Details for: HNF4A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: precursor cell (CL0011115)
Fold Change: 12.2082
Cell Significance Index: 92.5800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 6.1337
Cell Significance Index: 278.0200 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 5.3886
Cell Significance Index: 54.3600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 4.5946
Cell Significance Index: 99.5400 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 3.4896
Cell Significance Index: 29.6600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 3.1966
Cell Significance Index: 92.1000 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 2.9985
Cell Significance Index: 50.5100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.9534
Cell Significance Index: 586.1100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 2.4854
Cell Significance Index: 270.3400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 2.3191
Cell Significance Index: 57.9700 - Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 2.2125
Cell Significance Index: 15.5700 - Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 2.1887
Cell Significance Index: 23.7200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.9655
Cell Significance Index: 319.6700 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 1.9561
Cell Significance Index: -5.2400 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.6467
Cell Significance Index: 34.1600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.6433
Cell Significance Index: 191.5100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.5293
Cell Significance Index: 32.5700 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.4676
Cell Significance Index: 21.9900 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.3207
Cell Significance Index: 31.9900 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.0706
Cell Significance Index: 6.1700 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.0590
Cell Significance Index: 8.4600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.0144
Cell Significance Index: 35.6500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7399
Cell Significance Index: 44.4200 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.5712
Cell Significance Index: 8.1800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5258
Cell Significance Index: 52.0100 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.5185
Cell Significance Index: 8.7200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4463
Cell Significance Index: 84.9400 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.3786
Cell Significance Index: 9.4400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3528
Cell Significance Index: 24.4000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2847
Cell Significance Index: 9.1200 - Cell Name: colonocyte (CL1000347)
Fold Change: 0.1537
Cell Significance Index: 0.9500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1500
Cell Significance Index: 2.5700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1485
Cell Significance Index: 25.3600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1132
Cell Significance Index: 102.1800 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.1030
Cell Significance Index: 1.5200 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.0669
Cell Significance Index: 0.6600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0439
Cell Significance Index: 5.0100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0389
Cell Significance Index: 7.8000 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.0386
Cell Significance Index: 0.3000 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: 0.0379
Cell Significance Index: 0.1000 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.0345
Cell Significance Index: 0.1300 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0169
Cell Significance Index: 0.1800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0038
Cell Significance Index: 0.6900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0016
Cell Significance Index: 2.9900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0014
Cell Significance Index: 1.8400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0013
Cell Significance Index: 2.0000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.0010
Cell Significance Index: 0.7100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0009
Cell Significance Index: 1.7300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.0001
Cell Significance Index: 0.0200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0001
Cell Significance Index: -0.0900 - Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: -0.0011
Cell Significance Index: -0.0100 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0013
Cell Significance Index: -0.7200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0015
Cell Significance Index: -0.8600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0021
Cell Significance Index: -0.7600 - Cell Name: enterocyte (CL0000584)
Fold Change: -0.0032
Cell Significance Index: -0.0200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0032
Cell Significance Index: -0.4600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0050
Cell Significance Index: -0.5700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0054
Cell Significance Index: -1.5400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0063
Cell Significance Index: -4.6200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0069
Cell Significance Index: -4.3600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0074
Cell Significance Index: -3.3800 - Cell Name: stem cell (CL0000034)
Fold Change: -0.0083
Cell Significance Index: -0.0600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0182
Cell Significance Index: -2.2400 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0184
Cell Significance Index: -0.2800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0213
Cell Significance Index: -2.1800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0223
Cell Significance Index: -3.0600 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0271
Cell Significance Index: -1.1800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0279
Cell Significance Index: -0.7800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0300
Cell Significance Index: -3.1200 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: -0.0358
Cell Significance Index: -0.2900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0372
Cell Significance Index: -2.2800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0373
Cell Significance Index: -2.5100 - Cell Name: epithelial cell (CL0000066)
Fold Change: -0.0417
Cell Significance Index: -0.4400 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0465
Cell Significance Index: -1.4700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0474
Cell Significance Index: -1.2700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0490
Cell Significance Index: -5.7800 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0491
Cell Significance Index: -0.7400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0529
Cell Significance Index: -4.1900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0536
Cell Significance Index: -4.1100 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0546
Cell Significance Index: -1.7400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0615
Cell Significance Index: -1.5800 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.0616
Cell Significance Index: -0.4200 - Cell Name: goblet cell (CL0000160)
Fold Change: -0.0619
Cell Significance Index: -0.5600 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0631
Cell Significance Index: -1.0400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0703
Cell Significance Index: -4.3200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0786
Cell Significance Index: -4.4100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0796
Cell Significance Index: -2.7900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0823
Cell Significance Index: -3.6400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0864
Cell Significance Index: -2.8300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0876
Cell Significance Index: -4.5500 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0893
Cell Significance Index: -1.5400 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.0920
Cell Significance Index: -0.6000 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: -0.0954
Cell Significance Index: -0.5600 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.0969
Cell Significance Index: -1.0000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0969
Cell Significance Index: -3.6700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0981
Cell Significance Index: -6.3300 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1002
Cell Significance Index: -2.8600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1027
Cell Significance Index: -5.3900 - Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: -0.1031
Cell Significance Index: -0.5400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1049
Cell Significance Index: -4.8900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 943854242
Symbol: HNF4A_HUMAN
Name: Hepatocyte nuclear factor 4-alpha
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8964514
Title: Isolation and characterization of a third isoform of human hepatocyte nuclear factor 4.
