Details for: MOS

Gene ID: 4342

Symbol: MOS

Ensembl ID: ENSG00000172680

Description: MOS proto-oncogene, serine/threonine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.9566
    Cell Significance Index: 49.8500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.7882
    Cell Significance Index: 28.9600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.0735
    Cell Significance Index: 18.3500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.6858
    Cell Significance Index: 9.4100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.5027
    Cell Significance Index: 5.3400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0572
    Cell Significance Index: 0.8300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0349
    Cell Significance Index: 0.5000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0272
    Cell Significance Index: 0.3300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0025
    Cell Significance Index: 0.0500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0019
    Cell Significance Index: 0.0300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0042
    Cell Significance Index: -0.8500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0043
    Cell Significance Index: -0.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0077
    Cell Significance Index: -0.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0102
    Cell Significance Index: -0.2200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0103
    Cell Significance Index: -0.1100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0104
    Cell Significance Index: -0.1100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0114
    Cell Significance Index: -0.1500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0116
    Cell Significance Index: -0.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0137
    Cell Significance Index: -0.9200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0156
    Cell Significance Index: -0.3400
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0162
    Cell Significance Index: -0.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0165
    Cell Significance Index: -0.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0193
    Cell Significance Index: -0.7300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0195
    Cell Significance Index: -0.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0205
    Cell Significance Index: -0.6700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0206
    Cell Significance Index: -0.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0207
    Cell Significance Index: -0.6100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0210
    Cell Significance Index: -0.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0224
    Cell Significance Index: -0.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0229
    Cell Significance Index: -0.7300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0247
    Cell Significance Index: -0.5400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0261
    Cell Significance Index: -0.6500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0269
    Cell Significance Index: -0.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0270
    Cell Significance Index: -0.7700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0332
    Cell Significance Index: -0.4000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0334
    Cell Significance Index: -0.8000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0361
    Cell Significance Index: -0.7100
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0366
    Cell Significance Index: -0.4000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0371
    Cell Significance Index: -0.4000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0389
    Cell Significance Index: -0.4600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0411
    Cell Significance Index: -0.3400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0442
    Cell Significance Index: -0.5200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0443
    Cell Significance Index: -0.4900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0464
    Cell Significance Index: -0.4000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0472
    Cell Significance Index: -0.5400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0472
    Cell Significance Index: -0.2800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0472
    Cell Significance Index: -0.4200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0475
    Cell Significance Index: -0.6200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0483
    Cell Significance Index: -0.6300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0483
    Cell Significance Index: -0.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0510
    Cell Significance Index: -0.4900
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0516
    Cell Significance Index: -0.6200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0517
    Cell Significance Index: -1.0100
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: -0.0520
    Cell Significance Index: -0.4000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0523
    Cell Significance Index: -0.5700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0601
    Cell Significance Index: -0.7100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0616
    Cell Significance Index: -0.6500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0623
    Cell Significance Index: -0.7400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0628
    Cell Significance Index: -0.5900
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.0632
    Cell Significance Index: -0.6900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0647
    Cell Significance Index: -0.6400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0652
    Cell Significance Index: -0.6100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0662
    Cell Significance Index: -0.7100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0662
    Cell Significance Index: -0.6400
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0665
    Cell Significance Index: -0.7300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0675
    Cell Significance Index: -0.6400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0675
    Cell Significance Index: -0.8300
  • Cell Name: basophil (CL0000767)
    Fold Change: -0.0685
    Cell Significance Index: -0.6300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0706
    Cell Significance Index: -0.7500
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0709
    Cell Significance Index: -0.8100
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0712
    Cell Significance Index: -0.6700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0719
    Cell Significance Index: -0.8600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0725
    Cell Significance Index: -0.7400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0734
    Cell Significance Index: -0.7400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0736
    Cell Significance Index: -0.4700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0737
    Cell Significance Index: -0.6700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0748
    Cell Significance Index: -1.0100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0759
    Cell Significance Index: -0.9100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0762
    Cell Significance Index: -0.6300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0767
    Cell Significance Index: -0.5900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0820
    Cell Significance Index: -1.0400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0840
    Cell Significance Index: -0.7400
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.0851
    Cell Significance Index: -0.8600
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0948
    Cell Significance Index: -0.6000
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0953
    Cell Significance Index: -0.5100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1045
    Cell Significance Index: -0.6800
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1054
    Cell Significance Index: -0.6600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1076
    Cell Significance Index: -1.0200
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.1134
    Cell Significance Index: -0.8700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1143
    Cell Significance Index: -1.0000
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: -0.1150
    Cell Significance Index: -0.7300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1311
    Cell Significance Index: -1.0200
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1324
    Cell Significance Index: -1.0000
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.1456
    Cell Significance Index: -1.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine/Threonine Kinase Activity:** MOS is a serine/threonine kinase that phosphorylates and regulates various substrates, including proteins involved in meiotic spindle organization and cell cycle progression. 2. **Meiotic Spindle Organization:** MOS is essential for the proper organization of the meiotic spindle, which is critical for the accurate segregation of chromosomes during meiosis. 3. **Oocyte Maturation:** MOS is involved in the regulation of oocyte maturation, a complex process that requires precise control of cell cycle progression and meiotic spindle organization. 4. **Cell Cycle Regulation:** MOS regulates the negative regulation of the metaphase/anaphase transition of the meiotic cell cycle, ensuring that chromosomes are properly segregated during meiosis. **Pathways and Functions:** 1. **MAPK Cascade:** MOS is a key regulator of the MAPK cascade, which is involved in the regulation of various cellular processes, including cell growth, differentiation, and survival. 2. **Meiotic Spindle Organization:** MOS is involved in the regulation of meiotic spindle organization, which is critical for the accurate segregation of chromosomes during meiosis. 3. **Chromatin Organization:** MOS regulates chromatin organization, which is essential for the proper expression of genes involved in meiotic spindle organization and cell cycle progression. 4. **Protein Autophosphorylation:** MOS undergoes protein autophosphorylation, which is a critical step in the activation of its kinase activity. **Clinical Significance:** 1. **Cancer:** Abnormal expression of MOS has been implicated in various cancers, including ovarian and breast cancer. 2. **Meiotic Disorders:** MOS dysfunction has been linked to meiotic disorders, including premature ovarian failure and infertility. 3. **Neurological Disorders:** MOS has been implicated in the regulation of oligodendrocyte maturation and myelination, which is critical for the proper functioning of the nervous system. 4. **Infectious Diseases:** MOS has been implicated in the regulation of immune responses, including the activation of immune cells and the production of cytokines. In conclusion, the MOS proto-oncogene is a critical regulator of meiotic spindle organization, oocyte maturation, and cell cycle progression. Its dysregulation has been implicated in various diseases, including cancer, meiotic disorders, and neurological disorders. Further research is needed to fully elucidate the functions of MOS and its role in human disease.

