Details for: HOXA10

Gene ID: 3206

Symbol: HOXA10

Ensembl ID: ENSG00000253293

Description: homeobox A10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 12.11
    Marker Score: 12679
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 3.05
    Marker Score: 3686
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.41
    Marker Score: 5038
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.37
    Marker Score: 26724
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.8
    Marker Score: 1199.5
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.77
    Marker Score: 2312
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.66
    Marker Score: 389
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.56
    Marker Score: 589
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.52
    Marker Score: 6562
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.47
    Marker Score: 973
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.45
    Marker Score: 14679
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.44
    Marker Score: 1528
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.4
    Marker Score: 2634
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.39
    Marker Score: 2369
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4806
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.1
    Marker Score: 1926
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.09
    Marker Score: 14362
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48041
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.95
    Marker Score: 688
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.95
    Marker Score: 463.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5293
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.91
    Marker Score: 2168
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.9
    Marker Score: 256
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.88
    Marker Score: 1293
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.86
    Marker Score: 220
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.81
    Marker Score: 257
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.8
    Marker Score: 413
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.8
    Marker Score: 1875
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1273
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 597.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.77
    Marker Score: 3145
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.76
    Marker Score: 243
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 682
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.74
    Marker Score: 1057
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.72
    Marker Score: 478
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.72
    Marker Score: 419
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7
    Marker Score: 698
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.68
    Marker Score: 272
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.67
    Marker Score: 1037
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.67
    Marker Score: 2089
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.65
    Marker Score: 446
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.65
    Marker Score: 477
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.64
    Marker Score: 1511
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.64
    Marker Score: 241
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.6
    Marker Score: 209
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.57
    Marker Score: 2746
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.55
    Marker Score: 292
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.55
    Marker Score: 142
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.54
    Marker Score: 1087
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.53
    Marker Score: 756
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.53
    Marker Score: 140
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.52
    Marker Score: 333
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.5
    Marker Score: 830
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.5
    Marker Score: 476
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.49
    Marker Score: 168
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.47
    Marker Score: 3131
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.47
    Marker Score: 332
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.47
    Marker Score: 472
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.45
    Marker Score: 450
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.44
    Marker Score: 115
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.44
    Marker Score: 5862
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.43
    Marker Score: 879
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.43
    Marker Score: 198
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.41
    Marker Score: 657
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.41
    Marker Score: 118
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.41
    Marker Score: 1444
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.4
    Marker Score: 166
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.39
    Marker Score: 100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.37
    Marker Score: 254
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.36
    Marker Score: 682
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.35
    Marker Score: 961
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.34
    Marker Score: 333
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.34
    Marker Score: 207
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.34
    Marker Score: 101
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.34
    Marker Score: 338
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.33
    Marker Score: 96
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.33
    Marker Score: 160
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.33
    Marker Score: 227
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.32
    Marker Score: 218
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.32
    Marker Score: 171
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.31
    Marker Score: 114
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.3
    Marker Score: 290
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.3
    Marker Score: 74
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.3
    Marker Score: 75
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.3
    Marker Score: 348
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.29
    Marker Score: 148

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Other Information

**Key characteristics:** * HOXA10 is a homeobox protein, which are a family of transcription factors that are involved in tissue and organ development. * It is expressed in a variety of cell types, including thymocytes, mesangial cells, epithelial cells of the nephron, and decidual cells. * It is a key regulator of anterior/posterior pattern specification in the developing embryo. * It is also involved in embryonic limb morphogenesis, prostate gland development, and response to estrogen and testosterone. **Pathways and functions:** * HOXA10 is a key regulator of anterior/posterior pattern specification in the developing embryo. It is expressed in a region of the developing embryo known as the prosencephalon, which is responsible for setting the overall body plan. * It is also involved in the development of the male reproductive tract and the prostate gland. * It is involved in response to estrogen and testosterone. Estrogen promotes the expression of HOXA10, which leads to the development of female reproductive characteristics. Testosterone inhibits the expression of HOXA10, which leads to the development of male reproductive characteristics. **Clinical significance:** HOXA10 is a promising target for cancer therapy. Mutations in HOXA10 have been linked to a number of human cancers, including breast cancer, prostate cancer, and ovarian cancer. Targeting HOXA10 can inhibit cancer cell growth and metastasis. **Additional notes:** * HOXA10 is a highly conserved gene, with a similar gene found in mice and zebrafish. * It is a member of the HOX family of homeobox genes, which are known for their ability to regulate gene expression by binding to specific DNA sequences. * HOXA10 is a key regulator of stem cell differentiation and proliferation.

Genular Protein ID: 177316000

Symbol: HXA10_HUMAN

Name: Homeobox protein Hox-A10

UniProtKB Accession Codes:

P31260 O43370 O43605 Q15949 Q504T1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 11 Ensembl 2 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 4 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1676505

Title: A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells.

PubMed ID: 1676505

DOI: 10.1093/nar/19.12.3443

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2573064

Title: Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines.

PubMed ID: 2573064

DOI: 10.1073/pnas.86.21.8536

PubMed ID: 2574852

Title: The human HOX gene family.

PubMed ID: 2574852

DOI: 10.1093/nar/17.24.10385

PubMed ID: 7906121

Title: Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype.

PubMed ID: 7906121

DOI: 10.1016/0006-2952(94)90447-2

PubMed ID: 15213244

Title: Human histone deacetylase SIRT2 interacts with the homeobox transcription factor HOXA10.

PubMed ID: 15213244

DOI: 10.1093/jb/mvh084

Sequence Information:

  • Length: 410
  • Mass: 42414
  • Checksum: E9544C35145FE7A4
  • Sequence:
    • MSARKGYLLP SPNYPTTMSC SESPAANSFL VDSLISSGRG EAGGGGGGAG GGGGGGYYAH 
GGVYLPPAAD LPYGLQSCGL FPTLGGKRNE AASPGSGGGG GGLGPGAHGY GPSPIDLWLD 
APRSCRMEPP DGPPPPPQQQ PPPPPQPPQP APQATSCSFA QNIKEESSYC LYDSADKCPK 
VSATAAELAP FPRGPPPDGC ALGTSSGVPV PGYFRLSQAY GTAKGYGSGG GGAQQLGAGP 
FPAQPPGRGF DLPPALASGS ADAARKERAL DSPPPPTLAC GSGGGSQGDE EAHASSSAAE 
ELSPAPSESS KASPEKDSLG NSKGENAANW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY 
LTRERRLEIS RSVHLTDRQV KIWFQNRRMK LKKMNRENRI RELTANFNFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.