Details for: IGLV3 9

Gene ID: 28804

Symbol: IGLV3 9

Ensembl ID: ENSG00000211670

Description: immunoglobulin lambda variable 3-9

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 875
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,692
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 801
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,818
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.03
    Marker Score: 2,608
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,351
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.89
    Marker Score: 1,448
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 494
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.55
    Marker Score: 337
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.43
    Marker Score: 336
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.32
    Marker Score: 267
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.25
    Marker Score: 331
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.17
    Marker Score: 75
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.16
    Marker Score: 379
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.15
    Marker Score: 133
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.15
    Marker Score: 364
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.13
    Marker Score: 109
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.13
    Marker Score: 84
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.13
    Marker Score: 58
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.12
    Marker Score: 139
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.1
    Marker Score: 69
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.1
    Marker Score: 1,137
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.1
    Marker Score: 157
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.09
    Marker Score: 51
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.09
    Marker Score: 37
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.08
    Marker Score: 83
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.08
    Marker Score: 98
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 82
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 68
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.07
    Marker Score: 69
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.07
    Marker Score: 73
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 135
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.06
    Marker Score: 52
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.06
    Marker Score: 50
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.05
    Marker Score: 113
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.05
    Marker Score: 52
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.04
    Marker Score: 58
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.04
    Marker Score: 58
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.04
    Marker Score: 80
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.04
    Marker Score: 65
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.03
    Marker Score: 60
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.03
    Marker Score: 48
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.03
    Marker Score: 85
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.02
    Marker Score: 84
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.02
    Marker Score: 36
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.02
    Marker Score: 14

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLV3-9 is a gene that encodes for a variable region of the lambda immunoglobulin light chain. This light chain is essential for the proper functioning of immunoglobulins, which are composed of heavy and light chains. The lambda light chain is responsible for the specificity and affinity of immunoglobulins for antigens. IGLV3-9 is part of the immunoglobulin locus, a complex region of the genome that contains genes involved in the production of immunoglobulins. **Pathways and Functions:** IGLV3-9 is involved in the adaptive immune response, which is a specific and targeted defense against pathogens. The adaptive immune response involves the activation of immune cells, such as T cells and B cells, which recognize and respond to specific antigens. IGLV3-9 plays a crucial role in this process by providing the specificity and affinity for antigens. The gene is expressed in various cell types, including granulocyte-monocyte progenitor cells, goblet cells, and intestinal epithelial cells, which highlights its involvement in different aspects of the immune response. The pathways and functions of IGLV3-9 can be summarized as follows: * **Immunoglobulin production:** IGLV3-9 is involved in the production of immunoglobulins, which are essential for recognizing and eliminating pathogens. * **Adaptive immune response:** IGLV3-9 plays a crucial role in the adaptive immune response, which is a specific and targeted defense against pathogens. * **Antigen recognition:** IGLV3-9 provides the specificity and affinity for antigens, enabling the recognition and response to specific pathogens. * **Immunoglobulin complex formation:** IGLV3-9 is involved in the formation of immunoglobulin complexes, which are composed of heavy and light chains. **Clinical Significance:** IGLV3-9 has significant clinical implications, particularly in the context of autoimmune diseases and cancer. Abnormal expression of IGLV3-9 has been linked to various diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. In cancer, IGLV3-9 has been implicated in the development and progression of tumors, particularly those of the intestinal and breast cancers. Furthermore, IGLV3-9 has been identified as a potential biomarker for disease diagnosis and monitoring. For example, elevated levels of IGLV3-9 have been detected in patients with autoimmune diseases, suggesting its potential as a diagnostic biomarker. In conclusion, IGLV3-9 is a gene that plays a critical role in the adaptive immune response. Its expression in various cell types and involvement in immunoglobulin production, antigen recognition, and immunoglobulin complex formation highlight its broad immunological significance. The clinical implications of IGLV3-9 are significant, particularly in the context of autoimmune diseases and cancer. Further research is needed to fully elucidate the functions and clinical significance of IGLV3-9.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.