Details for: MTNR1B

Gene ID: 4544

Symbol: MTNR1B

Ensembl ID: ENSG00000134640

Description: melatonin receptor 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 9.1079
    Cell Significance Index: 232.0500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.2871
    Cell Significance Index: 56.1900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.0947
    Cell Significance Index: 28.7300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 1.7688
    Cell Significance Index: 18.7900
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.7204
    Cell Significance Index: 5.1900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4185
    Cell Significance Index: 6.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2360
    Cell Significance Index: 3.3800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1770
    Cell Significance Index: 2.5700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0849
    Cell Significance Index: 1.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0675
    Cell Significance Index: 1.6400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0424
    Cell Significance Index: 0.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0328
    Cell Significance Index: 1.4500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0265
    Cell Significance Index: 0.4300
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.0251
    Cell Significance Index: 0.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0228
    Cell Significance Index: 0.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0214
    Cell Significance Index: 0.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0069
    Cell Significance Index: 1.0100
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0038
    Cell Significance Index: 0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0018
    Cell Significance Index: 0.3700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0005
    Cell Significance Index: 0.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0004
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0008
    Cell Significance Index: -0.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0013
    Cell Significance Index: -0.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0014
    Cell Significance Index: -0.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0014
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0014
    Cell Significance Index: -0.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0014
    Cell Significance Index: -0.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0014
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0022
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0037
    Cell Significance Index: -0.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0045
    Cell Significance Index: -0.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0046
    Cell Significance Index: -0.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0051
    Cell Significance Index: -0.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0068
    Cell Significance Index: -0.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0071
    Cell Significance Index: -0.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0075
    Cell Significance Index: -0.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0102
    Cell Significance Index: -0.5700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0102
    Cell Significance Index: -0.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0104
    Cell Significance Index: -0.6400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0115
    Cell Significance Index: -0.1700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0118
    Cell Significance Index: -0.2300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0120
    Cell Significance Index: -0.1300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0127
    Cell Significance Index: -0.1200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0131
    Cell Significance Index: -0.2200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0160
    Cell Significance Index: -0.2700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0169
    Cell Significance Index: -0.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0180
    Cell Significance Index: -0.6300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0181
    Cell Significance Index: -0.2100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0183
    Cell Significance Index: -0.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0211
    Cell Significance Index: -0.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0217
    Cell Significance Index: -0.6900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0246
    Cell Significance Index: -0.6000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0263
    Cell Significance Index: -0.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0263
    Cell Significance Index: -0.7500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0265
    Cell Significance Index: -0.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0273
    Cell Significance Index: -0.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0273
    Cell Significance Index: -0.6800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0281
    Cell Significance Index: -0.5600
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0281
    Cell Significance Index: -0.2100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0282
    Cell Significance Index: -0.3400
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0296
    Cell Significance Index: -0.3000
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0299
    Cell Significance Index: -0.2700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0304
    Cell Significance Index: -0.6100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0304
    Cell Significance Index: -0.7300
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0305
    Cell Significance Index: -0.2800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0308
    Cell Significance Index: -0.4100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0313
    Cell Significance Index: -0.3900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0319
    Cell Significance Index: -0.6900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0324
    Cell Significance Index: -0.6400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0326
    Cell Significance Index: -0.3800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0341
    Cell Significance Index: -0.4300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0350
    Cell Significance Index: -0.7300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0352
    Cell Significance Index: -0.3600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0353
    Cell Significance Index: -0.4700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0358
    Cell Significance Index: -0.3900
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0368
    Cell Significance Index: -0.4500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0378
    Cell Significance Index: -0.6100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0382
    Cell Significance Index: -0.5000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0393
    Cell Significance Index: -0.6800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0393
    Cell Significance Index: -0.5300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0395
    Cell Significance Index: -0.7800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0403
    Cell Significance Index: -0.5000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0414
    Cell Significance Index: -0.5900
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.0418
    Cell Significance Index: -0.2000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0422
    Cell Significance Index: -0.4600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0435
    Cell Significance Index: -0.5600
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0438
    Cell Significance Index: -0.4800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0438
    Cell Significance Index: -0.5500
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0445
    Cell Significance Index: -0.5700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0446
    Cell Significance Index: -0.5600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0447
    Cell Significance Index: -0.6600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0452
    Cell Significance Index: -0.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The MTNR1B gene exhibits several key characteristics that underscore its significance: 1. **Expression in diverse cell types**: MTNR1B is expressed in a wide range of cell types, including erythrocytes, progenitor cells, and hematopoietic stem cells, suggesting its involvement in various physiological processes. 2. **Melatonin receptor activity**: MTR1B is a melatonin receptor, which means it responds to melatonin, a hormone that regulates circadian rhythms and other physiological processes. 3. **G-protein coupled receptor activity**: MTR1B belongs to the G-protein coupled receptor family, which is involved in signal transduction and response to various ligands. 4. **Regulation of circadian sleep/wake cycle**: MTNR1B plays a crucial role in regulating the circadian sleep/wake cycle, particularly non-rapid eye movement (NREM) sleep. **Pathways and Functions:** The MTNR1B gene is involved in various signaling pathways and processes, including: 1. **G alpha (i) signaling events**: MTR1B is coupled to G alpha (i) proteins, which are involved in regulating cellular responses to melatonin. 2. **Chemical synaptic transmission**: MTNR1B is involved in regulating chemical synaptic transmission, which is essential for neuronal communication. 3. **Glucose homeostasis**: MTR1B regulates insulin secretion and glucose homeostasis, highlighting its role in maintaining energy balance. 4. **Negative regulation of various physiological processes**: MTNR1B negatively regulates various physiological processes, including cgmp-mediated signaling, cytosolic calcium ion concentration, insulin secretion, neuron apoptotic process, transmission of nerve impulse, vasoconstriction, and circadian sleep/wake cycle. **Clinical Significance:** The MTNR1B gene has significant clinical implications, particularly in relation to: 1. **Sleep disorders**: MTNR1B dysfunction has been implicated in various sleep disorders, including insomnia and narcolepsy. 2. **Circadian rhythm disorders**: MTNR1B plays a crucial role in regulating the circadian sleep/wake cycle, making it a potential therapeutic target for circadian rhythm disorders. 3. **Metabolic disorders**: MTR1B regulates glucose homeostasis, making it a potential therapeutic target for metabolic disorders, such as type 2 diabetes. 4. **Neurological disorders**: MTNR1B is involved in regulating neuronal communication and apoptosis, highlighting its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the MTNR1B gene is a vital component of the circadian clock system, playing a significant role in regulating sleep-wake cycles, glucose homeostasis, and various physiological processes. Further research is needed to fully understand the complex mechanisms underlying MTNR1B function and its clinical significance.