PubMed ID: 8964514
PubMed ID: 8622695
Title: Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes.
PubMed ID: 8622695
DOI: 10.1128/mcb.16.3.925
PubMed ID: 8945471
Title: Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1).
PubMed ID: 8945471
DOI: 10.1038/384458a0
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7926813
Title: Cloning and sequencing of cDNAs encoding the human hepatocyte nuclear factor 4 indicate the presence of two isoforms in human liver.
PubMed ID: 7926813
PubMed ID: 7568236
Title: Recruitment of hepatocyte nuclear factor 4 into specific intranuclear compartments depends on tyrosine phosphorylation that affects its DNA-binding and transactivation potential.
PubMed ID: 7568236
PubMed ID: 12740371
Title: AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability.
PubMed ID: 12740371
PubMed ID: 21708125
Title: Multiple post-translational modifications in hepatocyte nuclear factor 4alpha.
PubMed ID: 21708125
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28128295
Title: RNA helicase DDX3 maintains lipid homeostasis through upregulation of the microsomal triglyceride transfer protein by interacting with HNF4 and SHP.
PubMed ID: 28128295
DOI: 10.1038/srep41452
PubMed ID: 30468856
Title: Nuclear hormone receptors: Ancient 9aaTAD and evolutionally gained NCoA activation pathways.
PubMed ID: 30468856
PubMed ID: 30597922
Title: HNF4A regulates the formation of hepatic progenitor cells from human iPSC-Derived endoderm by facilitating efficient recruitment of RNA Pol II.
PubMed ID: 30597922
PubMed ID: 30530698
Title: Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks.
PubMed ID: 30530698
PubMed ID: 14982928
Title: Structural basis for HNF-4alpha activation by ligand and coactivator binding.
PubMed ID: 14982928
PubMed ID: 9313765
Title: Organization and partial sequence of the hepatocyte nuclear factor-4-alpha/MODY1 gene and identification of a missense mutation, R127W, in a Japanese family with MODY.
PubMed ID: 9313765
PubMed ID: 9243109
Title: A missense mutation in the hepatocyte nuclear factor 4 alpha gene in a UK pedigree with maturity-onset diabetes of the young.
PubMed ID: 9243109
PubMed ID: 9267996
Title: Studies of the genetic variability of the coding region of the hepatocyte nuclear factor-4alpha in Caucasians with maturity onset NIDDM.
PubMed ID: 9267996
PubMed ID: 9449683
Title: A missense mutation in hepatocyte nuclear factor-4-alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus.
PubMed ID: 9449683
DOI: 10.1172/jci1403
PubMed ID: 10389854
Title: Functional characterization of the MODY1 gene mutations HNF4(R127W), HNF4(V255M), and HNF4(E276Q).
PubMed ID: 10389854
PubMed ID: 17407387
Title: Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene.
PubMed ID: 17407387
PubMed ID: 22802087
Title: Novel presentations of congenital hyperinsulinism due to mutations in the MODY genes: HNF1A and HNF4A.
PubMed ID: 22802087
DOI: 10.1210/jc.2012-1356
PubMed ID: 24285859
Title: The HNF4A R76W mutation causes atypical dominant Fanconi syndrome in addition to a beta cell phenotype.
