IGKV5 2 | ENSG00000211599 | NCBI 28907

Details for: IGKV5 2

Gene ID: 28907

Symbol: IGKV5 2

Ensembl ID: ENSG00000211599

Description: immunoglobulin kappa variable 5-2

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: odontoblast (CL0000060)
Fold Change: -0.0227
Cell Significance Index: -2.9100
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0614
Cell Significance Index: -0.9500
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1448
Cell Significance Index: -3.6900
Cell Name: stromal cell (CL0000499)
Fold Change: -0.1556
Cell Significance Index: -1.5900
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.1609
Cell Significance Index: -2.3100
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.1723
Cell Significance Index: -2.1000
Cell Name: erythroblast (CL0000765)
Fold Change: -0.2020
Cell Significance Index: -2.4100
Cell Name: ciliated cell (CL0000064)
Fold Change: -0.2086
Cell Significance Index: -2.2600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2160
Cell Significance Index: -10.0700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2385
Cell Significance Index: -6.3800
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2820
Cell Significance Index: -6.8300
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.2875
Cell Significance Index: -7.1700
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.3294
Cell Significance Index: -6.4400
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.3563
Cell Significance Index: -6.0900
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.3600
Cell Significance Index: -5.8300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.3610
Cell Significance Index: -4.1000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3793
Cell Significance Index: -7.0100
Cell Name: monocyte (CL0000576)
Fold Change: -0.4215
Cell Significance Index: -4.8500
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.4925
Cell Significance Index: -7.1500
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.4930
Cell Significance Index: -6.7600
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.5077
Cell Significance Index: -6.2800
Cell Name: T cell (CL0000084)
Fold Change: -0.5184
Cell Significance Index: -6.1200
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.5398
Cell Significance Index: -6.3800
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.5576
Cell Significance Index: -6.5600
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.5639
Cell Significance Index: -5.9900
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.5642
Cell Significance Index: -7.1500
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.5673
Cell Significance Index: -6.1000
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.5697
Cell Significance Index: -6.4200
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.5712
Cell Significance Index: -6.7500
Cell Name: neutrophil (CL0000775)
Fold Change: -0.5804
Cell Significance Index: -7.2500
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.5826
Cell Significance Index: -6.4500
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.5978
Cell Significance Index: -6.8800
Cell Name: platelet (CL0000233)
Fold Change: -0.6012
Cell Significance Index: -6.1900
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: -0.6172
Cell Significance Index: -6.1600
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.6185
Cell Significance Index: -6.8200
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.6206
Cell Significance Index: -8.0300
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.6413
Cell Significance Index: -7.0400
Cell Name: leukocyte (CL0000738)
Fold Change: -0.6435
Cell Significance Index: -10.9300
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.6473
Cell Significance Index: -7.5200
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.6492
Cell Significance Index: -7.1900
Cell Name: blood cell (CL0000081)
Fold Change: -0.6629
Cell Significance Index: -5.6500
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.6660
Cell Significance Index: -7.1800
Cell Name: club cell (CL0000158)
Fold Change: -0.6746
Cell Significance Index: -7.3500
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.6805
Cell Significance Index: -8.9300
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.6807
Cell Significance Index: -6.0600
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -0.6817
Cell Significance Index: -6.0900
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.6841
Cell Significance Index: -9.0900
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.6843
Cell Significance Index: -6.6700
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.6927
Cell Significance Index: -6.4500
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: -0.6932
Cell Significance Index: -6.2100
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.6997
Cell Significance Index: -6.1200
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.7013
Cell Significance Index: -7.1200
Cell Name: transitional stage B cell (CL0000818)
Fold Change: -0.7040
Cell Significance Index: -6.1900
Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.7071
Cell Significance Index: -11.3700
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: -0.7078
Cell Significance Index: -7.3400
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: -0.7136
Cell Significance Index: -7.1900
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.7175
Cell Significance Index: -6.4000
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.7184
Cell Significance Index: -5.9300
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.7221
Cell Significance Index: -6.9400
Cell Name: intermediate monocyte (CL0002393)
Fold Change: -0.7235
Cell Significance Index: -6.7400
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.7269
Cell Significance Index: -11.0400
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.7303
Cell Significance Index: -7.0100
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.7333
Cell Significance Index: -6.8600
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.7392
Cell Significance Index: -7.5400
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: -0.7397
Cell Significance Index: -5.9900
