Details for: MOS

Gene ID: 4342

Symbol: MOS

Ensembl ID: ENSG00000172680

Description: MOS proto-oncogene, serine/threonine kinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Unknown (CL0000003)
    Fold Change: 18.45
    Marker Score: 57013.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8271
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 5.06
    Marker Score: 32620
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 3.51
    Marker Score: 1942
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3177
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.62
    Marker Score: 10802
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7567
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3650
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.07
    Marker Score: 608
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32711
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.03
    Marker Score: 1417
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71807
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48043
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5339
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.81
    Marker Score: 475
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 742
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 405
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.69
    Marker Score: 363
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.57
    Marker Score: 1080
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.52
    Marker Score: 1063
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 201
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 285
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.41
    Marker Score: 238.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.38
    Marker Score: 6005
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.31
    Marker Score: 188.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.29
    Marker Score: 191
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.24
    Marker Score: 1449
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.19
    Marker Score: 92
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.18
    Marker Score: 89
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.15
    Marker Score: 174
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.15
    Marker Score: 47
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.13
    Marker Score: 42
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.11
    Marker Score: 47
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 43
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.09
    Marker Score: 96
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.09
    Marker Score: 184
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.07
    Marker Score: 121
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.06
    Marker Score: 36
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 50
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.05
    Marker Score: 41
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.05
    Marker Score: 57
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.05
    Marker Score: 90
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.04
    Marker Score: 34
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.04
    Marker Score: 42
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.04
    Marker Score: 443
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.04
    Marker Score: 41
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.04
    Marker Score: 45
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 86
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.03
    Marker Score: 40
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.03
    Marker Score: 43
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.03
    Marker Score: 41
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.03
    Marker Score: 42
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.02
    Marker Score: 40
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.02
    Marker Score: 43
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 23.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.01
    Marker Score: 32
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 53
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 32
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.01
    Marker Score: 45
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.01
    Marker Score: 29
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.01
    Marker Score: 41
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.01
    Marker Score: 55
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0
    Marker Score: 43
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0
    Marker Score: 44
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0
    Marker Score: 24
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0
    Marker Score: 45
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 39

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Other Information

**Key characteristics:** - The MOS proto-oncogene is located on chromosome 17q23.3 in humans. - It is a member of the MAPK family of kinases, which are involved in a wide range of cellular processes, including cell cycle regulation, differentiation, and apoptosis. - The MOS proto-oncogene is a key regulator of the oocyte maturation process. - It is required for the proper formation of the polar bodies, which are the structures that contain the egg and sperm in mammalian females. - Mutations in the MOS proto-oncogene have been linked to female infertility and cancer. **Pathways and functions:** - The MOS proto-oncogene is a key regulator of the MAPK cascade, a signaling pathway that is involved in cell cycle regulation, differentiation, and apoptosis. - Activation of the MAPK cascade by MOS is essential for the initiation of oocyte maturation. - The MAPK cascade is also involved in the regulation of the establishment of meiotic spindle orientation, which is the process by which the chromosomes align along the metaphase plate during cell division. - In addition to its role in oocyte maturation and spindle orientation, MOS is also involved in the regulation of other cellular processes, including cell cycle regulation, differentiation, and apoptosis. **Clinical significance:** Mutations in the MOS proto-oncogene have been linked to female infertility and cancer. In humans, mutations in MOS are responsible for causing a genetic disorder called dyskeratosis pigmentosa, which is characterized by skin and eye abnormalities. In addition, mutations in MOS have also been linked to the development of breast cancer, ovarian cancer, and other cancers.

Genular Protein ID: 1959076384

Symbol: MOS_HUMAN

Name: Oocyte maturation factor mos

UniProtKB Accession Codes:

P00540 Q3KPG9 Q3KPH0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 5 Ensembl 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6287464

Title: Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus.

PubMed ID: 6287464

DOI: 10.1073/pnas.79.13.4078

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 346
  • Mass: 37820
  • Checksum: 68B1AB906ED4B308
  • Sequence:
    • MPSPLALRPY LRSEFSPSVD ARPCSSPSEL PAKLLLGATL PRAPRLPRRL AWCSIDWEQV 
CLLQRLGAGG FGSVYKATYR GVPVAIKQVN KCTKNRLASR RSFWAELNVA RLRHDNIVRV 
VAASTRTPAG SNSLGTIIME FGGNVTLHQV IYGAAGHPEG DAGEPHCRTG GQLSLGKCLK 
YSLDVVNGLL FLHSQSIVHL DLKPANILIS EQDVCKISDF GCSEKLEDLL CFQTPSYPLG 
GTYTHRAPEL LKGEGVTPKA DIYSFAITLW QMTTKQAPYS GERQHILYAV VAYDLRPSLS 
AAVFEDSLPG QRLGDVIQRC WRPSAAQRPS ARLLLVDLTS LKAELG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.