Gene PLCG2 - ENSG00000197943 | NCBI Gene ID: 5336

Details for: PLCG2

Gene ID: 5336

Symbol: PLCG2

Ensembl ID: ENSG00000197943

Description: phospholipase C gamma 2

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Dap12 interactions
(R-HSA-2172127)
Dap12 signaling
(R-HSA-2424491)
Dectin-2 family
(R-HSA-5621480)
Disease
(R-HSA-1643685)
Erythropoietin activates phospholipase c gamma (plcg)
(R-HSA-9027277)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Generation of second messenger molecules
(R-HSA-202433)
Gpvi-mediated activation cascade
(R-HSA-114604)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Inositol phosphate metabolism
(R-HSA-1483249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism
(R-HSA-1430728)
Parasitic infection pathways
(R-HSA-9824443)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Potential therapeutics for sars
(R-HSA-9679191)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Signaling by csf1 (m-csf) in myeloid cells
(R-HSA-9680350)
Signaling by erythropoietin
(R-HSA-9006335)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signal transduction
(R-HSA-162582)
Synthesis of ip3 and ip4 in the cytosol
(R-HSA-1855204)
Tcr signaling
(R-HSA-202403)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Viral infection pathways
(R-HSA-9824446)
B cell differentiation
(GO:0030183)
B cell receptor signaling pathway
(GO:0050853)
Calcium-mediated signaling
(GO:0019722)
Cell activation
(GO:0001775)
Fc-epsilon receptor signaling pathway
(GO:0038095)
Follicular b cell differentiation
(GO:0002316)
Inositol trisphosphate biosynthetic process
(GO:0032959)
Intracellular signal transduction
(GO:0035556)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Macrophage activation involved in immune response
(GO:0002281)
Negative regulation of programmed cell death
(GO:0043069)
Phosphatidylinositol-mediated signaling
(GO:0048015)
Phosphatidylinositol biosynthetic process
(GO:0006661)
Phosphatidylinositol metabolic process
(GO:0046488)
Phosphatidylinositol phospholipase c activity
(GO:0004435)
Phospholipase c activity
(GO:0004629)
Phospholipid catabolic process
(GO:0009395)
Phosphorylation-dependent protein binding
(GO:0140031)
Phosphotyrosine residue binding
(GO:0001784)
Platelet activation
(GO:0030168)
Positive regulation of calcium-mediated signaling
(GO:0050850)
Positive regulation of dendritic cell cytokine production
(GO:0002732)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of epithelial cell migration
(GO:0010634)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of interleukin-23 production
(GO:0032747)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of receptor internalization
(GO:0002092)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of type i interferon production
(GO:0032481)
Programmed cell death
(GO:0012501)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein tyrosine kinase binding
(GO:1990782)
Regulation of canonical nf-kappab signal transduction
(GO:0043122)
Regulation of lipid metabolic process
(GO:0019216)
Release of sequestered calcium ion into cytosol
(GO:0051209)
Response to axon injury
(GO:0048678)
Response to yeast
(GO:0001878)
Scaffold protein binding
(GO:0097110)
Stimulatory c-type lectin receptor signaling pathway
(GO:0002223)
T cell receptor signaling pathway
(GO:0050852)
Toll-like receptor signaling pathway
(GO:0002224)
Wnt signaling pathway
(GO:0016055)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 3.05
Marker Score: 3508
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.92
Marker Score: 1539
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.76
Marker Score: 1648
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.73
Marker Score: 93012
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.64
Marker Score: 56308
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.41
Marker Score: 4000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 2.25
Marker Score: 2233
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.24
Marker Score: 85032
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.23
Marker Score: 1108
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.2
Marker Score: 9116
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.16
Marker Score: 32340
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.09
Marker Score: 6191
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.06
Marker Score: 75918
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.05
Marker Score: 1012
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.04
Marker Score: 40490
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.01
Marker Score: 15370
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.96
Marker Score: 7565
Cell Name: centroblast (CL0009112)
Fold Change: 1.93
Marker Score: 950
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.87
Marker Score: 17620
Cell Name: renal principal cell (CL0005009)
Fold Change: 1.87
Marker Score: 1443
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.85
Marker Score: 3231
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.84
Marker Score: 113164
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.84
Marker Score: 5077
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.82
Marker Score: 1062
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.76
Marker Score: 556
Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.74
Marker Score: 502
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.74
Marker Score: 17614
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.73
Marker Score: 961
Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.7
Marker Score: 615
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.69
Marker Score: 16058
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.64
Marker Score: 14108
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.59
Marker Score: 955
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.55
Marker Score: 7606
Cell Name: podocyte (CL0000653)
Fold Change: 1.53
Marker Score: 566
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.52
Marker Score: 2349
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.49
Marker Score: 526
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.47
Marker Score: 82413
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.47
Marker Score: 3700
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167484
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.46
Marker Score: 457
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.43
Marker Score: 461.5
Cell Name: memory B cell (CL0000787)
Fold Change: 1.42
Marker Score: 1072
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 1.37
Marker Score: 1348
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.34
Marker Score: 808
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 1.34
Marker Score: 824
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 1.32
Marker Score: 1243
Cell Name: germinal center B cell (CL0000844)
Fold Change: 1.31
Marker Score: 795
Cell Name: centrocyte (CL0009111)
Fold Change: 1.3
Marker Score: 309
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.29
Marker Score: 3174
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.28
Marker Score: 3026
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 1.27
Marker Score: 457
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 1.27
Marker Score: 418
Cell Name: microglial cell (CL0000129)
Fold Change: 1.27
Marker Score: 2304
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 1.25
Marker Score: 1498
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.24
Marker Score: 467
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.24
Marker Score: 1246
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 1.22
Marker Score: 652
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 1.22
Marker Score: 336
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.18
Marker Score: 18436
Cell Name: B-1b B cell (CL0000821)
Fold Change: 1.18
Marker Score: 271
Cell Name: naive B cell (CL0000788)
Fold Change: 1.13
Marker Score: 1007
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.12
Marker Score: 766
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.11
Marker Score: 539
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.1
Marker Score: 2990
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.1
Marker Score: 2111
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.1
Marker Score: 4583
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 1.08
Marker Score: 283
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.07
Marker Score: 1519
Cell Name: immature B cell (CL0000816)
Fold Change: 1.06
Marker Score: 705
Cell Name: plasma cell (CL0000786)
Fold Change: 1.05
Marker Score: 1170
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 1.05
Marker Score: 2191
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.03
Marker Score: 2565.5
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 1.01
Marker Score: 363
Cell Name: plasmablast (CL0000980)
Fold Change: 1.01
Marker Score: 1340
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1
Marker Score: 3719
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71699
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47923
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1
Marker Score: 1446
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30393
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.96
Marker Score: 562
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.96
Marker Score: 1032
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.96
Marker Score: 330
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.95
Marker Score: 408
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2399
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 486
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 441
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.93
Marker Score: 349
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.92
Marker Score: 885
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.92
Marker Score: 863
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.92
Marker Score: 916
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2706
Cell Name: B cell (CL0000236)
Fold Change: 0.9
Marker Score: 856
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.89
Marker Score: 47181
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.89
Marker Score: 2814
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.89
Marker Score: 434
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.88
Marker Score: 942
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.88
Marker Score: 231
Cell Name: myelocyte (CL0002193)
Fold Change: 0.87
Marker Score: 378
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 314

