Details for: MAGEA11

Gene ID: 4110

Symbol: MAGEA11

Ensembl ID: ENSG00000185247

Description: MAGE family member A11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 3.1974
    Cell Significance Index: 29.9100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2480
    Cell Significance Index: 30.2300
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.9554
    Cell Significance Index: 1.2400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.6878
    Cell Significance Index: 5.9100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3038
    Cell Significance Index: 4.3500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1933
    Cell Significance Index: 1.7800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.1590
    Cell Significance Index: 1.5100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.1024
    Cell Significance Index: 2.6100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0589
    Cell Significance Index: 0.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0393
    Cell Significance Index: 2.0400
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.0356
    Cell Significance Index: 0.2200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0334
    Cell Significance Index: 0.5500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0287
    Cell Significance Index: 0.4200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0209
    Cell Significance Index: 0.1300
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.0167
    Cell Significance Index: 0.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0150
    Cell Significance Index: 0.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0127
    Cell Significance Index: 1.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0114
    Cell Significance Index: 0.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0094
    Cell Significance Index: 0.4400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0080
    Cell Significance Index: 0.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0075
    Cell Significance Index: 1.3500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0073
    Cell Significance Index: 0.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0044
    Cell Significance Index: 0.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0015
    Cell Significance Index: 0.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0015
    Cell Significance Index: 0.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0014
    Cell Significance Index: 0.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0009
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0005
    Cell Significance Index: -0.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0006
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0007
    Cell Significance Index: -0.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0008
    Cell Significance Index: -0.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0008
    Cell Significance Index: -0.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0010
    Cell Significance Index: -0.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0012
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0015
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0020
    Cell Significance Index: -0.4300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0024
    Cell Significance Index: -0.0400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0033
    Cell Significance Index: -0.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0040
    Cell Significance Index: -0.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0045
    Cell Significance Index: -0.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0046
    Cell Significance Index: -0.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0047
    Cell Significance Index: -0.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0048
    Cell Significance Index: -0.2400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0051
    Cell Significance Index: -0.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0057
    Cell Significance Index: -0.2100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0061
    Cell Significance Index: -0.4100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0063
    Cell Significance Index: -0.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0068
    Cell Significance Index: -0.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0073
    Cell Significance Index: -0.2100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0074
    Cell Significance Index: -0.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0078
    Cell Significance Index: -0.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0081
    Cell Significance Index: -0.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0097
    Cell Significance Index: -0.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0098
    Cell Significance Index: -0.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0103
    Cell Significance Index: -0.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0103
    Cell Significance Index: -0.1400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0115
    Cell Significance Index: -0.2300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0119
    Cell Significance Index: -0.1700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0124
    Cell Significance Index: -0.3100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0126
    Cell Significance Index: -0.2200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0135
    Cell Significance Index: -0.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0137
    Cell Significance Index: -0.3900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0140
    Cell Significance Index: -0.3500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0144
    Cell Significance Index: -0.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0148
    Cell Significance Index: -0.3100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0152
    Cell Significance Index: -0.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0152
    Cell Significance Index: -0.4000
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.0152
    Cell Significance Index: -0.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0153
    Cell Significance Index: -0.3300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0155
    Cell Significance Index: -0.3300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0158
    Cell Significance Index: -0.3800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0158
    Cell Significance Index: -0.2100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0162
    Cell Significance Index: -0.3200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0169
    Cell Significance Index: -0.3400
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0170
    Cell Significance Index: -0.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0173
    Cell Significance Index: -0.2900
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0177
    Cell Significance Index: -0.1700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0180
    Cell Significance Index: -0.1900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0182
    Cell Significance Index: -0.2400
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0182
    Cell Significance Index: -0.1800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0187
    Cell Significance Index: -0.3900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0187
    Cell Significance Index: -0.2600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0188
    Cell Significance Index: -0.2000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0190
    Cell Significance Index: -0.2300
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0192
    Cell Significance Index: -0.2000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0197
    Cell Significance Index: -0.2700
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0204
    Cell Significance Index: -0.3100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0205
    Cell Significance Index: -0.2600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0206
    Cell Significance Index: -0.2700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0207
    Cell Significance Index: -0.2700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0207
    Cell Significance Index: -0.3000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0207
    Cell Significance Index: -0.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAGEA11 is a transcription factor that belongs to the MAGE family of genes, which are known to be overexpressed in various cancers, including melanoma. The gene encodes a protein, MAGAB_HUMAN, which is characterized by its ability to bind to histone deacetylase (HDAC) and other proteins, thereby modulating gene expression. MAGEA11 is also involved in the regulation of transcription by RNA polymerase II, a key enzyme responsible for transcribing DNA into RNA. **Pathways and Functions:** MAGEA11 is involved in several cellular pathways, including: 1. **Negative regulation of transcription by RNA polymerase II**: MAGEA11 acts as a transcriptional repressor, influencing the expression of genes involved in cell growth, differentiation, and survival. 2. **Histone deacetylase binding**: MAGEA11 interacts with HDAC, modulating chromatin structure and gene expression. 3. **Nuclear body organization**: MAGEA11 is associated with nuclear bodies, which are dynamic structures involved in RNA processing and gene regulation. 4. **Protein binding**: MAGEA11 interacts with various proteins, including transcription factors, co-repressors, and histone-modifying enzymes. **Functions:** The MAGEA11 gene has been implicated in several cellular processes, including: 1. **Immune cell regulation**: MAGEA11 is expressed in immune cells, such as T cells and B cells, and influences their development and function. 2. **Epithelial cell differentiation**: MAGEA11 is involved in the differentiation of epithelial cells, which is crucial for maintaining tissue homeostasis. 3. **Neuronal development**: MAGEA11 is expressed in neurons and plays a role in their development and function, particularly in the context of GABAergic transmission. **Clinical Significance:** The MAGEA11 gene has been associated with various diseases, including: 1. **Cancer**: MAGEA11 is overexpressed in several types of cancer, including melanoma, and has been implicated in tumor progression and immune evasion. 2. **Autoimmune diseases**: MAGEA11 has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it may contribute to immune dysregulation. 3. **Neurological disorders**: MAGEA11 has been implicated in neurological disorders, such as Parkinson's disease and Alzheimer's disease, where it may play a role in neuronal development and function. In conclusion, the MAGEA11 gene is a complex transcription factor that plays a crucial role in regulating immune responses, cell proliferation, and differentiation. Its clinical significance is underscored by its association with various diseases, including cancer, autoimmune diseases, and neurological disorders. Further research is needed to fully elucidate the functions of MAGEA11 and its implications for human health and disease.

