Details for: ST8SIA3

Gene ID: 51046

Symbol: ST8SIA3

Ensembl ID: ENSG00000177511

Description: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.8774
    Cell Significance Index: 127.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.5876
    Cell Significance Index: 97.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9158
    Cell Significance Index: 384.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.6831
    Cell Significance Index: 48.0300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.6733
    Cell Significance Index: 36.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2091
    Cell Significance Index: 26.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8829
    Cell Significance Index: 316.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8631
    Cell Significance Index: 39.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7782
    Cell Significance Index: 148.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7283
    Cell Significance Index: 23.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6334
    Cell Significance Index: 42.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3589
    Cell Significance Index: 324.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2692
    Cell Significance Index: 26.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1178
    Cell Significance Index: 19.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0809
    Cell Significance Index: 55.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0282
    Cell Significance Index: 5.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0027
    Cell Significance Index: -2.0100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0115
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0152
    Cell Significance Index: -9.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0228
    Cell Significance Index: -12.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0262
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0335
    Cell Significance Index: -7.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0442
    Cell Significance Index: -4.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0580
    Cell Significance Index: -1.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0661
    Cell Significance Index: -4.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0680
    Cell Significance Index: -11.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0770
    Cell Significance Index: -4.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0881
    Cell Significance Index: -25.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1286
    Cell Significance Index: -6.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1558
    Cell Significance Index: -2.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1756
    Cell Significance Index: -20.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2282
    Cell Significance Index: -15.7800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2821
    Cell Significance Index: -32.2000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2974
    Cell Significance Index: -3.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3150
    Cell Significance Index: -18.9100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3281
    Cell Significance Index: -3.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3343
    Cell Significance Index: -38.9600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3457
    Cell Significance Index: -6.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3824
    Cell Significance Index: -9.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4032
    Cell Significance Index: -12.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4629
    Cell Significance Index: -11.5700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4710
    Cell Significance Index: -11.4100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4834
    Cell Significance Index: -10.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5103
    Cell Significance Index: -10.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5417
    Cell Significance Index: -30.4000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.5817
    Cell Significance Index: -7.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5909
    Cell Significance Index: -20.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6109
    Cell Significance Index: -20.0000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6152
    Cell Significance Index: -12.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6240
    Cell Significance Index: -39.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7264
    Cell Significance Index: -18.1200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7549
    Cell Significance Index: -15.6600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.9367
    Cell Significance Index: -19.5500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.9954
    Cell Significance Index: -15.0000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.0225
    Cell Significance Index: -11.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.0398
    Cell Significance Index: -22.1500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -1.1405
    Cell Significance Index: -14.7900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -1.1516
    Cell Significance Index: -15.3500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.2519
    Cell Significance Index: -24.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.2928
    Cell Significance Index: -33.2300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -1.3600
    Cell Significance Index: -12.9400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -1.3756
    Cell Significance Index: -16.4500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.3783
    Cell Significance Index: -17.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.3838
    Cell Significance Index: -69.9400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.3875
    Cell Significance Index: -19.8700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.4239
    Cell Significance Index: -28.4000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.4412
    Cell Significance Index: -36.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.4531
    Cell Significance Index: -38.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.4628
    Cell Significance Index: -38.4700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -1.4835
    Cell Significance Index: -12.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.5141
    Cell Significance Index: -40.5700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.5540
    Cell Significance Index: -31.6200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.6159
    Cell Significance Index: -20.1500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -1.6511
    Cell Significance Index: -11.4500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.6842
    Cell Significance Index: -29.1200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.7006
    Cell Significance Index: -25.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.7261
    Cell Significance Index: -70.7300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -1.7651
    Cell Significance Index: -23.8200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.7807
    Cell Significance Index: -22.4700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.8163
    Cell Significance Index: -14.0000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.8351
    Cell Significance Index: -35.8800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.8786
    Cell Significance Index: -23.7100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -1.8851
    Cell Significance Index: -22.8500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.9366
    Cell Significance Index: -41.4000
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -1.9784
    Cell Significance Index: -20.3400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -1.9935
    Cell Significance Index: -22.6500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -2.0255
    Cell Significance Index: -27.0000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -2.0706
    Cell Significance Index: -30.1800
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -2.0856
    Cell Significance Index: -23.0100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -2.1282
    Cell Significance Index: -35.8500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -2.1573
    Cell Significance Index: -28.3100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -2.1670
    Cell Significance Index: -28.3400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -2.1882
    Cell Significance Index: -35.4400
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -2.2066
    Cell Significance Index: -23.8200
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -2.2233
    Cell Significance Index: -24.8700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -2.2298
    Cell Significance Index: -33.3600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -2.2428
    Cell Significance Index: -34.1200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -2.2758
    Cell Significance Index: -25.7100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -2.2887
    Cell Significance Index: -31.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.2888
    Cell Significance Index: -38.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme Activity:** ST8SIA3 is a type II transmembrane glycosyltransferase that exhibits alpha-2,8-sialyltransferase activity, meaning it transfers sialic acid residues to specific glycoproteins and glycosphingolipids. 2. **Cellular Expression:** ST8SIA3 is widely expressed in various cell types, including neurons, epithelial cells, immune cells, and specific neural populations such as medium spiny neurons and Purkinje cells. 3. **Substrate Specificity:** ST8SIA3 exhibits a broad substrate specificity, transferring sialic acid residues to a range of glycoproteins and glycosphingolipids, including gangliosides, glycoproteins, and glycosphingolipids. **Pathways and Functions:** 1. **Glycosphingolipid Biosynthesis:** ST8SIA3 plays a crucial role in the biosynthesis of glycosphingolipids, which are essential components of cell membranes and play a key role in cellular signaling and immune responses. 2. **Glycoprotein Metabolic Process:** ST8SIA3 is involved in the metabolic processing of glycoproteins, including the transfer of sialic acid residues, which modulates immune responses and cellular signaling. 3. **Sialylation:** ST8SIA3 catalyzes the transfer of sialic acid residues to specific glycoproteins and glycosphingolipids, thereby regulating immune responses and cellular signaling. 4. **N-Glycan Antennae Elongation:** ST8SIA3 is involved in the elongation of N-glycan antennae in the medial/trans-Golgi, which is a crucial step in the biosynthesis of glycoproteins. **Clinical Significance:** 1. **Neurological Disorders:** Abnormalities in ST8SIA3 expression and function have been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. 2. **Immunological Disorders:** ST8SIA3 plays a critical role in immune responses, and alterations in its expression and function have been linked to various immunological disorders, including rheumatoid arthritis and multiple sclerosis. 3. **Cancer:** ST8SIA3 has been identified as a potential biomarker for cancer diagnosis and prognosis, as its expression and function are altered in various types of cancer. 4. **Infectious Diseases:** ST8SIA3 has been implicated in the pathogenesis of infectious diseases, including influenza and HIV-1, as its expression and function are altered in response to infection. In conclusion, ST8SIA3 is a critical enzyme involved in the biosynthesis of glycosphingolipids and glycoproteins, and its dysregulation has been implicated in various neurological, immunological, and infectious diseases. Further research is necessary to fully elucidate the role of ST8SIA3 in human health and disease.