Genular Protein ID: 1959076384

Symbol: MOS_HUMAN

Name: Oocyte maturation factor mos

UniProtKB Accession Codes:

P00540 Q3KPG9 Q3KPH0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 5 Ensembl 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6287464

Title: Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus.

PubMed ID: 6287464

DOI: 10.1073/pnas.79.13.4078

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 34779126

Title: Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation.

PubMed ID: 34779126

DOI: 10.15252/emmm.202114887

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 36403623

Title: MOS mutation causes female infertility with large polar body oocytes.

PubMed ID: 36403623

DOI: 10.1080/09513590.2022.2147158

PubMed ID: 34997960

Title: Bi-allelic mutations in MOS cause female infertility characterized by preimplantation embryonic arrest.

PubMed ID: 34997960

DOI: 10.1093/humrep/deab281

PubMed ID: 35670744

Title: Biallelic variants in MOS cause large polar body in oocyte and human female infertility.

PubMed ID: 35670744

DOI: 10.1093/humrep/deac120

Sequence Information:

  • Length: 346
  • Mass: 37820
  • Checksum: 68B1AB906ED4B308
  • Sequence:
    • MPSPLALRPY LRSEFSPSVD ARPCSSPSEL PAKLLLGATL PRAPRLPRRL AWCSIDWEQV 
CLLQRLGAGG FGSVYKATYR GVPVAIKQVN KCTKNRLASR RSFWAELNVA RLRHDNIVRV 
VAASTRTPAG SNSLGTIIME FGGNVTLHQV IYGAAGHPEG DAGEPHCRTG GQLSLGKCLK 
YSLDVVNGLL FLHSQSIVHL DLKPANILIS EQDVCKISDF GCSEKLEDLL CFQTPSYPLG 
GTYTHRAPEL LKGEGVTPKA DIYSFAITLW QMTTKQAPYS GERQHILYAV VAYDLRPSLS 
AAVFEDSLPG QRLGDVIQRC WRPSAAQRPS ARLLLVDLTS LKAELG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.