Hover over a box to see details here...

**Key Characteristics** 1. **Phosphatidylinositol phospholipase C activity**: PLCG2 is a member of the phosphatidylinositol phospholipase C (PLC) family, which catalyzes the hydrolysis of PIP2 into DAG and IP3. 2. **Cellular localization**: PLCG2 is expressed in a wide range of cell types, including immune cells, endothelial cells, and neurons. 3. **Signaling pathways**: PLCG2 is involved in multiple signaling pathways, including calcium-mediated signaling, phosphatidylinositol-mediated signaling, and MAPK cascades. 4. **Regulation of immune responses**: PLCG2 plays a crucial role in regulating immune responses, including the activation of B cells, macrophages, and dendritic cells. **Pathways and Functions** 1. **Adaptive immune system**: PLCG2 is involved in the activation of B cells, which is essential for the development of immune responses against pathogens. 2. **Anti-inflammatory response**: PLCG2 can regulate anti-inflammatory responses by modulating the production of cytokines and other immune mediators. 3. **Calcium-mediated signaling**: PLCG2 is involved in calcium-mediated signaling, which is critical for the regulation of various cellular processes, including muscle contraction, cell proliferation, and differentiation. 4. **Phosphatidylinositol biosynthetic process**: PLCG2 is responsible for the hydrolysis of PIP2, which is a key step in the biosynthesis of phosphatidylinositol. **Clinical Significance** 1. **Immunodeficiency disorders**: Mutations in the PLCG2 gene have been associated with immunodeficiency disorders, highlighting the importance of PLCG2 in maintaining immune homeostasis. 2. **Infectious diseases**: PLCG2's involvement in regulating immune responses makes it a potential target for the treatment of infectious diseases, such as Leishmania parasite infections. 3. **Neurological disorders**: PLCG2's expression in neurons and its involvement in calcium-mediated signaling suggest its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Cancer**: PLCG2's involvement in cell signaling pathways makes it a potential target for the treatment of cancer. In conclusion, PLCG2 is a critical enzyme involved in various cellular signaling pathways, playing a pivotal role in regulating immune responses, cellular activation, and metabolic processes. Its clinical significance highlights its potential as a therapeutic target for the treatment of various diseases, including immunodeficiency disorders, infectious diseases, and neurological disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Phosphoinositide phospholipase C-gamma-2

Genular Protein ID: 4200598222

Symbol: PLCG2_HUMAN

Name: Phosphoinositide phospholipase C-gamma-2

UniProtKB Accession Codes:

P16885 D3DUL3 Q3ZTS2 Q59H45 Q969T5

Database IDs:

Citations:

PubMed ID: 2849563

Title: Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes.

