Details for: CFHR2

Gene ID: 3080

Symbol: CFHR2

Ensembl ID: ENSG00000080910

Description: complement factor H related 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2
    Marker Score: 1201
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 488
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4823
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 504
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.82
    Marker Score: 481
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.79
    Marker Score: 1501
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.66
    Marker Score: 2173
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.63
    Marker Score: 1279
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 319
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.35
    Marker Score: 5549
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.34
    Marker Score: 231
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.33
    Marker Score: 1972
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.28
    Marker Score: 827
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.26
    Marker Score: 99
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.24
    Marker Score: 114
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.21
    Marker Score: 78
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.2
    Marker Score: 848
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.15
    Marker Score: 372
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.13
    Marker Score: 136.5
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.13
    Marker Score: 684
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.13
    Marker Score: 260
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.12
    Marker Score: 34
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 54
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.11
    Marker Score: 686
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.09
    Marker Score: 733
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.08
    Marker Score: 72
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.08
    Marker Score: 51
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 30.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.05
    Marker Score: 133
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.04
    Marker Score: 78
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.04
    Marker Score: 20.5
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.03
    Marker Score: 36.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.03
    Marker Score: 66
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.03
    Marker Score: 165
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.02
    Marker Score: 6
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.02
    Marker Score: 33
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.02
    Marker Score: 58
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 61
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 52
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.01
    Marker Score: 57
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.01
    Marker Score: 10

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Other Information

**Key characteristics:** * CFHR2 is a glycoprotein with a molecular weight of approximately 150 kDa. * It is a member of the complement factor H family of proteins. * CFHR2 is expressed in high levels in the colon and small intestine. * It is a key regulator of the complement cascade. **Pathways and functions:** * CFHR2 is a component of the classical pathway of the complement cascade. * It is involved in the formation of the C3b convertase complex, which is a key step in the complement cascade. * CFHR2 also plays a role in the regulation of inflammation. * It can interact with other proteins in the complement system, including C1q, C3, and C5. **Clinical significance:** * Mutations in CFHR2 have been linked to a number of human diseases, including recurrent infections and inflammatory diseases. * These diseases are often caused by infections that can activate the complement system. * CFHR2 inhibitors are being developed as potential treatments for these diseases. **Additional information:** * CFHR2 is a highly conserved protein. * It is expressed in almost all tissues in the human body. * It is a key regulator of the immune response.

Genular Protein ID: 4196134529

Symbol: FHR2_HUMAN

Name: Complement factor H-related protein 2

UniProtKB Accession Codes:

P36980 Q14310 Q5T9T1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1533657

Title: Two additional human serum proteins structurally related to complement factor H. Evidence for a family of factor H-related genes.

PubMed ID: 1533657

PubMed ID: 7672821

Title: The human factor H-related gene 2 (FHR2): structure and linkage to the coagulation factor XIIIb gene.

PubMed ID: 7672821

DOI: 10.1007/bf00176444

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8172644

Title: Complement factor H and related proteins: an expanding family of complement-regulatory proteins?

PubMed ID: 8172644

DOI: 10.1016/0167-5699(94)90155-4

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 23487775

Title: Dimerization of complement factor H-related proteins modulates complement activation in vivo.

PubMed ID: 23487775

DOI: 10.1073/pnas.1219260110

Sequence Information:

  • Length: 270
  • Mass: 30651
  • Checksum: E1B2E9F139B217A8
  • Sequence:
    • MWLLVSVILI SRISSVGGEA MFCDFPKINH GILYDEEKYK PFSQVPTGEV FYYSCEYNFV 
SPSKSFWTRI TCAEEGWSPT PKCLRLCFFP FVENGHSESS GQTHLEGDTV QIICNTGYRL 
QNNENNISCV ERGWSTPPKC RSTISAEKCG PPPPIDNGDI TSFLLSVYAP GSSVEYQCQN 
LYQLEGNNQI TCRNGQWSEP PKCLDPCVIS QEIMEKYNIK LKWTNQQKLY SRTGDIVEFV 
CKSGYHPTKS HSFRAMCQNG KLVYPSCEEK

Genular Protein ID: 2391875278

Symbol: A0A3B3IS28_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A3B3IS28

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 146
  • Mass: 16399
  • Checksum: 30858DD0D289D2FC
  • Sequence:
    • MWLLVSVILI SRISSVGGEV SAEKCGPPPP IDNGDITSFL LSVYAPGSSV EYQCQNLYQL 
EGNNQITCRN GQWSEPPKCL DPCVISQEIM EKYNIKLKWT NQQKLYSRTG DIVEFVCKSG 
YHPTKSHSFR AMCQNGKLVY PSCEEK

Genular Protein ID: 1450119515

Symbol: A0A8V8TQS1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TQS1

Database IDs:

ARBA 3 CDD 1 CTD 1 EMBL 1 Ensembl 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 250
  • Mass: 28538
  • Checksum: D3316A01EF981C5F
  • Sequence:
    • MFCDFPKINH GILYDEEKYK PFSQVPTGEV FYYSCEYNFV SPSKSFWTRI TCAEEGWSPT 
PKCLRLCFFP FVENGHSESS GQTHLEGDTV QIICNTGYRL QNNENNISCV ERGWSTPPKC 
RSTISAEKCG PPPPIDNGDI TSFLLSVYAP GSSVEYQCQN LYQLEGNNQI TCRNGQWSEP 
PKCLDPCVIS QEIMEKYNIK LKWTNQQKLY SRTGDIVEFV CKSGYHPTKS HSFRAMCQNG 
KLVYPSCEEK

Genular Protein ID: 1022381259

Symbol: A0A3B3ISW6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A3B3ISW6

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 211
  • Mass: 24009
  • Checksum: 0D75FE9F89B99062
  • Sequence:
    • MWLLVSVILI SRISSVGGEA MFCDFPKINH GILYDEEKYK PFSQVPTGEV FYYSCEYNFV 
SPSKSFWTRI TCAEEGWSPT PKCLISAEKC GPPPPIDNGD ITSFLLSVYA PGSSVEYQCQ 
NLYQLEGNNQ ITCRNGQWSE PPKCLDPCVI SQEIMEKYNI KLKWTNQQKL YSRTGDIVEF 
VCKSGYHPTK SHSFRAMCQN GKLVYPSCEE K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.