Details for: IGLV4 60

Gene ID: 28785

Symbol: IGLV4 60

Ensembl ID: ENSG00000211639

Description: immunoglobulin lambda variable 4-60

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,083
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.24
    Marker Score: 53,067
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8,279
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,845
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,176
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.26
    Marker Score: 3,903
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.62
    Marker Score: 10,801
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 877
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,575
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,651
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,725
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 803
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,814
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,056
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,401
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,335
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 738
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,261
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1,192
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.73
    Marker Score: 703
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.67
    Marker Score: 386
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.67
    Marker Score: 388
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 236
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 386
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.37
    Marker Score: 1,146
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.25
    Marker Score: 142
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.25
    Marker Score: 277
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.23
    Marker Score: 153
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.22
    Marker Score: 288
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.22
    Marker Score: 168
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.2
    Marker Score: 190
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.19
    Marker Score: 182
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.17
    Marker Score: 231
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.16
    Marker Score: 165
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.15
    Marker Score: 64
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.13
    Marker Score: 57
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.11
    Marker Score: 174
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.11
    Marker Score: 138
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.11
    Marker Score: 57
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.1
    Marker Score: 112
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.09
    Marker Score: 78
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.08
    Marker Score: 180
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.08
    Marker Score: 196
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.07
    Marker Score: 82
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 137
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.06
    Marker Score: 51
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.05
    Marker Score: 63
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.05
    Marker Score: 41
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.04
    Marker Score: 49
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.04
    Marker Score: 153
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.03
    Marker Score: 70
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.03
    Marker Score: 43
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.02
    Marker Score: 289
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.02
    Marker Score: 67
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.02
    Marker Score: 49
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.02
    Marker Score: 19

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Location and Structure:** The IGLV4-60 gene is located on chromosome 22, and its sequence is composed of a variable region that encodes a light chain of an immunoglobulin. 2. **Expression Patterns:** IGLV4-60 is expressed in a wide range of cell types, including T cells, B cells, endothelial cells, and progenitor cells. Its expression is also observed in neoplastic cells and abnormal cells, suggesting a potential role in cancer development. 3. **Cellular Localization:** The IGLV4-60 gene is primarily localized to the plasma membrane, where it is involved in the formation of immunoglobulin complexes. **Pathways and Functions:** 1. **Adaptive Immune Response:** IGLV4-60 is essential for the development and function of the adaptive immune response. It contributes to the formation of immunoglobulin complexes, which are critical for recognizing and eliminating pathogens. 2. **Immunoglobulin Production:** The IGLV4-60 gene plays a crucial role in immunoglobulin production, which is a key function of B cells. The variable region encoded by IGLV4-60 is responsible for the specificity of antibody production. 3. **Cell-Cell Interactions:** IGLV4-60 is involved in cell-cell interactions, including adhesion and signaling events. Its expression on endothelial cells and immune cells contributes to the regulation of immune responses and tissue homeostasis. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations or deletions in the IGLV4-60 gene can lead to immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA). Individuals with XLA lack functional B cells and are susceptible to recurrent infections. 2. **Cancer Development:** The expression of IGLV4-60 in neoplastic cells and abnormal cells suggests a potential role in cancer development. Further studies are needed to determine the relationship between IGLV4-60 and cancer progression. 3. **Inflammation and Autoimmunity:** The IGLV4-60 gene is involved in the regulation of inflammation and autoimmunity. Its expression on endothelial cells and immune cells contributes to the development of inflammatory responses and autoimmune diseases. In conclusion, the IGLV4-60 gene plays a critical role in the adaptive immune response, immunoglobulin production, and cell-cell interactions. Its expression in various cell types and its association with immunodeficiency disorders, cancer development, and inflammation highlight its importance in maintaining immune homeostasis. Further studies are needed to elucidate the functional significance of IGLV4-60 and its potential applications in immunotherapy and disease treatment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.