Genular Protein ID: 3430100791

Symbol: MTR1B_HUMAN

Name: Melatonin receptor type 1B

UniProtKB Accession Codes:

P49286

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 2 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EMBL 4 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 7568007

Title: Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.

PubMed ID: 7568007

DOI: 10.1073/pnas.92.19.8734

PubMed ID: 10696804

Title: Genetic polymorphisms of human melatonin 1b receptor gene in circadian rhythm sleep disorders and controls.

PubMed ID: 10696804

DOI: 10.1016/s0304-3940(99)00981-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28827538

Title: Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions.

PubMed ID: 28827538

DOI: 10.1038/s41598-017-08996-7

PubMed ID: 31019305

Title: XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity.

PubMed ID: 31019305

DOI: 10.1038/s41586-019-1144-0

Sequence Information:

  • Length: 362
  • Mass: 40188
  • Checksum: EECD78649DD79121
  • Sequence:
    • MSENGSFANC CEAGGWAVRP GWSGAGSARP SRTPRPPWVA PALSAVLIVT TAVDVVGNLL 
VILSVLRNRK LRNAGNLFLV SLALADLVVA FYPYPLILVA IFYDGWALGE EHCKASAFVM 
GLSVIGSVFN ITAIAINRYC YICHSMAYHR IYRRWHTPLH ICLIWLLTVV ALLPNFFVGS 
LEYDPRIYSC TFIQTASTQY TAAVVVIHFL LPIAVVSFCY LRIWVLVLQA RRKAKPESRL 
CLKPSDLRSF LTMFVVFVIF AICWAPLNCI GLAVAINPQE MAPQIPEGLF VTSYLLAYFN 
SCLNAIVYGL LNQNFRREYK RILLALWNPR HCIQDASKGS HAEGLQSPAP PIIGVQHQAD 
AL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.