:** The IGLV5-45 gene is involved in the extracellular space, where immunoglobulins can interact with pathogens and other molecules. 4. **Immunoglobulin production:** The IGLV5-45 gene plays a role in immunoglobulin production, a critical process for generating antibodies against pathogens. **Clinical Significance:** 1. **Autoimmune diseases:** Alterations in the IGLV5-45 gene may contribute to autoimmune diseases, such as rheumatoid arthritis, where immune system dysregulation leads to inflammation and tissue damage. 2. **Immunodeficiency disorders:** Mutations in the IGLV5-45 gene may impair immunoglobulin production, leading to immunodeficiency disorders, such as agammaglobulinemia. 3. **Cancer:** The IGLV5-45 gene may be involved in cancer development, as dysregulation of the adaptive immune response can contribute to tumor growth and progression. 4. **Infectious diseases:** The IGLV5-45 gene plays a role in the immune response to infectious diseases, such as HIV, where immunoglobulin production is impaired. In conclusion, the IGLV5-45 gene is a vital component of the adaptive immune system, and its dysregulation can contribute to various immune-related disorders. Further research is necessary to fully understand the mechanisms underlying the IGLV5-45 gene's involvement in immune homeostasis and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.