Details for: MAGEA8

Gene ID: 4107

Symbol: MAGEA8

Ensembl ID: ENSG00000156009

Description: MAGE family member A8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.4565
    Cell Significance Index: -0.6000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2760
    Cell Significance Index: 4.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1976
    Cell Significance Index: 2.8300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1014
    Cell Significance Index: 0.6300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0279
    Cell Significance Index: 0.3500
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.0136
    Cell Significance Index: 0.1300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0091
    Cell Significance Index: 0.1100
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.0038
    Cell Significance Index: 0.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0034
    Cell Significance Index: 0.1000
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.0033
    Cell Significance Index: 0.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0011
    Cell Significance Index: 0.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0006
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0004
    Cell Significance Index: 0.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0004
    Cell Significance Index: -0.0500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0008
    Cell Significance Index: -0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0008
    Cell Significance Index: -0.3700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0008
    Cell Significance Index: -0.0300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0015
    Cell Significance Index: -0.3100
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0021
    Cell Significance Index: -0.0200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0024
    Cell Significance Index: -0.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0025
    Cell Significance Index: -0.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0026
    Cell Significance Index: -0.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0030
    Cell Significance Index: -0.3700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0045
    Cell Significance Index: -0.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0046
    Cell Significance Index: -0.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0053
    Cell Significance Index: -0.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0062
    Cell Significance Index: -0.3800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0062
    Cell Significance Index: -0.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0064
    Cell Significance Index: -0.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0071
    Cell Significance Index: -0.0700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0082
    Cell Significance Index: -0.2600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0089
    Cell Significance Index: -0.0900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0090
    Cell Significance Index: -0.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0097
    Cell Significance Index: -0.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0118
    Cell Significance Index: -0.5200
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0121
    Cell Significance Index: -0.1400
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0122
    Cell Significance Index: -0.1300
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.0125
    Cell Significance Index: -0.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0132
    Cell Significance Index: -0.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0137
    Cell Significance Index: -0.4500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0140
    Cell Significance Index: -0.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0143
    Cell Significance Index: -0.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0158
    Cell Significance Index: -0.4500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0159
    Cell Significance Index: -0.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0161
    Cell Significance Index: -0.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0167
    Cell Significance Index: -0.4400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0188
    Cell Significance Index: -0.3700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0192
    Cell Significance Index: -0.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0195
    Cell Significance Index: -0.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0199
    Cell Significance Index: -0.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0203
    Cell Significance Index: -0.4300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0206
    Cell Significance Index: -0.3300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0207
    Cell Significance Index: -0.4100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0212
    Cell Significance Index: -0.2300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0213
    Cell Significance Index: -0.1400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0219
    Cell Significance Index: -0.4400
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0223
    Cell Significance Index: -0.2400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0228
    Cell Significance Index: -0.1600
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0231
    Cell Significance Index: -0.2100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0233
    Cell Significance Index: -0.1900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0235
    Cell Significance Index: -0.4600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0245
    Cell Significance Index: -0.3200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0249
    Cell Significance Index: -0.4300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0250
    Cell Significance Index: -0.3200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0254
    Cell Significance Index: -0.3200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0255
    Cell Significance Index: -0.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0263
    Cell Significance Index: -0.4400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0263
    Cell Significance Index: -0.3600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0264
    Cell Significance Index: -0.3300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0266
    Cell Significance Index: -0.2900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0267
    Cell Significance Index: -0.3600
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0269
    Cell Significance Index: -0.2500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0284
    Cell Significance Index: -0.2900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0289
    Cell Significance Index: -0.3400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0290
    Cell Significance Index: -0.3800
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0291
    Cell Significance Index: -0.2200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0293
    Cell Significance Index: -0.2900
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0293
    Cell Significance Index: -0.3400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0299
    Cell Significance Index: -0.4300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0303
    Cell Significance Index: -0.3200
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0309
    Cell Significance Index: -0.2200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0313
    Cell Significance Index: -0.3700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0314
    Cell Significance Index: -0.3700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0315
    Cell Significance Index: -0.3600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0315
    Cell Significance Index: -0.3800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0317
    Cell Significance Index: -0.3900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0318
    Cell Significance Index: -0.3700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0319
    Cell Significance Index: -0.3300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0320
    Cell Significance Index: -0.3500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0322
    Cell Significance Index: -0.4200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0324
    Cell Significance Index: -0.4300
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0328
    Cell Significance Index: -0.4200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0329
    Cell Significance Index: -0.3500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0330
    Cell Significance Index: -0.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAGEA8 is a non-coding gene, meaning that it does not encode a protein. However, its expression is regulated by histone deacetylase binding, a mechanism that allows it to control chromatin structure and transcriptional activity. MAGEA8 is also involved in negative regulation of transcription by RNA polymerase II, a process that ensures the proper expression of genes. Additionally, its protein binding capabilities suggest a role in protein-protein interactions, which could be important for regulating cellular processes. **Pathways and Functions:** MAGEA8 is involved in several biological pathways, including: 1. **Histone deacetylase binding**: MAGEA8 interacts with histone deacetylases, which are enzymes that remove acetyl groups from histones, leading to chromatin compaction and reduced gene expression. 2. **Negative regulation of transcription by RNA polymerase II**: MAGEA8 regulates the activity of RNA polymerase II, a key enzyme involved in transcription, by controlling the recruitment of RNA polymerase II to specific genomic regions. 3. **Cellular differentiation**: MAGEA8 is expressed in various cell types, including neuronal cells, suggesting a role in regulating cell differentiation and development. 4. **Immune regulation**: MAGEA8 has been implicated in immune regulation, possibly by controlling the expression of genes involved in immune response. **Clinical Significance:** MAGEA8 has been studied in the context of cancer, where its expression has been linked to tumor suppression. MAGEA8 is overexpressed in various types of cancer, including melanoma, lung cancer, and breast cancer. Its expression is often downregulated in tumor cells, suggesting a tumor suppressor function. Additionally, MAGEA8 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where its expression is altered in affected cells. Further studies are needed to fully understand the role of MAGEA8 in human disease and to explore its potential as a therapeutic target. In conclusion, MAGEA8 is a multifunctional gene involved in immune regulation, cell differentiation, and tumor suppression. Its expression is widespread in different cell types, and its regulatory mechanisms suggest a broad role in maintaining cellular homeostasis. Further studies are needed to fully understand the role of MAGEA8 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1432001321

