Details for: IGLV5 45

Gene ID: 28781

Symbol: IGLV5 45

Ensembl ID: ENSG00000211650

Description: immunoglobulin lambda variable 5-45

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,084
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8,278
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,844
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.21
    Marker Score: 2,223
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2,001
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1,175
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.39
    Marker Score: 2,389
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 876
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 861
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 491
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,691
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,820
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 802
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,815
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.02
    Marker Score: 467
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,057
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,327
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.88
    Marker Score: 1,433
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.8
    Marker Score: 461
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 508
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.51
    Marker Score: 816
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.5
    Marker Score: 390
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.42
    Marker Score: 378
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.36
    Marker Score: 113
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.32
    Marker Score: 85
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.32
    Marker Score: 360
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.27
    Marker Score: 353
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.23
    Marker Score: 278
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.21
    Marker Score: 119
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.21
    Marker Score: 174
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.19
    Marker Score: 128
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.19
    Marker Score: 118
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.19
    Marker Score: 128
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.17
    Marker Score: 422
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.17
    Marker Score: 79
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.15
    Marker Score: 367
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.14
    Marker Score: 115
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.13
    Marker Score: 130
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.12
    Marker Score: 121
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.12
    Marker Score: 112
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.11
    Marker Score: 129
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.11
    Marker Score: 45
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.1
    Marker Score: 110
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.1
    Marker Score: 47
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.1
    Marker Score: 44
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.1
    Marker Score: 89
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.09
    Marker Score: 108
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.09
    Marker Score: 112
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.09
    Marker Score: 57
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.08
    Marker Score: 984
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.08
    Marker Score: 79
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.08
    Marker Score: 69
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.08
    Marker Score: 133
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 136
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.05
    Marker Score: 38
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.05
    Marker Score: 100
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.05
    Marker Score: 47
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.05
    Marker Score: 45
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.05
    Marker Score: 61
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.05
    Marker Score: 11
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.04
    Marker Score: 34
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.04
    Marker Score: 43
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.04
    Marker Score: 30
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.04
    Marker Score: 91

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin lambda variable region:** The IGLV5-45 gene encodes for a lambda light chain variable region, a critical component of the immunoglobulin structure. 2. **Significant expression in diverse cell types:** This gene is expressed in various cell types, including glutamatergic neurons, oligodendrocyte precursor cells, microglial cells, blood vessel endothelial cells, enterocytes, and immune cells. 3. **Adaptive immune response involvement:** The IGLV5-45 gene plays a role in the adaptive immune response, a complex process involving the activation and regulation of immune cells. **Pathways and Functions:** 1. **Adaptive immune response:** The IGLV5-45 gene contributes to the adaptive immune response by participating in the assembly of immunoglobulins, which are essential for recognizing and neutralizing pathogens. 2. **Immunoglobulin complex formation:** The lambda light chain variable region encoded by IGLV5-45 interacts with other immunoglobulin chains to form a functional antibody-antigen complex. 3. **Extracellular space:** The IGLV5-45 gene is involved in the extracellular space, where immunoglobulins can interact with pathogens and other molecules. 4. **Immunoglobulin production:** The IGLV5-45 gene plays a role in immunoglobulin production, a critical process for generating antibodies against pathogens. **Clinical Significance:** 1. **Autoimmune diseases:** Alterations in the IGLV5-45 gene may contribute to autoimmune diseases, such as rheumatoid arthritis, where immune system dysregulation leads to inflammation and tissue damage. 2. **Immunodeficiency disorders:** Mutations in the IGLV5-45 gene may impair immunoglobulin production, leading to immunodeficiency disorders, such as agammaglobulinemia. 3. **Cancer:** The IGLV5-45 gene may be involved in cancer development, as dysregulation of the adaptive immune response can contribute to tumor growth and progression. 4. **Infectious diseases:** The IGLV5-45 gene plays a role in the immune response to infectious diseases, such as HIV, where immunoglobulin production is impaired. In conclusion, the IGLV5-45 gene is a vital component of the adaptive immune system, and its dysregulation can contribute to various immune-related disorders. Further research is necessary to fully understand the mechanisms underlying the IGLV5-45 gene's involvement in immune homeostasis and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.