Genular Protein ID: 4197141161

Symbol: SIA8C_HUMAN

Name: Alpha-2,8-sialyltransferase 8C

UniProtKB Accession Codes:

O43173 A8K0F2 Q6B085 Q9NS41

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 37 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 14 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9826427

Title: Cloning and expression of cDNA for a human Sia alpha 2,3Gal beta 1,4GlcNA:alpha 2,8-sialyltransferase (hST8Sia III).

PubMed ID: 9826427

DOI: 10.1006/abbi.1998.0909

PubMed ID: 10766765

Title: Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha2,8-Sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III.

PubMed ID: 10766765

DOI: 10.1074/jbc.m910204199

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26192331

Title: Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation.

PubMed ID: 26192331

DOI: 10.1038/nsmb.3060

Sequence Information:

  • Length: 380
  • Mass: 43970
  • Checksum: 70D782A2CAD2666A
  • Sequence:
    • MRNCKMARVA SVLGLVMLSV ALLILSLISY VSLKKENIFT TPKYASPGAP RMYMFHAGFR 
SQFALKFLDP SFVPITNSLT QELQEKPSKW KFNRTAFLHQ RQEILQHVDV IKNFSLTKNS 
VRIGQLMHYD YSSHKYVFSI SNNFRSLLPD VSPIMNKHYN ICAVVGNSGI LTGSQCGQEI 
DKSDFVFRCN FAPTEAFQRD VGRKTNLTTF NPSILEKYYN NLLTIQDRNN FFLSLKKLDG 
AILWIPAFFF HTSATVTRTL VDFFVEHRGQ LKVQLAWPGN IMQHVNRYWK NKHLSPKRLS 
TGILMYTLAS AICEEIHLYG FWPFGFDPNT REDLPYHYYD KKGTKFTTKW QESHQLPAEF 
QLLYRMHGEG LTKLTLSHCA

Genular Protein ID: 2778525293

Symbol: Q59GW3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59GW3

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 2

Sequence Information:

  • Length: 489
  • Mass: 55199
  • Checksum: A75873445E9E14A5
  • Sequence:
    • AGGRGRTALR APSPRRRAAP PSSCSAPGPA RPCLRGPAAL RGSCQPQPPA PVASPHPRPG 
PPPPPHARAL THTHTHTHTH THTHIYTPAS CWPLNGPISP VSLNPAQPGM RNCKMARVAS 
VLGLVMLSVA LLILSLISYV SLKKENIFTT PKYASPGAPR MYMFHAGFRS QFALKFLDPS 
FVPITNSLTQ ELQEKPSKWK FNRTAFLHQR QEILQHVDVI KNFSLTKNSV RIGQLMHYDY 
SSHKYVFSIS NNFRSLLPDV SPIMNKHYNI CAVVGNSGIL TGSQCGQEID KSDFVFRCNF 
APTEAFQRDV GRKTNLTTFN PSILEKYYNN LLTIQDRNNF FLSLKKLDGA ILWIPAFFFH 
TSATVTRTLV DFFVEHRGQL KVQLAWPGNI MQHVNRYWKN KHLSPKRLST GILMYTLASA 
ICEEIHLYGF WPFGFDPNTR EDLPYHYYDK KGTKFTTKWQ ESHQLPAEFQ LLYRMHGEGL 
TKLTLSHCA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.