IGKV5 2 | ENSG00000211599 | NCBI 28907

Details for: IGKV5 2

Gene ID: 28907

Symbol: IGKV5 2

Ensembl ID: ENSG00000211599

Description: immunoglobulin kappa variable 5-2

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin production
(GO:0002377)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: endothelial cell (CL0000115)
Fold Change: 20.66
Marker Score: 18,517
Cell Name: macrophage (CL0000235)
Fold Change: 7.96
Marker Score: 8,858
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.38
Marker Score: 874
Cell Name: monocyte (CL0000576)
Fold Change: 1.36
Marker Score: 1,765
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,823
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: neutrophil (CL0000775)
Fold Change: 0.64
Marker Score: 388
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.62
Marker Score: 471
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 148
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 476
Cell Name: mast cell (CL0000097)
Fold Change: 0.37
Marker Score: 215
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 373
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.23
Marker Score: 524
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.22
Marker Score: 125
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.17
Marker Score: 131
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.14
Marker Score: 75
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.13
Marker Score: 207
Cell Name: stromal cell (CL0000499)
Fold Change: 0.12
Marker Score: 143
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.12
Marker Score: 80
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.12
Marker Score: 153
Cell Name: Unknown (CL0000003)
Fold Change: 0.12
Marker Score: 364
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.08
Marker Score: 113
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.08
Marker Score: 33
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.08
Marker Score: 95
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.07
Marker Score: 63
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.07
Marker Score: 134
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.06
Marker Score: 35
Cell Name: plasmablast (CL0000980)
Fold Change: 0.06
Marker Score: 79
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.06
Marker Score: 70
Cell Name: immature B cell (CL0000816)
Fold Change: 0.06
Marker Score: 37
Cell Name: platelet (CL0000233)
Fold Change: 0.05
Marker Score: 23
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.05
Marker Score: 23
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.05
Marker Score: 32
Cell Name: B cell (CL0000236)
Fold Change: 0.04
Marker Score: 42
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.04
Marker Score: 23
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.04
Marker Score: 39
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.04
Marker Score: 22
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.04
Marker Score: 14
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.04
Marker Score: 9
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.04
Marker Score: 10
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.04
Marker Score: 26
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.04
Marker Score: 79
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.04
Marker Score: 90
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.03
Marker Score: 15
Cell Name: naive B cell (CL0000788)
Fold Change: 0.03
Marker Score: 30
Cell Name: memory B cell (CL0000787)
Fold Change: 0.03
Marker Score: 24
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.03
Marker Score: 33
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.03
Marker Score: 8
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.03
Marker Score: 10
Cell Name: fibroblast (CL0000057)
Fold Change: 0.02
Marker Score: 24
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.02
Marker Score: 100
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.02
Marker Score: 16
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.02
Marker Score: 19
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.02
Marker Score: 11
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.02
Marker Score: 13
Cell Name: plasma cell (CL0000786)
Fold Change: 0.02
Marker Score: 23
Cell Name: blood cell (CL0000081)
Fold Change: 0.02
Marker Score: 211
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.02
Marker Score: 10
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.02
Marker Score: 41
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.02
Marker Score: 10
Cell Name: mature B cell (CL0000785)
Fold Change: 0.02
Marker Score: 12
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.02
Marker Score: 10
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.02
Marker Score: 27
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.02
Marker Score: 7
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.01
Marker Score: 10
Cell Name: Unknown (CL0000548)
Fold Change: 0.01
Marker Score: 10
Cell Name: T cell (CL0000084)
Fold Change: 0.01
Marker Score: 20
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.01
Marker Score: 31
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 0.01
Marker Score: 10
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.01
Marker Score: 8
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.01
Marker Score: 10
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.01
Marker Score: 12
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.01
Marker Score: 10
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.01
Marker Score: 8
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.01
Marker Score: 8
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.01
Marker Score: 9
Cell Name: glial cell (CL0000125)
Fold Change: 0.01
Marker Score: 10
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.01
Marker Score: 10
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.01
Marker Score: 14
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.01
Marker Score: 6
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.01
Marker Score: 9
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.01
Marker Score: 14
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.01
Marker Score: 7
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.01
Marker Score: 8
Cell Name: basal cell (CL0000646)
Fold Change: 0.01
Marker Score: 10
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.01
Marker Score: 6
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.01
Marker Score: 6
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.01
Marker Score: 6
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.01
Marker Score: 5
Cell Name: secretory cell (CL0000151)
Fold Change: 0
Marker Score: 9
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0
Marker Score: 9
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0
Marker Score: 8
Cell Name: myeloid cell (CL0000763)
Fold Change: 0
Marker Score: 6
Cell Name: progenitor cell (CL0011026)
Fold Change: 0
Marker Score: 15
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0
Marker Score: 14
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0
Marker Score: 10
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0
Marker Score: 7
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0
Marker Score: 85
Cell Name: malignant cell (CL0001064)
Fold Change: 0
Marker Score: 10
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0
Marker Score: 37

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Description

**Key Characteristics** IGKV5-2 is a member of the immunoglobulin superfamily, which consists of genes that encode components of the BCR complex. The IGKV5-2 gene is specifically involved in the kappa chain of the BCR complex, which is responsible for recognizing and binding to antigens. The gene product is a variable region of the kappa chain, which is critical for the specificity and affinity of the BCR for antigens. IGKV5-2 is also involved in the regulation of immune responses, including the activation of complement and the regulation of actin dynamics, which is essential for phagocytosis. **Pathways and Functions** IGKV5-2 is involved in multiple signaling pathways that regulate immune responses, including: 1. **Adaptive Immune Response**: IGKV5-2 is essential for the recognition and binding of antigens by the BCR complex, which is critical for the activation of B cells and the initiation of the adaptive immune response. 2. **Antigen Binding**: IGKV5-2 is involved in the binding of antigens to the BCR complex, which is critical for the specificity and affinity of the BCR for antigens. 3. **Complement Activation**: IGKV5-2 is involved in the regulation of complement activation, which is a critical component of the innate immune response. 4. **Phagocytosis**: IGKV5-2 is involved in the regulation of actin dynamics, which is essential for phagocytosis, the process by which immune cells engulf and destroy pathogens. 5. **Calcium Mobilization**: IGKV5-2 is involved in the regulation of calcium mobilization, which is critical for the activation of immune cells. **Clinical Significance** IGKV5-2 has significant implications for the understanding and treatment of various immune-related diseases, including: 1. **Leishmaniasis**: IGKV5-2 is implicated in the regulation of Leishmania parasite growth and survival, which is critical for the development of effective treatments for this disease. 2. **Infectious Diseases**: IGKV5-2 is involved in the regulation of immune responses to infectious diseases, including viral and bacterial infections. 3. **Immunodeficiency Disorders**: IGKV5-2 is critical for the function of B cells, which are essential for the adaptive immune response. Mutations in the IGKV5-2 gene have been implicated in immunodeficiency disorders, including X-linked agammaglobulinemia. 4. **Cancer**: IGKV5-2 is involved in the regulation of immune responses to cancer, including the activation of complement and the regulation of phagocytosis. In conclusion, IGKV5-2 is a critical component of the BCR complex, and its dysregulation has significant implications for the development of immune-related diseases. Further research is needed to fully understand the role of IGKV5-2 in the regulation of immune responses and to develop effective treatments for diseases associated with this gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.