Details for: PSG3

Gene ID: 5671

Symbol: PSG3

Ensembl ID: ENSG00000221826

Description: pregnancy specific beta-1-glycoprotein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.8041
    Cell Significance Index: 11.2100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.9688
    Cell Significance Index: 16.5600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8438
    Cell Significance Index: 20.4400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.7319
    Cell Significance Index: 9.4700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7314
    Cell Significance Index: 19.5300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5677
    Cell Significance Index: 7.7900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.3162
    Cell Significance Index: 1.4600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2615
    Cell Significance Index: 1.5800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2491
    Cell Significance Index: 3.6300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.1416
    Cell Significance Index: 1.3700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1355
    Cell Significance Index: 2.1500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.1211
    Cell Significance Index: 1.1500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0331
    Cell Significance Index: 0.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0237
    Cell Significance Index: 4.7500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0171
    Cell Significance Index: 0.2500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0166
    Cell Significance Index: 0.2300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0138
    Cell Significance Index: 0.6000
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.0111
    Cell Significance Index: 0.0800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0095
    Cell Significance Index: 0.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0055
    Cell Significance Index: 1.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0027
    Cell Significance Index: 0.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0027
    Cell Significance Index: 5.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0015
    Cell Significance Index: 2.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0013
    Cell Significance Index: 2.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0006
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0021
    Cell Significance Index: -1.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0023
    Cell Significance Index: -0.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0026
    Cell Significance Index: -1.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0027
    Cell Significance Index: -1.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0033
    Cell Significance Index: -2.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0043
    Cell Significance Index: -1.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0070
    Cell Significance Index: -1.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0071
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0073
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0076
    Cell Significance Index: -1.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0077
    Cell Significance Index: -0.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0082
    Cell Significance Index: -0.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0092
    Cell Significance Index: -1.2700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0102
    Cell Significance Index: -0.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0102
    Cell Significance Index: -0.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0111
    Cell Significance Index: -0.4200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0115
    Cell Significance Index: -0.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0118
    Cell Significance Index: -2.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0131
    Cell Significance Index: -1.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0134
    Cell Significance Index: -1.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0135
    Cell Significance Index: -0.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0169
    Cell Significance Index: -0.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0184
    Cell Significance Index: -2.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0185
    Cell Significance Index: -1.4200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0231
    Cell Significance Index: -0.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0247
    Cell Significance Index: -0.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0248
    Cell Significance Index: -0.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0257
    Cell Significance Index: -0.8200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0269
    Cell Significance Index: -0.3400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0324
    Cell Significance Index: -0.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0335
    Cell Significance Index: -1.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0338
    Cell Significance Index: -1.7100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0341
    Cell Significance Index: -0.4300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0365
    Cell Significance Index: -0.9100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0379
    Cell Significance Index: -0.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0381
    Cell Significance Index: -1.7900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0392
    Cell Significance Index: -1.1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0420
    Cell Significance Index: -1.5400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0430
    Cell Significance Index: -1.3600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0438
    Cell Significance Index: -0.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0441
    Cell Significance Index: -1.2000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0480
    Cell Significance Index: -0.9500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0506
    Cell Significance Index: -1.0000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0546
    Cell Significance Index: -1.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0571
    Cell Significance Index: -1.3700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0574
    Cell Significance Index: -1.1500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0575
    Cell Significance Index: -1.0000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0580
    Cell Significance Index: -0.9400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0622
    Cell Significance Index: -0.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0633
    Cell Significance Index: -1.3900
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0652
    Cell Significance Index: -0.4100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0689
    Cell Significance Index: -1.0000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0693
    Cell Significance Index: -1.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0707
    Cell Significance Index: -1.3800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0725
    Cell Significance Index: -1.7700
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0730
    Cell Significance Index: -0.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0733
    Cell Significance Index: -1.0000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0736
    Cell Significance Index: -2.1100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0737
    Cell Significance Index: -1.4400
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0740
    Cell Significance Index: -1.0400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0768
    Cell Significance Index: -0.9700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0810
    Cell Significance Index: -1.0100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0813
    Cell Significance Index: -1.2000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0821
    Cell Significance Index: -1.0300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0826
    Cell Significance Index: -1.3900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0841
    Cell Significance Index: -1.0900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0847
    Cell Significance Index: -1.0100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0878
    Cell Significance Index: -1.1700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0885
    Cell Significance Index: -0.9400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0891
    Cell Significance Index: -0.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0902
    Cell Significance Index: -1.5100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0920
    Cell Significance Index: -1.1200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0945
    Cell Significance Index: -1.2600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0951
    Cell Significance Index: -1.3300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0956
    Cell Significance Index: -1.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Tissue-Specific Expression:** PSG3 is predominantly expressed in female reproductive tissues, including the placenta, and in various cell types of the nervous system, such as retinal ganglion cells and bipolar neurons. 2. **Cell Surface Localization:** PSG3 is primarily membrane-bound, suggesting its involvement in cell-cell interactions and signaling. 3. **High Expression in Hematopoietic Cells:** PSG3 is significantly expressed in plasma cells, erythrocytes, and other hematopoietic cells, indicating its potential role in immune regulation and blood coagulation. 4. **Evolutionary Conservation:** PSG3 is highly conserved across species, suggesting its essential role in fundamental biological processes. **Pathways and Functions:** 1. **Cell Surface Interactions:** PSG3 interacts with various cell surface receptors, including protein tyrosine kinases, to modulate cell signaling and adhesion. 2. **Regulation of Immune System Processes:** PSG3 may influence immune cell function, including proliferation, differentiation, and cytokine production, thereby maintaining immune homeostasis. 3. **Hemostasis and Coagulation:** PSG3's expression in hematopoietic cells and endothelial cells suggests its involvement in blood coagulation and hemostasis. 4. **Signal Transduction:** PSG3 may act as a signal transducer, integrating extracellular and intracellular signals to regulate cellular responses. **Clinical Significance:** 1. **Pregnancy and Reproductive Health:** PSG3's expression in the placenta and reproductive tissues suggests its potential role in maintaining pregnancy and reproductive health. 2. **Immune Dysregulation:** Dysregulation of PSG3 expression or function may contribute to immune-related disorders, such as autoimmune diseases or immune-mediated cancers. 3. **Hemostatic Disorders:** Alterations in PSG3 expression or function may impact blood coagulation and hemostasis, leading to bleeding or thrombotic disorders. 4. **Cancer and Inflammation:** PSG3's involvement in immune regulation and signal transduction may also influence cancer development and inflammation, highlighting its potential as a therapeutic target. In conclusion, PSG3 is a multifunctional gene that plays a crucial role in immune regulation, hemostasis, and cellular signaling. Further research is necessary to elucidate the exact mechanisms by which PSG3 influences these processes and to explore its potential therapeutic applications in various diseases.

