Details for: PSG5

Gene ID: 5673

Symbol: PSG5

Ensembl ID: ENSG00000204941

Description: pregnancy specific beta-1-glycoprotein 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 4.2057
    Cell Significance Index: 54.4200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.9611
    Cell Significance Index: 67.7100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 3.5221
    Cell Significance Index: 48.3000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.7950
    Cell Significance Index: 4.9400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6133
    Cell Significance Index: 14.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4891
    Cell Significance Index: 13.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3495
    Cell Significance Index: 5.9900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.3182
    Cell Significance Index: 3.3800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.2369
    Cell Significance Index: 2.6700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.1590
    Cell Significance Index: 1.5100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.1187
    Cell Significance Index: 1.7300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0813
    Cell Significance Index: 1.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0690
    Cell Significance Index: 43.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0158
    Cell Significance Index: 3.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0084
    Cell Significance Index: 0.9700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0072
    Cell Significance Index: 0.8200
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.0042
    Cell Significance Index: 0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0002
    Cell Significance Index: 0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0009
    Cell Significance Index: -1.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0017
    Cell Significance Index: -0.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0021
    Cell Significance Index: -2.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0042
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0045
    Cell Significance Index: -0.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0051
    Cell Significance Index: -0.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0053
    Cell Significance Index: -3.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0054
    Cell Significance Index: -2.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0071
    Cell Significance Index: -2.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0076
    Cell Significance Index: -3.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0147
    Cell Significance Index: -2.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0159
    Cell Significance Index: -2.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0162
    Cell Significance Index: -0.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0165
    Cell Significance Index: -1.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0179
    Cell Significance Index: -2.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0185
    Cell Significance Index: -0.9300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0190
    Cell Significance Index: -0.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0226
    Cell Significance Index: -3.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0246
    Cell Significance Index: -3.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0248
    Cell Significance Index: -3.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0251
    Cell Significance Index: -1.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0288
    Cell Significance Index: -3.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0318
    Cell Significance Index: -2.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0339
    Cell Significance Index: -1.1100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0343
    Cell Significance Index: -0.2800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0364
    Cell Significance Index: -1.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0415
    Cell Significance Index: -1.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0430
    Cell Significance Index: -2.0200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0435
    Cell Significance Index: -0.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0455
    Cell Significance Index: -3.3900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0492
    Cell Significance Index: -0.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0501
    Cell Significance Index: -3.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0518
    Cell Significance Index: -2.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0526
    Cell Significance Index: -2.9500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0580
    Cell Significance Index: -1.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0610
    Cell Significance Index: -2.3100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0618
    Cell Significance Index: -1.3400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0621
    Cell Significance Index: -1.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0629
    Cell Significance Index: -3.2700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0767
    Cell Significance Index: -1.5400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0850
    Cell Significance Index: -1.0300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0856
    Cell Significance Index: -1.0800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0863
    Cell Significance Index: -2.2000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0880
    Cell Significance Index: -1.7400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0947
    Cell Significance Index: -2.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0957
    Cell Significance Index: -2.7300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0960
    Cell Significance Index: -0.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1004
    Cell Significance Index: -2.6900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1038
    Cell Significance Index: -2.0700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1067
    Cell Significance Index: -2.1000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1092
    Cell Significance Index: -2.2800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1097
    Cell Significance Index: -2.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1097
    Cell Significance Index: -2.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1107
    Cell Significance Index: -2.9100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1148
    Cell Significance Index: -1.4500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1165
    Cell Significance Index: -1.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1217
    Cell Significance Index: -3.4900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1221
    Cell Significance Index: -1.3300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1227
    Cell Significance Index: -3.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1275
    Cell Significance Index: -3.7600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1299
    Cell Significance Index: -1.6200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1313
    Cell Significance Index: -2.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1326
    Cell Significance Index: -2.2200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1334
    Cell Significance Index: -2.1600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1352
    Cell Significance Index: -3.3000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1399
    Cell Significance Index: -0.8500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1511
    Cell Significance Index: -2.2600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1524
    Cell Significance Index: -2.0000
  • Cell Name: diffuse bipolar 4 cell (CL4033031)
    Fold Change: -0.1545
    Cell Significance Index: -1.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1580
    Cell Significance Index: -3.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1603
    Cell Significance Index: -4.4800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1671
    Cell Significance Index: -1.9500
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.1705
    Cell Significance Index: -1.5800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1726
    Cell Significance Index: -3.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1765
    Cell Significance Index: -4.5400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1797
    Cell Significance Index: -1.7100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1817
    Cell Significance Index: -2.5200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1843
    Cell Significance Index: -3.1000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1880
    Cell Significance Index: -3.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** PSG5 is significantly expressed in cells of the erythrocyte, glial cell, retinal ganglion cell, amacrine cell, OFF-bipolar cell, retinal cone cell, double negative thymocyte, blood vessel endothelial cell, hematopoietic stem cell, and trophoblast giant cell. This broad expression profile suggests a wide range of cellular functions and interactions. 2. **Cell Surface and Plasma Membrane Association:** PSG5 is primarily associated with the cell surface and plasma membrane, where it interacts with various cell adhesion molecules and receptors, influencing cellular behavior and communication. 3. **Glycoprotein Nature:** PSG5 is a glycoprotein, which implies that it contains carbohydrate moieties attached to its polypeptide chain. This feature is crucial for its interactions with other proteins and cells. **Pathways and Functions:** 1. **Hemostasis and Vascular Wall Interactions:** PSG5 is involved in hemostasis, which is the process of stopping bleeding after an injury. It interacts with endothelial cells and platelets, regulating blood coagulation and vascular integrity. 2. **Cell Surface Interactions:** PSG5 facilitates heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, enabling the formation of cell-cell junctions and modulating cellular behavior. 3. **Protein Binding:** PSG5 binds to various proteins, including cell surface receptors, influencing signaling pathways and cellular responses. 4. **Female Pregnancy:** PSG5 is specifically expressed during pregnancy, where it plays a crucial role in maintaining fetal development and placental function. **Clinical Significance:** 1. **Pregnancy-Related Disorders:** Abnormalities in PSG5 expression or function may contribute to pregnancy-related disorders, such as preeclampsia, gestational diabetes, and placental insufficiency. 2. **Hemostatic Disorders:** Alterations in PSG5-mediated hemostasis may lead to bleeding disorders, such as hemophilia, or thrombotic events, like deep vein thrombosis. 3. **Neurological Disorders:** PSG5's role in retinal cell development and function suggests that dysregulation of this gene may contribute to retinal diseases, such as age-related macular degeneration. 4. **Cancer and Immune System:** PSG5's involvement in immune cell development and function implies that its dysregulation may be linked to cancer and autoimmune diseases. In conclusion, PSG5 is a complex gene that plays a pivotal role in various biological processes, including pregnancy, hemostasis, and cellular interactions. Further research is essential to fully elucidate the functions and clinical significance of PSG5, ultimately enabling the development of targeted therapies for related disorders.

