Details for: IGLV4 60

Gene ID: 28785

Symbol: IGLV4 60

Ensembl ID: ENSG00000211639

Description: immunoglobulin lambda variable 4-60

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0376
    Cell Significance Index: -1.7500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0536
    Cell Significance Index: -0.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0912
    Cell Significance Index: -18.2900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1428
    Cell Significance Index: -1.8100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2044
    Cell Significance Index: -2.2300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2556
    Cell Significance Index: -6.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2740
    Cell Significance Index: -7.3300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2763
    Cell Significance Index: -7.0400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2871
    Cell Significance Index: -3.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3159
    Cell Significance Index: -14.3200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3308
    Cell Significance Index: -5.6600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3365
    Cell Significance Index: -6.2200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3458
    Cell Significance Index: -3.2800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3519
    Cell Significance Index: -6.8800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3570
    Cell Significance Index: -9.1200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3640
    Cell Significance Index: -4.4300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3681
    Cell Significance Index: -5.3500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4146
    Cell Significance Index: -6.7200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4337
    Cell Significance Index: -4.9900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.4528
    Cell Significance Index: -4.8100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.5207
    Cell Significance Index: -7.1400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.5208
    Cell Significance Index: -7.3100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5338
    Cell Significance Index: -6.0600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.5512
    Cell Significance Index: -6.1600
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.5540
    Cell Significance Index: -5.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5541
    Cell Significance Index: -18.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5743
    Cell Significance Index: -18.2900
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.5760
    Cell Significance Index: -6.2100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.5804
    Cell Significance Index: -7.5100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.5853
    Cell Significance Index: -7.2400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.5885
    Cell Significance Index: -7.8200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.6158
    Cell Significance Index: -7.2500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.6165
    Cell Significance Index: -8.0900
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.6227
    Cell Significance Index: -6.0800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.6323
    Cell Significance Index: -5.5300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.6408
    Cell Significance Index: -8.3800
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.6421
    Cell Significance Index: -5.3000
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.6465
    Cell Significance Index: -5.0700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.6479
    Cell Significance Index: -6.6200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.6566
    Cell Significance Index: -7.2700
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.6620
    Cell Significance Index: -6.8600
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.6887
    Cell Significance Index: -5.8700
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.7000
    Cell Significance Index: -6.1500
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.7029
    Cell Significance Index: -6.3500
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.7092
    Cell Significance Index: -5.8200
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.7142
    Cell Significance Index: -5.7400
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.7147
    Cell Significance Index: -7.8300
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.7164
    Cell Significance Index: -6.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.7241
    Cell Significance Index: -6.9600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.7247
    Cell Significance Index: -8.3400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.7278
    Cell Significance Index: -8.6000
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.7299
    Cell Significance Index: -7.8700
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.7442
    Cell Significance Index: -6.2800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.7534
    Cell Significance Index: -9.5200
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.7553
    Cell Significance Index: -8.0700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.7579
    Cell Significance Index: -6.7600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.7648
    Cell Significance Index: -12.9900
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.7674
    Cell Significance Index: -7.0900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.7717
    Cell Significance Index: -9.1200
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.7812
    Cell Significance Index: -6.9600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.7836
    Cell Significance Index: -7.9000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.7840
    Cell Significance Index: -7.3600
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.7868
    Cell Significance Index: -8.1000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.8019
    Cell Significance Index: -9.5200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.8030
    Cell Significance Index: -9.0900
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.8115
    Cell Significance Index: -7.7900
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.8161
    Cell Significance Index: -7.9800
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.8214
    Cell Significance Index: -5.9700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.8252
    Cell Significance Index: -6.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8254
    Cell Significance Index: -19.0700
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.8314
    Cell Significance Index: -7.8500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.8342
    Cell Significance Index: -8.9700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.8445
    Cell Significance Index: -10.5500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.8448
    Cell Significance Index: -9.5200
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.8455
    Cell Significance Index: -9.0300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.8511
    Cell Significance Index: -9.3100
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: -0.8546
    Cell Significance Index: -7.6600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.8578
    Cell Significance Index: -9.1100
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.8657
    Cell Significance Index: -7.8900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.8749
    Cell Significance Index: -10.3300
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.8780
    Cell Significance Index: -7.1100
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.8825
    Cell Significance Index: -6.0700
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.8855
    Cell Significance Index: -8.9900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.8871
    Cell Significance Index: -7.0900
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.8889
    Cell Significance Index: -6.1600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.8905
    Cell Significance Index: -9.0300
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.8965
    Cell Significance Index: -5.9700
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.9117
    Cell Significance Index: -7.0000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.9204
    Cell Significance Index: -7.8400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.9274
    Cell Significance Index: -8.6400
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: -0.9312
    Cell Significance Index: -7.8500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.9334
    Cell Significance Index: -9.5200
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.9441
    Cell Significance Index: -10.0100
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.9496
    Cell Significance Index: -8.9900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9537
    Cell Significance Index: -14.2900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.9562
    Cell Significance Index: -10.5900
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.9570
    Cell Significance Index: -7.1200
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: -0.9603
    Cell Significance Index: -5.8000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.9616
    Cell Significance Index: -10.1300
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.9629
    Cell Significance Index: -10.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Location and Structure:** The IGLV4-60 gene is located on chromosome 22, and its sequence is composed of a variable region that encodes a light chain of an immunoglobulin. 2. **Expression Patterns:** IGLV4-60 is expressed in a wide range of cell types, including T cells, B cells, endothelial cells, and progenitor cells. Its expression is also observed in neoplastic cells and abnormal cells, suggesting a potential role in cancer development. 3. **Cellular Localization:** The IGLV4-60 gene is primarily localized to the plasma membrane, where it is involved in the formation of immunoglobulin complexes. **Pathways and Functions:** 1. **Adaptive Immune Response:** IGLV4-60 is essential for the development and function of the adaptive immune response. It contributes to the formation of immunoglobulin complexes, which are critical for recognizing and eliminating pathogens. 2. **Immunoglobulin Production:** The IGLV4-60 gene plays a crucial role in immunoglobulin production, which is a key function of B cells. The variable region encoded by IGLV4-60 is responsible for the specificity of antibody production. 3. **Cell-Cell Interactions:** IGLV4-60 is involved in cell-cell interactions, including adhesion and signaling events. Its expression on endothelial cells and immune cells contributes to the regulation of immune responses and tissue homeostasis. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations or deletions in the IGLV4-60 gene can lead to immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA). Individuals with XLA lack functional B cells and are susceptible to recurrent infections. 2. **Cancer Development:** The expression of IGLV4-60 in neoplastic cells and abnormal cells suggests a potential role in cancer development. Further studies are needed to determine the relationship between IGLV4-60 and cancer progression. 3. **Inflammation and Autoimmunity:** The IGLV4-60 gene is involved in the regulation of inflammation and autoimmunity. Its expression on endothelial cells and immune cells contributes to the development of inflammatory responses and autoimmune diseases. In conclusion, the IGLV4-60 gene plays a critical role in the adaptive immune response, immunoglobulin production, and cell-cell interactions. Its expression in various cell types and its association with immunodeficiency disorders, cancer development, and inflammation highlight its importance in maintaining immune homeostasis. Further studies are needed to elucidate the functional significance of IGLV4-60 and its potential applications in immunotherapy and disease treatment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.