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.7415
Cell Significance Index: -9.6800
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: -0.7447
Cell Significance Index: -6.8800
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: -0.7477
Cell Significance Index: -6.3100
Cell Name: memory B cell (CL0000787)
Fold Change: -0.7482
Cell Significance Index: -7.9600
Cell Name: dendritic cell, human (CL0001056)
Fold Change: -0.7493
Cell Significance Index: -6.9100
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: -0.7533
Cell Significance Index: -6.8000
Cell Name: lung macrophage (CL1001603)
Fold Change: -0.7581
Cell Significance Index: -8.2800
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.7604
Cell Significance Index: -10.8300
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: -0.7622
Cell Significance Index: -7.1700
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.7686
Cell Significance Index: -10.6600
Cell Name: plasmablast (CL0000980)
Fold Change: -0.7693
Cell Significance Index: -7.1400
Cell Name: mast cell (CL0000097)
Fold Change: -0.7766
Cell Significance Index: -10.2200
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: -0.7773
Cell Significance Index: -7.1900
Cell Name: plasma cell (CL0000786)
Fold Change: -0.7814
Cell Significance Index: -8.7300
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.7828
Cell Significance Index: -9.0800
Cell Name: fibroblast (CL0000057)
Fold Change: -0.7893
Cell Significance Index: -7.4100
Cell Name: B cell (CL0000236)
Fold Change: -0.7904
Cell Significance Index: -9.3400
Cell Name: immature B cell (CL0000816)
Fold Change: -0.7937
Cell Significance Index: -7.5100
Cell Name: helper T cell (CL0000912)
Fold Change: -0.7967
Cell Significance Index: -11.3200
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.7990
Cell Significance Index: -10.8700
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: -0.8008
Cell Significance Index: -6.2300
Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.8090
Cell Significance Index: -11.3400
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.8152
Cell Significance Index: -10.0200
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: -0.8176
Cell Significance Index: -8.2600
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: -0.8193
Cell Significance Index: -7.0700
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.8208
Cell Significance Index: -8.6500
Cell Name: naive B cell (CL0000788)
Fold Change: -0.8244
Cell Significance Index: -8.6800
Cell Name: myofibroblast cell (CL0000186)
Fold Change: -0.8300
Cell Significance Index: -8.7000
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: -0.8303
Cell Significance Index: -8.1900
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.8398
Cell Significance Index: -9.5400
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: -0.8435
Cell Significance Index: -7.0500
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -0.8470
Cell Significance Index: -8.0300
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.8478
Cell Significance Index: -12.4000
Cell Name: basal cell (CL0000646)
Fold Change: -0.8488
Cell Significance Index: -10.1000
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.8518
Cell Significance Index: -5.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** IGKV5-2 is a member of the immunoglobulin superfamily, which consists of genes that encode components of the BCR complex. The IGKV5-2 gene is specifically involved in the kappa chain of the BCR complex, which is responsible for recognizing and binding to antigens. The gene product is a variable region of the kappa chain, which is critical for the specificity and affinity of the BCR for antigens. IGKV5-2 is also involved in the regulation of immune responses, including the activation of complement and the regulation of actin dynamics, which is essential for phagocytosis. **Pathways and Functions** IGKV5-2 is involved in multiple signaling pathways that regulate immune responses, including: 1. **Adaptive Immune Response**: IGKV5-2 is essential for the recognition and binding of antigens by the BCR complex, which is critical for the activation of B cells and the initiation of the adaptive immune response. 2. **Antigen Binding**: IGKV5-2 is involved in the binding of antigens to the BCR complex, which is critical for the specificity and affinity of the BCR for antigens. 3. **Complement Activation**: IGKV5-2 is involved in the regulation of complement activation, which is a critical component of the innate immune response. 4. **Phagocytosis**: IGKV5-2 is involved in the regulation of actin dynamics, which is essential for phagocytosis, the process by which immune cells engulf and destroy pathogens. 5. **Calcium Mobilization**: IGKV5-2 is involved in the regulation of calcium mobilization, which is critical for the activation of immune cells. **Clinical Significance** IGKV5-2 has significant implications for the understanding and treatment of various immune-related diseases, including: 1. **Leishmaniasis**: IGKV5-2 is implicated in the regulation of Leishmania parasite growth and survival, which is critical for the development of effective treatments for this disease. 2. **Infectious Diseases**: IGKV5-2 is involved in the regulation of immune responses to infectious diseases, including viral and bacterial infections. 3. **Immunodeficiency Disorders**: IGKV5-2 is critical for the function of B cells, which are essential for the adaptive immune response. Mutations in the IGKV5-2 gene have been implicated in immunodeficiency disorders, including X-linked agammaglobulinemia. 4. **Cancer**: IGKV5-2 is involved in the regulation of immune responses to cancer, including the activation of complement and the regulation of phagocytosis. In conclusion, IGKV5-2 is a critical component of the BCR complex, and its dysregulation has significant implications for the development of immune-related diseases. Further research is needed to fully understand the role of IGKV5-2 in the regulation of immune responses and to develop effective treatments for diseases associated with this gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.