Genular Protein ID: 3126755915

Symbol: MAGAB_HUMAN

Name: Melanoma-associated antigen 11

UniProtKB Accession Codes:

P43364 Q5ETU4 Q6ZRZ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7927540

Title: Structure, chromosomal localization, and expression of 12 genes of the MAGE family.

PubMed ID: 7927540

DOI: 10.1007/bf01246677

PubMed ID: 15684378

Title: Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction.

PubMed ID: 15684378

DOI: 10.1128/mcb.25.4.1238-1257.2005

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28397838

Title: Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families.

PubMed ID: 28397838

DOI: 10.1038/mp.2017.60

Sequence Information:

  • Length: 429
  • Mass: 48129
  • Checksum: FB399ABF47B4C49B
  • Sequence:
    • METQFRRGGL GCSPASIKRK KKREDSGDFG LQVSTMFSED DFQSTERAPY GPQLQWSQDL 
PRVQVFREQA NLEDRSPRRT QRITGGEQVL WGPITQIFPT VRPADLTRVI MPLEQRSQHC 
KPEEGLQAQE EDLGLVGAQA LQAEEQEAAF FSSTLNVGTL EELPAAESPS PPQSPQEESF 
SPTAMDAIFG SLSDEGSGSQ EKEGPSTSPD LIDPESFSQD ILHDKIIDLV HLLLRKYRVK 
GLITKAEMLG SVIKNYEDYF PEIFREASVC MQLLFGIDVK EVDPTSHSYV LVTSLNLSYD 
GIQCNEQSMP KSGLLIIVLG VIFMEGNCIP EEVMWEVLSI MGVYAGREHF LFGEPKRLLT 
QNWVQEKYLV YRQVPGTDPA CYEFLWGPRA HAETSKMKVL EYIANANGRD PTSYPSLYED 
ALREEGEGV

Genular Protein ID: 2312028815

Symbol: G5E962_HUMAN

Name: N/A

UniProtKB Accession Codes:

G5E962

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 3 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 400
  • Mass: 44910
  • Checksum: D0BF361AF2D3D47C
  • Sequence:
    • MSKVSTMFSE DDFQSTERAP YGPQLQWSQD LPRVQVFREQ ANLEDRSPRR TQRITGGEQV 
LWGPITQIFP TVRPADLTRV IMPLEQRSQH CKPEEGLQAQ EEDLGLVGAQ ALQAEEQEAA 
FFSSTLNVGT LEELPAAESP SPPQSPQEES FSPTAMDAIF GSLSDEGSGS QEKEGPSTSP 
DLIDPESFSQ DILHDKIIDL VHLLLRKYRV KGLITKAEML GSVIKNYEDY FPEIFREASV 
CMQLLFGIDV KEVDPTSHSY VLVTSLNLSY DGIQCNEQSM PKSGLLIIVL GVIFMEGNCI 
PEEVMWEVLS IMGVYAGREH FLFGEPKRLL TQNWVQEKYL VYRQVPGTDP ACYEFLWGPR 
AHAETSKMKV LEYIANANGR DPTSYPSLYE DALREEGEGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.