Details for: ANKRD34C

Gene ID: 390616

Symbol: ANKRD34C

Ensembl ID: ENSG00000235711

Description: ankyrin repeat domain 34C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.2452
    Cell Significance Index: 2.8600
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.1454
    Cell Significance Index: 1.6600
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: 0.1028
    Cell Significance Index: 1.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0571
    Cell Significance Index: 39.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0532
    Cell Significance Index: 10.6700
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.0464
    Cell Significance Index: 0.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0091
    Cell Significance Index: 3.2800
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0063
    Cell Significance Index: 0.0600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: 0.0055
    Cell Significance Index: 0.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0008
    Cell Significance Index: 1.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0009
    Cell Significance Index: -1.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0011
    Cell Significance Index: -2.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0012
    Cell Significance Index: -0.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0035
    Cell Significance Index: -1.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0042
    Cell Significance Index: -3.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0046
    Cell Significance Index: -3.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0057
    Cell Significance Index: -3.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0070
    Cell Significance Index: -3.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0109
    Cell Significance Index: -2.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0190
    Cell Significance Index: -3.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0202
    Cell Significance Index: -1.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0227
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0312
    Cell Significance Index: -3.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0325
    Cell Significance Index: -0.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0360
    Cell Significance Index: -2.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0425
    Cell Significance Index: -2.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0453
    Cell Significance Index: -2.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0459
    Cell Significance Index: -1.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0480
    Cell Significance Index: -1.6800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0528
    Cell Significance Index: -0.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0573
    Cell Significance Index: -3.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0599
    Cell Significance Index: -1.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0628
    Cell Significance Index: -3.1700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0630
    Cell Significance Index: -0.8500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0653
    Cell Significance Index: -0.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0675
    Cell Significance Index: -3.0600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0680
    Cell Significance Index: -1.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0685
    Cell Significance Index: -3.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0779
    Cell Significance Index: -2.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0811
    Cell Significance Index: -3.0700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0820
    Cell Significance Index: -1.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0824
    Cell Significance Index: -1.8100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0860
    Cell Significance Index: -0.6300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0914
    Cell Significance Index: -2.2800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0931
    Cell Significance Index: -1.0800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0986
    Cell Significance Index: -3.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1022
    Cell Significance Index: -2.7300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1047
    Cell Significance Index: -2.0700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1101
    Cell Significance Index: -1.4400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1129
    Cell Significance Index: -1.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1148
    Cell Significance Index: -3.0800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1151
    Cell Significance Index: -1.4000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1159
    Cell Significance Index: -1.3700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1170
    Cell Significance Index: -1.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1185
    Cell Significance Index: -3.4900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1207
    Cell Significance Index: -3.0800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1322
    Cell Significance Index: -1.6400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1325
    Cell Significance Index: -1.6000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1365
    Cell Significance Index: -1.9400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1365
    Cell Significance Index: -1.7300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1397
    Cell Significance Index: -3.3500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1404
    Cell Significance Index: -1.5200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1425
    Cell Significance Index: -2.8600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1426
    Cell Significance Index: -3.0800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1435
    Cell Significance Index: -1.4200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1437
    Cell Significance Index: -1.8600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1465
    Cell Significance Index: -1.8300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1488
    Cell Significance Index: -2.9100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1488
    Cell Significance Index: -1.6000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1550
    Cell Significance Index: -3.0500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1553
    Cell Significance Index: -3.3200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1581
    Cell Significance Index: -1.7500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1585
    Cell Significance Index: -2.0000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1593
    Cell Significance Index: -2.6800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1594
    Cell Significance Index: -1.6600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1610
    Cell Significance Index: -3.2100
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.1636
    Cell Significance Index: -1.7300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1657
    Cell Significance Index: -1.6900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1667
    Cell Significance Index: -1.4000
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.1703
    Cell Significance Index: -2.0200
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.1704
    Cell Significance Index: -1.9400
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1713
    Cell Significance Index: -1.8300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1730
    Cell Significance Index: -3.5200
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1788
    Cell Significance Index: -1.8600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1806
    Cell Significance Index: -1.8200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1822
    Cell Significance Index: -2.6900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1828
    Cell Significance Index: -2.5100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1852
    Cell Significance Index: -2.7000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1856
    Cell Significance Index: -2.2200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1857
    Cell Significance Index: -3.2100
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1880
    Cell Significance Index: -2.3600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1901
    Cell Significance Index: -2.7800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1909
    Cell Significance Index: -2.9000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1915
    Cell Significance Index: -2.0200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1926
    Cell Significance Index: -1.5900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1928
    Cell Significance Index: -2.5300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1939
    Cell Significance Index: -2.9500
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1959
    Cell Significance Index: -2.0700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1966
    Cell Significance Index: -1.7500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1979
    Cell Significance Index: -1.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ANKRD34C is a gene that belongs to the ankyrin repeat domain family, which is characterized by the presence of repetitive domains that facilitate protein-protein interactions. The gene is primarily expressed in progenitor cells, blood vessel endothelial cells, and other cell types involved in tissue development and maintenance. Notably, ANKRD34C is also expressed in cells of the immune system, including GABAergic interneurons in the cerebral cortex, which suggests a potential role in neuroimmunology. **Pathways and Functions:** ANKRD34C is involved in the regulation of cellular processes through its interactions with other proteins. One of the most significant pathways associated with ANKRD34C is the pi-body pathway, which is a complex network of RNA-binding proteins that regulate mRNA stability and translation. Pi-bodies are essential for the regulation of gene expression, and ANKRD34C is thought to play a crucial role in the formation and function of these complexes. In addition to its involvement in the pi-body pathway, ANKRD34C has been shown to regulate cellular processes such as cell proliferation, differentiation, and survival. The gene's expression in progenitor cells and stem cells suggests that ANKRD34C may play a role in tissue development and regeneration. **Clinical Significance:** The clinical significance of ANKRD34C is an area of ongoing research, but preliminary studies suggest that the gene may be involved in various diseases. For example, ANKRD34C has been implicated in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, where dysregulation of the pi-body pathway has been observed. Furthermore, ANKRD34C may also play a role in immune-related disorders, such as multiple sclerosis, where alterations in the expression of ANKRD34C have been detected. The gene's expression in goblet cells and intestinal epithelial cells suggests that ANKRD34C may also be involved in the regulation of the gut microbiome. **Conclusion:** In conclusion, ANKRD34C is a gene of emerging importance in immunology and beyond. Its unique expression patterns and involvement in various cellular processes make it an attractive target for further research. As we continue to unravel the mysteries of ANKRD34C, we may uncover new insights into the regulation of gene expression, tissue development, and disease pathogenesis. Further studies are needed to fully elucidate the clinical significance of ANKRD34C and its potential applications in medicine. **Recommendations:** Based on the current state of knowledge, I recommend that researchers continue to investigate the role of ANKRD34C in various diseases, including neurodegenerative disorders and immune-related conditions. Additionally, studies on the gene's expression in different tissues and cell types may provide further insights into its functions and potential applications. **Future Directions:** Future studies should focus on the following areas: 1. Elucidation of the molecular mechanisms underlying ANKRD34C's involvement in the pi-body pathway. 2. Investigation of the gene's expression in various diseases, including neurodegenerative disorders and immune-related conditions. 3. Exploration of ANKRD34C's potential as a therapeutic target for diseases characterized by dysregulation of the pi-body pathway. By continuing to explore the mysteries of ANKRD34C, we may uncover new insights into the regulation of gene expression and tissue development, ultimately leading to the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 876841853

