Details for: KLK12

Gene ID: 43849

Symbol: KLK12

Ensembl ID: ENSG00000186474

Description: kallikrein related peptidase 12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5552
    Cell Significance Index: 70.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9534
    Cell Significance Index: 20.3100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8108
    Cell Significance Index: 19.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6694
    Cell Significance Index: 40.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6296
    Cell Significance Index: 568.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5841
    Cell Significance Index: 63.5400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.5671
    Cell Significance Index: 5.8500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.4901
    Cell Significance Index: 6.1900
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.4290
    Cell Significance Index: 3.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4165
    Cell Significance Index: 67.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3885
    Cell Significance Index: 5.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3234
    Cell Significance Index: 22.3700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.2968
    Cell Significance Index: 1.9700
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.2306
    Cell Significance Index: 2.4700
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 0.1947
    Cell Significance Index: 1.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1900
    Cell Significance Index: 36.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1741
    Cell Significance Index: 4.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0960
    Cell Significance Index: 9.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0850
    Cell Significance Index: 2.4500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0618
    Cell Significance Index: 0.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0299
    Cell Significance Index: 0.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0088
    Cell Significance Index: 4.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0047
    Cell Significance Index: 0.1700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0011
    Cell Significance Index: -0.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -2.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0020
    Cell Significance Index: -3.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0022
    Cell Significance Index: -3.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0030
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0042
    Cell Significance Index: -3.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0050
    Cell Significance Index: -3.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0074
    Cell Significance Index: -2.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0082
    Cell Significance Index: -3.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0108
    Cell Significance Index: -0.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0140
    Cell Significance Index: -2.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0142
    Cell Significance Index: -1.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0142
    Cell Significance Index: -2.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0144
    Cell Significance Index: -0.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0147
    Cell Significance Index: -4.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0149
    Cell Significance Index: -2.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0149
    Cell Significance Index: -2.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0151
    Cell Significance Index: -3.1900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0152
    Cell Significance Index: -0.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0158
    Cell Significance Index: -1.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0173
    Cell Significance Index: -1.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0208
    Cell Significance Index: -3.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0208
    Cell Significance Index: -0.8500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0209
    Cell Significance Index: -0.2200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0234
    Cell Significance Index: -0.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0242
    Cell Significance Index: -3.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0244
    Cell Significance Index: -2.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0260
    Cell Significance Index: -0.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0309
    Cell Significance Index: -3.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0339
    Cell Significance Index: -1.5800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.0349
    Cell Significance Index: -0.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0349
    Cell Significance Index: -4.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0388
    Cell Significance Index: -0.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0433
    Cell Significance Index: -1.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0464
    Cell Significance Index: -3.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0470
    Cell Significance Index: -3.1600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0511
    Cell Significance Index: -0.7700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0602
    Cell Significance Index: -0.7900
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0648
    Cell Significance Index: -0.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0738
    Cell Significance Index: -3.4700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0753
    Cell Significance Index: -1.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0825
    Cell Significance Index: -2.2100
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0869
    Cell Significance Index: -1.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0904
    Cell Significance Index: -5.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0912
    Cell Significance Index: -3.2000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0921
    Cell Significance Index: -1.0500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0975
    Cell Significance Index: -0.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0996
    Cell Significance Index: -3.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1031
    Cell Significance Index: -3.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1075
    Cell Significance Index: -2.9300
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1077
    Cell Significance Index: -0.8900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1111
    Cell Significance Index: -3.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1112
    Cell Significance Index: -4.9200
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.1117
    Cell Significance Index: -1.0100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1173
    Cell Significance Index: -1.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1182
    Cell Significance Index: -3.1600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1201
    Cell Significance Index: -1.7500
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.1221
    Cell Significance Index: -0.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1223
    Cell Significance Index: -2.6500
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.1237
    Cell Significance Index: -1.1800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1242
    Cell Significance Index: -1.4800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1261
    Cell Significance Index: -3.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1289
    Cell Significance Index: -4.8800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1307
    Cell Significance Index: -3.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1361
    Cell Significance Index: -2.9800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.1427
    Cell Significance Index: -1.4400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1450
    Cell Significance Index: -1.8400
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1484
    Cell Significance Index: -1.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1488
    Cell Significance Index: -4.2700
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1498
    Cell Significance Index: -1.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1534
    Cell Significance Index: -3.6800
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.1544
    Cell Significance Index: -1.3300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1546
    Cell Significance Index: -3.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1576
    Cell Significance Index: -3.3500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1610
    Cell Significance Index: -3.3600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1635
    Cell Significance Index: -3.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLK12 is a member of the kallikrein-related peptidase family, which comprises serine-type endopeptidases with similar substrate specificity. KLK12 shares a high degree of sequence homology with other KLK family members, such as KLK5 and KLK7, which are also involved in epithelial homeostasis and disease pathogenesis. KLK12 has a distinct tissue-specific expression profile, with highest expression levels in keratinocytes and enterocytes. The enzyme's substrate specificity and tissue distribution suggest that KLK12 plays a unique role in regulating epithelial cell functions. **Pathways and Functions:** KLK12 is involved in several cellular pathways, including: 1. **Peptidolysis**: KLK12 participates in the degradation of various peptides and proteins, which is essential for maintaining epithelial homeostasis and regulating cellular signaling pathways. 2. **Keratinization**: KLK12 is required for the formation of the cornified envelope, a complex structure composed of keratin filaments and other proteins. This process is critical for maintaining the integrity of the skin's outermost layer. 3. **Developmental biology**: KLK12 is expressed in embryonic tissues, including the cerebral cortex and forebrain radial glial cells, suggesting a role in neural development and patterning. 4. **Secretory granule**: KLK12 is localized to secretory granules in certain cells, such as GABAergic interneurons, indicating a role in neurotransmitter release and synaptic transmission. **Clinical Significance:** KLK12 has been implicated in several disease pathogenesis, including: 1. **Cancer**: Elevated KLK12 expression has been observed in various types of cancer, including breast, prostate, and colon cancer. KLK12's role in epithelial homeostasis and cancer progression is complex, with potential implications for tumor development and metastasis. 2. **Neurological disorders**: KLK12 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may contribute to neurodegeneration and synapse dysfunction. 3. **Inflammatory diseases**: KLK12 has been implicated in inflammatory diseases, such as atherosclerosis and inflammatory bowel disease, where it may regulate immune cell function and tissue remodeling. In conclusion, KLK12 is a serine-type peptidase involved in epithelial homeostasis and disease pathogenesis. Its unique tissue-specific expression profile and substrate specificity suggest a complex role in regulating cellular functions, including keratinization, peptidolysis, and neurotransmitter release. Further research is needed to elucidate the mechanisms by which KLK12 contributes to disease pathogenesis and to explore its potential as a therapeutic target.

