Details for: IGKV5 2

Gene ID: 28907

Symbol: IGKV5 2

Ensembl ID: ENSG00000211599

Description: immunoglobulin kappa variable 5-2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 20.66
    Marker Score: 18,517
  • Cell Name: macrophage (CL0000235)
    Fold Change: 7.96
    Marker Score: 8,858
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.36
    Marker Score: 1,765
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,823
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 388
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.62
    Marker Score: 471
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 476
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 215
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.23
    Marker Score: 524
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.22
    Marker Score: 125
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.17
    Marker Score: 131
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.14
    Marker Score: 75
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.13
    Marker Score: 207
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.12
    Marker Score: 143
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.12
    Marker Score: 80
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.12
    Marker Score: 153
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.12
    Marker Score: 364
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.08
    Marker Score: 113
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.08
    Marker Score: 95
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.07
    Marker Score: 63
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 134
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.06
    Marker Score: 79
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.06
    Marker Score: 70
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.04
    Marker Score: 42
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.04
    Marker Score: 39
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.04
    Marker Score: 9
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.04
    Marker Score: 79
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.04
    Marker Score: 90
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.02
    Marker Score: 100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.02
    Marker Score: 211
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.02
    Marker Score: 41
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.01
    Marker Score: 31
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0
    Marker Score: 15
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0
    Marker Score: 14
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 85
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 37

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IGKV5-2 is a member of the immunoglobulin superfamily, which consists of genes that encode components of the BCR complex. The IGKV5-2 gene is specifically involved in the kappa chain of the BCR complex, which is responsible for recognizing and binding to antigens. The gene product is a variable region of the kappa chain, which is critical for the specificity and affinity of the BCR for antigens. IGKV5-2 is also involved in the regulation of immune responses, including the activation of complement and the regulation of actin dynamics, which is essential for phagocytosis. **Pathways and Functions** IGKV5-2 is involved in multiple signaling pathways that regulate immune responses, including: 1. **Adaptive Immune Response**: IGKV5-2 is essential for the recognition and binding of antigens by the BCR complex, which is critical for the activation of B cells and the initiation of the adaptive immune response. 2. **Antigen Binding**: IGKV5-2 is involved in the binding of antigens to the BCR complex, which is critical for the specificity and affinity of the BCR for antigens. 3. **Complement Activation**: IGKV5-2 is involved in the regulation of complement activation, which is a critical component of the innate immune response. 4. **Phagocytosis**: IGKV5-2 is involved in the regulation of actin dynamics, which is essential for phagocytosis, the process by which immune cells engulf and destroy pathogens. 5. **Calcium Mobilization**: IGKV5-2 is involved in the regulation of calcium mobilization, which is critical for the activation of immune cells. **Clinical Significance** IGKV5-2 has significant implications for the understanding and treatment of various immune-related diseases, including: 1. **Leishmaniasis**: IGKV5-2 is implicated in the regulation of Leishmania parasite growth and survival, which is critical for the development of effective treatments for this disease. 2. **Infectious Diseases**: IGKV5-2 is involved in the regulation of immune responses to infectious diseases, including viral and bacterial infections. 3. **Immunodeficiency Disorders**: IGKV5-2 is critical for the function of B cells, which are essential for the adaptive immune response. Mutations in the IGKV5-2 gene have been implicated in immunodeficiency disorders, including X-linked agammaglobulinemia. 4. **Cancer**: IGKV5-2 is involved in the regulation of immune responses to cancer, including the activation of complement and the regulation of phagocytosis. In conclusion, IGKV5-2 is a critical component of the BCR complex, and its dysregulation has significant implications for the development of immune-related diseases. Further research is needed to fully understand the role of IGKV5-2 in the regulation of immune responses and to develop effective treatments for diseases associated with this gene.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.