Genular Protein ID: 989383378

Symbol: PSG3_HUMAN

Name: Pregnancy-specific beta-1-glycoprotein 3

UniProtKB Accession Codes:

Q16557 Q08265 Q9BRW2 Q9UPL4 Q9UQ77

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2341148

Title: Structure, evolution and chromosomal localization of the human pregnancy-specific beta 1 glycoprotein gene family.

PubMed ID: 2341148

DOI: 10.1016/0888-7543(90)90492-d

PubMed ID: 2387594

Title:

PubMed ID: 2387594

DOI: 10.1016/0888-7543(90)90216-h

PubMed ID: 3265688

Title: Molecular cloning of a cDNA for human pregnancy-specific beta 1-glycoprotein: homology with human carcinoembryonic antigen and related proteins.

PubMed ID: 3265688

DOI: 10.1016/0378-1119(88)90061-3

PubMed ID: 2350345

Title: Carcinoembryonic antigen gene family members in submandibular salivary gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning.

PubMed ID: 2350345

DOI: 10.1016/0006-291x(90)91455-2

PubMed ID: 8487756

Title: Pregnancy specific beta 1-glycoprotein in human intestine.

PubMed ID: 8487756

DOI: 10.1007/bf00926089

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2302228

Title: Expression of the pregnancy-specific beta 1-glycoprotein genes in human testis.

PubMed ID: 2302228

DOI: 10.1016/0006-291x(90)90854-g

Sequence Information:

  • Length: 428
  • Mass: 47945
  • Checksum: 98750D7CDA426245
  • Sequence:
    • MGPLSAPPCT QRITWKGLLL TALLLNFWNL PTTAQVTIEA EPTKVSKGKD VLLLVHNLPQ 
NLAGYIWYKG QMKDLYHYIT SYVVDGQIII YGPAYSGRET VYSNASLLIQ NVTREDAGSY 
TLHIVKRGDG TRGETGHFTF TLYLETPKPS ISSSNLYPRE DMEAVSLTCD PETPDASYLW 
WMNGQSLPMT HSLQLSKNKR TLFLFGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLP 
KPYITINNLN PRENKDVLAF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV 
TRNETGPYQC EIQDRYGGIR SYPVTLNVLY GPDLPRIYPS FTYYHSGENL YLSCFADSNP 
PAEYSWTING KFQLSGQKLF IPQITTKHSG LYACSVRNSA TGMESSKSMT VKVSAPSGTG 
HLPGLNPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.