PubMed ID: 24285859
Sequence Information:
- Length: 474
- Mass: 52785
- Checksum: 5F1309B89D95DCAF
- Sequence:
MRLSKTLVDM DMADYSAALD PAYTTLEFEN VQVLTMGNDT SPSEGTNLNA PNSLGVSALC AICGDRATGK HYGASSCDGC KGFFRRSVRK NHMYSCRFSR QCVVDKDKRN QCRYCRLKKC FRAGMKKEAV QNERDRISTR RSSYEDSSLP SINALLQAEV LSRQITSPVS GINGDIRAKK IASIADVCES MKEQLLVLVE WAKYIPAFCE LPLDDQVALL RAHAGEHLLL GATKRSMVFK DVLLLGNDYI VPRHCPELAE MSRVSIRILD ELVLPFQELQ IDDNEYAYLK AIIFFDPDAK GLSDPGKIKR LRSQVQVSLE DYINDRQYDS RGRFGELLLL LPTLQSITWQ MIEQIQFIKL FGMAKIDNLL QEMLLGGSPS DAPHAHHPLH PHLMQEHMGT NVIVANTMPT HLSNGQMCEW PRPRGQAATP ETPQPSPPGG SGSEPYKLLP GAVATIVKPL SAIPQPTITK QEVI
Genular Protein ID: 127878254
Symbol: F1D8T0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
Sequence Information:
- Length: 452
- Mass: 50150
- Checksum: 96854D18F389B0F9
- Sequence:
MVSVNAPLGA PVESSYDTSP SEGTNLNAPN SLGVSALCAI CGDRATGKHY GASSCDGCKG FFRRSVRKNH MYSCRFSRQC VVDKDKRNQC RYCRLKKCFR AGMKKEAVQN ERDRISTRRS SYEDSSLPSI NALLQAEVLS RQITSPVSGI NGDIRAKKIA SIADVCESMK EQLLVLVEWA KYIPAFCELP LDDQVALLRA HAGEHLLLGA TKRSMVFKDV LLLGNDYIVP RHCPELAEMS RVSIRILDEL VLPFQELQID DNEYAYLKAI IFFDPDAKGL SDPGKIKRLR SQVQVSLEDY INDRQYDSRG RFGELLLLLP TLQSITWQMI EQIQFIKLFG MAKIDNLLQE MLLGGSPSDA PHAHHPLHPH LMQEHMGTNV IVANTMPTHL SNGQMCEWPR PRGQAATPET PQPSPPGGSG SEPYKLLPGA VATIVKPLSA IPQPTITKQE VI
Genular Protein ID: 1536292568
Symbol: B9VVT8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
Sequence Information:
- Length: 103
- Mass: 11507
- Checksum: DEC3966F09802721
- Sequence:
MSDWGQGFPQ DPPDTSPSEG TNLNAPNSLG VSALCAICGD RATGKHYGAS SCDGCKGFFR RSVRKNHMYS CRFSRQCVVD KDKRNQCRYC RLKKCFRAGM KKE
Genular Protein ID: 206450864
Symbol: F1D8S2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 464
- Mass: 51619
- Checksum: FF0A4FB233ADCC56
- Sequence:
MRLSKTLVDM DMADYSAALD PAYTTLEFEN VQVLTMGNDT SPSEGTNLNA PNSLGVSALC AICGDRATGK HYGASSCDGC KGFFRRSVRK NHMYSCRFSR QCVVDKDKRN QCRYCRLKKC FRAGMKKEAV QNERDRISTR RSSYEDSSLP SINALLQAEV LSRQITSPVS GINGDIRAKK IASIADVCES MKEQLLVLVE WAKYIPAFCE LPLDDQVALL RAHAGEHLLL GATKRSMVFK DVLLLGNDYI VPRHCPELAE MSRVSIRILD ELVLPFQELQ IDDNEYAYLK AIIFFDPDAK GLSDPGKIKR LRSQVQVSLE DYINDRQYDS RGRFGELLLL LPTLQSITWQ MIEQIQFIKL FGMAKIDNLL QEMLLGGSPS DAPHAHHPLH PHLMQEHMGT NVIVANTMPT HLSNGQMSTP ETPQPSPPGG SGSEPYKLLP GAVATIVKPL SAIPQPTITK QEVI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.