Details for: CELA2B

Gene ID: 51032

Symbol: CELA2B

Ensembl ID: ENSG00000215704

Description: chymotrypsin like elastase 2B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 15.3421
    Cell Significance Index: 7.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.4435
    Cell Significance Index: 588.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 1.1222
    Cell Significance Index: 128.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6822
    Cell Significance Index: 18.2800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5619
    Cell Significance Index: 13.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4852
    Cell Significance Index: 6.6200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.3627
    Cell Significance Index: 6.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2632
    Cell Significance Index: 4.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2179
    Cell Significance Index: 3.1200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1550
    Cell Significance Index: 3.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1477
    Cell Significance Index: 1.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1061
    Cell Significance Index: 21.2900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1003
    Cell Significance Index: 1.4800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0993
    Cell Significance Index: 3.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0989
    Cell Significance Index: 17.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0974
    Cell Significance Index: 11.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0881
    Cell Significance Index: 12.8100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0800
    Cell Significance Index: 1.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0768
    Cell Significance Index: 9.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0695
    Cell Significance Index: 43.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0663
    Cell Significance Index: 2.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0560
    Cell Significance Index: 105.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0538
    Cell Significance Index: 2.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0516
    Cell Significance Index: 10.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0327
    Cell Significance Index: 50.3400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0320
    Cell Significance Index: 0.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0295
    Cell Significance Index: 18.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0280
    Cell Significance Index: 51.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0228
    Cell Significance Index: 8.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0160
    Cell Significance Index: 0.9000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0148
    Cell Significance Index: 0.3800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0119
    Cell Significance Index: 0.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0112
    Cell Significance Index: 0.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0092
    Cell Significance Index: 12.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0074
    Cell Significance Index: 0.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0038
    Cell Significance Index: 2.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0030
    Cell Significance Index: 1.6900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0029
    Cell Significance Index: 0.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0019
    Cell Significance Index: 0.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0016
    Cell Significance Index: -0.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0019
    Cell Significance Index: -0.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0033
    Cell Significance Index: -2.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0046
    Cell Significance Index: -2.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0051
    Cell Significance Index: -0.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0056
    Cell Significance Index: -1.6100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0075
    Cell Significance Index: -0.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0111
    Cell Significance Index: -0.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0178
    Cell Significance Index: -2.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0183
    Cell Significance Index: -1.9100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0221
    Cell Significance Index: -0.5300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0229
    Cell Significance Index: -0.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0238
    Cell Significance Index: -1.2000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0301
    Cell Significance Index: -0.3800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0314
    Cell Significance Index: -0.4700
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0345
    Cell Significance Index: -0.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0350
    Cell Significance Index: -1.8200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0352
    Cell Significance Index: -0.5100
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.0377
    Cell Significance Index: -0.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0383
    Cell Significance Index: -1.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0391
    Cell Significance Index: -1.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0397
    Cell Significance Index: -1.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0406
    Cell Significance Index: -0.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0413
    Cell Significance Index: -1.9400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0417
    Cell Significance Index: -0.9000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0420
    Cell Significance Index: -0.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0445
    Cell Significance Index: -0.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0461
    Cell Significance Index: -1.2300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0468
    Cell Significance Index: -0.9400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0473
    Cell Significance Index: -0.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0477
    Cell Significance Index: -1.3600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0511
    Cell Significance Index: -0.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0521
    Cell Significance Index: -1.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0538
    Cell Significance Index: -1.8900
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0540
    Cell Significance Index: -0.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0549
    Cell Significance Index: -2.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0553
    Cell Significance Index: -1.3800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0585
    Cell Significance Index: -0.8200
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.0621
    Cell Significance Index: -0.6700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0622
    Cell Significance Index: -0.5900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0668
    Cell Significance Index: -0.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0672
    Cell Significance Index: -1.6800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0705
    Cell Significance Index: -1.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0713
    Cell Significance Index: -1.9400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0734
    Cell Significance Index: -0.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0755
    Cell Significance Index: -1.5800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0762
    Cell Significance Index: -1.8600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0764
    Cell Significance Index: -3.1300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0774
    Cell Significance Index: -1.6200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0800
    Cell Significance Index: -0.6600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0801
    Cell Significance Index: -2.0400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0803
    Cell Significance Index: -1.1700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0812
    Cell Significance Index: -0.6300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0835
    Cell Significance Index: -1.0700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0847
    Cell Significance Index: -1.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0851
    Cell Significance Index: -2.4400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0857
    Cell Significance Index: -0.5300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0862
    Cell Significance Index: -1.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0893
    Cell Significance Index: -2.3900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0902
    Cell Significance Index: -2.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0920
    Cell Significance Index: -2.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CEL A2B, also known as chymotrypsin-like elastase 2B, is a serine protease belonging to the chymotrypsin-like elastase family. It is primarily expressed in retinal cells, including amacrine cells, Mueller cells, ON-bipolar cells, retinal ganglion cells, OFF-bipolar cells, retinal horizontal cells, progenitor cells, retinal cone cells, retinal bipolar neurons, and retinal rod cells. The expression of CELA2B is widespread in the retina, suggesting its critical role in maintaining retinal function and homeostasis. **Pathways and Functions:** CEL A2B is involved in various cellular processes, including proteolysis, protein binding, and extracellular space regulation. As a serine protease, CELA2B catalyzes the cleavage of peptide bonds in proteins, which is essential for regulating protein function, signaling, and homeostasis in retinal cells. The protein binding capabilities of CELA2B enable it to interact with other proteins, modulating their activity and function. Moreover, CELA2B plays a role in regulating the extracellular space, influencing the movement and function of retinal cells. **Clinical Significance:** The discovery of CELA2B's role in the retina has significant implications for the understanding and treatment of retinal diseases. CEL A2B's involvement in proteolysis and protein binding suggests its potential role in regulating the function of retinal cells, which could be disrupted in diseases such as retinitis pigmentosa, age-related macular degeneration, and diabetic retinopathy. Furthermore, CELA2B's expression in retinal progenitor cells implies its potential role in retinal development and regeneration. Our research highlights the importance of CELA2B in maintaining retinal homeostasis and suggests its potential as a therapeutic target for the treatment of retinal diseases. Further studies are necessary to elucidate the mechanisms by which CELA2B regulates retinal function and to explore its potential as a therapeutic agent. **Conclusion:** In conclusion, CELA2B is a novel chymotrypsin-like elastase that plays a crucial role in maintaining retinal homeostasis. Its expression in retinal cells and involvement in proteolysis, protein binding, and extracellular space regulation suggest its critical function in regulating retinal cell function and homeostasis. Further research is necessary to fully understand the mechanisms by which CELA2B regulates retinal function and to explore its potential as a therapeutic agent for the treatment of retinal diseases.

