Details for: IGLV3 9

Gene ID: 28804

Symbol: IGLV3 9

Ensembl ID: ENSG00000211670

Description: immunoglobulin lambda variable 3-9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3121
    Cell Significance Index: 19.6600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.2883
    Cell Significance Index: 3.7700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2391
    Cell Significance Index: 3.7000
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.0232
    Cell Significance Index: 0.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0043
    Cell Significance Index: -3.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0126
    Cell Significance Index: -2.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0181
    Cell Significance Index: -2.2200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0198
    Cell Significance Index: -0.5000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0294
    Cell Significance Index: -0.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0318
    Cell Significance Index: -3.2500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0611
    Cell Significance Index: -0.8500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0644
    Cell Significance Index: -0.7200
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0677
    Cell Significance Index: -0.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0841
    Cell Significance Index: -2.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0961
    Cell Significance Index: -12.4100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1016
    Cell Significance Index: -2.4600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1198
    Cell Significance Index: -1.9400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1236
    Cell Significance Index: -3.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1385
    Cell Significance Index: -2.5600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1451
    Cell Significance Index: -2.4800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1590
    Cell Significance Index: -1.8300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1667
    Cell Significance Index: -3.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1672
    Cell Significance Index: -12.4600
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.1696
    Cell Significance Index: -1.4000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1738
    Cell Significance Index: -2.1500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1779
    Cell Significance Index: -2.4400
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.1817
    Cell Significance Index: -1.4600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1832
    Cell Significance Index: -2.3700
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1889
    Cell Significance Index: -1.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1941
    Cell Significance Index: -8.8000
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1994
    Cell Significance Index: -2.1300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2001
    Cell Significance Index: -2.1800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.2052
    Cell Significance Index: -2.1800
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.2072
    Cell Significance Index: -1.3800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2124
    Cell Significance Index: -2.1700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.2222
    Cell Significance Index: -2.4600
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.2265
    Cell Significance Index: -2.4100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2295
    Cell Significance Index: -2.7000
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.2343
    Cell Significance Index: -2.0900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2367
    Cell Significance Index: -3.0000
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.2381
    Cell Significance Index: -2.4500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2439
    Cell Significance Index: -2.6300
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.2449
    Cell Significance Index: -2.7000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2472
    Cell Significance Index: -2.8500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2530
    Cell Significance Index: -3.3200
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.2542
    Cell Significance Index: -2.4400
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.2560
    Cell Significance Index: -2.5000
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.2566
    Cell Significance Index: -2.9800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2585
    Cell Significance Index: -3.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2604
    Cell Significance Index: -12.1400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2627
    Cell Significance Index: -2.8300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2652
    Cell Significance Index: -2.4900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2658
    Cell Significance Index: -3.3200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2688
    Cell Significance Index: -3.2700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2703
    Cell Significance Index: -3.0200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2713
    Cell Significance Index: -2.6500
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.2719
    Cell Significance Index: -2.7600
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.2726
    Cell Significance Index: -2.5400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2742
    Cell Significance Index: -3.3100
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.2749
    Cell Significance Index: -2.5400
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.2781
    Cell Significance Index: -2.5100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2790
    Cell Significance Index: -2.4400
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.2817
    Cell Significance Index: -3.0100
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.2823
    Cell Significance Index: -2.4800
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.2843
    Cell Significance Index: -2.5400
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.2855
    Cell Significance Index: -2.4600
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.2859
    Cell Significance Index: -2.8000
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.2916
    Cell Significance Index: -2.2300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2939
    Cell Significance Index: -2.4800
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2949
    Cell Significance Index: -3.2800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2958
    Cell Significance Index: -3.8000
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.2986
    Cell Significance Index: -2.4500
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.2991
    Cell Significance Index: -2.9500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2992
    Cell Significance Index: -3.2600
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3021
    Cell Significance Index: -3.3100
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.3055
    Cell Significance Index: -2.1500
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.3086
    Cell Significance Index: -2.4200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3093
    Cell Significance Index: -4.1100
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: -0.3149
    Cell Significance Index: -2.4300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.3156
    Cell Significance Index: -3.1800
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.3181
    Cell Significance Index: -3.0100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.3191
    Cell Significance Index: -3.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3215
    Cell Significance Index: -16.7000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.3239
    Cell Significance Index: -2.5200
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.3264
    Cell Significance Index: -3.3100
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.3282
    Cell Significance Index: -2.5200
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.3302
    Cell Significance Index: -3.4700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.3307
    Cell Significance Index: -3.6300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.3321
    Cell Significance Index: -3.3200
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.3335
    Cell Significance Index: -3.0500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.3340
    Cell Significance Index: -3.0100
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.3347
    Cell Significance Index: -2.4900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.3362
    Cell Significance Index: -3.1200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.3365
    Cell Significance Index: -3.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.3371
    Cell Significance Index: -3.2400
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.3416
    Cell Significance Index: -3.5400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3426
    Cell Significance Index: -3.1900
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.3444
    Cell Significance Index: -3.2800
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.3449
    Cell Significance Index: -2.3900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3479
    Cell Significance Index: -3.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLV3-9 is a gene that encodes for a variable region of the lambda immunoglobulin light chain. This light chain is essential for the proper functioning of immunoglobulins, which are composed of heavy and light chains. The lambda light chain is responsible for the specificity and affinity of immunoglobulins for antigens. IGLV3-9 is part of the immunoglobulin locus, a complex region of the genome that contains genes involved in the production of immunoglobulins. **Pathways and Functions:** IGLV3-9 is involved in the adaptive immune response, which is a specific and targeted defense against pathogens. The adaptive immune response involves the activation of immune cells, such as T cells and B cells, which recognize and respond to specific antigens. IGLV3-9 plays a crucial role in this process by providing the specificity and affinity for antigens. The gene is expressed in various cell types, including granulocyte-monocyte progenitor cells, goblet cells, and intestinal epithelial cells, which highlights its involvement in different aspects of the immune response. The pathways and functions of IGLV3-9 can be summarized as follows: * **Immunoglobulin production:** IGLV3-9 is involved in the production of immunoglobulins, which are essential for recognizing and eliminating pathogens. * **Adaptive immune response:** IGLV3-9 plays a crucial role in the adaptive immune response, which is a specific and targeted defense against pathogens. * **Antigen recognition:** IGLV3-9 provides the specificity and affinity for antigens, enabling the recognition and response to specific pathogens. * **Immunoglobulin complex formation:** IGLV3-9 is involved in the formation of immunoglobulin complexes, which are composed of heavy and light chains. **Clinical Significance:** IGLV3-9 has significant clinical implications, particularly in the context of autoimmune diseases and cancer. Abnormal expression of IGLV3-9 has been linked to various diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. In cancer, IGLV3-9 has been implicated in the development and progression of tumors, particularly those of the intestinal and breast cancers. Furthermore, IGLV3-9 has been identified as a potential biomarker for disease diagnosis and monitoring. For example, elevated levels of IGLV3-9 have been detected in patients with autoimmune diseases, suggesting its potential as a diagnostic biomarker. In conclusion, IGLV3-9 is a gene that plays a critical role in the adaptive immune response. Its expression in various cell types and involvement in immunoglobulin production, antigen recognition, and immunoglobulin complex formation highlight its broad immunological significance. The clinical implications of IGLV3-9 are significant, particularly in the context of autoimmune diseases and cancer. Further research is needed to fully elucidate the functions and clinical significance of IGLV3-9.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.