Genular Protein ID: 3794592329

Symbol: PSG5_HUMAN

Name: Pregnancy-specific beta-1-glycoprotein 5

UniProtKB Accession Codes:

Q15238 Q15239 Q96QJ1 Q9UQ75

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 5 Ensembl 3 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2789512

Title: A pregnancy-specific beta 1-glycoprotein, a CEA gene family member, expressed in a human promyelocytic leukemia cell line, HL-60: structures of protein, mRNA and gene.

PubMed ID: 2789512

DOI: 10.1016/0006-291x(89)92324-3

PubMed ID: 1922019

Title: Characterization of new members of the pregnancy-specific beta 1-glycoprotein family.

PubMed ID: 1922019

DOI: 10.1007/bf00230182

PubMed ID: 2735907

Title: Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS-beta-G/FL-NCA glycoprotein with a novel domain arrangement.

PubMed ID: 2735907

DOI: 10.1016/0006-291x(89)92631-4

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 335
  • Mass: 37713
  • Checksum: E14EA6E9DAA88296
  • Sequence:
    • MGPLSAPPCT QHITWKGLLL TASLLNFWNL PITAQVTIEA LPPKVSEGKD VLLLVHNLPQ 
NLAGYIWYKG QLMDLYHYIT SYVVDGQINI YGPAYTGRET VYSNASLLIQ NVTREDAGSY 
TLHIIKRGDR TRGVTGYFTF NLYLKLPKPY ITINNSKPRE NKDVLAFTCE PKSENYTYIW 
WLNGQSLPVS PRVKRPIENR ILILPSVTRN ETGPYECEIR DRDGGMRSDP VTLNVLYGPD 
LPSIYPSFTY YRSGENLYLS CFAESNPPAE YFWTINGKFQ QSGQKLSIPQ ITTKHRGLYT 
CSVRNSATGK ESSKSMTVEV SAPSGIGRLP LLNPI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.