Details for: MC5R

Gene ID: 4161

Symbol: MC5R

Ensembl ID: ENSG00000176136

Description: melanocortin 5 receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2787
    Cell Significance Index: 19.7100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1163
    Cell Significance Index: 1.6700
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.0788
    Cell Significance Index: 0.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0621
    Cell Significance Index: 1.3600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0372
    Cell Significance Index: 0.5900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0336
    Cell Significance Index: 0.4000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0316
    Cell Significance Index: 0.3000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0313
    Cell Significance Index: 0.3500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0133
    Cell Significance Index: 0.1900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0130
    Cell Significance Index: 0.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0106
    Cell Significance Index: 4.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0078
    Cell Significance Index: 0.4900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0020
    Cell Significance Index: 0.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0005
    Cell Significance Index: 0.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0004
    Cell Significance Index: 0.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0007
    Cell Significance Index: -0.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0007
    Cell Significance Index: -0.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0015
    Cell Significance Index: -0.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0019
    Cell Significance Index: -0.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0023
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0023
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0041
    Cell Significance Index: -0.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0042
    Cell Significance Index: -0.7500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0055
    Cell Significance Index: -0.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0064
    Cell Significance Index: -0.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0065
    Cell Significance Index: -0.9400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0071
    Cell Significance Index: -0.0900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0082
    Cell Significance Index: -0.1000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0096
    Cell Significance Index: -0.2400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0111
    Cell Significance Index: -0.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0117
    Cell Significance Index: -0.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0120
    Cell Significance Index: -0.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0134
    Cell Significance Index: -0.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0135
    Cell Significance Index: -0.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0146
    Cell Significance Index: -0.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0172
    Cell Significance Index: -1.0600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0173
    Cell Significance Index: -0.2000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0176
    Cell Significance Index: -0.3000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0181
    Cell Significance Index: -0.1200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0184
    Cell Significance Index: -0.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0185
    Cell Significance Index: -0.8700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0192
    Cell Significance Index: -0.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0196
    Cell Significance Index: -0.4100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0210
    Cell Significance Index: -0.3100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0221
    Cell Significance Index: -0.4700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0224
    Cell Significance Index: -0.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0238
    Cell Significance Index: -0.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0257
    Cell Significance Index: -0.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0267
    Cell Significance Index: -0.7700
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0270
    Cell Significance Index: -0.3000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0306
    Cell Significance Index: -0.3800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0308
    Cell Significance Index: -0.3400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0321
    Cell Significance Index: -0.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0327
    Cell Significance Index: -0.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0333
    Cell Significance Index: -0.9800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0343
    Cell Significance Index: -0.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0345
    Cell Significance Index: -0.9200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0347
    Cell Significance Index: -1.0200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0361
    Cell Significance Index: -0.7100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0361
    Cell Significance Index: -1.0300
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0367
    Cell Significance Index: -0.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0369
    Cell Significance Index: -0.9900
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.0369
    Cell Significance Index: -0.3600
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0371
    Cell Significance Index: -0.3600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0372
    Cell Significance Index: -0.3600
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0374
    Cell Significance Index: -0.3700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0376
    Cell Significance Index: -0.4500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0377
    Cell Significance Index: -0.9100
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0381
    Cell Significance Index: -0.3500
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0382
    Cell Significance Index: -0.4700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0386
    Cell Significance Index: -0.7700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0386
    Cell Significance Index: -0.4100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0392
    Cell Significance Index: -0.4900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0396
    Cell Significance Index: -0.4100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0405
    Cell Significance Index: -0.8000
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0408
    Cell Significance Index: -0.3900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0411
    Cell Significance Index: -0.3900
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.0412
    Cell Significance Index: -0.3600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0412
    Cell Significance Index: -0.8900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0412
    Cell Significance Index: -0.5500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0420
    Cell Significance Index: -0.4900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0427
    Cell Significance Index: -0.6400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0432
    Cell Significance Index: -0.5200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0436
    Cell Significance Index: -0.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0454
    Cell Significance Index: -0.8400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0460
    Cell Significance Index: -0.5600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0473
    Cell Significance Index: -0.7200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0475
    Cell Significance Index: -0.4900
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0475
    Cell Significance Index: -0.4900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0487
    Cell Significance Index: -0.7400
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0488
    Cell Significance Index: -0.5400
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0488
    Cell Significance Index: -0.5300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0492
    Cell Significance Index: -0.6800
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0497
    Cell Significance Index: -0.5700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0504
    Cell Significance Index: -0.6800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0507
    Cell Significance Index: -0.6400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0512
    Cell Significance Index: -0.8300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0512
    Cell Significance Index: -0.5600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0521
    Cell Significance Index: -0.7000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0525
    Cell Significance Index: -0.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G Protein-Coupled Receptor (GPCR) Structure**: The MC5R is a rhodopsin-like receptor, characterized by a characteristic 7-transmembrane domain structure. 2. **Melanocortin Peptide Binding**: The MC5R is activated by melanocortin peptides, such as alpha-melanocyte-stimulating hormone (α-MSH) and β-endorphin. 3. **Signaling Cascade**: The activation of MC5R triggers a signaling cascade that modulates adenylate cyclase activity, leading to changes in cyclic nucleotide levels. 4. **Expression in Immune Cells**: The MC5R is significantly expressed in microglial cells, which are resident immune cells in the brain, suggesting a potential role in immune regulation. **Pathways and Functions:** 1. **Adenylate Cyclase-Activating Signaling Pathway**: The activation of MC5R triggers the activation of adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels and modulating downstream signaling pathways. 2. **Metabolic Regulation**: The MC5R plays a role in regulating metabolic processes, including glucose and lipid metabolism, through its interaction with melanocortin peptides. 3. **Immune Response**: The MC5R is involved in regulating immune responses, including the modulation of cytokine production and immune cell activation, particularly in microglial cells. 4. **Neurotransmission**: The MC5R is also expressed in neurons and plays a role in regulating neurotransmission, particularly in the regulation of GABAergic neurotransmission. **Clinical Significance:** 1. **Metabolic Disorders**: Alterations in MC5R expression and function have been implicated in various metabolic disorders, including obesity, diabetes, and metabolic syndrome. 2. **Autoimmune Diseases**: The MC5R has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it regulates immune cell activation and cytokine production. 3. **Neurological Disorders**: The MC5R has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates neurotransmission and immune responses. 4. **Cancer**: The MC5R has been implicated in the regulation of cancer cell growth and metastasis, suggesting a potential role in cancer therapy. In conclusion, the melanocortin 5 receptor (MC5R) is a multifaceted gene that plays a crucial role in regulating various physiological processes, including metabolic function, immune response, and neurotransmission. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic interventions.