Symbol: MAGA8_HUMAN

Name: Melanoma-associated antigen 8

UniProtKB Accession Codes:

P43361 Q9BUN9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 1 Ensembl 3 GO 3 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7927540

Title: Structure, chromosomal localization, and expression of 12 genes of the MAGE family.

PubMed ID: 7927540

DOI: 10.1007/bf01246677

Sequence Information:

  • Length: 318
  • Mass: 35215
  • Checksum: EA02C1FB42F6C080
  • Sequence:
    • MLLGQKSQRY KAEEGLQAQG EAPGLMDVQI PTAEEQKAAS SSSTLIMGTL EEVTDSGSPS 
PPQSPEGASS SLTVTDSTLW SQSDEGSSSN EEEGPSTSPD PAHLESLFRE ALDEKVAELV 
RFLLRKYQIK EPVTKAEMLE SVIKNYKNHF PDIFSKASEC MQVIFGIDVK EVDPAGHSYI 
LVTCLGLSYD GLLGDDQSTP KTGLLIIVLG MILMEGSRAP EEAIWEALSV MGLYDGREHS 
VYWKLRKLLT QEWVQENYLE YRQAPGSDPV RYEFLWGPRA LAETSYVKVL EHVVRVNARV 
RISYPSLHEE ALGEEKGV

Genular Protein ID: 1347493561

Symbol: B2R9W4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R9W4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 3 SAM 1 SMART 2

Sequence Information:

  • Length: 318
  • Mass: 35157
  • Checksum: ACD9ACBDA69887DD
  • Sequence:
    • MLLGQKSQRY KAEEGLQAQG EAPGLMDVQI PTAEEQKAAS SSSTLIMGTL EEVTDSGSPS 
PPQSPEGASS SLTVTDSTLW SQSGEGSSSN EEEGPSTSPD PAHLESLFRE ALDEKVAELV 
RFLLRKYQIK EPVTKAEMLE SVIKNYKNHF PDIFSKASEC MQVIFGIDVK EVDPAGHSYI 
LVTCLGLSYD GLLGDDQSTP KTGLLIIVLG MILMEGSRAP EEAIWEALSV MGLYDGREHS 
VYWKLRKLLT QEWVQENYLE YRQAPGSDPV RYEFLWGPRA LAETSYVKVL EHVVRVNARV 
RISYPSLHEE ALGEEKGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.