Details for: MTNR1B

Gene ID: 4544

Symbol: MTNR1B

Ensembl ID: ENSG00000134640

Description: melatonin receptor 1B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 7.56
    Marker Score: 4186
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.66
    Marker Score: 30036
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3174
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.12
    Marker Score: 4304
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.75
    Marker Score: 1562
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2221
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.96
    Marker Score: 1032
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.29
    Marker Score: 753
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.28
    Marker Score: 537
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7692
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.02
    Marker Score: 1931
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.99
    Marker Score: 653
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 497
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.85
    Marker Score: 1377
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.78
    Marker Score: 1592
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1178
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.67
    Marker Score: 1154
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.66
    Marker Score: 530
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.57
    Marker Score: 546
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.55
    Marker Score: 8614
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.47
    Marker Score: 284
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.4
    Marker Score: 390
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.33
    Marker Score: 355
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.32
    Marker Score: 151
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.32
    Marker Score: 655
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.22
    Marker Score: 199
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.2
    Marker Score: 69
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.19
    Marker Score: 166
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 81
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.18
    Marker Score: 195
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.14
    Marker Score: 107.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.13
    Marker Score: 66
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.12
    Marker Score: 140
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.11
    Marker Score: 141.5
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.11
    Marker Score: 60
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.11
    Marker Score: 296
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.11
    Marker Score: 71
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.1
    Marker Score: 23.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.09
    Marker Score: 535
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.09
    Marker Score: 362
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.08
    Marker Score: 150
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.08
    Marker Score: 37.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.07
    Marker Score: 24.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.06
    Marker Score: 267
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.06
    Marker Score: 20.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.06
    Marker Score: 47
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.06
    Marker Score: 94
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.06
    Marker Score: 28.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.06
    Marker Score: 23.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.05
    Marker Score: 126
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.05
    Marker Score: 15.5
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.05
    Marker Score: 25.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.05
    Marker Score: 52
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.05
    Marker Score: 22.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.05
    Marker Score: 89
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.05
    Marker Score: 146
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.05
    Marker Score: 25.5
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.05
    Marker Score: 45
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.04
    Marker Score: 17.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.04
    Marker Score: 13.5
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.04
    Marker Score: 22.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.04
    Marker Score: 16.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.03
    Marker Score: 23.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.03
    Marker Score: 117
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.03
    Marker Score: 24.5
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.02
    Marker Score: 30
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.02
    Marker Score: 85
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.02
    Marker Score: 24.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.02
    Marker Score: 19.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.02
    Marker Score: 40
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.02
    Marker Score: 20.5
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 45

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Other Information

**Key characteristics:** * MTNR1B is a transmembrane protein with seven transmembrane domains and a extracellular domain that is involved in protein-protein interactions. * It is expressed in a variety of cell types, including erythrocytes, progenitor cells, blood vessel endothelial cells, and immune cells. * MTNR1B is a negatively regulated protein, meaning that its expression is typically low in resting cells and is induced upon exposure to certain stimuli. * It is a key regulator of circadian sleep/wake cycles, regulating the release of melatonin, a hormone that helps to maintain sleep-wake rhythms. * It also plays a role in insulin secretion and the regulation of glucose homeostasis. **Pathways and functions:** * MTNR1B is involved in the regulation of the circadian sleep/wake cycle through its interaction with the circadian clock proteins, including period circadian protein (Per) and circadian clock protein-like 1 (CCK1). * It also regulates insulin secretion, glucose metabolism, and vasoconstriction. * In addition, MTNR1B has been shown to play a role in the development of the camera-type eye. **Clinical significance:** * Mutations in MTNR1B have been linked to a number of human diseases, including circadian sleep disorders, diabetes, and obesity. * MTNR1B is a potential target for the treatment of these diseases. **Overall, MTNR1B is a key regulator of circadian sleep/wake cycles, insulin secretion, and glucose homeostasis. Its dysfunction may contribute to the development of a variety of human diseases.**

Genular Protein ID: 3430100791

Symbol: MTR1B_HUMAN

Name: Melatonin receptor type 1B

UniProtKB Accession Codes:

P49286

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 2 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EMBL 4 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 7568007

Title: Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.

PubMed ID: 7568007

DOI: 10.1073/pnas.92.19.8734

PubMed ID: 10696804

Title: Genetic polymorphisms of human melatonin 1b receptor gene in circadian rhythm sleep disorders and controls.

PubMed ID: 10696804

DOI: 10.1016/s0304-3940(99)00981-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28827538

Title: Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions.

PubMed ID: 28827538

DOI: 10.1038/s41598-017-08996-7

PubMed ID: 31019305

Title: XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity.

PubMed ID: 31019305

DOI: 10.1038/s41586-019-1144-0

Sequence Information:

  • Length: 362
  • Mass: 40188
  • Checksum: EECD78649DD79121
  • Sequence:
    • MSENGSFANC CEAGGWAVRP GWSGAGSARP SRTPRPPWVA PALSAVLIVT TAVDVVGNLL 
VILSVLRNRK LRNAGNLFLV SLALADLVVA FYPYPLILVA IFYDGWALGE EHCKASAFVM 
GLSVIGSVFN ITAIAINRYC YICHSMAYHR IYRRWHTPLH ICLIWLLTVV ALLPNFFVGS 
LEYDPRIYSC TFIQTASTQY TAAVVVIHFL LPIAVVSFCY LRIWVLVLQA RRKAKPESRL 
CLKPSDLRSF LTMFVVFVIF AICWAPLNCI GLAVAINPQE MAPQIPEGLF VTSYLLAYFN 
SCLNAIVYGL LNQNFRREYK RILLALWNPR HCIQDASKGS HAEGLQSPAP PIIGVQHQAD 
AL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.