PubMed ID: 2849563

DOI: 10.1016/0014-5793(88)80979-7

PubMed ID: 16533400

Title: NovelFam3000 -- uncharacterized human protein domains conserved across model organisms.

PubMed ID: 16533400

DOI: 10.1186/1471-2164-7-48

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11606584

Title: Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling.

PubMed ID: 11606584

DOI: 10.1074/jbc.m107577200

PubMed ID: 12181444

Title: Activation of phospholipase Cgamma2 by tyrosine phosphorylation.

PubMed ID: 12181444

DOI: 10.1124/mol.62.3.672

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23478294

Title: Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis.

PubMed ID: 23478294

DOI: 10.1038/cr.2013.33

PubMed ID: 22236196

Title: Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.

PubMed ID: 22236196

DOI: 10.1056/nejmoa1102140

PubMed ID: 23000145

Title: A hypermorphic missense mutation in PLCG2, encoding phospholipase Cgamma2, causes a dominantly inherited autoinflammatory disease with immunodeficiency.

PubMed ID: 23000145

DOI: 10.1016/j.ajhg.2012.08.006

PubMed ID: 24869598

Title: Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib.

PubMed ID: 24869598

DOI: 10.1056/nejmoa1400029

Sequence Information:

Length: 1265
Mass: 147870
Checksum: 1D56BCBF51D7A0D3
Sequence:

MSTTVNVDSL AEYEKSQIKR ALELGTVMTV FSFRKSTPER RTVQVIMETR QVAWSKTADK 
IEGFLDIMEI KEIRPGKNSK DFERAKAVRQ KEDCCFTILY GTQFVLSTLS LAADSKEDAV 
NWLSGLKILH QEAMNASTPT IIESWLRKQI YSVDQTRRNS ISLRELKTIL PLINFKVSSA 
KFLKDKFVEI GAHKDELSFE QFHLFYKKLM FEQQKSILDE FKKDSSVFIL GNTDRPDASA 
VYLHDFQRFL IHEQQEHWAQ DLNKVRERMT KFIDDTMRET AEPFLFVDEF LTYLFSRENS 
IWDEKYDAVD MQDMNNPLSH YWISSSHNTY LTGDQLRSES SPEAYIRCLR MGCRCIELDC 
WDGPDGKPVI YHGWTRTTKI KFDDVVQAIK DHAFVTSSFP VILSIEEHCS VEQQRHMAKA 
FKEVFGDLLL TKPTEASADQ LPSPSQLREK IIIKHKKLGP RGDVDVNMED KKDEHKQQGE 
LYMWDSIDQK WTRHYCAIAD AKLSFSDDIE QTMEEEVPQD IPPTELHFGE KWFHKKVEKR 
TSAEKLLQEY CMETGGKDGT FLVRESETFP NDYTLSFWRS GRVQHCRIRS TMEGGTLKYY 
LTDNLTFSSI YALIQHYRET HLRCAEFELR LTDPVPNPNP HESKPWYYDS LSRGEAEDML 
MRIPRDGAFL IRKREGSDSY AITFRARGKV KHCRINRDGR HFVLGTSAYF ESLVELVSYY 
EKHSLYRKMR LRYPVTPELL ERYNMERDIN SLYDVSRMYV DPSEINPSMP QRTVKALYDY 
KAKRSDELSF CRGALIHNVS KEPGGWWKGD YGTRIQQYFP SNYVEDISTA DFEELEKQII 
EDNPLGSLCR GILDLNTYNV VKAPQGKNQK SFVFILEPKQ QGDPPVEFAT DRVEELFEWF 
QSIREITWKI DTKENNMKYW EKNQSIAIEL SDLVVYCKPT SKTKDNLENP DFREIRSFVE 
TKADSIIRQK PVDLLKYNQK GLTRVYPKGQ RVDSSNYDPF RLWLCGSQMV ALNFQTADKY 
MQMNHALFSL NGRTGYVLQP ESMRTEKYDP MPPESQRKIL MTLTVKVLGA RHLPKLGRSI 
ACPFVEVEIC GAEYDNNKFK TTVVNDNGLS PIWAPTQEKV TFEIYDPNLA FLRFVVYEED 
MFSDPNFLAH ATYPIKAVKS GFRSVPLKNG YSEDIELASL LVFCEMRPVL ESEEELYSSC 
RQLRRRQEEL NNQLFLYDTH QNLRNANRDA LVKEFSVNEN QLQLYQEKCN KRLREKRVSN 
SKFYS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: PLCG2

Associated with

Cells (max top 100)

Other Information

Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes. PubMed ID: 2849563

NovelFam3000 -- uncharacterized human protein domains conserved across model organisms. PubMed ID: 16533400

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling. PubMed ID: 11606584

Activation of phospholipase Cgamma2 by tyrosine phosphorylation. PubMed ID: 12181444

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. PubMed ID: 15144186

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis. PubMed ID: 23478294

Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. PubMed ID: 22236196

A hypermorphic missense mutation in PLCG2, encoding phospholipase Cgamma2, causes a dominantly inherited autoinflammatory disease with immunodeficiency. PubMed ID: 23000145

Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib. PubMed ID: 24869598