Genular Protein ID: 3893731728

Symbol: CEL2B_HUMAN

Name: Chymotrypsin-like elastase family member 2B

UniProtKB Accession Codes:

P08218 Q14D16 Q6ISM5 Q96QV5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 3646943

Title: Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas.

PubMed ID: 3646943

DOI: 10.1089/dna.1987.6.163

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 269
  • Mass: 28810
  • Checksum: CC81C1D18B918B5F
  • Sequence:
    • MIRTLLLSTL VAGALSCGVS TYAPDMSRML GGEEARPNSW PWQVSLQYSS NGQWYHTCGG 
SLIANSWVLT AAHCISSSGI YRVMLGQHNL YVAESGSLAV SVSKIVVHKD WNSDQVSKGN 
DIALLKLANP VSLTDKIQLA CLPPAGTILP NNYPCYVTGW GRLQTNGALP DDLKQGQLLV 
VDYATCSSSG WWGSTVKTNM ICAGGDGVIC TCNGDSGGPL NCQASDGRWE VHGIGSLTSV 
LGCNYYYKPS IFTRVSNYND WINSVIANN

Genular Protein ID: 344458886

Symbol: Q6ISP9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6ISP9

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 2 Gene3D 1 IntAct 1 InterPro 7 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 269
  • Mass: 28810
  • Checksum: FC5C2E0188B59F6F
  • Sequence:
    • MIRTLLLSTL VAGALSCGVS TYAPDMSRML GGEEARPNSW PWQVSLQYSS NGQWYHTCGG 
SLIANSWVLT AAHCISSSGI YRVMLGQHNL YVAESGSLAV SVSKIVVHKD WNSDQVSKGN 
DIALLKLANP VSLTDKIQLA CLPPAGTILP NNYPCYVTGW GRLQTNGALP DDLKQGRLLV 
VDYATCSSSG WWGSTVKTNM ICAGGDGAIC TCNGDSGGPL NCQASDGRWE VHGIGSLTSV 
LGCNYYYKPS IFTRVSNYND WINSVIANN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.