Genular Protein ID: 1251290473

Symbol: KLK12_HUMAN

Name: Kallikrein-12

UniProtKB Accession Codes:

Q9UKR0 Q9UKR1 Q9UKR2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 Ensembl 5 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10652563

Title: Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4.

PubMed ID: 10652563

PubMed ID: 10675891

Title: The new human kallikrein gene family: implications in carcinogenesis.

PubMed ID: 10675891

DOI: 10.1016/s1043-2760(99)00225-8

PubMed ID: 11054574

Title: Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.

PubMed ID: 11054574

DOI: 10.1016/s0378-1119(00)00382-6

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

Sequence Information:

  • Length: 248
  • Mass: 26734
  • Checksum: BB473E98F8BAF703
  • Sequence:
    • MGLSIFLLLC VLGLSQAATP KIFNGTECGR NSQPWQVGLF EGTSLRCGGV LIDHRWVLTA 
AHCSGSRYWV RLGEHSLSQL DWTEQIRHSG FSVTHPGYLG ASTSHEHDLR LLRLRLPVRV 
TSSVQPLPLP NDCATAGTEC HVSGWGITNH PRNPFPDLLQ CLNLSIVSHA TCHGVYPGRI 
TSNMVCAGGV PGQDACQGDS GGPLVCGGVL QGLVSWGSVG PCGQDGIPGV YTYICKYVDW 
IRMIMRNN

Genular Protein ID: 2689676399

Symbol: B9EGA9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B9EGA9

Database IDs:

ARBA 1 AlphaFoldDB 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 5 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 138
  • Mass: 14183
  • Checksum: 780059A7626708DD
  • Sequence:
    • MALSVGVTHS RGRWGCLRAP ACAAGVSLLT TGGSSQRLTA AADPFPDLLQ CLNLSIVSHA 
TCHGVYPGRI TSNMVCAGGV PGQDACQGDS GGPLVCGGVL QGLVSWGSVG PCGQDGIPGV 
YTYICKYVDW IRMIMRNN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.