Gene GUCA1A - ENSG00000048545 | NCBI Gene ID: 2978

Details for: GUCA1A

Gene ID: 2978

Symbol: GUCA1A

Ensembl ID: ENSG00000048545

Description: guanylate cyclase activator 1A

Associated with

Inactivation, recovery and regulation of the phototransduction cascade
(R-HSA-2514859)
Sensory perception
(R-HSA-9709957)
The phototransduction cascade
(R-HSA-2514856)
Visual phototransduction
(R-HSA-2187338)
Calcium ion binding
(GO:0005509)
Calcium sensitive guanylate cyclase activator activity
(GO:0008048)
Cellular response to calcium ion
(GO:0071277)
Cone photoreceptor outer segment
(GO:0120199)
Guanylate cyclase regulator activity
(GO:0030249)
Photoreceptor disc membrane
(GO:0097381)
Photoreceptor inner segment
(GO:0001917)
Phototransduction
(GO:0007602)
Positive regulation of cgmp-mediated signaling
(GO:0010753)
Positive regulation of guanylate cyclase activity
(GO:0031284)
Protein binding
(GO:0005515)
Signal transduction
(GO:0007165)
Visual perception
(GO:0007601)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: retinal rod cell (CL0000604)
Fold Change: 3.43
Marker Score: 9787
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 3.15
Marker Score: 3171
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 2.89
Marker Score: 861
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.27
Marker Score: 2633.5
Cell Name: goblet cell (CL0000160)
Fold Change: 1.09
Marker Score: 7269
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71823
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48048
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2426
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5350
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2742
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5286
Cell Name: mast cell (CL0000097)
Fold Change: 0.82
Marker Score: 473
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1262
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 396
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.76
Marker Score: 807
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.71
Marker Score: 1449
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.71
Marker Score: 981
Cell Name: brush cell (CL0002204)
Fold Change: 0.69
Marker Score: 633
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.66
Marker Score: 1901.5
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.59
Marker Score: 474
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.5
Marker Score: 628.5
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 277
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.46
Marker Score: 434.5
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.45
Marker Score: 862
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.45
Marker Score: 6986
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.42
Marker Score: 504
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.32
Marker Score: 650
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.29
Marker Score: 362
Cell Name: stromal cell (CL0000499)
Fold Change: 0.28
Marker Score: 333
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.28
Marker Score: 147
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.28
Marker Score: 128
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.28
Marker Score: 93
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.26
Marker Score: 137
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.26
Marker Score: 248
Cell Name: oocyte (CL0000023)
Fold Change: 0.25
Marker Score: 63
Cell Name: macrophage (CL0000235)
Fold Change: 0.25
Marker Score: 274
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.25
Marker Score: 103
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.24
Marker Score: 71
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.23
Marker Score: 80
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.23
Marker Score: 659
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.22
Marker Score: 527.5
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.22
Marker Score: 69
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.22
Marker Score: 97
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.21
Marker Score: 62
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.21
Marker Score: 127
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.21
Marker Score: 336
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.21
Marker Score: 159.5
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.2
Marker Score: 73
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.2
Marker Score: 163
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.19
Marker Score: 61
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.18
Marker Score: 182
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.18
Marker Score: 62
Cell Name: S cone cell (CL0003050)
Fold Change: 0.16
Marker Score: 49
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.16
Marker Score: 627
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.16
Marker Score: 77
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.16
Marker Score: 473
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.16
Marker Score: 51
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.16
Marker Score: 106
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.15
Marker Score: 39
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.15
Marker Score: 287
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.14
Marker Score: 37
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.13
Marker Score: 146.5
Cell Name: melanocyte (CL0000148)
Fold Change: 0.13
Marker Score: 52
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.12
Marker Score: 29
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.12
Marker Score: 26
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.12
Marker Score: 32
Cell Name: brush cell of trachebronchial tree (CL0002075)
Fold Change: 0.11
Marker Score: 35
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 0.11
Marker Score: 27
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.11
Marker Score: 27
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.11
Marker Score: 151
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.1
Marker Score: 875
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.1
Marker Score: 47
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.1
Marker Score: 24
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.1
Marker Score: 32
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.1
Marker Score: 61
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.1
Marker Score: 26
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.1
Marker Score: 104
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.09
Marker Score: 57
Cell Name: fast muscle cell (CL0000190)
Fold Change: 0.09
Marker Score: 27
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.09
Marker Score: 35
Cell Name: germ cell (CL0000586)
Fold Change: 0.09
Marker Score: 152
Cell Name: basophil mast progenitor cell (CL0002028)
Fold Change: 0.09
Marker Score: 26
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.08
Marker Score: 1111
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.08
Marker Score: 142
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.08
Marker Score: 51
Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 0.08
Marker Score: 23
Cell Name: fibroblast (CL0000057)
Fold Change: 0.08
Marker Score: 79
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.08
Marker Score: 73
Cell Name: ionocyte (CL0005006)
Fold Change: 0.08
Marker Score: 24
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.08
Marker Score: 109
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.08
Marker Score: 42
Cell Name: pericyte (CL0000669)
Fold Change: 0.08
Marker Score: 46
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 0.08
Marker Score: 26
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.08
Marker Score: 27
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.08
Marker Score: 27
Cell Name: podocyte (CL0000653)
Fold Change: 0.08
Marker Score: 28
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.08
Marker Score: 27
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.08
Marker Score: 27
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.07
Marker Score: 27

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Other Information

Description

## Summary GUCA1A is a key regulator of the visual phototransduction cascade in the human retina. It is a guanylate cyclase activator protein that is expressed in retinal rod and cone photoreceptors, as well as in endothelial cells and other cell types. GUCA1A is a key regulatory element in the negative feedback loop of the visual phototransduction cascade, which is responsible for the initial step of visual perception. ## Key characteristics * GUCA1A is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a member of the guanylate cyclase family of proteins, which are involved in the regulation of intracellular calcium levels. * GUCA1A is a key activator of the visual phototransduction cascade. * It is also a regulator of the cell cycle and apoptosis. ## Pathways and functions * GUCA1A is involved in the negative feedback loop of the visual phototransduction cascade. * It helps to maintain the resting calcium concentration in the retina. * When light is absorbed by the retina, it triggers a conformational change in GUCA1A that activates it. * Activated GUCA1A then binds to guanosine 5'-triphosphate (GTP), which inhibits the activity of a guanosine 5'-monophosphate dehydrogenase (GMP-dependent protein kinase) complex. * This prevents the degradation of guanosine 5'-triphosphate (GTP), which would otherwise lead to the activation of the visual phototransduction cascade. * By maintaining the resting calcium concentration in the retina, GUCA1A helps to ensure that the visual phototransduction cascade can function properly. ## Clinical significance GUCA1A gene mutations have been linked to a number of eye diseases, including retinitis pigmentosa and retinal degenerative diseases. These mutations can disrupt the negative feedback loop of the visual phototransduction cascade, leading to excessive calcium signaling and the development of eye diseases. ## Other notes * GUCA1A is a highly conserved protein, with a similar gene found in other mammals. * It is a promising target for the treatment of eye diseases that are caused by mutations in the GUCA1A gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.