Symbol: AN34C_HUMAN

Name: Ankyrin repeat domain-containing protein 34C

UniProtKB Accession Codes:

P0C6C1 H3BNM1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 EMBL 1 Ensembl 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

  • Length: 535
  • Mass: 58256
  • Checksum: 8B2757427F9F3686
  • Sequence:
    • MMDDDTELRT DGNSLLKAVW LGRLRLTRLL LEGGAYINES NDKGETALMV ACITKHVDQQ 
SISKSKMVKY LLDNRADPNI QDKSGKTALI HACIRRAGGE VVSLLLENGA DPSLEDRTGA 
SALVYAINAD DKDALKHLLD ACKAKGKEVI IITTDKSSSG TKTTKQYLNV PPSPKVEDRH 
SPPLCASPSD IELKALGLDS PLTEKEDDFF SLQAGHPSSC NTSKAVNEPG SPTRKVSNLK 
RARLPQLKRL QSEPWGLIAP SVLAASTRQD ETHGASTDNE VIKSISDISF PKRGPLSRTN 
SIDSKDPTLF HTVTEQVLKI PVSSAPASWK AAYEKGQAPH PRLARRGTLP VDQEKCGMGP 
SGPSALKEPA SLKWLENDLY DLDIQPGPDP PNSISLESGK GPLDRKKLNS SHLSLFHGSR 
ESLDTVPSTS PSSARRRPPH LLERRGSGTL LLDRISHTRP GFLPPLNVNL NPPIPDIRSS 
SKPSCSLASG LKSMVPVAPS SPKRVDLRSK KKLLRRHSMQ IEQMKQLSDF EEIMT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.