Genular Protein ID: 3699662096

Symbol: MC5R_HUMAN

Name: Melanocortin receptor 5

UniProtKB Accession Codes:

P33032 B0YJ34 Q502V1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 9 EMDB 2 Ensembl 2 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 2 PRINTS 4 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8396929

Title: Molecular cloning of a novel human melanocortin receptor.

PubMed ID: 8396929

DOI: 10.1006/bbrc.1993.2125

PubMed ID: 8179577

Title: Molecular cloning and characterization of the rat fifth melanocortin receptor.

PubMed ID: 8179577

DOI: 10.1006/bbrc.1994.1550

PubMed ID: 7739752

Title: Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype.

PubMed ID: 7739752

DOI: 10.1007/bf00995160

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9240466

Title: Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH.

PubMed ID: 9240466

DOI: 10.1006/bbrc.1997.6994

PubMed ID: 11286624

Title: Expression, candidate gene, and population studies of the melanocortin 5 receptor.

PubMed ID: 11286624

DOI: 10.1046/j.0022-202x.2001.01286.x

Sequence Information:

  • Length: 325
  • Mass: 36601
  • Checksum: 8BEC17E1BDA059BB
  • Sequence:
    • MNSSFHLHFL DLNLNATEGN LSGPNVKNKS SPCEDMGIAV EVFLTLGVIS LLENILVIGA 
IVKNKNLHSP MYFFVCSLAV ADMLVSMSSA WETITIYLLN NKHLVIADAF VRHIDNVFDS 
MICISVVASM CSLLAIAVDR YVTIFYALRY HHIMTARRSG AIIAGIWAFC TGCGIVFILY 
SESTYVILCL ISMFFAMLFL LVSLYIHMFL LARTHVKRIA ALPGASSARQ RTSMQGAVTV 
TMLLGVFTVC WAPFFLHLTL MLSCPQNLYC SRFMSHFNMY LILIMCNSVM DPLIYAFRSQ 
EMRKTFKEII CCRGFRIACS FPRRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.